Stereo Investigator®

The microscopic world just got a whole lot clearer for scientists around the world who use MBF Bioscience software. When images are magnified as intensely as they are in today's world of highly advanced scientific research, they don't always appear crystal clear. But by incorporating the clarifying process of deconvolution to microscopic images, previously hidden details emerge, allowing scientists to work with greater facility.   Deconvolution is...

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Stomach pain, heartburn, and head rushes are frequent complaints of patients suffering from long-term diabetes. Doctors usually blame these symptoms on autonomic neuropathy, a dysfunction of the nerves that regulate blood pressure, heart rate, and digestion. But there's really not all that much evidence out there to prove this diagnosis. Researchers at the University of Minnesota and Wake Forest University set out to discover the...

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Scientists who research genetic disorders might want to reconsider the way they transfer therapeutic genes to cells in the central nervous system.   Adeno-associated virus (AAV) vectors are the most common way to transfer DNA into neural cells because of their nonpathogenic nature and long-term transduction abilities. Specifically, researchers most frequently use AAV serotype 2 (AAV2). But scientists at the Yale University School of Medicine believe that...

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How do you find the volume of a sphere? It is a question that you’ve answered on math exams stretching all the way back to the sixth grade, but the formula eludes your brain. What is it that causes you to forget something that has been ingrained in your brain   Dr. John Morrison of Mount Sinai School of Medicine and Peter R. Rapp, PHD and other...

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History is being made at George Washington University’s Laboratory for Evolutionary Neuroanatomy, and Stereo Investigator is playing a part. Using Stereo Investigator to count neurons, estimate axon fiber length, and quantify cellular volumes, Dr. Chet C. Sherwood and his team are carrying out "detailed comparisons of neural phenotypes between humans and our closest relatives, the great apes."   A recent focus at the lab is the emergence...

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There may be more evidence that schizophrenia results from a combination of genetic and environmental factors. One of these hereditary influences may be an impaired ability to synthesize the antioxidant glutathione (GSH), which results in oxidative stress, according to a study conducted by scientists at the University of Lausanne in Switzerland.   By observing mice with a GSH deficit, Dr. Kim Q. Do and her team determined...

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Alzheimer's disease is the most common form of dementia. Most cases occur in people over 65, and are not genetically inherited. Roughly five percent of Alzheimer's patients suffer from familial Alzheimer's disease (FAD), an uncommon form that tends to strike sooner, and is related to a genetic predisposition - most commonly, a mutation in the presenilin 1 gene (PS1).   A recent study, led by Dr. Miguel...

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Thousands of people in the United States have spinal cord injuries (SCIs), with associated loss of movement and sensation below the site of the injury. Neural and glial cell transplants into research animals after SCI have correlated with recovery of function. The improvement may be caused by the transplanted cells; it’s thought that remyelination by the transplanted glial cells is the main reason for the...

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Stereo Investigator Pulmonary Edition, our latest stereology software solution, is designed specifically to assist pulmonary researchers with quantitative stereological analysis. Stereo Investigator Pulmonary Edition introduces the Connectivity Assay. Using live video superimposed over captured images, pulmonary researchers can quickly mark bridges and islands.   "Whether you’re counting alveoli or quantifying cells, lengths, or volumes, Stereo Investigator Pulmonary Edition’s intuitive workflow technology simplifies stereology," said MBF Bioscience President...

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  Stereology allows us to estimate the amount and size of biological features that are impossible or prohibitive to measure exhaustively. If the stereological probe is designed well, and we can manage to follow all the rules, bias due to sampling design and estimation methods will be eliminated, resulting in a more accurate estimate. For instance, when using the Optical Fractionator to estimate the number of cells...

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