Vesselucida Explorer is the analytical software companion for Vesselucida and Vesselucida 360 – engineered to perform extensive morphometric analyses on microvascular models and serial section reconstructions.
Dynamically visualize and comprehensively analyze vessels, puncta, and regions in an intuitive 3D environment while making quantitative measurements. Vesselucida Explorer is highly interactive, enabling researchers to explore their data models and export quantitative metrics generated directly from the models.
Comprehensive quantitative vascular and anatomical morphometric analysis
Understanding the vascular makeup of cerebral architecture or visceral organs is an integral part of uncovering mechanisms of disease and finding new treatments. With Vesselucida Explorer, you can quantify vascular morphology from vessel reconstruction data derived in Vesselucida 360 or Vesselucida.
Vesselucida Explorer is equipped with dozens of neuronal and regional analyses that are customizable to your specific research questions. We have removed the obstacles for rapid, high-volume, quantitative data analysis by programming all the complex morphological analyses, so you don’t have to.
Minimum System Requirements
Windows 10, 64-bit
Supported image file formats
XML, ASC, or DAT generated in Vesselucida 360 or Vesselucida
Tracing export formats
Data model: XML*, ASC, DAT, NRX
Images: TIFF, JPEG, PNG
Marker coordinates: TXT
* Our XML data file format, the Neuromorphological File Specification (NFS), was recently endorsed as a standard by the INCF.
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Jaffey, D. M., L. Chesney, et al. (2021). "Stomach serosal arteries distinguish gastric regions of the rat." Journal of Anatomy 239(4): 903-912. https://doi.org/10.1111/joa.13480
Gama Sosa, M. A., R. De Gasperi, et al. (2019). "Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain." Acta Neuropathologica Communications 7(1): 6. https://doi.org/10.1186/s40478-018-0647-5
Sullivan, A. E., S. J. Tappan, et al. (2021). "A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling." Neuroinformatics. https://doi.org/10.1007/s12021-021-09530-x
Gama Sosa, M. A., R. De Gasperi, et al. (2021). "Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation." Acta Neuropathologica Communications 9(1): 167. https://doi.org/10.1186/s40478-021-01269-5
Yao, Y., A. B. n. Taub, et al. (2021). "Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain." Nature Communications 12(1): 5643. https://doi.org/10.1038/s41467-021-25793-z
Button, E. B., Boyce, G. K., Wilkinson, A., Stukas, S., Hayat, A., Fan, J., . . . Wellington, C. L. (2019). ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice. Alzheimer's Research & Therapy, 11(1), 44. doi: 10.1186/s13195-019-0497-9. https://doi.org/10.1186/s13195-019-0497-9
Munarin, F., Kant, R. J., Rupert, C. E., Khoo, A., & Coulombe, K. L. K. (2020). Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts. Biomaterials, 120033. doi: https://doi.org/10.1016/j.biomaterials.2020.120033. http://www.sciencedirect.com/science/article/pii/S0142961220302799
Rountree, I., Polucha, C., Coulombe, K. L. K., & Munarin, F. (2021). Assessing the angiogenic efficacy of pleiotrophin released from injectable heparin-alginate gels. Tissue Engineering Part A. doi: 10.1089/ten.TEA.2020.0335. https://doi.org/10.1089/ten.TEA.2020.0335
Download our product sheet here.
Vesselucida Explorer is used across the globe by the most prestigious laboratories.
Vesselucida Explorer’s utility is underscored by the number of references it receives in the worlds most important scientific publications. See examples below:
Isobel Rountree, Collin Polucha, Kareen L.K. Coulombe, and Fabiola Munarin
Assessing the Angiogenic Efficacy of Pleiotrophin Released from Injectable Heparin-Alginate Gels. Tissue Engineering Part A.Jun 2021.703-713.http://doi.org/10.1089/ten.tea.2020.0335View Publication
Munarin, F., Kant, R. J., Rupert, C. E., Khoo, A., & Coulombe, K. L. K.
Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts. (2020). Biomaterials, 120033. doi: https://doi.org/10.1016/j.biomaterials.2020.120033.View Publication
Sullivan, A.E., Tappan, S.J., Angstman, P.J. et al.
A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling. Neuroinform (2021). https://doi.org/10.1007/s12021-021-09530-xView Publication
Jacobsen NL, Norton CE, Shaw RL, Cornelison DDW, Segal SS.
Myofibre injury induces capillary disruption and regeneration of disorganized microvascular networks. J Physiol. 2022 Jan;600(1):41-60. doi: 10.1113/JP282292. Epub 2021 Dec 8. PMID: 34761825; PMCID: PMC8965732.View Publication
Gama Sosa, M.A., De Gasperi, R., Pryor, D. et al.
Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation. acta neuropathol commun 9, 167 (2021). https://doi.org/10.1186/s40478-021-01269-5View Publication
Button, E.B., Boyce, G.K., Wilkinson, A. et al.
ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice. Alz Res Therapy 11, 44 (2019).View Publication
Vesselucida Explorer software is complimentary to the purchase of Vesselucida or Vesselucida 360 software. Additional licenses of Vesselucida Explorer sold separately.
Yes. Though Vesselucida Explorer can be directly launched from Vesselucida or Vesselucida 360 applications, the software can be installed separately on other computers in your lab to increase data generation and interpretation throughput.
With a click of a button, the tabular morphometric data generated by Vesselucida Explorer can be easily exported to Excel. For researchers who prefer to program custom analyses and operations, data can be exported as separate files for loading into other software such as Matlab, Python, or R.
MBF is proud to help bioscience leaders and experts push the next wave of innovation and discovery to benefit humanity. Given this, it’s possible you’re looking for customized technology for your needs. If that is the case, click here to get in touch with us directly. We’d be happy and honored to see if we can create something together that will move all of us forward.
Vesselucida Explorer is the analytical software companion for Vesselucida and Vesselucida 360. Researchers can use Vesselucida 360 or Vesselucida to generate vessel reconstructions and anatomical models from acquired image data or directly from slides at the microscope, respectively. Then you can leave the image data and microscope behind, and employ Vesselucida Explorer to quantify the Vesselucida 360 or Vesselucida -derived models.
All MBF Bioscience software comes with comprehensive, context-sensitive help guides accessible online or offline. All of the analysis available in Vesselucida Explorer have been fully documented in the product user-guide.
"I rarely have encountered a company so committed to support and troubleshooting as MBF."
"Vesselucida enables us to visualize and quantify microvascular networks in a way that has not been done before. The ability to render 3D maps is integral to analysis of network structure, remodeling and blood flow distribution."
"MBF Bioscience is extremely responsive to the needs of scientists and is genuinely interested in helping all of us in science do the best job we can."
"After examining different vessel quantification tools for use with neovessel formation in the heart, we chose to use Vesselucida 360 because it offered us flexibility in viewing and adjusting vessel geometries in 3D to accurately represent our microCT dataset. Also, the quantitative parameter extrapolation is excellent."
"I am so happy to be a customer of your company. I always get great help related with your product or not. With the experienced members, you are the best team I've ever met. All of your staff are very kind and helpful. Thank you for your great help and support all the time."
"We’ve been very happy for many years with MBF products and the course of upgrades and improvements. Your service department is outstanding. I have gotten great help from the staff with the software and hardware."
We offer both a free demonstration and a free trial copy of Vesselucida Explorer. During your demonstration you’ll have the opportunity to talk to us about your hardware, software, or experimental design questions with our team of Ph.D. neuroscientists and experts in microscopy, neuron tracing, and image processing.
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