Vesselucida®Explorer
A comprehensive solution for quantitative vascular morphometric analysisProduct Overview
Vesselucida Explorer is the analytical software companion for Vesselucida and Vesselucida 360 – engineered to perform extensive morphometric analyses on microvascular models and serial section reconstructions.
Dynamically visualize and comprehensively analyze vessels, puncta, and regions in an intuitive 3D environment while making quantitative measurements. Vesselucida Explorer is highly interactive, enabling researchers to explore their data models and export quantitative metrics generated directly from the models.
Key Benefits
- Sophisticated tools for morphometric analyses
- Trusted, accurate, reliable, and reproducible results
- Easily generate and export quantitative data
- Graphical 3D displays for intuitive visualization
- Generate publication-ready figures of vascular models
- Multi-file processing with batch analysis tools
Comprehensive quantitative vascular and anatomical morphometric analysis
Understanding the vascular makeup of cerebral architecture or visceral organs is an integral part of uncovering mechanisms of disease and finding new treatments. With Vesselucida Explorer, you can quantify vascular morphology from vessel reconstruction data derived in Vesselucida 360 or Vesselucida.
Vesselucida Explorer is equipped with dozens of neuronal and regional analyses that are customizable to your specific research questions. We have removed the obstacles for rapid, high-volume, quantitative data analysis by programming all the complex morphological analyses, so you don’t have to.
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Minimum System Requirements |
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Operating system |
Windows 10, 64-bit |
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Input Specifications |
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Supported image file formats |
XML, ASC, or DAT generated in Vesselucida 360 or Vesselucida |
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Output Specifications |
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Tracing export formats |
Data model: XML*, ASC, DAT, NRX Vector: SVG Images: TIFF, JPEG, PNG Marker coordinates: TXT |
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* Our XML data file format, the Neuromorphological File Specification (NFS), was recently endorsed as a standard by the INCF. |
Case Study
Vesselucida Helps Researchers at University of Missouri to Quantify Post-Injury Capillary Damage and Regeneration
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Case Study
New Therapy May Aid Heart Repair After Heart Attack
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Case Study
Scientists at Icahn School of Medicine at Mount Sinai use Vesselucida 360 to quantify brain vasculature in mTBI model
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Jaffey, D. M., L. Chesney, et al. (2021). "Stomach serosal arteries distinguish gastric regions of the rat." Journal of Anatomy 239(4): 903-912. https://doi.org/10.1111/joa.13480
Gama Sosa, M. A., R. De Gasperi, et al. (2019). "Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain." Acta Neuropathologica Communications 7(1): 6. https://doi.org/10.1186/s40478-018-0647-5
Sullivan, A. E., S. J. Tappan, et al. (2021). "A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling." Neuroinformatics. https://doi.org/10.1007/s12021-021-09530-x
Gama Sosa, M. A., R. De Gasperi, et al. (2021). "Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation." Acta Neuropathologica Communications 9(1): 167. https://doi.org/10.1186/s40478-021-01269-5
Yao, Y., A. B. n. Taub, et al. (2021). "Identification of the suprachiasmatic nucleus venous portal system in the mammalian brain." Nature Communications 12(1): 5643. https://doi.org/10.1038/s41467-021-25793-z
Button, E. B., Boyce, G. K., Wilkinson, A., Stukas, S., Hayat, A., Fan, J., . . . Wellington, C. L. (2019). ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice. Alzheimer's Research & Therapy, 11(1), 44. doi: 10.1186/s13195-019-0497-9. https://doi.org/10.1186/s13195-019-0497-9
Munarin, F., Kant, R. J., Rupert, C. E., Khoo, A., & Coulombe, K. L. K. (2020). Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts. Biomaterials, 120033. doi: https://doi.org/10.1016/j.biomaterials.2020.120033. http://www.sciencedirect.com/science/article/pii/S0142961220302799
Rountree, I., Polucha, C., Coulombe, K. L. K., & Munarin, F. (2021). Assessing the angiogenic efficacy of pleiotrophin released from injectable heparin-alginate gels. Tissue Engineering Part A. doi: 10.1089/ten.TEA.2020.0335. https://doi.org/10.1089/ten.TEA.2020.0335
Download our product sheet here.
Vesselucida Explorer: Key Features
Automatically quantify vessel network morphology
Use Vesselucida Explorer to comprehensively analyze whole vascular networks and generate reports for:
- Individual and Total Networks — Vessel name, number of endings, total length, total volume
- Nodes — Node diameter, volume, node coordinates
Vesselucida Explorer: Key Features
Identify and quantify vascular loops
With the anastomoses analysis, Vesselucida Explorer finds and analyses vascular loops for you:
- Anastomoses — User defined criteria, length, volume, average diameter, ability to navigate loops in 3D
Vesselucida Explorer: Key Features
Look deeper into vessel networks with segment analysis
- Segment Detail Report — Measurements about vessel segments including total length of the path used to trace the segment, average diameter, and tortuosity
- Contiguous Segments — Measurements of the average length and diameter of the path used to trace the contiguous segment
- Binned Segments — Analyze segments categorized by user defined vessel diameter
Vesselucida Explorer: Key Features
Visualize and quantify vascular densities and distributions
- Closed Surface Analysis: Measure neuronal processes within a 3D structure
- Convex Hull – Measure the size of the vascular network
- Colocalization — Determine a cell’s location based on multiple markers used in double labeling
- Marker and Regions Analyses — Analyze the distribution of cells and the size of organizations of regions within the tissue
Vesselucida Explorer: Key Features
Analyze punctate objects
Puncta analyses allow you to perform morphometric and quantitative measurements on the puncta that were detected in Vesselucida 360. The specific channels used for the detections are respected and can be used to compare the different populations of puncta to each other and to vessel structures. The analyses include area, volume, colocalization, nearest neighbor, distance to structures, and number of puncta in closed contours, closed surface and layers.
Vesselucida Explorer: Key Features
Batch analysis
Who Is Using Vesselucida Explorer?
Vesselucida Explorer is used across the globe by the most prestigious laboratories.
Cited in Peer Reviewed Scientific Publications
Vesselucida Explorer’s utility is underscored by the number of references it receives in the worlds most important scientific publications. See examples below:
Isobel Rountree, Collin Polucha, Kareen L.K. Coulombe, and Fabiola Munarin
Assessing the Angiogenic Efficacy of Pleiotrophin Released from Injectable Heparin-Alginate Gels. Tissue Engineering Part A.Jun 2021.703-713.http://doi.org/10.1089/ten.tea.2020.0335View Publication
Munarin, F., Kant, R. J., Rupert, C. E., Khoo, A., & Coulombe, K. L. K.
Engineered human myocardium with local release of angiogenic proteins improves vascularization and cardiac function in injured rat hearts. (2020). Biomaterials, 120033. doi: https://doi.org/10.1016/j.biomaterials.2020.120033.View Publication
Sullivan, A.E., Tappan, S.J., Angstman, P.J. et al.
A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling. Neuroinform (2021). https://doi.org/10.1007/s12021-021-09530-xView Publication
Jacobsen NL, Norton CE, Shaw RL, Cornelison DDW, Segal SS.
Myofibre injury induces capillary disruption and regeneration of disorganized microvascular networks. J Physiol. 2022 Jan;600(1):41-60. doi: 10.1113/JP282292. Epub 2021 Dec 8. PMID: 34761825; PMCID: PMC8965732.View Publication
Gama Sosa, M.A., De Gasperi, R., Pryor, D. et al.
Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation. acta neuropathol commun 9, 167 (2021). https://doi.org/10.1186/s40478-021-01269-5View Publication
Button, E.B., Boyce, G.K., Wilkinson, A. et al.
ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice. Alz Res Therapy 11, 44 (2019).View Publication
Frequently Asked Questions (FAQ)
Do I have to purchase Vesselucida 360 and Vesselucida Explorer separately?
Vesselucida Explorer software is complimentary to the purchase of Vesselucida or Vesselucida 360 software. Additional licenses of Vesselucida Explorer sold separately.
Can I install Vesselucida Explorer on a different computer than Vesselucida or Vesselucida 360?
Yes. Though Vesselucida Explorer can be directly launched from Vesselucida or Vesselucida 360 applications, the software can be installed separately on other computers in your lab to increase data generation and interpretation throughput.
Can I export Vesselucida Explorer-derived metrics?
With a click of a button, the tabular morphometric data generated by Vesselucida Explorer can be easily exported to Excel. For researchers who prefer to program custom analyses and operations, data can be exported as separate files for loading into other software such as Matlab, Python, or R.
Can I request a custom analysis that isn’t already included in the Vesselucida Explorer toolset?
MBF is proud to help bioscience leaders and experts push the next wave of innovation and discovery to benefit humanity. Given this, it’s possible you’re looking for customized technology for your needs. If that is the case, click here to get in touch with us directly. We’d be happy and honored to see if we can create something together that will move all of us forward.
What are the differences between Vesselucida 360 and Vesselucida Explorer?
Vesselucida Explorer is the analytical software companion for Vesselucida and Vesselucida 360. Researchers can use Vesselucida 360 or Vesselucida to generate vessel reconstructions and anatomical models from acquired image data or directly from slides at the microscope, respectively. Then you can leave the image data and microscope behind, and employ Vesselucida Explorer to quantify the Vesselucida 360 or Vesselucida -derived models.
Are there online resources to help me learn the software and better understand the analysis formulas in Vesselucida Explorer?
All MBF Bioscience software comes with comprehensive, context-sensitive help guides accessible online or offline. All of the analysis available in Vesselucida Explorer have been fully documented in the product user-guide.
Testimonials
"I rarely have encountered a company so committed to support and troubleshooting as MBF."
"Vesselucida enables us to visualize and quantify microvascular networks in a way that has not been done before. The ability to render 3D maps is integral to analysis of network structure, remodeling and blood flow distribution."
"MBF Bioscience is extremely responsive to the needs of scientists and is genuinely interested in helping all of us in science do the best job we can."
"After examining different vessel quantification tools for use with neovessel formation in the heart, we chose to use Vesselucida 360 because it offered us flexibility in viewing and adjusting vessel geometries in 3D to accurately represent our microCT dataset. Also, the quantitative parameter extrapolation is excellent."
"I am so happy to be a customer of your company. I always get great help related with your product or not. With the experienced members, you are the best team I've ever met. All of your staff are very kind and helpful. Thank you for your great help and support all the time."
"We’ve been very happy for many years with MBF products and the course of upgrades and improvements. Your service department is outstanding. I have gotten great help from the staff with the software and hardware."
Robust Professional Support
Our service sets us apart, with a team that includes Ph.D. neuroscientists, experts in microscopy, stereology, neuron tracing, and image processing. We’ve also developed a host of additional support services, including:
- Forums
We have over 25 active forums where open discussions take place.
>> Learn More - On-Site/Training
We’ve conducted over 750 remote software installations.
>> Learn More - Webinars
We’ve created over 55 webinars that demonstrate our products & their uses.
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Request an Expert Demonstration
We offer both a free demonstration and a free trial copy of Vesselucida Explorer. During your demonstration you’ll have the opportunity to talk to us about your hardware, software, or experimental design questions with our team of Ph.D. neuroscientists and experts in microscopy, neuron tracing, and image processing.
