Whole Brain Analysis

MBF Bioscience > Whole Brain Analysis


Whole brain analysis consists of analytical and graphical methods to study the anatomy and function of the brain and spinal cord in combination with the use of imaging, immunohistochemistry, molecular & optogenetics, stem cell and cellular biology, engineering, neurophysiology and nanotechnology. Techniques to analyze whole brain are constantly evolving, and rely on the development and refinement of microscopic and tomographic image acquisition, representation, analysis, visualization and interpretation techniques. 


MBF Bioscience has been a pioneer and leader in the field of whole brain analysis and neuroimaging since the invention by MBF Bioscience co-founder, Dr. Edmund Glaser, of the image combining computer microscope. MBF Bioscience continues the tradition of innovation by working collaboratively with scientists in research institutions around the world, including the National Institutes of Mental Health (NIMH), RIKEN, and the Allen Institute for Brain Research to develop and refine new whole brain analysis and neuroimaging techniques.

Fields Of Study

MBF Bioscience products are used for whole brain analysis in numerous ways, including the following:

Our Solutions for Whole Brain Analysis


BrainMaker automatically creates full-resolution, 3D reconstructions of the entire brain (or any organ) from serial sections of whole slide images.






NeuroInfo enables whole brain experimentation for laboratories of every size. Neuronal populations and circuits are automatically characterized in brain volumes and overlain with brain region delineations in a standardized reference space to provide visual and quantitative anatomic context.


Vesselucida® 360

Vesselucida 360 is designed to quickly segment and fully reconstruct vessels and microvasculature in 3D to obtain reliable data about the length, connections, and complexity of vessels and microvessels.


Neurolucida® 360

Neurolucida 360 is the premier tool used by neuroscientists to quickly and accurately reconstruct intricate neuronal structures that range in scale from complex, multicellular networks of neurons to sub-cellular dendritic spines and putative synapses.


The Neurolucida system is specifically designed for accurately tracing neuronal structures directly from histological specimens and generating quantitative morphometric data. Neuroscientists around the world trust Neurolucida as the gold standard for producing accurate anatomical models that can be quantitatively analyzed in hundreds of different ways to address perplexing biological questions.

Stereo Investigator®

A Stereo Investigator system provides you with accurate, unbiased estimates of the number, length, area, and volume of cells or biological structures in a tissue specimen. It is a key research tool that has led to advances in numerous areas of neuroscience including neurodegenerative diseases, neuropathy, memory, and behavior, as well as other research fields including pulmonary research, spinal cord research, and toxicology.

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At MBF, we’ve spent decades understanding the needs of researchers and their labs — and have a suite of products and solutions that have been specifically designed for the needs of today’s most important and advanced labs. Our commitment to you is to spend time with you discussing the needs of your lab — so that we can make sure the solutions we provide for you are exactly what you’ll need. It’s part of our commitment to supporting you — before, during, and after you’ve made your decision. We look forward to talking with you!