TissueMaker automatically creates full-resolution 3D reconstructions of entire organs or other structures from serial sections or whole slide images. Simply load high resolution images of serial sections acquired from a slide scanner or research microscope, then let the software do the work of automatically aligning sections and reconstructing the specimen in 3D.
With just a glance and full anatomical context, you can identify cells or structures that express a particular gene or visualize morphologies that span multiple individual fields of view. Use TissueMaker to assist you with cell mapping, cytoarchitectonics and other characteristics of organs or structures to create a comprehensive anatomical reference.
TissueMaker generates high-resolution 3D volume reconstructions from serial sections imaged using whole slide scanners and research microscopes. Load the images into TissueMaker and then direct your attention to other projects while TissueMaker automatically detects the individual sections on each slide, and then aligns the sections to create the full 3D organ reconstruction. Image features found in multiple serial sections are automatically aligned using innovative computational algorithms.
It's fast. And it's smart. If you mounted a section upside down, TissueMaker automatically corrects it during the alignment process. If additional adjustments need to be made to the automatic alignment, you can easily edit the 3D reconstruction.
|Minimum Hardware Requirements|
|64-bit Windows 10 operating system|
|Solid state drive(s)|
|NVIDIA 1060 graphics card (1060=6GB)|
Compatible image file formats: View PDF
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Download TissueMaker product sheet here.
TissueMaker is used across the globe by the most prestigious laboratories.
FOR IMMEDIATE RELEASE MBF Bioscience Williston, VT – January 9, 2019 – MBF Bioscience is pleased to announce our participation in the Stimulating
MBF’s software utility is underscored by the number of references it receives in the worlds most important scientific publications.
Sellinger, E. P., A. S. Brinks, et al.
Region- and age-specific effects of perinatal phthalate exposure on developmental cell death and adult anatomy of dorsal and ventral hippocampus and associated cognitive behaviorsView Publication
Muduli, N., S. Aparna, et al.
Saffron stigma extract and crocin play an important neuroprotective role in therapeutic measures against benzo[a]pyrene-induced behavioral alterations in zebrafishView Publication
Gergues, M. M., K. J. Han, et al.
“Circuit and molecular architecture of a ventral hippocampal network.”View Publication
Lindberg, P. T., J. W. Mitchell, et al.
“Pituitary Adenylate Cyclase-Activating Peptide (PACAP)-Glutamate Co-transmission Drives Circadian Phase-Advancing Responses to Intrinsically Photosensitive Retinal Ganglion Cell Projections by Suprachiasmatic Nucleus.”View Publication
TissueMaker works with images acquired from most slide scanners and research microscope imaging systems.
Any single-plane group of images will work, whether they come from a slide scanner, brightfield or fluorescence wide-field microscope or confocal. TissueMaker can convert your multiplane images encompassing your entire section depth to a max projection or extended depth of focus single-plane image (i.e. using our free software MicroFile+) for ulterior analysis with TissueMaker.
Absolutely. TissueMaker uses the shape and image information to do the alignment irrespectively of the tissue, species, sectioning orientation, markers or labels you are using.
Yes. TissueMaker uses the shape and image information across multiple sections to detect laterality and flip the sections to the right orientation.
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"MBF Bioscience is extremely responsive to the needs of scientists and is genuinely interested in helping all of us in science do the best job we can."
"I am so happy to be a customer of your company. I always get great help related with your product or not. With the experienced members, you are the best team I've ever met. All of your staff are very kind and helpful. Thank you for your great help and support all the time."
"We’ve been very happy for many years with MBF products and the course of upgrades and improvements. Your service department is outstanding. I have gotten great help from the staff with the software and hardware."
"Our experience with the MBF equipment and especially the MBF people has been outstanding. I cannot speak any higher about their professionalism and attention for our needs."
"MBF provides excellent technical support and helps you to find the best technical tools for your research challenges on morphometry."
We offer both a free demonstration and a free trial copy of TissueMaker. During your demonstration you’ll also have the opportunity to talk to us about your hardware, software, or experimental design questions with our team of Ph.D. neuroscientists and experts in microscopy, neuron tracing, and image processing.
Intelligent brain-wide cellular screening with anatomic specificity.
A fast, and versatile whole slide scanner for quantitative analysis.
Makes it easy to view, analyze, and share big image data from many sources.
Generates full-resolution 3D whole brain reconstructions from 2D whole slide images.