The SLAP2 is a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection two photon laser scanning microscopy that was recently developed by Dr. Kaspar Podgorski at the Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.
Build your own state-of-the-art 2-photon microscope using the complete set of components and parts, including comprehensive instructions, supplied with the SLAP2 kit.
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The game-changing innovation in the SLAP2 is the ability to perform unparalleled optical imaging of neuronal activity in populations of neurons at subcellular spatial resolution and temporal resolution in the millisecond range (i.e., at 1000 Hz and higher) both in vivo and in vitro using a variety of fluorescent indicators (e.g. voltage, neurotransmitter).
For the first time, this technology makes it possible to capture the dynamics of populations of neurons in vivo with millisecond temporal resolution and at least single-cell spatial resolution. This capability is critical for decoding how information is represented and processed by the billions of densely interconnected neurons comprising the mammalian CNS.
The neuroscience research implications of the SLAP2 are unprecedented. This novel microscope will enable groundbreaking optical imaging of neuronal activity in populations of neurons using fluorescent voltage indicators as well as fluorescent biosensors for neurotransmitters.
Kazemipour, A., Novak, O., Flickinger, D. et al. Author Correction: Kilohertz frame-rate two-photon tomography. Nat Methods 16, 932 (2019). https://doi.org/10.1038/s41592-019-0545-1
Download SLAP2 product sheet here.
MBF’s utility is underscored by the number of references it receives in the worlds most important scientific publications.
Zhang, L., L. Li, et al.
The C2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca2+-regulated exocytosisView Publication
Teixeira, L. L., H. M. Alencar, et al.
Oral Treatment with the Extract of Euterpe oleracea Mart. Improves Motor Dysfunction and Reduces Brain Injury in Rats Subjected to Ischemic StrokeView Publication
Tchantchou, F., R.-c. Hsia, et al.
Hippocampal vulnerability to hyperhomocysteinemia worsens pathological outcomes of mild traumatic brain injury in ratsView Publication
Vidyadhara, D. J., M. Somayaji, et al.
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s diseaseView Publication
Stevens, H. E., S. Scuderi, et al.
Neonatal loss of FGFR2 in astroglial cells affects locomotion, sociability, working memory, and glia-neuron interactions in miceView Publication
Ritzel, R. M., Y. Li, et al.
Brain injury accelerates the onset of a reversible age-related microglial phenotype associated with inflammatory neurodegenerationView Publication
Lim, J., H.-L. Lee, et al.
Adolescent exposure to low-dose Δ9-tetrahydrocannabinol (THC) depletes the ovarian reserve in female miceView Publication
Ferrer Ortas, J., P. Mahou, et al.
“Label-free imaging of red blood cells and oxygenation with color third-order sum-frequency generation microscopy.” Light: Science & ApplicationsView Publication
Lu, J., Behbahani, A.H., Hamburg, L. et al.
"Transforming representations of movement from body- to world-centric space."
MBF products are used across the globe by the most prestigious laboratories.
The MBF team has been highly receptive to the project needs and constantly strived to improve TissueMapper to enable smooth handling of large image stacks, in-depth annotation, and seamless mapping of external data sets onto a 3D map of the intrinsic cardiac nervous system. The all-around expertise of scientists and technologists at MBF was crucial to preprocess and assemble the large scale imaging data to jumpstart the 3D map building process. It is heartening to see MBF, a commercial entity, drive the development, standardization and dissemination of open data formats for complex anatomical annotation towards enabling friction-free exchange of these data sets in the scientific community.
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If you’re interested in building your own SLAP2 microscope, MBF Bioscience has everything you need! Contact us for more details.
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