The SLAP2 is a revolutionary new microscope based on a technological breakthrough called second-generation Scanned Line Angular Projection two photon laser scanning microscopy that was recently developed by Dr. Kaspar Podgorski at the Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA.
Build your own state-of-the-art 2-photon microscope using the complete set of components and parts, including comprehensive instructions, supplied with the SLAP2 kit.
If you would like to be added to the waiting list, then please fill out the webform below. We will contact you as soon as SLAP2 Kit becomes available.
The game-changing innovation in the SLAP2 is the ability to perform unparalleled optical imaging of neuronal activity in populations of neurons at subcellular spatial resolution and temporal resolution in the millisecond range (i.e., at 1000 Hz and higher) both in vivo and in vitro using a variety of fluorescent indicators (e.g. voltage, neurotransmitter).
For the first time, this technology makes it possible to capture the dynamics of populations of neurons in vivo with millisecond temporal resolution and at least single-cell spatial resolution. This capability is critical for decoding how information is represented and processed by the billions of densely interconnected neurons comprising the mammalian CNS.
The neuroscience research implications of the SLAP2 are unprecedented. This novel microscope will enable groundbreaking optical imaging of neuronal activity in populations of neurons using fluorescent voltage indicators as well as fluorescent biosensors for neurotransmitters.
Kazemipour, A., Novak, O., Flickinger, D. et al. Author Correction: Kilohertz frame-rate two-photon tomography. Nat Methods 16, 932 (2019). https://doi.org/10.1038/s41592-019-0545-1
Download SLAP2 product sheet here.
MBF’s utility is underscored by the number of references it receives in the worlds most important scientific publications.
Zhang, L., L. Li, et al.
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Tchantchou, F., R.-c. Hsia, et al.
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Vidyadhara, D. J., M. Somayaji, et al.
Dopamine transporter and synaptic vesicle sorting defects underlie auxilin-associated Parkinson’s diseaseView Publication
Stevens, H. E., S. Scuderi, et al.
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Ritzel, R. M., Y. Li, et al.
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Adolescent exposure to low-dose Δ9-tetrahydrocannabinol (THC) depletes the ovarian reserve in female miceView Publication
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Lu, J., Behbahani, A.H., Hamburg, L. et al.
"Transforming representations of movement from body- to world-centric space."
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Our service sets us apart, with a team that includes Ph.D. neuroscientists, experts in microscopy, stereology, neuron reconstruction, and image processing. We’ve also developed a host of additional support services, including:
If you’re interested in building your own SLAP2 microscope, MBF Bioscience has everything you need! Contact us for more details.
The most advanced software for controlling 2P and 3P laser scanning microscopes.
Vidrio’s Data Acquisition Card is a next generation all in one controller for your microscope. It controls Galvos, Pockels Cells, Fast Z devices, shutters and much more.