WormLab is a complete hardware/software solution for imaging and quantitative analysis of C. elegans behavior. We have collaborated with world leading C. elegans researchers to develop an easy-to-use worm tracking system with powerful analysis tools.
The patented WormLab tracking technology employs a groundbreaking algorithm designed to fully automatically characterize a broad spectrum of behaviors of C.elegans. Crawling worms, swimming/thrashing worms, whole plate and long-term tracking – WormLab supports all your assays. With WormLab you can focus on your research, rather than your research tools.
The Ultimate Worm Tracking & Analysis Solution
WormLab performs fully automated quantification of the behavior of C. elegans and other nematodes. Using the WormLab patented worm-tracking technology, you have access to dozens of detailed metrics, including speed, direction, and distance travelled. Fully characterize dynamic changes in posture, amplitude of sinusoidal movement and accurately quantify complex movements such as omega bends, coiling, self-overlap, swimming, and thrashing. Easily and efficiently investigate subtle effects on social interactions such as aggregation, social foraging and mating.
Worm Tracking Made Easy
The WormLab Imaging System is turn-key hardware and software for imaging and analyzing the behavior of C. elegans—just add worms. We have worked closely with C. elegans researchers to develop a worm tracking system that requires no programming or imaging expertise, so you can spend less time setting up and maintaining your system and more time on your research.
The optimized WormLab video acquisition system fully automates optogenetic and mechanosensation assays so that you can easily correlate behavior with programmable stimuli. This also frees up lab resources considerably while improving the efficiency and reproducibility of worm-behavior assays. Easy image acquisition and analysis using the intuitive WormLab software interface enables you to start working immediately.
WormLab has been developed with support from the National Institute of Environmental Health Sciences (NIEHS)
System Requirements for Microsoft Windows or Apple macOS |
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Windows 10 64-bit is required. The recommended configuration includes at least 16GB RAM, an Intel Core (i5,i7,i9) or Xeon processor, adequate hard disk space for video files (at least 500GB recommended) and an internet connection for activation. |
MacOS 10.9 or later is required. The recommended configuration includes at least 16GB RAM, an Intel Core (i5,i7,i9), Intel Xeon or Apple M1 processor, adequate hard disk space for video files (at least 500GB recommended) and an internet connection for activation. |
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Download WormLab product sheet here.
WormLab® 2022 Release Notes
Released January 2022
New features and enhancements
Video Recording
General
View Full Version History Here.
The WormLab Imaging System is a complete, scalable hardware solution for automated imaging and quantitative analysis of the behavior of C. elegans and other nematodes. MBF Bioscience worked closely with world leading C. elegans researchers to develop a unique worm tracking system that is intuitive and easy to use. For example, in conjunction with the WormLab software, the WormLab Imaging System enables researchers to correlate C. elegans locomotory behavior with the delivery of tapping or light stimuli.
Accurately tracking and quantifying locomotory behavior such as speed, distance travelled, and direction as well as more complex movements like coiling, entanglements, omega bends or self-overlap present significant challenges for quantitation. The patented WormLab tracking technology meets that challenge, employing a groundbreaking worm model with peristaltic progression movement designed to fully characterize and quantitate a broad spectrum of worm behaviors.
The software’s workflow guides you through each step to acquire, track and analyze image data from the WormLab Imaging System or your own video-acquisition system. Videos acquired using the WormLab Imaging System are immediately available for tracking and analysis or you may import previously acquired videos into WormLab software for analysis. Wormlab automatically detects worms, accurately tracks worm movement and displays tracking data in a tabular and user-configurable graphical format, with frame-by-frame detail data for each worm tracked, as well as summary reports. Comprehensive built-in and customizable metrics may be exported to Excel or Matlab, or create your own analyses.
Easily visualize, share and validate the automated tracking results superimposed on the original video sequence. Automatic WormLab head/tail identification leverages bending amplitude data near the end points of the worm, body morphometry and motion direction to improve recognition accuracy even in low resolution videos.
Behavioral analysis of swimming C. elegans offers new insights for aging and neurodegenerative disease studies.
Citation: Restif C, Ibáñez-Ventoso C, Vora MM, Guo S, Metaxas D, Driscoll M (2014) CeleST: Computer Vision Software for Quantitative Analysis of C. elegans Swim Behavior Reveals Novel Features of Locomotion. PLoS Comput Biol 10(7): e1003702. https://doi.org/10.1371/journal.pcbi.1003702
Studying the effects of external stimuli on C.elegans behavior can be a time-consuming task prone to bias. WormLab enables you to easily correlate behavior with programmable light or tapping stimuli in a fully automated manner, improving efficiency and repeatability of assays.
Batch tracking enables you to load a queue of videos for unattended processing (e.g., overnight). Your data is automatically saved and ready for analysis when you return to the lab. Using the built-in Group Analytics tool, you can easily compare trends among user-defined groups across multiple data sets. Batch exporting gives you efficient access to all your data for any custom analyses.
WormLab is used across the globe by the most prestigious laboratories.
WormLab’s utility is underscored by the number of references it receives in the worlds most important scientific publications.
Kropp, P. A., P. Rogers, et al.
Patient-specific variants of NFU1/NFU-1 cause aberrant cholinergic signaling in a Caenorhabditis elegans model of MMDS1View Publication
Yuan, Y., K. Xin, et al.
A GNN-based model for capturing spatio-temporal changes in locomotion behaviors of aging C. elegansView Publication
Zhang, L., L. Li, et al.
The C2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca2+-regulated exocytosisView Publication
Liao, C.-P., Y.-C. Chiang, et al.
“Neurophysiological basis of stress-induced aversive memory in the nematode Caenorhabditis elegans.” Current BiologyView Publication
Romero-Márquez, J. M., M. D. Navarro-Hortal, et al.
“In Vivo Anti-Alzheimer and Antioxidant Properties of Avocado (Persea americana Mill.) Honey from Southern Spain.” AntioxidantsView Publication
Mattison, K. A., G. Tossing, et al.
“ATP6V0C variants impair vacuolar V-ATPase causing a neurodevelopmental disorder often associated with epilepsy.” BrainView Publication
Zhao, K., Y. Zhang, et al.
“The joint effects of nanoplastics and TBBPA on neurodevelopmental toxicity in Caenorhabditis elegans.” Toxicology ResearchView Publication
Gildea, H. K., P. A. Frankino, et al.
“Glia of C. elegans coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit.” Science AdvancesView Publication
Latimer, C. S., J. G. Stair, et al.
“TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans.” Disease Models & MechanismsView Publication
The standard WormLab software license is tied to one specific computer, however, we do offer a floating license option, providing additional flexibility. A single floating license enables you to access your software license at any computer, but only one computer at a time.
Yes! You can purchase a Wormlab software license separately from the complete WormLab Imaging System; it is a cost-effective way to quantify worm behavior from videos acquired using your own camera system. An important consideration for obtaining optimal results with WormLab software is the quality of the video to be analyzed. A solid, high contrast image of the worm on an evenly illuminated background (as achieved with the WormLab Imaging System) is ideal.
The Wormlab Imaging System is modular by design and can be field upgraded to include stimulus delivery options such as high power LEDs for optogenetic assays or a tapper for mechanosensation assays. General purpose input/output ports are also available for custom applications.
The WormLab Imaging System is designed to produce optimal videos for worm tracking. It features a stable, flat field illumination system and state-of-the-art, high resolution video camera enabling high contrast visualization of the transparent worms. Its enclosure blocks out ambient light that could influence worm behavior, creating an ideal platform for performing reproducible experiments. Fully automate optogenetic and mechanosensation assays eliminates observer bias and improving efficiency.
WormLab was originally designed for tracking C. elegans, however, researchers have used the software for behavioral analysis of other nematodes (such as parasitic worms). In fact, WormLab has also been used to track Drosophila larvae. Contact us to arrange a demonstration using your videos.
Technically, there is no inherent software limit to the number of tracked worms, however, from a practical perspective we suggest tracking fewer than 30 worms in an area sufficiently large to mitigate worm clustering. The WormLab Imaging System supports video acquisition from plates up to 50mm in diameter.
WormLab supports many video files (eg. .avi, .mov, .mpg, .mp4, .wmv) and includes support for hundreds of different video codecs. We typically suggest using an acquisition rate of 5-10 fps for crawling worm assays and 14-30fps for swimming assays to ensure sufficient temporal resolution for accurate tracking. Higher resolution videos (e.g. 10um or less per pixel scaling) are recommended for more accurate tracking through complex movements such as omega bends, entanglements, self-overlap or coiling
Yes - we offer a Software Upgrade and Support Subscription (SUSS) enabling customers to download the latest version of WormLab and full remote access to our technical support team of experts. Our WormLab development roadmap is very customer feedback driven – as you provide feedback and we make enhancements to WormLab, you can then download those latest releases. This collaborative relationship with WormLab users is an integral part of our continuous improvement process and improves the WormLab community experience.
"I rarely have encountered a company so committed to support and troubleshooting as MBF."
Andrew Hardaway, Ph.D.
"MBF Bioscience is extremely responsive to the needs of scientists and is genuinely interested in helping all of us in science do the best job we can."
Sigrid C. Veasey, MD
"I am so happy to be a customer of your company. I always get great help related with your product or not. With the experienced members, you are the best team I've ever met. All of your staff are very kind and helpful. Thank you for your great help and support all the time."
Mazhar Özkan
"We’ve been very happy for many years with MBF products and the course of upgrades and improvements. Your service department is outstanding. I have gotten great help from the staff with the software and hardware."
William E. Armstrong, Ph.D.
WormLab provides far superior data than the other conventional programs used for worms. Our work with WormLab has been extremely rewarding because it puts us on the frontier of the behavior studies of C.elegans and allows us to carry out differentiated experiments, with software that is easy to use and needs only simple equipment.
Félix Soares, PhD
We really appreciate the help from all the staff at MBF Bioscience. Expert support combined with their excellent product WormLab are essential for our research on c. elegans behavior in my lab.
Jihong Bai, PhD
Our service sets us apart, with a team that includes Ph.D. neuroscientists, experts in microscopy, stereology, neuron reconstruction, and image processing. We’ve also developed a host of additional support services, including:
We offer both a free demonstration and a free trial copy of WormLab. During your personal session, you’ll also have the opportunity to talk to us about your hardware, software and experimental design questions with our team of Ph.D. neuroscientists and experts in microscopy, worm tracking and image processing.
Neuron tracing & analysis directly at the microscope. The gold standard for neuron tracing.
The complete stereology solution. The gold standard for unbiased cell counting.