Zhang X, Flick K, Rizzo M, Pignatelli M, Tonegawa S.
Dopamine from the ventral tegmental area signals unexpected threat omission to D1-rich neurons in the basolateral amygdala. Manipulating this pathway alters extinction behavior, showing that VTA-to-BLA dopamine acts as a teaching signal that drives fear extinction memory formation.... Read More
Inácio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S.
Movement-correlated neurons in somatosensory cortex receive stronger thalamic glutamatergic input and weaker motor cortical input than uncorrelated cells. Silencing thalamus reduces movement responses, indicating that stable movement encoding in wS1 is primarily driven by thalamic circuits.... Read More
Ryan MB, Girasole AE, Flores AJ, Twedell EL, McGregor MM, Brakaj R, Paletzki RF, Hnasko TS, Gerfen CR, Nelson AB.
A specific group of striatal direct-pathway neurons becomes hyperactive during levodopa-induced dyskinesia. Enhanced excitatory inputs and heightened D1 receptor sensitivity cause excessive firing, identifying a key circuit element that drives dyskinesia.... Read More
Eastwood BS, Hooks BM, Paletzki RF, O’Connor NJ, Glaser JR, Gerfen CR.
Serial-section images aligned to a reference atlas enables accurate, brain-wide quantification of labeled neurons and axons. Using automated detection and multistage registration, this approach yields high-precision whole-brain maps from standard histology.... Read More
Winter, C.C., Jacobi, A., Su, J. et al.
Single-nucleus sequencing, spatial transcriptomics, and whole-brain reconstructions reveal 76 distinct spinal-projecting neuron types. Defined by transcriptional signatures, anatomy, and physiology, these subclasses link molecular identity to specialized roles in descending motor control.... Read More
Tappan SJ, Eastwood BS, O’Connor N, Wang Q, Ng L, Feng D, Hooks BM, Gerfen CR, Hof PR, Schmitz C, Glaser JR.
NeuroInfo uses multi-stage 3D registration to align mouse brain sections to the Allen CCF v3 with expert-level accuracy. Tested across labs and imaging modalities, it provides a fast, objective, and reproducible solution for identifying brain regions. ... Read More
Hooks BM, Papale AE, Paletzki RF, Feroze MW, Eastwood BS, Couey JJ, Winnubst J, Chandrashekar J, Gerfen CR.
IT-type and PT-type cortical neurons show distinct projection patterns to the striatum. IT neurons create broad, consistent corticostriatal maps, while PT neurons form more focal and variable inputs, revealing cell-type–specific organization of motor-control pathways....
FOR IMMEDIATE RELEASE WILLISTON, VT – August 18, 2025 – MBF Bioscience today proudly announces that its revolutionary light sheet microscope, SLICE™, has been awarded a Microscopy Today Innovation Award. This prestigious recognition celebrates SLICE as a game-changing solution that is transforming the light sheet microscopy landscape by delivering superior performance at an exceptionally accessible price point, democratizing advanced 3D imaging and empowering laboratories of all sizes...
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In our recent discussions, we've introduced SLICE as a revolutionary light sheet microscope, making high-performance 3D imaging accessible for under $75,000. We've highlighted its integrated BrightSLICE software and transparent $5,000 annual support. For many, such claims might raise a natural question: how can a system that costs so much less also deliver superior image quality and a better overall experience than those multi-hundred-thousand-dollar legacy machines? This...
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For years, light sheet microscopy has stood out as a powerful technique, enabling stunning 3D imaging of large, live, and delicate biological samples. Its unique ability to provide deep tissue penetration with minimal phototoxicity has driven significant discoveries across neuroscience, developmental biology, and beyond. However, the path to acquiring this cutting-edge technology has been steep for most. High-end legacy light sheet systems often come with instrument...
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