Possik E, Schmitt C, Al-Mass A, Bai Y, Côté L, Morin J, Erb H, Oppong A, Kahloan W, Parker JA, Madiraju SRM, Prentki M.
Metabolic enzymes that limit glycerol-3-phosphate accumulation can promote stress resistance and longevity. This study identifies G3PP homologs as key regulators of fat metabolism and healthy aging in C. elegans. ... Read More
Jiang L, Wang X, Zhang D, Yee Yuen KW, Tse YC.
Maintaining sarcomere integrity is essential for preserving muscle function during aging. This study identifies RSU-1 as a key stabilizer of dense bodies and M-lines in aging C. elegans muscle. ... Read More
Xie J, Cai R, Hou X, Zhao K, Xiao J, Cao Y, Liu X.
Not all astaxanthin isomers are equally bioactive. This study shows that Z-isomer astaxanthins exert markedly stronger anti-obesity effects than the all-E form in C. elegans. ... Read More
Kim AT, Li S, Kim Y, You YJ, Park Y.
Activation or inhibition of opioid and cannabinoid receptors bidirectionally alters food preference in C. elegans. The assay enables behavior-based screening of candidate effectors. ... Read More
Maryam B, Wang Y, Li X, Asim M, Qayyum H, Zhang P, Liu X.
Tracking micro- and nanoplastic ingestion in living organisms remains technically challenging. This study introduces upconverted nanoparticles as high-sensitivity probes to reveal size-dependent plastic toxicity in C. elegans.... Read More
Cordeiro LM, Soares MV, da Silva AF, Dos Santos LV, de Souza LI, da Silveira TL, Baptista FBO, de Oliveira GV, Pappis C, Dressler VL, Arantes LP, Zheng F, Soares FAA.
Metal mixtures exacerbate neuronal dysfunction and Huntington’s disease–like phenotypes in a nematode model. A dietary flavonoid counteracts aggregation and neurodegeneration.... Read More
Gu Y, Jiang Y, Chen X, Li L, Chen H, Chen J, Wang C, Yu J, Chen C, Li H.
Free radicals formed during tire particle photoaging impair neurotransmitter balance and locomotion. Radical scavenging reverses these effects, implicating EPFRs as key toxic agents. ... Read More
Currie SD, Ji Y, Huang Q, Wang JS, Tang L.
Early-life exposure to PFAS disrupts learning and memory in a dose-dependent manner. This study links neurobehavioral impairment to PFAS bioaccumulation in C. elegans. ... Read More
Munasinghea M, Almotayria A, Thomasa J, Heydariana D, Weerasingheb M, Joisa M.
Dietary cocoa supplementation improves healthspan and modestly extends lifespan. In C. elegans, cocoa enhances neuromuscular, cognitive, and mitochondrial function during aging. ... Read More
Jacobsen NL, Norton CE, Shaw RL, Cornelison DDW, Segal SS.
Skeletal muscle injury triggers profound but reversible disruption of the capillary network. This study reveals how microvessels regenerate through a transient, disorganized phase before restoring normal architecture. ... Read More