Eastwood BS, Hooks BM, Paletzki RF, O’Connor NJ, Glaser JR, Gerfen CR.
Serial-section images aligned to a reference atlas enables accurate, brain-wide quantification of labeled neurons and axons. Using automated detection and multistage registration, this approach yields high-precision whole-brain maps from standard histology.... Read More
Winter, C.C., Jacobi, A., Su, J. et al.
Single-nucleus sequencing, spatial transcriptomics, and whole-brain reconstructions reveal 76 distinct spinal-projecting neuron types. Defined by transcriptional signatures, anatomy, and physiology, these subclasses link molecular identity to specialized roles in descending motor control.... Read More
Tappan SJ, Eastwood BS, O’Connor N, Wang Q, Ng L, Feng D, Hooks BM, Gerfen CR, Hof PR, Schmitz C, Glaser JR.
NeuroInfo uses multi-stage 3D registration to align mouse brain sections to the Allen CCF v3 with expert-level accuracy. Tested across labs and imaging modalities, it provides a fast, objective, and reproducible solution for identifying brain regions. ... Read More
Hooks BM, Papale AE, Paletzki RF, Feroze MW, Eastwood BS, Couey JJ, Winnubst J, Chandrashekar J, Gerfen CR.
IT-type and PT-type cortical neurons show distinct projection patterns to the striatum. IT neurons create broad, consistent corticostriatal maps, while PT neurons form more focal and variable inputs, revealing cell-type–specific organization of motor-control pathways....
Inácio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S.
Movement-correlated neurons in somatosensory cortex receive stronger thalamic glutamatergic input and weaker motor cortical input than uncorrelated cells. Silencing thalamus reduces movement responses, indicating that stable movement encoding in wS1 is primarily driven by thalamic circuits.... Read More
Zhang X, Flick K, Rizzo M, Pignatelli M, Tonegawa S.
Dopamine from the ventral tegmental area signals unexpected threat omission to D1-rich neurons in the basolateral amygdala. Manipulating this pathway alters extinction behavior, showing that VTA-to-BLA dopamine acts as a teaching signal that drives fear extinction memory formation.... Read More
Davis L, Radman I, Goutou A, Tynan A, Baxter K, Xi Z, O'Shea JM, Chin JW, Greiss S.
Precise, single-cell control of gene expression enables new insights into neural circuit function. This study introduces LaserTAC, an optical genetic toolkit for targeting individual neurons in C. elegans.... Read More
Nagarajan A, Ning Y, Reisner K, Buraei Z, Larsen JP, Hobert O, Doitsidou M.
A mechanosensitive TRP channel mutation can directly trigger dopaminergic neurodegeneration. This study identifies calcium dysregulation via TRP-4 as a driver of progressive neuronal loss in C. elegans.... Read More
Navarro-Hortal MD, Romero-Márquez JM, Muñoz-Ollero P, et al.
Antioxidant compounds in Manuka honey attenuate Aβ toxicity via HSP-16.2 and SKN-1/Nrf2 pathways. Behavioral outcomes highlight a trade-off between neuroprotection and sugar-related effects.... Read More
Tiwari V, Buvarp E, Borbolis F, Puligilla C, Croteau DL, Palikaras K, Bohr VA.
Altering DNA repair pathways can unexpectedly protect against tau-induced neurotoxicity. This study shows that reducing base excision repair initiation improves health span and cognition in a C. elegans tauopathy model. ... Read More