December 11, 2006
Leiwe MN, Fujimoto S, Baba T, Moriyasu D, Saha B, Sakaguchi R, Inagaki S, Imai T.
An automated hue-based clustering approach overcomes limitations of conventional multicolour tracing in densely labeled tissue.... Read More
MBF Bioscience News
December 11, 2006
Zhang Y, Bizanti A, Harden SW, Chen J, Bendowski K, Hoover DB, Gozal D, Shivkumar K, Heal M, Tappan S, Cheng ZJ.
Whole-mount imaging and 3D reconstruction reveal the topographical organization of cardiac sympathetic axons.... Read More
December 11, 2006
Konopaske GT, Lange N, Coyle JT, Benes FM.
Both schizophrenia and bipolar disorder displayed decreased spine density and dendritic length in layer III pyramidal neurons of the DLPFC, with marked reductions in total spines per dendrite. These structural deficits point to overlapping synaptic abnormalities across the two disorders.... Read More
December 11, 2006
Merino-Galán L, Zamarbide M, Belloso-Iguerategui A, Alonso-Moreno MC, Gago B, Reinares-Sebastián A, Blesa J, Dumitriu D, Quiroga-Varela A, Rodríguez-Oroz MC.
Early dopamine depletion disrupts striatal plasticity but elicits compensatory spine and dendritic remodeling in SPNs, supporting network resilience in premotor parkinsonism.... Read More
December 11, 2006
Földy C, Malenka RC, Südhof TC.
Dendritic spine density declined in AD but remained intact in cognitively resilient cases, and network analysis of synaptic proteomes highlighted TWF2 as a key determinant of thin spine length. CRISPR-mediated TWF2 enhancement selectively extended thin spines without altering their density.... Read More
December 11, 2006
Scholler J, Jonsson J, Jordá-Siquier T, Gantar I, Batti L, Cheeseman BL, Pagès S, Sbalzarini IF, Lamy CM.
APR-native processing through pAPRica enables massive ClearScope datasets to be compressed, segmented and analyzed rapidly and accurately on standard hardware, supporting scalable whole-organ histopathology.... Read More
December 11, 2006
Dayton H, Kiss J, Wei M, Chauhan S, LaMarre E, Cornell WC, Morgan CJ, Janakiraman A, Min W, Tomer R, Price-Whelan A, Nirody JA, Dietrich LEP.
Aligned clonal architectures within P. aeruginosa biofilms define nutrient flow, metabolic zoning and antibiotic tolerance. Mutants with disrupted pili or O-antigen features lose this organization and exhibit heightened sensitivity to tobramycin.... Read More
December 11, 2006
Datta MS, Chen Y, Chauhan S, Zhang J, De La Cruz ED, Gong C, Tomer R.
Chronic ketamine induces widespread, region-specific changes in TH+ neurons and their projections, enhancing dopaminergic input to associative cortex while diminishing signaling to sensory and striatal regions.... Read More
December 11, 2006
Fay MG, Lang PJ, Denu DS, O'Connor NJ, Haydock B, Blaisdell J, Roussel N, Wilson A, Aronson SM, Angstman PJ, Gong C, Butola T, Devinsky O, Basu J, Tomer R, Glaser JR.
A fully integrated LSTM platform, ClearScope provides sub-cellular lateral resolution and uniform axial performance across large cleared specimens, independent of their XY dimensions. Automated index correction and guided scanning workflows support high-quality... Read More
December 11, 2006
Migliori B, Datta MS, Dupre C, Apak MC, Asano S, Gao R, Boyden ES, Hermanson O, Yuste R, Tomer R.
A non-orthogonal illumination design combined with synchronized light-sheet and focal-plane scanning allows LSTM to achieve deep, uniform, high-resolution imaging in large intact tissues, outperforming traditional LSFM in clarity and coverage.... Read More