|

Follow Us:

Indeed Logo
mobile-logo

Light Sheet

MBF Bioscience >  Blog > Scientific Applications & Use Cases  > Light Sheet
May 20, 2026

Making High-Performance Whole-Brain Imaging More Accessible

by Pasang
in SLICE, Company News, Microscopy Imaging Systems, Light Sheet
Comments

A recent feature article in BioPhotonics magazine highlights how the SLICE Light Sheet Microscope combines projected light-sheet microscopy (pLSM), advanced optics for cleared tissue, and simplified system design to make high-performance whole-brain fluorescence imaging more accessible to researchers.   Light-sheet fluorescence microscopy (LSFM) has become an important tool for imaging large cleared tissue specimens because of its ability to rapidly acquire volumetric datasets while minimizing photobleaching and...

Read More
March 13, 2026

Breaking the size barrier: ClearScope light sheet microscope paper published in Journal of Imaging

by Pasang
in Company News, ClearScope®, Light Sheet
Comments

A new peer-reviewed study describes the design and capabilities of ClearScope®, MBF Bioscience's fully integrated light-sheet theta microscope for high-resolution 3D imaging of large biological specimens without lateral size constraints.   Reference Fay, M. G., Lang, P. J., Denu, D. S., et al. (2026). ClearScope: A Fully Integrated Light-Sheet Theta Microscope for Sub-Micron-Resolution Imaging Without Lateral Size Constraints. Journal of Imaging. https://doi.org/10.3390/jimaging12030118   Background Three-dimensional imaging of intact organs and large...

Read More
June 9, 2025

MBF Bioscience Introduces SLICE™: We Reimagined Light Sheet Microscopes From the Ground Up

by Pasang
in SLICE, Company News, Press Release, MBF Products & Service Solutions, Microscopy Imaging Systems, Light Sheet
Comments

FOR IMMEDIATE RELEASE   MBF Bioscience Introduces SLICE™: We Reimagined Light Sheet Microscopes From the Ground Up   Breakthrough system combines high performance with unprecedented affordability and compact design, making cutting-edge light sheet microscopy accessible to labs of all sizes   WILLISTON, VT – June 9, 2025 – MBF Bioscience, a world leader in quantitative microscopy solutions, today announced the commercial launch of SLICE™, a revolutionary light sheet microscope that represents...

Read More
October 2, 2024

Introducing SLICE™: A new era in low-cost, high-performance light-sheet microscopy

by Pasang
in SLICE, Company News, Press Release, Scientific Applications & Use Cases, Light Sheet
Comments

Throughout my career, I've been driven by a singular goal: to advance scientific research by making cutting-edge tools accessible to researchers worldwide. Today, I'm thrilled to share news that I believe will significantly impact our field.   In just a few days, at the Society for Neuroscience meeting in Chicago, we will be unveiling SLICE – our new affordable light sheet microscope that truly redefines what's possible...

Read More
September 28, 2022

Researchers quantify cortical cell numbers in cleared tissue with new unbiased stereology technique

by Pasang
in Software Applications For Quantitive Analysis, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Cleared Tissue and Whole Organ Research, Stereo Investigator®Cleared Tissue, Light Sheet, Optical Fractionator
Comments

The Image Volume Fractionator probe, available in Stereo Investigator - Cleared Tissue Edition, is facilitating huge efficiency gains for quantifying the number of cells.   At Dr. Patrick R. Hof’s lab at the Icahn School of Medicine at Mount Sinai, researchers imaged the cerebral cortex using light-sheet fluorescence microscopy and quantified the number of neurons, including those that express proteins involved in Alzheimer’s disease and schizophrenia, using...

Read More
December 10, 2020

MBF Bioscience Release ClearScope, Revolutionary Light Sheet Microscope for Imaging Large and Small Cleared Tissue Specimens

by Pasang
in Company News, ClearScope®, Press Release, Scientific Applications & Use Cases, Microscopy Imaging Systems, MBF Products & Service Solutions, Additional Subject Matter, Cleared Tissue and Whole Organ Research, Light Sheet
Comments

For Immediate Release  Williston, VT (December 10, 2020) — The ability to image large, intact biological specimens is about to get a whole lot better. Developed in collaboration with Columbia University, MBF Bioscience’s revolutionary light sheet theta microscope system, ClearScope®, has the ability to image whole tissue quickly and gently, in high resolution 3D.     The ClearScope system features a unique, two-axis scanning mode that goes beyond the capabilities of typical...

Read More
This is an image of a full Light Sheet Microscope called ClearScope
February 4, 2020

MBF Bioscience Secures Exclusive License from Columbia University to Create New Light-Sheet Microscope System

by Pasang
in Company News, ClearScope®, Press Release, Scientific Applications & Use Cases, Microscopy Imaging Systems, MBF Products & Service Solutions, Additional Subject Matter, Cleared Tissue and Whole Organ Research, Light Sheet
Comments

For Immediate Release: Williston, VT (February 04, 2020) — MBF Bioscience’s revolutionary light sheet microscope system, ClearScope, sets a new standard for microscopic imaging.   The new decade is poised to bring about incredible scientific innovations, and MBF Bioscience is leading the charge in 2020 with the creation of the “light sheet theta microscope” system, ClearScope.   MBF Bioscience secured exclusive license from Columbia University to develop the light...

Read More