Kreczmanski P, Heinsen H, Mantua V, Woltersdorf F, Masson T, Ulfig N, Schmidt-Kastner R, Korr H, Steinbusch HW, Hof PR, Schmitz C.
Structural vascular alterations have been proposed as contributors to schizophrenia, yet direct anatomical evidence remains limited. Using unbiased stereological methods, this study examined whether microvessel architecture is altered in key subcortical regions of the human brain. ... Read More
Gama Sosa MA, Gasperi RD, Rocher AB, Wang AC, Janssen WG, Flores T, Perez GM, Schmeidler J, Dickstein DL, Hof PR, Elder GA.
Presenilin-1 familial Alzheimer’s disease mutations cause progressive microvascular degeneration in the hippocampus. These vascular defects arise independently of amyloid plaque deposition. ... Read More
Pereda-Pérez I, Popović N, Otalora BB, Popović M, Madrid JA, Rol MA, Venero C.
Prolonged social isolation selectively impairs hippocampus-dependent contextual fear memory. This effect is associated with CA1 shrinkage and reduced synaptic PSA-NCAM expression. ... Read More
Kriks, S., Shim, JW., Piao, J. et al.
Floor plate–derived human dopamine neurons show robust survival and functional integration after transplantation. This approach advances stem cell–based therapy for Parkinson’s disease. ... Read More
Schmitz, Christoph et al
Hippocampal neuron loss occurs in APP/PS-1 transgenic mice independent of local amyloid plaque burden. These findings indicate that non–plaque-related mechanisms contribute to neurodegeneration in Alzheimer’s disease. ... Read More
Stranahan AM, Jiam NT, Spiegel AM, Gallagher M.
Aging leads to significant loss of both principal neurons and inhibitory interneurons in the dorsal prefrontal cortex. In contrast, ventral prefrontal regions remain structurally preserved.... Read More
Rapp PR, Gallagher M.
Unbiased stereological analysis reveals no neuron loss in hippocampal subfields of aged rats with memory deficits.... Read More
Hanafy AS, Steinlein P, Pitsch J, Silva MH, Vana N, Becker AJ, Graham ME, Schoch S, Lamprecht A, Dietrich D.
This study presents a live brain-slice model that enables high-resolution imaging and quantitative analysis of blood–brain barrier permeability and transporter function at the level of individual capillaries.... Read More
Bar-Noam AS, Farah N, Shoham S.
A model-guided two-photon optical design enables high-resolution retinal imaging and functional calcium recordings without the need for adaptive optics.... Read More
Bakker GJ, Weischer S, Ferrer Ortas J, Heidelin J, Andresen V, Beutler M, Beaurepaire E, Friedl P.
A multiphoton imaging approach using infrared excitation enables non-invasive, deep-tissue visualization with preserved resolution in highly scattering tissues.... Read More