Murphy, K. R., Farrell, J. S., Gomez, J. L., Stedman, Q. G., Li, N., Leung, S. A., Good, C. H., Qiu, Z., Firouzi, K., Butts Pauly, K., Khuri-Yakub, B. P. T., Michaelides, M., Soltesz, I., & de Lecea, L.
A fiber photometry–coupled ultrasound system enables real-time, cell type–specific neuromodulation in freely moving mice. Optimized stimulation preferentially activates inhibitory circuits in epilepsy. ... Read More
Alese OM, Wilson AC, Tessier KM, Loavenbruck A, Dedeker C, Lassig AA.
Three-dimensional analysis of cutaneous microvasculature reveals structural features linked to surgical wound healing. Increased isolated vascular elements are associated with poorer post-operative outcomes. ... Read More
Brady EL, Prado O, Johansson F, Mitchell SN, Martinson AM, Karbassi E, Reinecke H, Murry CE, Davis J, Stevens KR.
The success of engineered tissues depends strongly on the host environment. This study shows that host species and implant site critically shape vascular integration and cardiomyocyte engraftment. ... Read More
Fopiano KA, Zhazykbayeva S, El-Battrawy I, Buncha V, Pearson WM, Hardell DJ, Lang L, Hamdani N, Bagi Z.
Inhibition of PDE9A improves diastolic dysfunction and restores coronary microvascular integrity in a HFpEF model. These benefits are linked to reduced oxidative stress and enhanced antioxidant defenses. ... Read More
Button EB, Boyce GK, Wilkinson A, Stukas S, Hayat A, Fan J, Wadsworth BJ, Robert J, Martens KM, Wellington CL.
Apolipoprotein A-I plays a protective role against amyloid and vascular pathology in Alzheimer’s disease. Loss of apoA-I exacerbates cortical amyloid deposition and cerebrovascular astrogliosis. ... Read More
Avior Y, Ron S, Kroitorou D, Albeldas C, Lerner V, Corneo B, Nitzan E, Laifenfeld D, Cohen Solal T.
Neurons generated from bupropion responders showed increased synaptic puncta, elongated dendritic spines and distinct transcriptional responses compared with nonresponders. These in vitro signatures parallel clinical outcomes and point to candidate biomarkers for personalized antidepressant selection.... Read More
Földy C, Malenka RC, Südhof TC.
Neuroligin-3 mutations disrupt tonic endocannabinoid control of inhibition at CCK basket cell synapses, revealing a shared synaptic mechanism that alters inhibitory balance independent of structural changes.... Read More
Lázaro J, Hertel M, Sherwood CC, Muturi M, Dechmann DKN.
Common shrews exhibit large, reversible seasonal shifts in brain and regional volumes, driven by neuronal shrinkage and dendritic retraction rather than altered cell counts. The hypothalamus, thalamus and select cortical and striatal regions show the strongest changes, consistent with energetic adaptation to winter conditions.... Read More
Kusnoor SV, Parris J, Muly EC, Morgan JI, Deutch AY.
Parafascicular neurons express high levels of Cbln1 and innervate medium spiny neurons, and Cbln1 deletion increases MSN spine density while leaving dendritic architecture unchanged. These findings indicate a regulatory role for Cbln1 in limiting excitatory thalamostriatal input.... Read More
Wei L, Simen A, Mane S, Kaffman A.
Early life stress suppressed LBP expression in the developing hippocampus and led to increased spine density, abnormal spine structure and impaired cognition in adulthood. LBP knockout mice showed similar synaptic and behavioral abnormalities, indicating LBP’s role in microglia-mediated synaptic refinement.... Read More