Barik A, Sathyamurthy A, Thompson J, Seltzer M, Levine A, Chesler A.
A defined spinoparabrachial Tacr1 circuit selectively signals sustained, but not acute, noxious stimuli. Activation of this pathway amplifies pain while suppressing itch. ... Read More
Flanigan, M.E., Aleyasin, H., Li, L. et al.
Aggression can be intrinsically rewarding and is shaped by specific brain circuits. This study identifies an orexin-sensitive inhibitory microcircuit in the lateral habenula that promotes aggression and its rewarding properties. ... Read More
O'Neal TJ, Bernstein MX, MacDougall DJ, Ferguson SM.
Heroin-conditioned cues selectively enhance dMSN and dopamine activity while inhibiting iMSNs in the nucleus accumbens. These pathway-specific dynamics drive reward learning. ... Read More
Lange G, Gnazzo F, Faust RP, Beeler JA.
Repeated psychostimulant exposure reshapes dopamine–acetylcholine interactions in the nucleus accumbens. This study reveals sensitized, opposing adaptations in neuromodulator signaling during drug exposure. ... Read More
Hollon NG, Williams EW, Howard CD, Li H, Traut TI, Jin X.
Dopamine release is suppressed when rewards are the expected outcome of self-initiated actions. These signals reveal sequence-specific prediction errors during goal-directed behavior. ... Read More
Murphy, K. R., Farrell, J. S., Gomez, J. L., Stedman, Q. G., Li, N., Leung, S. A., Good, C. H., Qiu, Z., Firouzi, K., Butts Pauly, K., Khuri-Yakub, B. P. T., Michaelides, M., Soltesz, I., & de Lecea, L.
A fiber photometry–coupled ultrasound system enables real-time, cell type–specific neuromodulation in freely moving mice. Optimized stimulation preferentially activates inhibitory circuits in epilepsy. ... Read More
Alese OM, Wilson AC, Tessier KM, Loavenbruck A, Dedeker C, Lassig AA.
Three-dimensional analysis of cutaneous microvasculature reveals structural features linked to surgical wound healing. Increased isolated vascular elements are associated with poorer post-operative outcomes. ... Read More
Brady EL, Prado O, Johansson F, Mitchell SN, Martinson AM, Karbassi E, Reinecke H, Murry CE, Davis J, Stevens KR.
The success of engineered tissues depends strongly on the host environment. This study shows that host species and implant site critically shape vascular integration and cardiomyocyte engraftment. ... Read More
Fopiano KA, Zhazykbayeva S, El-Battrawy I, Buncha V, Pearson WM, Hardell DJ, Lang L, Hamdani N, Bagi Z.
Inhibition of PDE9A improves diastolic dysfunction and restores coronary microvascular integrity in a HFpEF model. These benefits are linked to reduced oxidative stress and enhanced antioxidant defenses. ... Read More
Button EB, Boyce GK, Wilkinson A, Stukas S, Hayat A, Fan J, Wadsworth BJ, Robert J, Martens KM, Wellington CL.
Apolipoprotein A-I plays a protective role against amyloid and vascular pathology in Alzheimer’s disease. Loss of apoA-I exacerbates cortical amyloid deposition and cerebrovascular astrogliosis. ... Read More