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MBF Bioscience >  Blog > MBF Products & Service Solutions
December 28, 2023

From Proteins to Dendritic Spines: Neurolucida 360 Plays a Crucial Role in Advancing Neuroscience

by Pasang
in Software Applications For Quantitive Analysis, MBF Products & Service Solutions, Neurolucida®360, Neurolucida®Explorer
Comments

In the fast-evolving field of neuroscience, groundbreaking research on the intricate workings of the vertebrate brain yields new information every day. A recent study published in the Journal of Neuroscience describes the establishment of an approach for better contextualization of proteins identified through proteomic analyses to identify candidate proteins for functional validation testing. The authors examined human synaptic processes from well-characterized human post-mortem samples and...

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May 1, 2023

Letter from the President: The Democratization of Neuroscience – Big Science in Individual Labs

by Pasang
in Software Applications For Quantitive Analysis, Company News, MBF Products & Service Solutions, NeuroInfo®, Additional Subject Matter
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The democratization of neuroscience is a movement that aims to make neuroscience research more accessible and inclusive to everyone. This movement is based on the principles of open science and aims to make neuroscience research more transparent, collaborative, and accessible to researchers around the world.   At MBF Bioscience, democratizing neuroscience has been part of our DNA since our founding 35 years ago when we launched Neurolucida....

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May 1, 2023

Light Beads Microscopy: A Breakthrough in Volumetric in vivo Brain Imaging

by Pasang
in 2 Photon, ScanImage®, Scientific Applications & Use Cases, MBF Products & Service Solutions, Multi-Photon Microscopy Solutions, Microscopic Imaging & Analysis, Multi-Photon Imaging
Comments

In their recent publication, Jeffrey Demas and co-authors introduced “Light Beads Microscopy”, an important technological breakthrough in 2 photon microscopy. The authors demonstrated how their innovative microscopy approach can be used to observe the activity of individual neurons in vivo in large volumes of mouse cortex, offering a long-sought approach to studying brain encoding.   Light Beads Microscopy is a new method of two-photon microscopy optimized for...

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May 1, 2023

Exploring the Relationship between Lifespan and Quality of Life in C. Elegans Mutants

by Pasang
in Software Applications For Quantitive Analysis, WormLab®, WormLab®Imaging System, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, C.elegans Behavioral Analysis Solutions, C. Elegans, Worm Tracking
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The question of whether an increased lifespan is associated with increased quality of life has been a topic of interest in the field of aging research. While there is evidence that improved somatic maintenance in model organisms can lead to increased longevity, recent studies have suggested that long-lived mutants may actually spend a higher percentage of their lives in an unhealthy state compared to non-mutants....

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January 12, 2023

Mini2P miniature microscope and ScanImage

by Pasang
in 2 Photon, Scientific Applications & Use Cases, ScanImage®, MBF Products & Service Solutions, vDAQ, Multi-Photon Microscopy Solutions, Mini2P, Multi-Photon Imaging
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ScanImage software from MBF Bioscience, along with the accompanying vDAQ acquisition and control card with analog to digital, digital to analog, breakout board, is built to control many combinations of hardware in order to carry out in-vivo imaging on a cellular scale. This makes it possible to observe the neural activities, such as those indicated by calcium concentration or voltage changes, of specific neuronal types...

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January 12, 2023

Unprecedented study reveals structure-function adaptations in the facial nucleus of elephants

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Stereology, Optical Fractionator
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Using specimens that were collected over three decades from zoos, researchers at Humboldt University of Berlin examined facial motor control in African and Asian elephants. As described in their recent paper in Science Advances, they examined cell number, size, and position in the facial nucleus; conducted quantitative nerve tracing, and performed comparative analyses with other animals and between the two elephant types. The researchers found...

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September 28, 2022

Researchers quantify cortical cell numbers in cleared tissue with new unbiased stereology technique

by Pasang
in Software Applications For Quantitive Analysis, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Cleared Tissue and Whole Organ Research, Light Sheet, Stereo Investigator®Cleared Tissue, Optical Fractionator
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The Image Volume Fractionator probe, available in Stereo Investigator - Cleared Tissue Edition, is facilitating huge efficiency gains for quantifying the number of cells.   At Dr. Patrick R. Hof’s lab at the Icahn School of Medicine at Mount Sinai, researchers imaged the cerebral cortex using light-sheet fluorescence microscopy and quantified the number of neurons, including those that express proteins involved in Alzheimer’s disease and schizophrenia, using...

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September 28, 2022

MBF Bioscience solutions for core imaging facilities

by Pasang
in Core Facilities Solutions, MBF Products & Service Solutions, Core Facilities Solution Suite
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To help meet the broad range of imaging and quantitative image analysis needs of scientific researchers, MBF Bioscience has developed a number of comprehensive solutions based on our state-of-the-art technology and bundled them into a productivity suite of software for use as a shared resource in core imaging-facilities or large laboratories.   The MBF Bioscience Core-Facility Suite includes our most popular image analysis tools installed on a...

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June 28, 2022

NYU scientists use ScanImage to monitor dopamine-induced brain activity in a model of Parkinson’s disease

by Pasang
in 2 Photon, Scientific Applications & Use Cases, ScanImage®, MBF Products & Service Solutions, Additional Subject Matter, Multi-Photon Microscopy Solutions, Parkinson’s Disease, Multi-Photon Imaging
Comments

Humans and animal species can move in controlled motion sequences because of a delicate balance in the signaling of certain neurons in the area of the brain called the striatum. In this brain region, some neurons tell muscles to move, while others tell muscles to hold steady. In the brains of patients with Parkinson’s disease, more of the neurons that signal movement are activated resulting...

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June 28, 2022

Blue Brain scientists develop pyramidal cell classification system using neurons reconstructed with Neurolucida 360

by Pasang
in Software Applications For Quantitive Analysis, MBF Products & Service Solutions, Neurolucida®360
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After decades of identifying brain cells subjectively, researchers can now make use of a standardized classification system for identifying pyramidal cells—the most common type of cells in the neocortex. Scientists at the Blue Brain Project developed the system using mathematics that identify the properties of shapes that stay constant under continuous transformation. This new method of classification gives researchers the ability to begin building a...

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