Using specimens that were collected over three decades from zoos, researchers at Humboldt University of Berlin examined facial motor control in African and Asian elephants. As described in their recent paper in Science Advances, they examined cell number, size, and position in the facial nucleus; conducted quantitative nerve tracing, and performed comparative analyses with other animals and between the two elephant types. The researchers found...
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The Image Volume Fractionator probe, available in Stereo Investigator - Cleared Tissue Edition, is facilitating huge efficiency gains for quantifying the number of cells. At Dr. Patrick R. Hof’s lab at the Icahn School of Medicine at Mount Sinai, researchers imaged the cerebral cortex using light-sheet fluorescence microscopy and quantified the number of neurons, including those that express proteins involved in Alzheimer’s disease and schizophrenia, using...
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[caption id="attachment_6326" align="aligncenter" width="600"] An immunostained image of myelin basic protein in the cerebella of a mouse brain with an iron-sufficient diet compared with the brain of a mouse exposed to alcohol and fed an iron-insufficient diet. It shows the reduced cerebellar size due to the ID-alcohol combination. Green is MBP immunostain, blue is DAPI for nuclei. Image courtesy of Susan Smith, PhD.[/caption] If a pregnant...
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[caption id="attachment_6175" align="aligncenter" width="480"] Phosphorylated tau pS422 immunoreactive profiles (dark brown) in the cortex of P301S mice after repetitive mild TBI. Image courtesy of Dr. Leyan Xu, Department of Pathology, Johns Hopkins University.[/caption] Over the course of a football game or a boxing match, athletes may experience a series of mild concussions. Some of these athletes develop a condition known as chronic traumatic encephalopathy (CTE), a...
Read MorePerforming stereology counts offline is easier than ever with the inclusion of a straightforward way to capture image stacks for quantification. Using systematic random sampling, the Stereo Investigator software drives the microscope stage to collect image stacks at each counting site of your brightfield or fluorescently labeled tissue. The system can even be configured to collect the entire region of interest, creating an exhaustive three-dimensional montage!...
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