Henny P, Brown MT, Micklem BR, Magill PJ, Bolam JP.
Using integrated light and electron microscopy, this work provides precise estimates of synapse number and distribution on single neurons. The approach enables quantitative links between neuronal structure and function. ... Read More
Riudavets MA, Iacono D, Resnick SM, O'Brien R, Zonderman AB, Martin LJ, Rudow G, Pletnikova O, Troncoso JC.
Some individuals remain cognitively normal despite significant Alzheimer’s pathology. This study identifies distinctive neuronal structural features that may underlie resilience to neurodegeneration. ... Read More
Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR.
Amyloid plaque accumulation varies dramatically across commonly used AβPP transgenic mouse models. This quantitative comparison reveals large differences in plaque timing, burden, and regional distribution. ... Read More
Kreczmanski P, Heinsen H, Mantua V, Woltersdorf F, Masson T, Ulfig N, Schmidt-Kastner R, Korr H, Steinbusch HW, Hof PR, Schmitz C.
Structural vascular alterations have been proposed as contributors to schizophrenia, yet direct anatomical evidence remains limited. Using unbiased stereological methods, this study examined whether microvessel architecture is altered in key subcortical regions of the human brain. ... Read More
Gama Sosa MA, Gasperi RD, Rocher AB, Wang AC, Janssen WG, Flores T, Perez GM, Schmeidler J, Dickstein DL, Hof PR, Elder GA.
Presenilin-1 familial Alzheimer’s disease mutations cause progressive microvascular degeneration in the hippocampus. These vascular defects arise independently of amyloid plaque deposition. ... Read More
Pereda-Pérez I, Popović N, Otalora BB, Popović M, Madrid JA, Rol MA, Venero C.
Prolonged social isolation selectively impairs hippocampus-dependent contextual fear memory. This effect is associated with CA1 shrinkage and reduced synaptic PSA-NCAM expression. ... Read More
Kriks, S., Shim, JW., Piao, J. et al.
Floor plate–derived human dopamine neurons show robust survival and functional integration after transplantation. This approach advances stem cell–based therapy for Parkinson’s disease. ... Read More
Schmitz, Christoph et al
Hippocampal neuron loss occurs in APP/PS-1 transgenic mice independent of local amyloid plaque burden. These findings indicate that non–plaque-related mechanisms contribute to neurodegeneration in Alzheimer’s disease. ... Read More
Stranahan AM, Jiam NT, Spiegel AM, Gallagher M.
Aging leads to significant loss of both principal neurons and inhibitory interneurons in the dorsal prefrontal cortex. In contrast, ventral prefrontal regions remain structurally preserved.... Read More
Rapp PR, Gallagher M.
Unbiased stereological analysis reveals no neuron loss in hippocampal subfields of aged rats with memory deficits.... Read More