2019

Posted on January 18, 2019 by MBF Bioscience

Stereo Investigator:

Branch, A., Monasterio, A., Blair, G., Knierim, J. J., Gallagher, M., & Haberman, R. P. (2019). Aged rats with preserved memory dynamically recruit hippocampal inhibition in a local/global cue mismatch environment. Neurobiology of Aging. doi: https://doi.org/10.1016/j.neurobiolaging.2018.12.015.

Chung, Y., Buechel, B. D., Sunwoo, W., Wagner, J. D., & Delgutte, B. (2019). Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness. Journal of the Association for Research in Otolaryngology. doi: 10.1007/s10162-018-00708-w.

Ganeshan, V., Skladnev, N. V., Kim, J. Y., Mitrofanis, J., Stone, J., & Johnstone, D. M. (2019). Pre-conditioning with Remote Photobiomodulation Modulates the Brain Transcriptome and Protects Against MPTP Insult in Mice. Neuroscience, 400, 85-97. doi: https://doi.org/10.1016/j.neuroscience.2018.12.050.

Gao, Ruixuan, Shoh M. Asano, Srigokul Upadhyayula, Igor Pisarev, Daniel E. Milkie, Tsung-Li Liu, Ved Singh, et al. Cortical Column and Whole-Brain Imaging with Molecular Contrast and Nanoscale Resolution. Science 363, no. 6424 (January 18, 2019): eaau8302. doi: https://doi.org/10.1126/science.aau8302. Continue reading “Researchers cited MBF Bioscience systems in 24 papers between 1/4/2019 and 1/18/2019” »

MBF Bioscience research team contributes novel dendritic spine analysis in study published in Science

Posted on January 18, 2019 by Celeste Sunderland

Combination of new microscopy and expansion tissue preparation methods facilitate better and faster analysis of subcellular neural elements.

Today, the journal Science published a paper authored by a research team led by Dr. Ed Boyden of MIT and Nobel Prize recipient Dr. Eric Betzig of Janelia Research Campus. Among the authors are MBF Bioscience Scientific Director Dr. Susan Tappan and Senior Software Engineer Alfredo Rodriguez. In the paper, the researchers introduce new analyses for neural circuits at nanoscale resolutions.

Combining microscopy methods that create high resolution 3D images from whole brains and tissue that have been made physically larger, the researchers imaged a mouse cortex and fruit fly brain in their study “Cortical column and whole-brain imaging of neural circuits with molecular contrast and nanoscale resolution (Gao et al, 2019).”

By creating enhanced processing and analysis tools in MBF Bioscience’s Stereo Investigator and Neurolucida 360 software, Dr. Tappan and Mr. Rodriguez analyzed these images to obtain comprehensive morphometrics of delicate dendritic spines at a greater accuracy than ever before.

GAO ET AL./SCIENCE 2019

“We combined expansion microscopy and lattice light sheet microscopy (ExLLSM) to image the nanoscale spatial relationships between proteins across the thickness of the mouse cortex or the entire Drosophila brain, including synaptic proteins at dendritic spines, myelination along axons, and presynaptic densities at dopaminergic neurons in every fly neuropil domain.” (Gao et al, 2019)

While several forms of microscopy exist that have the ability to image subcellular neural elements, scientists say that each of these methods is lacking in one way or another. According to the paper, the combination of expansion microscopy with lattice-light sheet microscopy gives the most effective results, while considerably decreasing the time spent carrying out the experiment.

“I believe this type of imaging represents a major milestone in terms of the accuracy that can be achieved in dendritic spine morphometry from light microscopy,” Mr. Rodriguez said.

Continue reading “MBF Bioscience research team contributes novel dendritic spine analysis in study published in Science” »

Researchers cited MBF Bioscience systems in 9 papers between 12/14/2018 and 12/21/2018

Posted on December 21, 2018 by MBF Bioscience

Stereo Investigator:

Kumar, A. J., Motta-Teixeira, L. C., Takada, S. H., Lee, V. Y., Machado-Nils, A. V., Xavier, G. F., & Nogueira, M. I. (2018). Behavioral, cognitive and histological changes following neonatal anoxia: male and female rats’ differences at adolescent age. International Journal of Developmental Neuroscience. doi: https://doi.org/10.1016/j.ijdevneu.2018.12.002.

Martínez Cerdeño, V., Hong, T., Amina, S., Lechpammer, M., Ariza, J., Tassone, F., . . . Hagerman, R. (2018). Microglial cell activation and senescence are characteristic of the pathology FXTAS. Movement Disorders, 0(0). doi: 10.1002/mds.27553.

Osipovitch, M., Asenjo Martinez, A., Mariani, J. N., Cornwell, A., Dhaliwal, S., Zou, L., . . . Goldman, S. A. (2018). Human ESC-Derived Chimeric Mouse Models of Huntington’s Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation. Cell Stem Cell. doi: https://doi.org/10.1016/j.stem.2018.11.010.

Neurolucida:

Chaaya, N., Jacques, A., Belmer, A., Richard, D. J., Bartlett, S. E., Battle, A. R., & Johnson, L. R. (2018). Localization of Contextual and Context Removed Auditory Fear Memory within the Basolateral Amygdala Complex. Neuroscience. doi: https://doi.org/10.1016/j.neuroscience.2018.12.004.

Eastwood, B. S., Hooks, B. M., Paletzki, R. F., O’Connor, N. J., Glaser, J. R., & Gerfen, C. R. (2018). Whole Mouse Brain Reconstruction and Registration to a Reference Atlas with Standard Histochemical Processing of Coronal Sections. Journal of Comparative Neurology, 0(ja), e24602. doi: 10.1002/cne.24602. Continue reading “Researchers cited MBF Bioscience systems in 9 papers between 12/14/2018 and 12/21/2018” »

Researchers cited MBF Bioscience systems in 14 papers between 12/7/2018 and 12/14/2018

Posted on December 14, 2018 by MBF Bioscience

Stereo Investigator:

Aldehri, M., Temel, Y., Jahanshahi, A., & Hescham, S. (2018). Fornix deep brain stimulation induces reduction of hippocampal synaptophysin levels. Journal of Chemical Neuroanatomy. doi: https://doi.org/10.1016/j.jchemneu.2018.12.001.

Carrica, L., Li, L., Newville, J., Kenton, J., Gustus, K., Brigman, J., & Cunningham, L. A. (2019). Genetic inactivation of hypoxia inducible factor 1-alpha (HIF-1α) in adult hippocampal progenitors impairs neurogenesis and pattern discrimination learning. Neurobiology of Learning and Memory, 157, 79-85. doi: https://doi.org/10.1016/j.nlm.2018.12.002.

Fowke, T. M., Galinsky, R., Davidson, J. O., Wassink, G., Karunasinghe, R. N., Prasad, J. D., . . . Dean, J. M. (2018). Loss of interneurons and disruption of perineuronal nets in the cerebral cortex following hypoxia-ischaemia in near-term fetal sheep. Scientific Reports, 8(1), 17686. doi: 10.1038/s41598-018-36083-y.

Gibson, E. M., Nagaraja, S., Ocampo, A., Tam, L. T., Wood, L. S., Pallegar, P. N., . . . Monje, M. (2018). Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment. Cell. doi: https://doi.org/10.1016/j.cell.2018.10.049. Continue reading “Researchers cited MBF Bioscience systems in 14 papers between 12/7/2018 and 12/14/2018” »

Researchers cited MBF Bioscience systems in 16 papers between 11/26/2018 and 12/7/2018

Posted on December 7, 2018 by MBF Bioscience

Stereo Investigator

Beldick, S. R., Hong, J., Altamentova, S., Khazaei, M., Hundal, A., Zavvarian, M.-M., . . . Fehlings, M. G. (2018). Severe-combined immunodeficient rats can be used to generate a model of perinatal hypoxic-ischemic brain injury to facilitate studies of engrafted human neural stem cells. Plos one, 13(11). doi: 10.1371/journal.pone.0208105.

Guimarães, M. R., Soares, A. R., Cunha, A. M., Esteves, M., Borges, S., Magalhães, R., . . . Leite-Almeida, H. (2018). Evidence for lack of direct causality between pain and affective disturbances in a rat peripheral neuropathy model. Genes, Brain and Behavior, 0(ja), e12542. doi: 10.1111/gbb.12542.

Killoran, K. E., Kropp, L. E., Lindrose, A. R., Curtis, H. E., Cook, D., & Mitre, E. (2018). Rush desensitization with a single antigen induces subclinical activation of mast cells and protects against bystander challenge in dually sensitized mice. Clinical and Experimental Allergy, 0(ja). doi: 10.1111/cea.13323.

Korkmaz, O. T., Ay, H., Aytan, N., Carreras, I., Kowall, N. W., Dedeoglu, A., & Tuncel, N. (2018). Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer’s Disease. Journal of Molecular Neuroscience. doi: 10.1007/s12031-018-1226-8. Continue reading “Researchers cited MBF Bioscience systems in 16 papers between 11/26/2018 and 12/7/2018” »

Researchers cited MBF Bioscience systems in 11 papers between 11/3/2018 and 11/26/2018

Posted on November 26, 2018 by MBF Bioscience

Stereo Investigator

Buchman, A. S., Leurgans, S. E., VanderHorst, V. G. J. M., Nag, S., Schneider, J. A., & Bennett, D. A. (2018). Spinal motor neurons and motor function in older adults. Journal of Neurology. doi: 10.1007/s00415-018-9118-y.

Chew, C., Kiley, B. J., & Sengelaub, D. R. (2018). Neuroprotective effects on the morphology of somatic motoneurons following the death of neighboring motoneurons: A role for microglia? Developmental Neurobiology, 0(ja). doi: 10.1002/dneu.22652.

Karasawa, M., Yokouchi, K., Kawagishi, K., Moriizumi, T., & Fukushima, N. (2018). Effects of various lengths of hypoglossal nerve resection on motoneuron survival. Journal of Clinical Neuroscience. doi: https://doi.org/10.1016/j.jocn.2018.11.020.

Khattak, S., Gupta, N., Zhou, X., Pires, L., Wilson, B. C., & Yucel, Y. (2018). Non-invasive dynamic assessment of conjunctival melanomas using photoacoustic imaging. Experimental Eye Research. doi: https://doi.org/10.1016/j.exer.2018.11.014. Continue reading “Researchers cited MBF Bioscience systems in 11 papers between 11/3/2018 and 11/26/2018” »

Researchers cited MBF Bioscience systems in 26 papers between 10/19/2018 and 11/2/2018

Posted on November 2, 2018 by MBF Bioscience

Stereo Investigator

Castillo-Ruiz, A., Mosley, M., Jacobs, A. J., Hoffiz, Y. C., & Forger, N. G. (2018). Birth delivery mode alters perinatal cell death in the mouse brain. Proceedings of the National Academy of Sciences. doi: https://doi.org/10.1073/pnas.1811962115.

Chen, Y.-H., Lee, H.-J., Lee, M. T., Wu, Y.-T., Lee, Y.-H., Hwang, L.-L., . . . Chiou, L.-C. (2018). Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray. Proceedings of the National Academy of Sciences. doi: https://doi.org/10.1073/pnas.1807991115.

Garcia-Miralles, M., Yusof, N. A. B. M., Tan, J. Y., Radulescu, C. I., Sidik, H., Tan, L. J., . . . Pouladi, M. A. (2018). Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease. Molecular Neurobiology. doi: 10.1007/s12035-018-1393-1.

Illouz, T., Madar, R., Biragyn, A., & Okun, E. (2018). Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model. Brain, Behavior, and Immunity. doi: https://doi.org/10.1016/j.bbi.2018.10.004. Continue reading “Researchers cited MBF Bioscience systems in 26 papers between 10/19/2018 and 11/2/2018” »

Researchers cited MBF Bioscience systems in 14 papers between 10/12/2018 and 10/19/2018

Posted on October 19, 2018 by MBF Bioscience

Stereo Investigator

Issa, H. A., Staes, N., Diggs-Galligan, S., Stimpson, C. D., Gendron-Fitzpatrick, A., Taglialatela, J. P., . . . Sherwood, C. C. (2018). Comparison of bonobo and chimpanzee brain microstructure reveals differences in socio-emotional circuits. Brain Structure and Function. doi: 10.1007/s00429-018-1751-9.

Jiang, Y., Cao, Z., Ma, H., Wang, G., Wang, X., Wang, Z., . . . Feng, T. (2018). Auricular Vagus Nerve Stimulation Exerts Antiinflammatory Effects and Immune Regulatory Function in a 6-OHDA Model of Parkinson’s Disease. Neurochemical Research, 43(11), 2155-2164. doi: 10.1007/s11064-018-2639-z.

Nuber, S., Rajsombath, M., Minakaki, G., Winkler, J., Müller, C. P., Ericsson, M., . . . Selkoe, D. J. (2018). Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease. Neuron, 100(1), 75-90.e75. doi: https://doi.org/10.1016/j.neuron.2018.09.014.

Wood, T. E., Barry, J., Yang, Z., Cepeda, C., Levine, M. S., & Gray, M. (2018). Mutant huntingtin reduction in astrocytes slows disease progression in the bachd conditional Huntington’s disease mouse model. Human Molecular Genetics, ddy363-ddy363. doi: 10.1093/hmg/ddy363. Continue reading “Researchers cited MBF Bioscience systems in 14 papers between 10/12/2018 and 10/19/2018” »

Researchers cited MBF Bioscience systems in 12 papers between 10/5/2018 and 10/12/2018

Posted on October 12, 2018 by MBF Bioscience

Stereo Investigator:

Dufour, B. D., & McBride, J. L. (2019). Normalizing glucocorticoid levels attenuates metabolic and neuropathological symptoms in the R6/2 mouse model of huntington’s disease. Neurobiology of Disease, 121, 214-229. doi: https://doi.org/10.1016/j.nbd.2018.09.025.

Heermann, T., Garrett, L., Wurst, W., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., . . . Hölter, S. M. (2018). Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice. Molecular Neurobiology. doi: 10.1007/s12035-018-1365-5.

Hussain, T., Kil, H., Hattiangady, B., Lee, J., Kodali, M., Shuai, B., . . . Aldaz, C. M. (2019). Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Neurobiology of Disease, 121, 163-176. doi: https://doi.org/10.1016/j.nbd.2018.09.026.

Maxan, A., Mason, S., Saint-Pierre, M., Smith, E., Ho, A., Harrower, T., . . . Cicchetti, F. (2018). Outcome of cell suspension allografts in a patient with Huntington’s disease. Annals of Neurology, 0(ja). doi: 10.1002/ana.25354.

Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, N. H., Parsons, M. P., Villanueva, E. B., . . . Hayden, M. R. (2018). Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease. Science translational medicine, 10(461). doi: 10.1126/scitranslmed.aar3959
Continue reading “Researchers cited MBF Bioscience systems in 12 papers between 10/5/2018 and 10/12/2018” »

Researchers cited MBF Bioscience systems in 21 papers between 9/28/2018 and 10/5/2018

Posted on October 5, 2018 by MBF Bioscience

Stereo Investigator:

Anselmi, L., Bove, C., Coleman, F. H., Le, K., Subramanian, M. P., Venkiteswaran, K., . . . Travagli, R. A. (2018). Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat. Npj Parkinson’s Disease, 4(1), 30. doi: 10.1038/s41531-018-0066-0.

Bauman, M. D., Schumann, C. M., Carlson, E. L., Taylor, S. L., Vázquez-Rosa, E., Cintrón-Pérez, C. J., . . . Pieper, A. A. (2018). Neuroprotective efficacy of P7C3 compounds in primate hippocampus. Translational Psychiatry, 8(1), 202. doi: 10.1038/s41398-018-0244-1.

Cope, E. C., Opendak, M., LaMarca, E. A., Murthy, S., Park, C. Y., Olson, L. B., . . . Gould, E. (2018). The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety-like behavior in response to nematode infection. Hippocampus, 0(ja). doi:10.1002/hipo.23033.

Ellwardt, E., Pramanik, G., Luchtman, D., Novkovic, T., Jubal, E. R., Vogt, J., . . . Stroh, A. (2018). Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. Nature Neuroscience, 21(10), 1392-1403. doi: 10.1038/s41593-018-0193-2.
Continue reading “Researchers cited MBF Bioscience systems in 21 papers between 9/28/2018 and 10/5/2018” »