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Software & Microscope Integrated Systems

MBF Bioscience >  Blog > MBF Products & Service Solutions  > Software & Microscope Integrated Systems (Page 3)
February 11, 2016

Genetic Mutation Accelerates CTE Pathology

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Stereology, Optical Fractionator
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[caption id="attachment_6175" align="aligncenter" width="480"] Phosphorylated tau pS422 immunoreactive profiles (dark brown) in the cortex of P301S mice after repetitive mild TBI. Image courtesy of Dr. Leyan Xu, Department of Pathology, Johns Hopkins University.[/caption]   Over the course of a football game or a boxing match, athletes may experience a series of mild concussions. Some of these athletes develop a condition known as chronic traumatic encephalopathy (CTE), a...

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December 1, 2015

New Software Released for Automated Neuron Reconstruction and Analysis

by Pasang
in Company News, Software Applications For Quantitive Analysis, Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360, 3D Reconstruction, Neuron Reconstruction
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How the brain works and how the brain is affected by disease are mysteries in large part because neurons are so dynamic, numerous, and complex. Neurolucida 360, a revolutionary, new software product from MBF Bioscience, enables neuroscientists to uncover more information about neurons at a faster rate.   “Neurolucida 360 is a technological revolution” says Jack Glaser, President of MBF Bioscience. “It is the state-of-the-art tool for neuroscientists to analyze...

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November 11, 2015

Dying neurons in Alzheimer’s patients show signs of improvement after gene therapy

by Pasang
in Software & Microscope Integrated Systems, Stereo Investigator®, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Alzheimer’s Disease, Stereology
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[caption id="attachment_6094" align="alignright" width="231"] Micrograph of cholinergic neurons in the nucleus basalis of Meynert. Image from Wikipedia.[/caption]   Cholinergic neurons degenerate at devastating rates in Alzheimer's disease, but Dr. Mark Tuszynski and his team at the University of California, San Diego may have found a way to slow the decline.   Their study, published in JAMA Neurology, reports that nerve growth factor gene therapy increased the size, axonal sprouting, and signaling of cholinergic neurons...

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March 4, 2015

Hippocampal Neurons Change After Melatonin Injection

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Neuron Reconstruction
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[caption id="attachment_5635" align="aligncenter" width="584"] Representative dendrites of dentate gyrus neurons of Siberian hamsters injected with melatonin (stained with Cresyl violet). Ikeno et al found hamsters injected with melatonin displayed decreased spine density on neurons in the dentate gyrus. Image courtesy of Tomoko Ikeno, Ph.D.[/caption]   Night falls and a powerful hormone called melatonin kicks in. The gears of the circadian clock are turning as you get ready...

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February 17, 2015

Stereo Investigator continues to be the leading stereology system

by Pasang
in Company News, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Stereology
Comments

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers - citing it almost three times more than all other stereology systems combined. Researchers tell us they use Stereo Investigator because: it works with many different microscopes and imaging technologies it provides unbiased data about neuron populations and regions of interest it comes with strong technical and research support provided by MBF Bioscience [caption id="attachment_5790" align="alignnone" width="1394"] source: google scholar[/caption] Dr. Mark West, co-developer of...

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February 4, 2015

How Transplanted Stem Cells Behave in Injured Spinal Cord Tissue

by Pasang
in Scientific Applications & Use Cases, Software & Microscope Integrated Systems, Stereo Investigator®, MBF Products & Service Solutions, Additional Subject Matter, Stem Cell Research, Stereology
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[caption id="attachment_5546" align="aligncenter" width="401"] A representative confocal image of spinal cord tissue fluorescently immunolabeled for SC121 (red) in conjunction with GFAP (green) – markers that allowed researchers to quantify stem cell differentiation and migration. (Image provided by study author Dr. Aileen J. Anderson)[/caption]   Research has shown that transplanting human neural stem cells into damaged spinal cords restores locomotor function in a mouse model of spinal cord injury1. Researchers...

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January 23, 2015

Dendritic Spine Loss Reported in Schizophrenia and Bipolar Disorder

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Neuron Reconstruction
Comments

[caption id="attachment_5745" align="aligncenter" width="307"] Golgi-stained human brain tissue from the dorsolateral prefrontal cortex.[/caption] Schizophrenia and bipolar disorder are very different mental illnesses, but researchers are discovering evidence that the two disorders have some common pathologies. According to a recent study, a shared characteristic appears to be dendritic spine loss.   The researchers used Neurolucida to study pyramidal cells in human brain tissue from individuals with schizophrenia (n=14), individuals with bipolar...

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October 23, 2014

Two 2014 Nobel Laureates Used Neurolucida to Create 3D Reconstructions of Neurons That Help Rats and Humans Navigate the World

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Neuron Reconstruction
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[caption id="attachment_5670" align="aligncenter" width="210"] Drs. May-Britt and Edvard Moser Image from GEIR MOGEN / NTNU[/caption]   Drs. May-Britt and Edvard Moser were awarded the 2014 Nobel Prize in Physiology or Medicine for discovering the cells that form a network for spatial navigation in the brain, and we're proud to say they are MBF Bioscience customers and used Neurolucida in their research.   In 2006, the Norwegian husband and wife...

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October 14, 2014

Anorexia Accelerates the Development of the Rat Hippocampus

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Neuron Reconstruction
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[caption id="attachment_5617" align="alignnone" width="700"] This image stack was used in the study to analyze spine density. Image courtesy of Tara Chowdhury, Ph.D. first author of the study.[/caption]   To find out how anorexia nervosa changes the brain, scientists at New York University are studying a rat model of the disease called activity-based anorexia (ABA). Previously, they discovered that ABA rats develop unusually robust dendritic branching of neurons...

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September 26, 2014

Scientists Use Neurolucida to Create 3D Reconstructions of Placental Villous Trees

by Pasang
in Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, Neuron Reconstruction
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When neuroscientists started studying neurons in 3D, it revolutionized brain science. Now, for the first time, scientists are using this same technology to study the human placenta, and they've made some fascinating new discoveries about its structure.   Using Neurolucida to create 3D reconstructions of villous trees – three-dimensional structures in the placenta that facilitate gas and nutrient exchange between the fetus and mother – researchers in...

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