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Neuron Reconstruction

MBF Bioscience >  Blog > Scientific Applications & Use Cases  > Neuron Reconstruction
November 30, 2017

NeuroMorpho.Org Releases Nearly 10,000 New Neuron Reconstructions and Neurolucida leads the way

by Pasang
in Software Applications For Quantitive Analysis, Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Neurolucida®360, 3D Reconstruction, Neuron Reconstruction
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[caption id="attachment_6839" align="aligncenter" width="632"] Image Courtesy: Bob Jacobs, Ph.D. , Colorado College[/caption]   With the release of its new version on November 28, NeuroMorpho.org adds 9,987 new images to its archive, bringing its impressive collection of digitally reconstructed neurons to 80,012.   Scientists used MBF Bioscience’s software, Neurolucida and Neurolucida 360, to reconstruct the majority of these cells. In fact, 64 times more neurons were reconstructed with MBF Bioscience...

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March 24, 2017

A complete guide to imaging and analyzing spines and neurons with Neurolucida 360

by Pasang
in Software Applications For Quantitive Analysis, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360, 3D Reconstruction, Neuron Reconstruction
Comments

Following a well-designed protocol is essential to achieving accurate and consistent results in scientific research. Now, scientists using Neurolucida 360 for dendritic spine and neuron analysis can follow a published set of guidelines to ensure optimal confocal data series for proper dendritic spine quantification and neuron reconstruction. The paper, written by MBF Bioscience scientists and researchers from the Icahn School of Medicine at Mount Sinai...

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January 11, 2017

Uncovering the role of microglia in fetal alcohol spectrum disorders

by Pasang
in Neurolucida®, Stereo Investigator®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Stereology, Neuron Reconstruction
Comments

[caption id="attachment_6526" align="aligncenter" width="800"] Representative images of Iba-1+ microglia in the postnatal day 10 rat hippocampus. Image courtesy of Anna Klintsova, PhD.[/caption] Children born with fetal alcohol spectrum disorders face a range of physical and cognitive impairments including long-term deficits in learning, behavior, and immune function. In a paper published in Neuroscience, Dr. Anna Klintsova and her lab at the University of Delaware report that activation...

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July 6, 2016

Scientists Observe Differences Between Brains of Stressed and Unstressed Rats After Fear Conditioning

by Pasang
in Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Neuron Reconstruction
Comments

[caption id="attachment_6403" align="aligncenter" width="632"] This figure illustrates the separate and combined effects of acute stress and fear conditioning/extinction on dendritic morphology of pyramidal neurons in the infralimbic region of medial prefrontal cortex. Each neuron shown is a composite made up of apical (blue) and basilar (orange) arbor near the mean of the group. The apical and basilar arbors of each composite are from different neurons....

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December 4, 2015

The U.S. Small Business Administration Publishes MBF Bioscience Success Story

by Pasang
in Company News, Scientific Applications & Use Cases, Additional Subject Matter, Neuron Reconstruction
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  The U.S. Small Business Administration recently published a success story about MBF Bioscience. The article highlights our success using federal Small Business Innovation Research (SBIR) grants to develop innovative products that help advance science. MBF Bioscience has a distinguished R&D program that develops cutting-edge tools for scientific research.   The SBIR grants have helped MBF Bioscience develop tools such as Neurolucida, the most widely used system for...

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December 1, 2015

New Software Released for Automated Neuron Reconstruction and Analysis

by Pasang
in Neurolucida®, Company News, Software Applications For Quantitive Analysis, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Neurolucida®360, 3D Reconstruction, Neuron Reconstruction
Comments

How the brain works and how the brain is affected by disease are mysteries in large part because neurons are so dynamic, numerous, and complex. Neurolucida 360, a revolutionary, new software product from MBF Bioscience, enables neuroscientists to uncover more information about neurons at a faster rate.   “Neurolucida 360 is a technological revolution” says Jack Glaser, President of MBF Bioscience. “It is the state-of-the-art tool for neuroscientists to analyze...

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March 4, 2015

Hippocampal Neurons Change After Melatonin Injection

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Neuron Reconstruction
Comments

[caption id="attachment_5635" align="aligncenter" width="584"] Representative dendrites of dentate gyrus neurons of Siberian hamsters injected with melatonin (stained with Cresyl violet). Ikeno et al found hamsters injected with melatonin displayed decreased spine density on neurons in the dentate gyrus. Image courtesy of Tomoko Ikeno, Ph.D.[/caption]   Night falls and a powerful hormone called melatonin kicks in. The gears of the circadian clock are turning as you get ready...

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January 23, 2015

Dendritic Spine Loss Reported in Schizophrenia and Bipolar Disorder

by Pasang
in Neurolucida®, Scientific Applications & Use Cases, Software & Microscope Integrated Systems, MBF Products & Service Solutions, Neuron Reconstruction
Comments

[caption id="attachment_5745" align="aligncenter" width="307"] Golgi-stained human brain tissue from the dorsolateral prefrontal cortex.[/caption] Schizophrenia and bipolar disorder are very different mental illnesses, but researchers are discovering evidence that the two disorders have some common pathologies. According to a recent study, a shared characteristic appears to be dendritic spine loss.   The researchers used Neurolucida to study pyramidal cells in human brain tissue from individuals with schizophrenia (n=14), individuals with bipolar...

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October 23, 2014

Two 2014 Nobel Laureates Used Neurolucida to Create 3D Reconstructions of Neurons That Help Rats and Humans Navigate the World

by Pasang
in Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Neuron Reconstruction
Comments

[caption id="attachment_5670" align="aligncenter" width="210"] Drs. May-Britt and Edvard Moser Image from GEIR MOGEN / NTNU[/caption]   Drs. May-Britt and Edvard Moser were awarded the 2014 Nobel Prize in Physiology or Medicine for discovering the cells that form a network for spatial navigation in the brain, and we're proud to say they are MBF Bioscience customers and used Neurolucida in their research.   In 2006, the Norwegian husband and wife...

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October 14, 2014

Anorexia Accelerates the Development of the Rat Hippocampus

by Pasang
in Neurolucida®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Neuron Reconstruction
Comments

[caption id="attachment_5617" align="alignnone" width="700"] This image stack was used in the study to analyze spine density. Image courtesy of Tara Chowdhury, Ph.D. first author of the study.[/caption]   To find out how anorexia nervosa changes the brain, scientists at New York University are studying a rat model of the disease called activity-based anorexia (ABA). Previously, they discovered that ABA rats develop unusually robust dendritic branching of neurons...

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