MBF Bioscience News

September 16, 2006

Different Brain Cells Use Different Strategies to Communicate with Movement Control Centers

Hooks BM, Papale AE, Paletzki RF, Feroze MW, Eastwood BS, Couey JJ, Winnubst J, Chandrashekar J, Gerfen CR.

IT-type and PT-type cortical neurons show distinct projection patterns to the striatum. IT neurons create broad, consistent corticostriatal maps, while PT neurons form more focal and variable inputs, revealing cell-type–specific organization of motor-control pathways....

February 26, 2006

Neuron-Specific Thalamic Connectivity Patterns Encode Spontaneous Movement in Sensory Cortex

by Pasang

in NeuroInfo Case Studies

Comments

Inácio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S.

Movement-correlated neurons in somatosensory cortex receive stronger thalamic glutamatergic input and weaker motor cortical input than uncorrelated cells. Silencing thalamus reduces movement responses, indicating that stable movement encoding in wS1 is primarily driven by thalamic circuits....

January 17, 2006

Ventral Tegmental Dopamine Initiates Fear Extinction by Activating Reward-Processing Circuits in the Amygdala

by Pasang

in NeuroInfo Case Studies

Comments

Zhang X, Flick K, Rizzo M, Pignatelli M, Tonegawa S.

Dopamine from the ventral tegmental area signals unexpected threat omission to D1-rich neurons in the basolateral amygdala. Manipulating this pathway alters extinction behavior, showing that VTA-to-BLA dopamine acts as a teaching signal that drives fear extinction memory formation....

January 10, 2006

Single-Cell Optical Control of Gene Expression in C. elegans

by Pasang

in WormLab Case Studies

Comments

Davis L, Radman I, Goutou A, Tynan A, Baxter K, Xi Z, O'Shea JM, Chin JW, Greiss S.

Precise, single-cell control of gene expression enables new insights into neural circuit function. This study introduces LaserTAC, an optical genetic toolkit for targeting individual neurons in C. elegans....

January 10, 2006

Calcium-Mediated Dopaminergic Neuron Loss Caused by TRP Channel Mutations

by Pasang

in WormLab Case Studies

Comments

Nagarajan A, Ning Y, Reisner K, Buraei Z, Larsen JP, Hobert O, Doitsidou M.

A mechanosensitive TRP channel mutation can directly trigger dopaminergic neurodegeneration. This study identifies calcium dysregulation via TRP-4 as a driver of progressive neuronal loss in C. elegans....

January 10, 2006

Manuka Honey Reduces Amyloid-β–Induced Neurotoxicity via Oxidative Stress Pathways

by Pasang

in WormLab Case Studies

Comments

Navarro-Hortal MD, Romero-Márquez JM, Muñoz-Ollero P, et al.

Antioxidant compounds in Manuka honey attenuate Aβ toxicity via HSP-16.2 and SKN-1/Nrf2 pathways. Behavioral outcomes highlight a trade-off between neuroprotection and sugar-related effects....

January 10, 2006

Reducing Base Excision Repair Alleviates Tau-Induced Neurotoxicity

by Pasang

in WormLab Case Studies

Comments

Tiwari V, Buvarp E, Borbolis F, Puligilla C, Croteau DL, Palikaras K, Bohr VA.

Altering DNA repair pathways can unexpectedly protect against tau-induced neurotoxicity. This study shows that reducing base excision repair initiation improves health span and cognition in a C. elegans tauopathy model. ...

January 10, 2006

Shock Wave–Induced Neuromodulation Assessed in C. Elegans

by Pasang

in WormLab Case Studies

Comments

Hochstrasser H, Kaub L, Maier L, Angstman NB, Kenmoku T, Nussbaum-Krammer C, Schmitz C.

Radial extracorporeal shock waves alter nervous system function beyond the neuromuscular junction. Using C. elegans, this study probes how shock waves modulate cholinergic-driven behavior....

January 10, 2006

Genetic Control of Neuroendocrine Signaling Underlies Behavioral Diversity in C. elegans

by Pasang

in WormLab Case Studies

Comments

Lee H, Boor SA, Hilbert ZA, Meisel JD, Park J, Wang Y, McKeown R, Fischer SEJ, Andersen EC, Kim DH.

Natural genetic variation can rewire neuroendocrine signaling to shape behavior. This study shows how gap-2 variants alter neuron-specific daf-7 expression to drive foraging diversity in C. elegans. ...

January 10, 2006

A Metabolic Brake on Aging: G3PP Activity Promotes Longevity

by Pasang

in WormLab Case Studies

Comments

Possik E, Schmitt C, Al-Mass A, Bai Y, Côté L, Morin J, Erb H, Oppong A, Kahloan W, Parker JA, Madiraju SRM, Prentki M.

Metabolic enzymes that limit glycerol-3-phosphate accumulation can promote stress resistance and longevity. This study identifies G3PP homologs as key regulators of fat metabolism and healthy aging in C. elegans. ...

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MBF Bioscience News

Different Brain Cells Use Different Strategies to Communicate with Movement Control Centers

Neuron-Specific Thalamic Connectivity Patterns Encode Spontaneous Movement in Sensory Cortex

Ventral Tegmental Dopamine Initiates Fear Extinction by Activating Reward-Processing Circuits in the Amygdala

Single-Cell Optical Control of Gene Expression in C. elegans

Calcium-Mediated Dopaminergic Neuron Loss Caused by TRP Channel Mutations

Manuka Honey Reduces Amyloid-β–Induced Neurotoxicity via Oxidative Stress Pathways

Reducing Base Excision Repair Alleviates Tau-Induced Neurotoxicity

Shock Wave–Induced Neuromodulation Assessed in C. Elegans

Genetic Control of Neuroendocrine Signaling Underlies Behavioral Diversity in C. elegans

A Metabolic Brake on Aging: G3PP Activity Promotes Longevity

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