Inácio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S.
Movement-correlated neurons in somatosensory cortex receive stronger thalamic glutamatergic input and weaker motor cortical input than uncorrelated cells. Silencing thalamus reduces movement responses, indicating that stable movement encoding in wS1 is primarily driven by thalamic circuits.... Read More
Zhang X, Flick K, Rizzo M, Pignatelli M, Tonegawa S.
Dopamine from the ventral tegmental area signals unexpected threat omission to D1-rich neurons in the basolateral amygdala. Manipulating this pathway alters extinction behavior, showing that VTA-to-BLA dopamine acts as a teaching signal that drives fear extinction memory formation.... Read More
Davis L, Radman I, Goutou A, Tynan A, Baxter K, Xi Z, O'Shea JM, Chin JW, Greiss S.
Precise, single-cell control of gene expression enables new insights into neural circuit function. This study introduces LaserTAC, an optical genetic toolkit for targeting individual neurons in C. elegans.... Read More
Nagarajan A, Ning Y, Reisner K, Buraei Z, Larsen JP, Hobert O, Doitsidou M.
A mechanosensitive TRP channel mutation can directly trigger dopaminergic neurodegeneration. This study identifies calcium dysregulation via TRP-4 as a driver of progressive neuronal loss in C. elegans.... Read More
Navarro-Hortal MD, Romero-Márquez JM, Muñoz-Ollero P, et al.
Antioxidant compounds in Manuka honey attenuate Aβ toxicity via HSP-16.2 and SKN-1/Nrf2 pathways. Behavioral outcomes highlight a trade-off between neuroprotection and sugar-related effects.... Read More
Tiwari V, Buvarp E, Borbolis F, Puligilla C, Croteau DL, Palikaras K, Bohr VA.
Altering DNA repair pathways can unexpectedly protect against tau-induced neurotoxicity. This study shows that reducing base excision repair initiation improves health span and cognition in a C. elegans tauopathy model. ... Read More
Hochstrasser H, Kaub L, Maier L, Angstman NB, Kenmoku T, Nussbaum-Krammer C, Schmitz C.
Radial extracorporeal shock waves alter nervous system function beyond the neuromuscular junction. Using C. elegans, this study probes how shock waves modulate cholinergic-driven behavior.... Read More
Lee H, Boor SA, Hilbert ZA, Meisel JD, Park J, Wang Y, McKeown R, Fischer SEJ, Andersen EC, Kim DH.
Natural genetic variation can rewire neuroendocrine signaling to shape behavior. This study shows how gap-2 variants alter neuron-specific daf-7 expression to drive foraging diversity in C. elegans. ... Read More
Possik E, Schmitt C, Al-Mass A, Bai Y, Côté L, Morin J, Erb H, Oppong A, Kahloan W, Parker JA, Madiraju SRM, Prentki M.
Metabolic enzymes that limit glycerol-3-phosphate accumulation can promote stress resistance and longevity. This study identifies G3PP homologs as key regulators of fat metabolism and healthy aging in C. elegans. ... Read More
Jiang L, Wang X, Zhang D, Yee Yuen KW, Tse YC.
Maintaining sarcomere integrity is essential for preserving muscle function during aging. This study identifies RSU-1 as a key stabilizer of dense bodies and M-lines in aging C. elegans muscle. ... Read More