Stranahan AM, Jiam NT, Spiegel AM, Gallagher M.
Aging leads to significant loss of both principal neurons and inhibitory interneurons in the dorsal prefrontal cortex. In contrast, ventral prefrontal regions remain structurally preserved.... Read More
Rapp PR, Gallagher M.
Unbiased stereological analysis reveals no neuron loss in hippocampal subfields of aged rats with memory deficits.... Read More
Hanafy AS, Steinlein P, Pitsch J, Silva MH, Vana N, Becker AJ, Graham ME, Schoch S, Lamprecht A, Dietrich D.
This study presents a live brain-slice model that enables high-resolution imaging and quantitative analysis of blood–brain barrier permeability and transporter function at the level of individual capillaries.... Read More
Bar-Noam AS, Farah N, Shoham S.
A model-guided two-photon optical design enables high-resolution retinal imaging and functional calcium recordings without the need for adaptive optics.... Read More
Bakker GJ, Weischer S, Ferrer Ortas J, Heidelin J, Andresen V, Beutler M, Beaurepaire E, Friedl P.
A multiphoton imaging approach using infrared excitation enables non-invasive, deep-tissue visualization with preserved resolution in highly scattering tissues.... Read More
Wang K, Pan Y, Tong S, Liang H, Qiu P.
Multiphoton excitation at 1700 nm enables high-resolution visualization of lymphatic structure and dynamics in strongly scattering skin tissue.... Read More
Heiser H, Kiessler F, Roggenbach A, Ibanez V, Wieckhorst M, Helmchen F, Gjorgjieva J, Wahl AS.
Chronic two-photon imaging reveals that loss of stable hippocampal place cells underlies memory impairment following microvascular injury.... Read More
Vallentin D, Kosche G, Lipkind D, Long MA.
Two-photon–guided electrophysiology reveals that inhibitory synaptic activity increases with song learning and suppresses sensory input to HVC premotor neurons.... Read More
Cox J, Pinto L, Dan Y.
Cell-type-specific calcium imaging revealed distinct and spatially organized activity patterns in the dorsal pons across sleep–wake states. Glutamatergic neurons were predominantly active during REM sleep, while GABAergic neurons were biased toward wakefulness, highlighting specialized subpopulations involved in sleep regulation.... Read More
Yang W, Miller JE, Carrillo-Reid L, Pnevmatikakis E, Paninski L, Yuste R, Peterka DS.
A holographic two-photon imaging system enables simultaneous multi-plane recording of neuronal activity across cortical layers with single-cell precision. Multiplexed excitation and synchronized acquisition capture fast, correlated calcium dynamics beyond the limits of sequential two-photon scanning.... Read More