Researchers cited MBF Bioscience systems in 19 papers between 7/27/2018 and 8/3/2018

Stereo Investigator:

Bassey, R. B., & Gondré-Lewis, M. C. (2018). Combined early life stressors: Prenatal nicotine and maternal deprivation interact to influence affective and drug seeking behavioral phenotypes in rats. Behavioural Brain Research. doi:

Deniz, Ö. G., Altun, G., Kaplan, A. A., Yurt, K. K., von Bartheld, C. S., & Kaplan, S. (2018). A concise review of optical, physical and isotropic fractionator techniques in neuroscience studies, including recent developments. Journal of Neuroscience Methods. doi:

Milanese, C., Cerri, S., Ulusoy, A., Gornati, S. V., Plat, A., Gabriels, S., . . . Mastroberardino, P. G. (2018). Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease. Cell death & disease, 9(8), 818. doi: 10.1038/s41419-018-0848-7.

Pozner, T., Vistoropsky, Y., Moaraf, S., Heiblum, R., & Barnea, A. (2018). Questioning Seasonality of Neuronal Plasticity in the Adult Avian Brain. Scientific Reports, 8(1), 11289. doi: 10.1038/s41598-018-29532-1.  Continue reading “Researchers cited MBF Bioscience systems in 19 papers between 7/27/2018 and 8/3/2018” »

Researchers cited MBF Bioscience systems in 23 papers between 6/8/2018 and 6/22/2018

Stereo Investigator:

Caracciolo, L., Marosi, M., Mazzitelli, J., Latifi, S., Sano, Y., Galvan, L., . . . Carmichael, S. T. (2018). CREB controls cortical circuit plasticity and functional recovery after stroke. Nature Communications, 9(1), 2250. doi: 10.1038/s41467-018-04445-9.

Darling, W. G., Ge, J., Stilwell-Morecraft, K. S., Rotella, D. L., Pizzimenti, M. A., & Morecraft, R. J. (2018). Hand Motor Recovery following Extensive Frontoparietal Cortical Injury is accompanied by Upregulated Corticoreticular Projections in the Monkey. The Journal of Neuroscience. doi:

George, P. M., Oh, B., Dewi, R., Hua, T., Cai, L., Levinson, A., . . . Steinberg, G. K. (2018). Engineered stem cell mimics to enhance stroke recovery. Biomaterials, 178, 63-72. doi:

Giza, J. I., Kim, J., Meyer, H. C., Anastasia, A., Dincheva, I., Zheng, C. I., . . . Lee, F. S. (2018). The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior. Neuron. doi:

LaPlaca, M. C., Lessing, M. C., Prado, G. R., Zhou, R., Tate, C. C., Geddes-Klein, D., . . . Zhang, L. (2018). Mechanoporation is a potential indicator of tissue strain and subsequent degeneration following experimental traumatic brain injury. Clinical Biomechanics. doi:  Continue reading “Researchers cited MBF Bioscience systems in 23 papers between 6/8/2018 and 6/22/2018” »

Researchers cited MBF Bioscience systems in 16 papers between 5/25/2018 and 6/1/2018

Stereo Investigator:

Durmuş, B., Aytül, K., & Sıla, C. (2018). Morphology and quantification of sheep pineal glands at pre‐pubertal, pubertal and post‐pubertal periods. Anatomia, Histologia, Embryologia, 0(0). doi:10.1111/ahe.12359.

Ehara, A., Nakadate, K., Sugimoto, H., Yoshimoto, K., & Ueda, S. (2018). Role of neuronal nitric oxide synthase in slowly progressive dopaminergic neurodegeneration in the Zitter rat. Nitric Oxide, 78, 41-50. doi:

Hain, E. G., Sparenberg, M., Rasińska, J., Klein, C., Akyüz, L., & Steiner, B. (2018). Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion. Journal of Neuroinflammation, 15(1), 162. doi: 10.1186/s12974-018-1179-4.

Harrell, C. S., Zainaldin, C., McFarlane, D., Hyer, M. M., Stein, D., Sayeed, I., & Neigh, G. N. (2018). High-fructose diet during adolescent development increases neuroinflammation and depressive-like behavior without exacerbating outcomes after stroke. Brain, Behavior, and Immunity. doi:

Nagahama, H., Nakazaki, M., Sasaki, M., Kataoka-Sasaki, Y., Namioka, T., Namioka, A., . . . Honmou, O. (2018). Preservation of interhemispheric cortical connections through corpus callosum following intravenous infusion of mesenchymal stem cells in a rat model of cerebral infarction. Brain Research, 1695, 37-44. doi:  Continue reading “Researchers cited MBF Bioscience systems in 16 papers between 5/25/2018 and 6/1/2018” »

Researchers cited MBF Bioscience systems in 14 papers between 4/27/2018 and 5/4/2018

Stereo Investigator:

Bhaduri, B., Abhilash, P. L., & Alladi, P. A. (2018). Baseline striatal and nigral interneuronal protein levels in two distinct mice strains differ in accordance with their MPTP susceptibility. Journal of Chemical Neuroanatomy, 91, 46-54. doi:

Dong, Y., Chunli, L., Jiang, W., & Bingren, H. (2018). Nest‐building activity as a reproducible and long‐term stroke deficit test in a mouse model of stroke. Brain and Behavior. doi:10.1002/brb3.993.

F.B. Beyazal Celiker, L. Tumkaya, t. Mercantepe, G. Turan, A. Yilmaz, M. Beyazal, A. Turan, M.F. Inecikli, M. Kosem. (2018). The effect of gadolinium‐based contrast agents on rat testis. Andrologia. doi:10.1111/and.13031.

Guma, E., Rocchetti, J., Devenyi, G. A., Tanti, A., Mathieu, A., Lerch, J. P., . . . Giros, B. (2018). Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor. Neuroimage. doi:

Kim, D., Hwang, H., Choi, S., Kwon, S. H., Lee, S., Park, J. H., . . . Ko, H. S. (2018). D409H GBA1 mutation accelerates the progression of pathology in A53T α-synuclein transgenic mouse model. Acta Neuropathologica Communications, 6(1), 32. doi: 10.1186/s40478-018-0538-9. Continue reading “Researchers cited MBF Bioscience systems in 14 papers between 4/27/2018 and 5/4/2018” »

Researchers cited MBF Bioscience systems in 16 papers between 4/6/2018 and 4/13/2018

Stereo Investigator: 

Chen, C., Li, X., Ge, G., Liu, J., Biju, K. C., Laing, S. D., . . . Li, S. (2018). GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice. Scientific Reports, 8(1), 5460. doi: 10.1038/s41598-018-23795-4.

Demars, F., Clark, K., Wyeth, M. S., Abrams, E., & Buckmaster, P. S. (2018). A single subconvulsant dose of domoic acid at mid-gestation does not cause temporal lobe epilepsy in mice. Neurotoxicology. doi:

Garrett, L., Ung, M. C., Heermann, T., Niedermeier, K. M., & Hölter, S. (2018). Analysis of Neuropsychiatric Disease‐Related Functional Neuroanatomical Markers in Mice. Current Protocols in Mouse Biology, 8(1), 79-128. doi:10.1002/cpmo.37.

Piontkewitz, Y., Arad, M., & Weiner, I. (2018). T194. BRAIN STRUCTURAL AND BEHAVIORAL ABNORMALITIES FOLLOWING PRENATAL EXPOSURE TO MATERNAL INFLAMMATION ARE PREVENTED BY EARLY BUT NOT LATE INTERVENTION. Schizophrenia Bulletin, 44(suppl_1), S191-S192. doi: 10.1093/schbul/sby016.470.  Continue reading “Researchers cited MBF Bioscience systems in 16 papers between 4/6/2018 and 4/13/2018” »

Researchers cited MBF Bioscience systems in 11 papers between 3/9/2018 and 3/16/2018

Stereo Investigator:
journal images sm

Deroche-Gamonet, V., Revest, J.-M., Fiancette, J.-F., Balado, E., Koehl, M., Grosjean, N., . . . Piazza, P.-V. (2018). Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Molecular Psychiatry. doi: 10.1038/s41380-018-0038-0.

Mendez-Gomez, H. R., Singh, J., Meyers, C., Chen, W., Gorbatyuk, O. S., & Muzyczka, N. (2018). The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson’s Disease. Neuroscience. doi:

Wang, Y., Wang, Y., Liu, J., & Wang, X. (2018). Electroacupuncture Alleviates Motor Symptoms and Up-Regulates Vesicular Glutamatergic Transporter 1 Expression in the Subthalamic Nucleus in a Unilateral 6-Hydroxydopamine-Lesioned Hemi-Parkinsonian Rat Model.  Neuroscience bulletin. doi: 10.1007/s12264-018-0213-y.


Borreca, A., Latina, V., Corsetti, V., Middei, S., Piccinin, S., Della Valle, F., . . . Amadoro, G. (2018). AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy. Molecular Neurobiology. doi: 10.1007/s12035-018-0974-3.

Continue reading “Researchers cited MBF Bioscience systems in 11 papers between 3/9/2018 and 3/16/2018” »

NeuroMorpho.Org Releases Nearly 10,000 New Neuron Reconstructions and Neurolucida leads the way

Image Courtesy: Bob Jacobs, Ph.D. , Colorado College

With the release of its new version on November 28, adds 9,987 new images to its archive, bringing its impressive collection of digitally reconstructed neurons to 80,012.

Scientists used MBF Bioscience’s software, Neurolucida and Neurolucida 360, to reconstruct the majority of these cells. In fact, 64 times more neurons were reconstructed with MBF Bioscience software than those imaged by our closest commercial competitor – that’s 42,121 reconstructions compared to 656. This metric demonstrates that Neurolucida and Neurolucida 360 are truly the gold standards for neuron reconstruction.

Featuring contributions from hundreds of laboratories from around the globe, NeuroMorpho.Org is the world’s leading database of publicly accessible 3D neuronal reconstructions and associated metadata. From the dragonfly to the humpback whale, researchers have access to accurate and verified data from an array of different organisms. Arranged by animal species, brain region, cell type, or contributing laboratory, each file contains specific details about the cell’s morphology such as age, developmental stage, soma volume, and number of branches – all of which are searchable.

Recently, NeuroMorpho.Org hit the 8 million download mark, with researchers in 166 different countries accessing this valuable resource, and more than one thousand published articles referencing its data

Researchers cited MBF Bioscience systems in 32 papers between 08/11/2017 and 08/18/2017

Stereo Investigator:journal images sm

Bazzigaluppi, P., Beckett, T. L., Koletar, M. M., Lai, A. Y., Joo, I. L., Brown, M. E., . . . Stefanovic, B. (2017). Early stage attenuation of phase amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of AD. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.14136.

Bull, C., Cooper, C., Lindahl, V., Fitting, S., Persson, A. I., Grandér, R., . . . Blomgren, K. (2017). Exercise in Adulthood after Irradiation of the Juvenile Brain Ameliorates Long-Term Depletion of Oligodendroglial Cells. Radiation Research, 0(0), null. doi: 10.1667/rr14737.1.

Edler, M. K., Sherwood, C. C., Meindl, R. S., Hopkins, W. D., Ely, J. J., Erwin, J. M., . . . Raghanti, M. A. (2017). Aged chimpanzees exhibit pathologic hallmarks of Alzheimer’s disease. Neurobiology of Aging. doi:

Fernandez, G. M., & Savage, L. M. (2017). Adolescent binge ethanol exposure alters specific forebrain cholinergic cell populations and leads to selective functional deficits in the prefrontal cortex. Neuroscience. doi:

Hong, J., Wang, L., Zhang, T., Zhang, B., & Chen, L. (2017). Sigma-1 receptor knockout increases α-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra. Neurobiology of Aging. doi:

Li, W.-Y., Wang, Y., Zhai, F.-G., Sun, P., Cheng, Y.-X., Deng, L.-X., & Wang, Z.-Y. (2017). AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury. Neural Plasticity, 2017.

Continue reading “Researchers cited MBF Bioscience systems in 32 papers between 08/11/2017 and 08/18/2017” »

Researchers cited MBF systems in 27 papers between 3/20/2017 and 3/30/2017

Stereo Investigator:journal images sm

Abe, C., Inoue, T., Inglis, M. A., Viar, K. E., Huang, L., Ye, H., . . . Guyenet, P. G. (2017). C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. Nature Neuroscience, advance online publication. doi: 10.1038/nn.4526

Caldwell, A. S. L., Edwards, M. C., Desai, R., Jimenez, M., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2017). Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1616467114.

Castro-Hernández, J., Adlard, P. A., & Finkelstein, D. I. (2017). Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion. Scientific Reports, 7, 44426. doi: 10.1038/srep44426.

Dawes, W. J., Zhang, X., Fancy, S. P., Rowitch, D., & Marino, S. (2017). Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone. Developmental Neuroscience.

Drobyshevsky, A., & Quinlan, K. A. (2017). Spinal cord injury in hypertonic newborns after antenatal hypoxia-ischemia in a rabbit model of cerebral palsy. Experimental Neurology, 293, 13-26. doi:

El Massri, N., Lemgruber, A. P., Rowe, I. J., Moro, C., Torres, N., Reinhart, F., . . . Mitrofanis, J. (2017). Photobiomodulation-induced changes in a monkey model of Parkinson’s disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum. Experimental Brain Research, 1-14. doi: 10.1007/s00221-017-4937-0.

Hühner, L., Rilka, J., Gilsbach, R., Zhou, X., Machado, V., & Spittau, B. (2017). Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo. Frontiers in Molecular Neuroscience, 10(62). doi: 10.3389/fnmol.2017.00062.

Meng, L., Huang, T., Sun, C., Hill, D. L., & Krimm, R. (2017). BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section. Experimental Neurology, 293, 27-42. doi:

Continue reading “Researchers cited MBF systems in 27 papers between 3/20/2017 and 3/30/2017” »

A complete guide to imaging and analyzing spines and neurons with Neurolucida 360

Following a well-designed protocol is essential to achieving accurate and consistent results in scientific research. Now, scientists using Neurolucida 360 for dendritic spine and neuron analysis can follow a published set of guidelines to ensure optimal confocal data series for proper dendritic spine quantification and neuron reconstruction. The paper, written by MBF Bioscience scientists and researchers from the Icahn School of Medicine at Mount Sinai in New York, was published in Current Protocols in Neuroscience.

The four protocols describe best practices for imaging and analyzing dendritic spines and entire neurons. Clearly laid out procedures specify necessary materials, image acquisition techniques, and analysis procedures with Neurolucida 360.

Imaging technique is crucial to obtaining unbiased, reproducible results. Clear, crisp images captured with an appropriate z-interval will make analysis with Neurolucida 360 easier and more accurate. Throughout the paper, the authors emphasize the importance of image scaling parameters and unbiased sampling for achieving repeatable results. They also discuss the benefits of correcting optical distortion, especially in the Z-plane, with deconvolution to acquire clear images – a process critical to getting the most accurate representation of dendrites and spines.

Dendritic spine analysis is traditionally performed through tedious, time-consuming manual techniques. According to the paper, this has spawned a growing interest in a more efficient solution for spine quantification and morphological analysis like the one Neurolucida 360 provides. A software platform for automatic neuron reconstruction and spine detection in a 3D environment, Neurolucida 360 offers a variety of benefits, including:


  • Fast and accurate spine detection and neuron reconstruction
  • Accurate spine classification and length quantification using a five-point segment that more accurately models the spine backbone.
  • 3 user-guided and automatic algorithms to accurately model neurons visualized with multiple methodologies and imaging techniques.
  • A large number of metrics, including volume, length, and surface area.


“We believe that the new quantitative software package, Neurolucida 360, provides the neuroscience research community with the ability to perform higher throughput automated 3D quantitative light microscopy spine analysis under standardized conditions to accelerate the characterization of dendritic spines with greater objectivity and reliability,” (Dickstein, et al. 2016)

The full paper can be found here.

An infographic quickly outlines Protocol 1: Imaging of fluorescently labeled dendritic segments. Use this as a quick reference tool in your lab (right-click on it to save as an image):

Dickstein, D.L., Dickstein, D.R., Janssen, W.G.M., Hof, P.R., Glaser, J.R., Rodriguez, A., O’Connor, N., Angstman, P., and Tappan, S.J. 2016. Automatic dendritic spine quantification from confocal data with Neurolucida 360. Curr. Protoc. Neurosci. 77:1.27.1-1.27.21. doi: 10.1002/cpns.16