Researchers cited MBF systems in 18 papers during the week of 4/25/2016

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Drzewiecki, C. M., Willing, J., & Juraska, J. M. (2016). Synaptic number changes in the medial prefrontal cortex across adolescence in male and female rats: A role for pubertal onset. Synapse, n/a-n/a. doi: 10.1002/syn.21909.

Inoue, T., Abe, C., Sung, S.-s. J., Moscalu, S., Jankowski, J., Huang, L., . . . Okusa, M. D. (2016). Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. The Journal of Clinical Investigation, 126(5). doi: 10.1172/jci83658.

Miller, A. N., Deal, D., Green, J., Houle, T., Brown, W., Thore, C., . . . Webb, L. X. (2016). Use of the Reamer/Irrigator/Aspirator Decreases Carotid and Cranial Embolic Events in a Canine Model. The Journal of Bone & Joint Surgery, 98(8), 658-664.

Ouda, L., Jílek, M., & Syka, J. (2016). Expression of c-Fos in rat auditory and limbic systems following 22-kHz calls. Behavioural Brain Research, 308, 196-204. doi: http://dx.doi.org/10.1016/j.bbr.2016.04.030.

Pantazopoulos, H., Wiseman, J. T., Markota, M., Ehrenfeld, L., & Berretta, S. (2016). Decreased numbers of somatostatin-expressing neurons in the amygdala of subjects with bipolar disorder or schizophrenia: Relationship to circadian rhythms. Biological Psychiatry. doi: http://dx.doi.org/10.1016/j.biopsych.2016.04.006.

Scheinert, R. B., Haeri, M. H., Lehmann, M. L., & Herkenham, M. (2016). Therapeutic effects of stress-programmed lymphocytes transferred to chronically stressed mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry. doi: http://dx.doi.org/10.1016/j.pnpbp.2016.04.010.

Türer, A., Coşkun Türer, Ç., Durmuşlar, M. C., Balli, U., & Önger, M. E. (2016). The influence of oral administration of rosuvastatin on calvarial bone healing in rats. Journal of Cranio-Maxillofacial Surgery. doi:http://dx.doi.org/10.1016/j.jcms.2016.04.021. Continue reading “Researchers cited MBF systems in 18 papers during the week of 4/25/2016” »

MBF Bioscience Awarded Two Patents in 2016

InteractingWorms

We continue our history of innovation and invention as the U.S. Patent and Trademark Office awards us two patents. The first is for WormLab – our unique worm tracking software that gives researchers an enormous amount of behavioral data about a single worm or multiple worms, even as they go through omega bends, reversals, and entanglements. The second is for our radial shock wave technology that improves antibody penetration and reduces the time for antibody incubation and fixation periods.

WormLab is commercially available, while our shock wave technology is in development.

+ Learn more about WormLab

+ Read the WormLab patent

Read the shock wave patent

Researchers cited MBF systems in 10 papers during the week of 4/18/2016

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Darkazalli, A., Ismail, A. A. O., Abad, N., Grant, S. C., & Levenson, C. W. (2016). Use of human mesenchymal stem cell treatment to prevent anhedonia in a rat model of traumatic brain injury. Restorative Neurology and Neuroscience(Preprint), 1-9.

Deep, S. N., Baitharu, I., Sharma, A., Gurjar, A. K. S., Prasad, D., & Singh, S. B. (2016). Neuroprotective Role of L-NG-Nitroarginine Methyl Ester (L-NAME) against Chronic Hypobaric Hypoxia with Crowding Stress (CHC) Induced Depression-Like Behaviour.  Plos one, 11(4), e0153371. doi: 10.1371/journal.pone.0153371.

Delbary-Gossart, S., Lee, S., Baroni, M., Lamarche, I., Arnone, M., Canolle, B., . . . Beattie, M. S. (2016). A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. Brain.

Gómez-López, S., Martínez-Silva, A. V., Montiel, T., Osorio-Gómez, D., Bermúdez-Rattoni, F., Massieu, L., & Escalante-Alcalde, D. (2016). Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration. Scientific Reports, 6, 24028. doi: 10.1038/srep24028

Haus, D. L., López-Velázquez, L., Gold, E. M., Cunningham, K. M., Perez, H., Anderson, A. J., & Cummings, B. J. (2016). Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury. Experimental Neurology. doi: http://dx.doi.org/10.1016/j.expneurol.2016.04.008.

Continue reading “Researchers cited MBF systems in 10 papers during the week of 4/18/2016” »

Researchers cited MBF systems in 20 papers during the week of 4/11/2016

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Baulch, J. E., Acharya, M. M., Allen, B. D., Ru, N., Chmielewski, N. N., Martirosian, V., . . . Limoli, C. L. (2016). Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1521668113.

Ettle, B., Kerman, B. E., Valera, E., Gillmann, C., Schlachetzki, J. C. M., Reiprich, S., . . . Winkler, J. (2016). α-Synuclein-induced myelination deficit defines a novel interventional target for multiple system atrophy. Acta Neuropathologica, 1-17. doi: 10.1007/s00401-016-1572-y.

Hays, S. A., Ruiz, A., Bethea, T., Khodaparast, N., Carmel, J. B., Rennaker Ii, R. L., & Kilgard, M. P. (2016). Vagus Nerve Stimulation during Rehabilitative Training Enhances Recovery of Forelimb Function after Ischemic Stroke in Aged Rats. Neurobiology of Aging. doi:http://dx.doi.org/10.1016/j.neurobiolaging.2016.03.030.

Li, A., Roy, S. H., & Nattie, E. E. (2016). An augmented CO2 chemoreflex and overactive orexin system are linked with hypertension in young and adult spontaneously hypertensive rats (SHRs). The Journal of physiology, n/a-n/a. doi: 10.1113/jp272199.

Moro, N., Ghavim, S. S., Harris, N. G., Hovda, D. A., & Sutton, R. L. (2016). Pyruvate treatment attenuates cerebral metabolic depression and neuronal loss after experimental traumatic brain injury. Brain Research, 1642, 270-277. doi: http://dx.doi.org/10.1016/j.brainres.2016.04.005.

Continue reading “Researchers cited MBF systems in 20 papers during the week of 4/11/2016” »

Researchers cited MBF systems in 18 papers during the week of 4/4/2016

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a Dzaye, O. D., Hu, F., Derkow, K., Haage, V., Euskirchen, P., Harms, C., . . . Kettenmann, H. (2016). Glioma Stem Cells but Not Bulk Glioma Cells Upregulate IL-6 Secretion in Microglia/Brain Macrophages via Toll-like Receptor 4 Signaling. Journal of Neuropathology and Experimental Neurology.

Kadoya, K., Lu, P., Nguyen, K., Lee-Kubli, C., Kumamaru, H., Yao, L., . . . Tuszynski, M. H. (2016). Spinal cord reconstitution with homologous neural grafts enables robust corticospinal regeneration. Nature Medicine, advance online publication. doi: 10.1038/nm.4066

Kneynsberg, A., Collier, T. J., Manfredsson, F. P., & Kanaan, N. M. (2016). Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures. Journal of Neuroscience Methods, 266, 32-41. doi: http://dx.doi.org/10.1016/j.jneumeth.2016.03.004.

Köse, O., Arabacı, T., Gedikli, S., Eminoglu, D. Ö., Kermen, E., Kızıldağ, A., . . . Yemenoglu, H. (2016). Biochemical and histopathologic analysis of the effects of periodontitis on left ventricular heart tissues of rats. Journal of Periodontal Research, n/a-n/a. doi: 10.1111/jre.12380.

Mohanty, R., Das, S. k., Singh, N. R., & Patri, M. (2016). Withania somnifera Leaf Extract Ameliorates Benzo[a]pyrene-Induced Behavioral and Neuromorphological Alterations by Improving Brain Antioxidant Status in Zebrafish (Danio rerio). Zebrafish. doi: 10.1089/zeb.2015.1215.

Continue reading “Researchers cited MBF systems in 18 papers during the week of 4/4/2016” »

Iron Deficiency Worsens Fetal Alcohol Spectrum Disorders

An immunostained image of myelin basic protein in the cerebella of a mouse brain with an iron-sufficient diet compared with the brain of a mouse exposed to alcohol and fed an iron-insufficient diet. It shows the reduced cerebellar size due to the ID-alcohol combination. Green is MBP immunostain, blue is DAPI for nuclei.

An immunostained image of myelin basic protein in the cerebella of a mouse brain with an iron-sufficient diet compared with the brain of a mouse exposed to alcohol and fed an iron-insufficient diet. It shows the reduced cerebellar size due to the ID-alcohol combination. Green is MBP immunostain, blue is DAPI for nuclei. Image courtesy of Susan Smith, PhD.

If a pregnant woman drinks alcohol, she risks giving birth to a baby with physical and cognitive deficits – characteristics of fetal alcohol spectrum disorders. In a new study, researchers say that when the mother is low in iron, the consequences are even worse.

The scientists examined two groups of pregnant rats – one group was fed an iron sufficient diet while the other was fed a diet with insufficient iron levels. The offspring from both groups were exposed to alcohol from 4 to 9 days after birth – a time when their brains are going through a growth spurt and are particularly sensitive to alcohol. They were compared to offspring who received an iron-sufficient diet but were not exposed to alcohol. This growth spurt correlates to a growth spurt in humans that occurs during the third trimester of pregnancy.

The researchers used delay and trace eye blink classical conditioning methods to assess the offspring’s learning and memory. Learning impairments were reported in both alcohol-exposed groups regardless of their iron status, but more extreme impairments were seen in iron deficient rats compared to iron sufficient rats. After the behavioral tests were completed, the researchers studied the cerebellum and hippocampus – brain regions involved in learning and memory – at a cellular level.

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Researchers cited MBF systems in 16 papers during the week of 3/28/2016

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Berggren, K. L., Lu, Z., Fox, J. A., Dudenhoeffer, M., Agrawal, S., & Fox, J. H. (2016). Neonatal iron supplementation induces striatal atrophy in female YAC128 Huntington’s disease mice. Journal of Huntington’s Disease(Preprint), 1-11.

Gee, D. G., Fetcho, R. N., Jing, D., Li, A., Glatt, C. E., Drysdale, A. T., . . . Consortium, t. P. (2016). Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1600013113.

Hakes, E. (2016). BDNF Knockdown in the VTA Blocks Social Stress‐Induced Deficits in Social Behavior and Nucleus Accumbens ΔFosB Expression. The University of Arizona. UA Campus Repository.

LaDage, L. D., Roth Ii, T. C., Sinervo, B., & Pravosudov, V. V. (2016). Environmental experiences influence cortical volume in territorial and nonterritorial side-blotched lizards, Uta stansburiana. Animal Behaviour, 115, 11-18. doi: http://dx.doi.org/10.1016/j.anbehav.2016.01.029.

Lastres.Becker, I., Garcia-Yague, A. J., Scannevin, R. H., Casarejos, M. J., Kügler, S., Rábano, A., & Cuadrado, A. (2016). Repurposing the NRF2 activator dimethyl fumarate as therapy against synucleinopathy in Parkinson’s disease. Antioxidants & redox signaling. doi: 10.1089/ars.2015.6549.

Continue reading “Researchers cited MBF systems in 16 papers during the week of 3/28/2016” »

Researchers cited MBF systems in 17 papers during the week of 3/21/2016

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Avsar, U., Halici, Z., Akpinar, E., Yayla, M., Harun, U., Hasan, T. A., & Bayraktutan, Z. (2016). The Effects of Argan Oil in Second-degree Burn Wound Healing in Rats. Ostomy/Wound Management, 62(3), 26.

Boschen, K. E., Ruggiero, M. J., & Klintsova, A. Y. (2016). Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus. Neuroscience. doi:http://dx.doi.org/10.1016/j.neuroscience.2016.03.033.

Chu, Y., Morfini, G. A., & Kordower, J. H. (2016). Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson’s Disease. Journal of Parkinson’s Disease(Preprint), 1-21.

Ghuman, H., Massensini, A. R., Donnelly, J., Kim, S.-M., Medberry, C. J., Badylak, S. F., & Modo, M. (2016). ECM hydrogel for the treatment of stroke: Characterization of the host cell infiltrate. Biomaterials. doi:http://dx.doi.org/10.1016/j.biomaterials.2016.03.014.

Guardia Clausi, M., & Levison, S. W. (2016). Delayed ALK5 inhibition improves functional recovery in neonatal brain injury. Journal of Cerebral Blood Flow and Metabolism. doi: 10.1177/0271678×16638669.

Continue reading “Researchers cited MBF systems in 17 papers during the week of 3/21/2016” »

Researchers cited MBF systems in 20 papers during the week of 3/14/2016

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Bayliss, J. A., Lemus, M. B., Stark, R., Santos, V. V., Thompson, A., Rees, D. J., . . . Davies, J. S. (2016). Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson’s Disease. The Journal of Neuroscience, 36(10), 3049-3063.

Chen, X., Rivard, L., Naqvi, S., Nakada, S., Padbury, J. F., Sanchez-Esteban, J., . . . Stonestreet, B. S. (2016). Expression and localization of Inter-alpha Inhibitors in rodent brain. Neuroscience, 324, 69-81. doi:http://dx.doi.org/10.1016/j.neuroscience.2016.03.009.

Chou, A., Morganti, J. M., & Rosi, S. (2016). Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior. Plos one, 11(3), e0151418. doi: 10.1371/journal.pone.0151418.

Harris, N. G., Verley, D. R., Gutman, B. A., & Sutton, R. L. (2016). Bi-directional changes in fractional anisotropy after experiment TBI: Disorganization and reorganization? Neuroimage. doi:http://dx.doi.org/10.1016/j.neuroimage.2016.03.012.

Humann, J., Mann, B., Gao, G., Moresco, P., Ramahi, J., Loh, Lip N., . . . Tuomanen, Elaine I. (2016). Bacterial Peptidoglycan Transverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. Cell Host & Microbe, 19(3), 388-399. doi: http://dx.doi.org/10.1016/j.chom.2016.02.009.

Mustafa, G., Hou, J., Tsuda, S., Nelson, R., Sinharoy, A., Wilkie, Z., . . . Bose, P. (2016). Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI). Neuropharmacology. doi: http://dx.doi.org/10.1016/j.neuropharm.2016.03.016.

Noguchi, K. K., Johnson, S. A., Kristich, L. E., Martin, L. D., Dissen, G. A., Olsen, E. A., . . . Brambrink, A. M. (2016). Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain. [Article]. Scientific Reports, 6, 22427. doi: 10.1038/srep22427.

Continue reading “Researchers cited MBF systems in 20 papers during the week of 3/14/2016” »

Researchers cited MBF systems in 13 papers during the week of 3/7/2016

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Braczynski, A. K., Harter, P. N., Zeiner, P. S., Drott, U., Tews, D.-S., Preusse, C., . . . Mittelbronn, M. (2016). C5b-9 deposits on endomysial capillaries in non-dermatomyositis cases. Neuromuscular Disorders. doi:http://dx.doi.org/10.1016/j.nmd.2016.02.014.

Dash, P. K., Zhao, J., Kobori, N., Redell, J. B., Hylin, M. J., Hood, K. N., & Moore, A. N. (2016). Activation of Alpha 7 Cholinergic Nicotinic Receptors Reduce Blood–Brain Barrier Permeability following Experimental Traumatic Brain Injury. The Journal of Neuroscience, 36(9), 2809-2818.

Durmuşlar, M. C., Türer, A., Ballı, U., Yılmaz, Z., Önger, M. E., Çelik, H. H., & Vatansever, A. (2016). The effect of infliximab on bone healing in osteoporotic rats. European Journal of Inflammation. doi: 10.1177/1721727×16636889.

Gondré-Lewis, M. C., Darius, P. J., Wang, H., & Allard, J. S. (2016). Stereological analyses of reward system nuclei in maternally deprived/separated alcohol drinking rats. Journal of Chemical Neuroanatomy. doi:http://dx.doi.org/10.1016/j.jchemneu.2016.02.004.

Liu, H., Rose, M. E., Culver, S., Ma, X., Dixon, C. E., & Graham, S. H. (2016). Rosiglitazone attenuates inflammation and CA3 neuronal loss following traumatic brain injury in rats. Biochemical and Biophysical Research Communications. doi: http://dx.doi.org/10.1016/j.bbrc.2016.03.003.

Maeda, S., Djukic, B., Taneja, P., Yu, G. Q., Lo, I., Davis, A., . . . Kim, D. (2016). Expression of A152T human tau causes age‐dependent neuronal dysfunction and loss in transgenic mice. EMBO reports, e201541438.

Matak, P., Matak, A., Moustafa, S., Aryal, D. K., Benner, E. J., Wetsel, W., & Andrews, N. C. (2016). Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1519473113.

Mendieta, L., Granado, N., Aguilera, J., Tizabi, Y., & Moratalla, R. (2016). Fragment C domain of tetanus toxin mitigates methamphetamine neurotoxicity and its motor consequences in mice. [10.1093/ijnp/pyw021]. International Journal of Neuropsychopharmacology.

Salama, M., & Mohamed, W. M. Y. (2016). Tau protein as a biomarker for asphyxia: A possible forensic tool? Applied & Translational Genomics. doi: http://dx.doi.org/10.1016/j.atg.2016.03.001.

Takase, H. M., & Nusse, R. (2016). Paracrine Wnt/β-catenin signaling mediates proliferation of undifferentiated spermatogonia in the adult mouse testis. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1601461113.

Neurolucida:

Nam, H., & Kerman, I. A. (2016). Distribution of catecholaminergic presympathetic-premotor neurons in the rat lower brainstem. Neuroscience. doi: http://dx.doi.org/10.1016/j.neuroscience.2016.02.066.

Wester, J. C., & McBain, C. J. (2016). Interneurons Differentially Contribute to Spontaneous Network Activity in the Developing Hippocampus Dependent on Their Embryonic Lineage. The Journal of Neuroscience, 36(9), 2646-2662.

Zhao, P., Hill, M., Liu, S., Chen, L., Bangalore, L., Waxman, S. G., & Tan, A. M. (2016). Dendritic Spine Remodeling Following Early and Late Rac1-Inhibition after Spinal Cord Injury: Evidence for a Pain Biomarker. Journal of Neurophysiology.