Using Stereo Investigator, Munich Researchers Find Humans Generate Most Cerebellar Granule Cells Postnatally

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

The human brain undergoes extraordinary development in utero, with major growth continuing throughout childhood, especially during the first year. Scientists know a lot about how the neurons and circuits of the human brain develop in infancy, but a lack of specific knowledge about key elements has left doctors mystified by certain childhood disorders like SIDS and autism.

However, neuroscientists at Ludwig-Maximillians-University of Munich have made new revelations about the development of a certain type of neuron—cerebellar granule cells. The smallest and most numerous type of neuron in the human brain, these cells transmit motor and sensory information to Purkinje cells, large neurons that are said to play a role in coordinating motor movement and are the sole source of output for the cerebellar cortex.

Continue reading “Using Stereo Investigator, Munich Researchers Find Humans Generate Most Cerebellar Granule Cells Postnatally” »

Researchers cited MBF systems in 16 papers during the week of 4/14/14

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

journal images smStereo Investigator:

Drury, P. P., Davidson, J. O., Mathai, S., van den Heuij, L. G., Ji, H., Bennet, L., . . . Gunn, A. J. (2014). nNOS inhibition during profound asphyxia reduces seizure burden and improves survival of striatal phenotypic neurons in preterm fetal sheep. Neuropharmacology.

Liu, X., Zhou, J., Abid, M. D. N., Yan, H., Huang, H., Wan, L., . . . Chen, J. (2014). Berberine Attenuates Axonal Transport Impairment and Axonopathy Induced by Calyculin A in N2a Cells. Plos one, 9(4), e93974. doi: 10.1371/journal.pone.0093974.

Smith, G. A., Rocha, E. M., McLean, J. R., Hayes, M. A., Izen, S. C., Isacson, O., & Hallett, P. J. (2014). Progressive axonal transport and synaptic protein changes correlate with behavioral and neuropathological abnormalities in the heterozygous Q175 KI mouse model of Huntington’s disease. Human Molecular Genetics. doi: 10.1093/hmg/ddu166.

Zhang, J., Saur, T., Duke, A. N., Grant, S. G. N., Platt, D. M., Rowlett, J. K., . . . Yao, W.-D. (2014). Motor Impairments, Striatal Degeneration, and Altered Dopamine-Glutamate Interplay in Mice Lacking PSD-95. Journal of Neurogenetics, 0(ja), 1-26. doi: doi:10.3109/01677063.2014.892486.

Neurolucida:

Cerri, S., Levandis, G., Ambrosi, G., Montepeloso, E., Antoninetti, G. F., Franco, R., . . . Pinna, A. (2014). Neuroprotective Potential of Adenosine A2A and Cannabinoid CB1 Receptor Antagonists in an Animal Model of Parkinson Disease. Journal of Neuropathology and Experimental Neurology.

Gyengesi, E., Mnch, G., Paxinos, G., & Zaborszky, L. (2014). Can you believe what you see: evaluation of choline acetyl transferase (ChAT) expression in the ChAT-eGFP transgenic mouse (89.1). The FASEB journal, 28(1 Supplement).

Continue reading “Researchers cited MBF systems in 16 papers during the week of 4/14/14” »

Researchers cited MBF systems in 6 papers during the week of 4/07/14

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

journal images smStereo Investigator:

Agassandian, K., Patel, M., Agassandian, M., Steren, K. E., Rahmouni, K., Sheffield, V. C., & Card, J. P. (2014). Ciliopathy Is Differentially Distributed in the Brain of a Bardet-Biedl Syndrome Mouse Model. Plos one, 9(4), e93484. doi: 10.1371/journal.pone.0093484.

Bellavance, M.-A., Gosselin, D., Yong, V. W., Stys, P., & Rivest, S. (2014). Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity. Brain Structure and Function, 1-18. doi: 10.1007/s00429-014-0759-z.

Neurolucida:

Lee, Y.-H., Lin, Y.-N., Chuang, C.-C., & Lo, C.-C. (2014). SPIN: A Method of Skeleton-Based Polarity Identification for Neurons. Neuroinformatics, 1-21. doi: 10.1007/s12021-014-9225-6.

Mangieri, L. R., Mader, B. J., Thomas, C. E., Taylor, C. A., Luker, A. M., Tse, T. E., . . . Shacka, J. J. (2014). ATP6V0C Knockdown in Neuroblastoma Cells Alters Autophagy-Lysosome Pathway Function and Metabolism of Proteins that Accumulate in Neurodegenerative Disease. PLoS ONE, 9(4), e93257. doi: 10.1371/journal.pone.0093257.

Rood, B. D., Calizo, L. H., Piel, D., Spangler, Z. P., Campbell, K., & Beck, S. G. (2014). Dorsal Raphe Serotonin Neurons in Mice: Immature Hyperexcitability Transitions to Adult State during First Three Postnatal Weeks Suggesting Sensitive Period for Environmental Perturbation. The Journal of Neuroscience, 34(14), 4809-4821.

Seidl, A. H., Rubel, E. W., & Barría, A. (2014). Differential Conduction Velocity Regulation in Ipsilateral and Contralateral Collaterals Innervating Brainstem Coincidence Detector Neurons. The Journal of Neuroscience, 34(14), 4914-4919. doi: 10.1523/jneurosci.5460-13.2014.

Brain Cleans Itself During Sleep; Scientists Image Cerebral Fluid Flow With Neurolucida

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

 

With some exceptions, humans and animals prefer to live in an environment free of filth. We clean our bodies and our homes so we can live healthy and productive lives. It turns out, the brain does too.

Researchers at the University of Rochester discovered that the brain cleans itself during sleep—explaining one of the major reasons we partake in a nightly ritual that has mystified scientists for centuries.

“Sleep has a critical function in ensuring metabolic homeostasis,” Dr. Maiken Nedergaard et al say in their paper published in Science. “The restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system.”

Instead of a lymphatic system, the brain has what the researchers call a “glymphatic system.” Waste products that build up during waking hours flush out through the membranes of glial cells in the brain’s interstitial space as cerebral spinal fluid (CSF) flows in. In the process, proteins like b-amyloid, which are associated with Alzheimer’s disease, are washed away. The exchange of fluids occurs along the brain’s vasculature; CSF flows in around arteries, while interstitial fluid (ISF) exits in the space around veins.

Continue reading “Brain Cleans Itself During Sleep; Scientists Image Cerebral Fluid Flow With Neurolucida” »

Researchers cited MBF systems in 18 papers during the week of 3/31/14

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

journal images smStereo Investigator:

Bekar, E., Altunkaynak, B., Balcı, K., Aslan, G., Ayyıldız, M., & Kaplan, S. (2014). Effects of high fat diet induced obesity on peripheral nerve regeneration and levels of GAP 43 and TGF-β in rats. Biotechnic and Histochemistry, 0(0), 1-11. doi: doi:10.3109/10520295.2014.894575.

Dautan, D., Huerta-Ocampo, I., Witten, I. B., Deisseroth, K., Bolam, J. P., Gerdjikov, T., & Mena-Segovia, J. (2014). A Major External Source of Cholinergic Innervation of the Striatum and Nucleus Accumbens Originates in the Brainstem. The Journal of Neuroscience, 34(13), 4509-4518.

He, F., Zou, J.-T., Zhou, Q.-F., Niu, D.-L., & Jia, W.-H. (2014). Glatiramer acetate reverses cognitive deficits from cranial- irradiated rat by inducing hippocampal neurogenesis. Journal of Neuroimmunology(0).

Jiang, J.-y., Jia, F., yin, y., Gao, G., Wang, Y., & cen, l. (2014). MMP-9 Inhibitor SB-3CT Attenuates Behavioral Impairments and Hippocampal Loss after Traumatic Brain Injury in Rat. Journal of Neurotrauma(ja).

Klein, C., Hain, E. G., Braun, J., Riek, K., Mueller, S., Steiner, B., & Sack, I. (2014). Enhanced Adult Neurogenesis Increases Brain Stiffness: In Vivo Magnetic Resonance Elastography in a Mouse Model of Dopamine Depletion. Plos one, 9(3), e92582.

Continue reading “Researchers cited MBF systems in 18 papers during the week of 3/31/14” »

Researchers cited MBF systems in 12 papers during the week of 3/24/14

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

Stereo Investigator:journal images sm

Baumhardt, P., Moore, B., Doppler, M., & Fernández-Juricic, E. (2014). Do American Goldfinches See Their World Like Passive Prey Foragers? A Study on Visual Fields, Retinal Topography, and Sensitivity of Photoreceptors. Brain, Behavior and Evolution.

English, S. J., Piert, M. R., Diaz, J. A., Gordon, D., Ghosh, A., D’Alecy, L. G., . . . Upchurch, G. R. J. (9000). Increased 18F-FDG Uptake Is Predictive of Rupture in a Novel Rat Abdominal Aortic Aneurysm Rupture Model. Annals of Surgery, Publish Ahead of Print, 10.1097/SLA.0000000000000602.

Flanigan, T. J., Xue, Y., Kishan Rao, S., Dhanushkodi, A., & McDonald, M. P. (2014). Abnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics. Genes, Brain and Behavior, n/a-n/a. doi: 10.1111/gbb.12133.

Kim, T.-G., Yao, R., Monnell, T., Cho, J.-H., Vasudevan, A., Koh, A., . . . Chung, S. (2014). Efficient specification of interneurons from human pluripotent stem cells by dorsoventral and rostrocaudal modulation. Stem Cells, n/a-n/a. doi: 10.1002/stem.1704.

Liu, Y., Lieberwirth, C., Jia, X., Curtis, J. T., Meredith, M., & Wang, Z. X. (2014). Chemosensory cues affect amygdaloid neurogenesis and alter behaviors in the socially monogamous prairie vole. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.12531.

Continue reading “Researchers cited MBF systems in 12 papers during the week of 3/24/14” »

Researchers cited MBF systems in 16 papers during the week of 3/17/14

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

Stereo Investigator:journal images sm

Acosta, S. A., Tajiri, N., Shinozuka, K., Ishikawa, H., Sanberg, P. R., Sanchez-Ramos, J., . . . Borlongan, C. V. (2014). Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury. Plos one, 9(3), e90953. doi: 10.1371/journal.pone.0090953.

Bethea, C. L., Kim, A., Reddy, A. P., Chin, A., Weraky, S. C., & Cameron, J. L. (2014). Hypothalamic KISS1 Expression, GnRH, and Neurotransmitter Innervation Vary with Stress and Sensitivity in Macaques. Journal of Neuroendocrinology, n/a-n/a. doi: 10.1111/jne.12146.

Claes, J. M., Nilsson, D.-E., Straube, N., Collin, S. P., & Mallefet, J. (2014). Iso-luminance counterillumination drove bioluminescent shark radiation. Scientific Reports, 4.

Demir, R., Yayla, M., Akpinar, E., Cakir, M., Calikoglu, C., Ozel, L., . . . Mercantepe, T. (2014). Protective effects of alpha-lipoic acid on experimental sciatic nerve crush injury in rats: assessed with functional, molecular and electromicroscopic analyses. International Journal of Neuroscience(0), 1-23.

Grieb, B., Engler, G., Sharott, A., von Nicolai, C., Streichert, T., Papageorgiou, I., . . . Hamel, W. (2014). High-Frequency Stimulation of the Subthalamic Nucleus Counteracts Cortical Expression of Major Histocompatibility Complex Genes in a Rat Model of Parkinson’s Disease. Plos one, 9(3), e91663. doi: 10.1371/journal.pone.0091663.

Kohn Cordeiro, K., Graciolli Cordeiro, J., Lopes Furlanetti, L., Garcia Salazar, J. A., Tenório, S. B., Winkler, C., . . . Nikkhah, G. (2014). Subthalamic nucleus lesion improves cell survival and functional recovery following dopaminergic cell transplantation in parkinsonian rats. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.12541.

Continue reading “Researchers cited MBF systems in 16 papers during the week of 3/17/14” »

Researchers cited MBF systems in 25 papers during the week of 3/10/14

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

Stereo Investigator:journal images sm

Balsevich, G., Poon, A., Goldowitz, D., & Wilking, J. A. (2014). The effects of pre- and post-natal nicotine exposure and genetic background on the striatum and behavioral phenotypes in the mouse. Behavioural Brain Research(0).

Burns, T., Miers, L., Xu, J., Man, A., Moreno, M., Pleasure, D., & Bannerman, P. (2014). Neuronopathy in the Motor Neocortex in a Chronic Model of Multiple Sclerosis. Journal of Neuropathology and Experimental Neurology, Publish Ahead of Print, 10.1097/NEN.0000000000000058.

Crotti, A., Benner, C., Kerman, B. E., Gosselin, D., Lagier-Tourenne, C., Zuccato, C., . . . Glass, C. K. (2014). Mutant Huntingtin promotes autonomous microglia activation via myeloid lineage-determining factors. Nature Neuroscience.

Dokter, M., Busch, R., Poser, R., Vogt, M. A., von Bohlen und Halbach, V., Gass, P., . . . von Bohlen und Halbach, O. (2014). Implications of p75NTR for dentate gyrus morphology and hippocampus-related behavior revisited. Brain Structure and Function, 1-14. doi: 10.1007/s00429-014-0737-5.

González-Gómez, P. L., Madrid-Lopez, N., Salazar, J. E., Suárez, R., Razeto-Barry, P., Mpodozis, J., . . . Vásquez, R. A. (2014). Cognitive Ecology in Hummingbirds: The Role of Sexual Dimorphism and Its Anatomical Correlates on Memory. Plos one, 9(3), e90165. doi: 10.1371/journal.pone.0090165.

Continue reading “Researchers cited MBF systems in 25 papers during the week of 3/10/14” »

3D Reconstructions of Neurons Reveal More Branching in Sedentary Rats

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share
Left: A neuron from the brain of a rat that exercised for two hours each day. Right: A neuron from the brain of a sedentary rat.

Left: A neuron from the brain of a rat that exercised for two hours each day.
Right: A neuron from the brain of a sedentary rat. Scientists saw greater branching in inactive versus active rats. (Image courtesy of Dr. Patrick Mueller)

Scientists discovered that inactivity makes brain cells grow, but not in a good way. In a study published in the Journal of Comparative Neurology, researchers found more neuronal branching in sedentary rats compared to active rats. The growth occurred in a region of the brain that controls blood pressure, leading the scientists to hypothesize that these changes may be part of the reason inactivity is linked to an increased risk of heart disease.

Using Neurolucida to reconstruct neurons in 3D, the scientists at Dr. Patrick Mueller’s lab at Wayne State University School of Medicine, in Detroit, saw structural differences between the brains of active and inactive rats.

Focusing on the rostral ventrolateral medulla (RVLM) – an area that controls several critical biological processes that rats as well as humans do unconsciously, like swallowing, breathing, and regulating blood pressure, the scientists saw longer dendrites, more dendritic branching, and more intersections with other neurons in sedentary rats.

Continue reading “3D Reconstructions of Neurons Reveal More Branching in Sedentary Rats” »

Researchers cited MBF systems in 24 papers during the week of 3/3/14

Posted on by
Reply
Share on FacebookShare on LinkedInShare on Twitter Share

Stereo Investigator:journal images sm

Arawaka, S., Fukushima, S., Sato, H., Sasaki, A., Koga, K., Koyama, S., & Kato, T. (2014). Zonisamide Attenuates α-Synuclein Neurotoxicity by an Aggregation-Independent Mechanism in a Rat Model of Familial Parkinson’s Disease. Plos one, 9(2), e89076. doi: 10.1371/journal.pone.0089076.

Bilella, A., Alvarez-Bolado, G., & Celio, M. R. (2014). Coaxiality of Foxb1- and parvalbumin-expressing neurons in the lateral hypothalamic PV1-nucleus. Neuroscience Letters(0).

Hamity, M. V., Walder, R. Y., & Hammond, D. L. (2014). Increased Neuronal Expression of Neurokinin-1 Receptor and Stimulus-Evoked Internalization of the Receptor in the Rostral Ventromedial Medulla of the Rat after Peripheral Inflammatory Injury. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23564.

Joensuu, T., Tegelberg, S., Reinmaa, E., Segerstråle, M., Hakala, P., Pehkonen, H., . . . Lehesjoki, A.-E. (2014). Gene Expression Alterations in the Cerebellum and Granule Neurons of Mouse Are Associated with Early Synaptic Changes and Inflammation. Plos one, 9(2), e89321. doi: 10.1371/journal.pone.0089321.

Kanca, H., Karakas, K., Dalgic, M. A., Salar, S., & Izgur, H. (2014). Vaginal cytology after induction of ovulation in the queen: comparison of postoestrus and dioestrus. Australian Veterinary Journal, 92(3), 65-70. doi: 10.1111/avj.12146.

Lenglos, C., Mitra, A., Guèvremont, G., & Timofeeva, E. (2014). Regulation of expression of relaxin-3 and its receptor RXFP3 in the brain of diet-induced obese rats. Neuropeptides(0).

Morris, M. C., Schneider, J. A., Li, H., Tangney, C. C., Nag, S., Bennett, D. A., . . . Barnes, L. L. (2014). Brain tocopherols related to Alzheimer’s disease neuropathology in humans. Alzheimer’s & Dementia(0).

Skefos, J., Cummings, C., Enzer, K., Holiday, J., Weed, K., Levy, E., . . . Bauman, M. (2014). Regional Alterations in Purkinje Cell Density in Patients with Autism. Plos one, 9(2), e81255. doi: 10.1371/journal.pone.0081255.

Williamson, L. L., & Bilbo, S. D. (2014). Neonatal infection modulates behavioral flexibility and hippocampal activation on a Morris Water Maze task. Physiology and Behavior(0).

Wojaczynski, G., Engel, E., Steren, K., Enquist, L., & Patrick Card, J. (2014). The neuroinvasive profiles of H129 (herpes simplex virus type 1) recombinants with putative anterograde-only transneuronal spread properties. Brain Structure and Function, 1-26. doi: 10.1007/s00429-014-0733-9.

Yu, Diana X., Di Giorgio, Francesco P., Yao, J., Marchetto, Maria C., Brennand, K., Wright, R., . . . Gage, Fred H. (2014). Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells. Stem Cell Reports(0).

Neurolucida:

Arslan, E., Garip, I. C., Gulseren, G., Tekinay, A. B., & Guler, M. O. (2014). Bioactive Supramolecular Peptide Nanofibers for Regenerative Medicine. Advanced Healthcare Materials, n/a-n/a. doi: 10.1002/adhm.201300491.

Bachmann, L. C., Lindau, N. T., Felder, P., & Schwab, M. E. (2014). Sprouting of Brainstem–Spinal Tracts in Response to Unilateral Motor Cortex Stroke in Mice. The Journal of Neuroscience, 34(9), 3378-3389.

Colciaghi, F., Finardi, A., Nobili, P., Locatelli, D., Spigolon, G., & Battaglia, G. S. (2014). Progressive Brain Damage, Synaptic Reorganization and NMDA Activation in a Model of Epileptogenic Cortical Dysplasia. PLoS ONE, 9(2), e89898. doi: 10.1371/journal.pone.0089898.

Hamity, M. V., Walder, R. Y., & Hammond, D. L. (2014). Increased Neuronal Expression of Neurokinin-1 Receptor and Stimulus-Evoked Internalization of the Receptor in the Rostral Ventromedial Medulla of the Rat after Peripheral Inflammatory Injury. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23564.

Klein, R. C., Acheson, S. K., Mace, B. E., Sullivan, P. M., & Moore, S. D. (2014). Altered neurotransmission in the lateral amygdala in aged human apoE4 targeted replacement mice. Neurobiology of Aging(0).

Levy, M., Lu, Z., Dion, G., & Kara, P. (2014). The Shape of Dendritic Arbors in Different Functional Domains of the Cortical Orientation Map. The Journal of Neuroscience, 34(9), 3231-3236.

Mohammad, M. G., Tsai, V. W., Ruitenberg, M. J., Hassanpour, M., Li, H., Hart, P. H., . . . Brown, D. A. (2014). Immune cell trafficking from the brain maintains CNS immune tolerance. The Journal of Clinical Investigation, 124(3), 1228.

Nascimento-Silva, S., Pinõn, C., Soares, J. G. M., & Gattass, R. (2014). Feedforward and feedback connections and their relation to the CytOx modules of V2 in Cebus monkeys. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23571.

Staiger, J., Bojak, I., Miceli, S., & Schubert, D. (2014). A gradual depth-dependent change in connectivity features of supragranular pyramidal cells in rat barrel cortex. Brain Structure and Function, 1-21. doi: 10.1007/s00429-014-0726-8.

Walker, C. L., & Xu, X.-M. (2014). PTEN inhibitor bisperoxovanadium protects oligodendrocytes and myelin and prevents neuronal atrophy in adult rats following cervical hemicontusive spinal cord injury. Neuroscience Letters(0).

Wang, T.-J., Chen, J.-R., Wang, W.-J., Wang, Y.-J., & Tseng, G.-F. (2014). Genistein Partly Eases Aging and Estropause-Induced Primary Cortical Neuronal Changes in Rats. PLoS ONE, 9(2), e89819. doi: 10.1371/journal.pone.0089819.

Yu, Diana X., Di Giorgio, Francesco P., Yao, J., Marchetto, Maria C., Brennand, K., Wright, R., . . . Gage, Fred H. (2014). Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells. Stem Cell Reports(0).

AutoNeuron:

Hamity, M. V., Walder, R. Y., & Hammond, D. L. (2014). Increased Neuronal Expression of Neurokinin-1 Receptor and Stimulus-Evoked Internalization of the Receptor in the Rostral Ventromedial Medulla of the Rat after Peripheral Inflammatory Injury. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23564.