Researchers cited MBF systems in 14 papers during the week of 4/13/15

Stereo Investigator:journal images sm

Drouin-Ouellet, J., Sawiak, S. J., Cisbani, G., Lagacé, M., Kuan, W.-L., Saint-Pierre, M., . . . Cicchetti, F. (2015). Cerebrovascular and blood–brain barrier impairments in Huntington’s disease: Potential implications for its pathophysiology. Annals of Neurology, n/a-n/a. doi: 10.1002/ana.24406.

Furlanetti, L. L., Cordeiro, J. G., Cordeiro, K. K., García, J. A., Winkler, C., Lepski, G. A., . . . Döbrössy, M. D. (2015). Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents. Neurorehabilitation and neural repair. doi: 10.1177/1545968315581419

Pan, J., Li, H., Zhang, B., Xiong, R., Zhang, Y., Kang, W.-Y., . . . Chen, S.-D. (2015). Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway. Plos one, 10(4), e0119204. doi: 10.1371/journal.pone.0119204.

Neurolucida:

Bizley, J. K., Bajo, V. M., Nodal, F. R., & King, A. J. (2015). Cortico-cortical connectivity within ferret auditory cortex. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23784.

Burke, P. G. R., Kanbar, R., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs. [10.1152/japplphysiol.00164.2015]. Journal of Applied Physiology

Fukumitsu, K., Fujishima, K., Yoshimura, A., Wu, Y. K., Heuser, J., & Kengaku, M. (2015). Synergistic Action of Dendritic Mitochondria and Creatine Kinase Maintains ATP Homeostasis and Actin Dynamics in Growing Neuronal Dendrites. The Journal of Neuroscience, 35(14), 5707-5723. doi: 10.1523/jneurosci.4115-14.2015.

Gombash, S. E., Cowley, C. J., Fitzgerald, J. A., Iyer, C. C., Fried, D., McGovern, V. L., . . . Foust, K. D. (2015). SMN Deficiency Disrupts Gastrointestinal and Enteric Nervous System Function in Mice. Human Molecular Genetics. doi: 10.1093/hmg/ddv127.

Khankan, R. R., Wanner, I. B., & Phelps, P. E. (2015). Olfactory ensheathing cell–neurite alignment enhances neurite outgrowth in scar-like cultures. Experimental Neurology, 269(0), 93-101. doi:http://dx.doi.org/10.1016/j.expneurol.2015.03.025.

Liao, C.-C., DiCarlo, G. E., Gharbawie, O. A., Qi, H.-X., & Kaas, J. H. (2015). Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23783.

Lőrincz, M. L., Gunner, D., Bao, Y., Connelly, W. M., Isaac, J. T. R., Hughes, S. W., & Crunelli, V. (2015). A Distinct Class of Slow (∼0.2–2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex. The Journal of Neuroscience, 35(14), 5442-5458. doi: 10.1523/jneurosci.3603-14.2015.

Louis, E., Vonsattel, J.-P., & Faust, P. (2015). Reduced Purkinje Cell Dendritic Arborization and Loss of Dendritic Spines in Essential Tremor (S32.001). Neurology, 84(14 Supplement).t

Oyola, M. G., Zuloaga, D. G., Carbone, D., Malysz, A. M., Acevedo-Rodriguez, A., Handa, R. J., & Mani, S. K. (2015). CYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male Mice. Endocrinology, 0(0), en.2014-1786. doi: doi:10.1210/en.2014-1786.

Smafield, T., Pasupuleti, V., Sharma, K., Huganir, R., Ye, B., & Zhou, J. (2015). Automatic Dendritic Length Quantification for High Throughput Screening of Mature Neurons. Neuroinformatics, 1-16. doi: 10.1007/s12021-015-9267-4.

Biolucida:

Castro, A., Becerra, M., Jesús Manso, M., & Anadón, R. (2015). Neuronal organization of the brain in the adult amphioxus (Branchiostoma lanceolatum): A study with acetylated tubulin immunohistochemistry. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23785.

Researchers cited MBF systems in 17 papers during the week of 4/6/15

Stereo Investigator: journal images sm

Choi, J. L., Tan, J.-K. Y., Sellers, D. L., Wei, H., Horner, P. J., & Pun, S. H. (2015). Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency. Biomaterials, 54(0), 87-96.

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., . . . Batrakova, E. V. (2015). Exosomes as drug delivery vehicles for Parkinson’s disease therapy. Journal of Controlled Release, 207(0), 18-30. doi: http://dx.doi.org/10.1016/j.jconrel.2015.03.033.

Iqbal, S., Howard, S., & LoGrasso, P. V. (2015). Serum- glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway. Molecular and Cellular Biology. doi: 10.1128/mcb.01510-14.

Meka, D. P., Müller-Rischart, A. K., Nidadavolu, P., Mohammadi, B., Motori, E., Ponna, S. K., . . . Kramer, E. R. (2015). Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. The Journal of Clinical Investigation, 125(5), 0-0. doi: 10.1172/jci79300.

Yue, M., Hinkle, K., Davies, P., Trushina, E., Fiesel, F., Christenson, T., . . . Melrose, H. (2015). Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice. Neurobiology of Disease(0). doi: http://dx.doi.org/10.1016/j.nbd.2015.02.031.

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Researchers Explore Spatial Memory with Stereo Investigator

The researchers quantified c-Fos positive cells in the CA1 region of the hippocampus. Image provided by Dr. Matthew Holahan.

The researchers quantified c-Fos positive cells in the CA1 region of the hippocampus. Image provided by Dr. Matthew Holahan.

Spacial memories help us navigate places like the office, the local coffee shop, or the supermarket. The hippocampus plays a key role in processing and recalling spacial memory, but as time passes, there is evidence that the anterior cingulate cortex (ACC) becomes more involved in recalling these memories. A recent paper published in PLOS ONE further investigates the ACC and found that taxing the hippocampus with spacial memory tasks accelerates the recruitment of the ACC for spacial memory recall.

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Researchers cited MBF systems in 20 papers during the week of 3/30/15

Stereo Investigator:journal images sm

Arabaci, T., Kermen, E., Özkanlar, S., Köse, O., Kara, A., Duman, Ş. B., & Ibişoğlu, E. (2015). Therapeutic Effects of Melatonin on Alveolar Bone Resorption After Experimental Periodontitis in Rats. A Biochemical and Immunohistochemical Study. Journal of Periodontology, 1-13. doi: 10.1902/jop.2015.140599.

Baburamani, A. A., Miyakuni, Y., Vontell, R., Supramaniam, V., Svedin, P., Rutherford, M., . . . Thornton, C. (2015). Does Caspase-6 Have a Role in Perinatal Brain Injury. Developmental Neuroscience.

Cameron, S. H., Alwakeel, A. J., Goddard, L., Hobbs, C. E., Gowing, E. K., Barnett, E. R., . . . Oorschot, D. E. (2015). Delayed post-treatment with bone marrow-derived mesenchymal stem cells is neurorestorative of striatal medium-spiny projection neurons and improves motor function after neonatal rat hypoxia–ischemia. Molecular and Cellular Neuroscience(0). doi: http://dx.doi.org/10.1016/j.mcn.2015.03.019.

Heggland, I., Storkaas, I. S., Soligard, H. T., Kobro-Flatmoen, A., & Witter, M. P. (2015). Stereological estimation of neuron number and plaque load in the hippocampal region of a transgenic rat model of Alzheimer’s disease. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.12876.

Luo, J., Chen, X., Pan, Y.-W., Lu, S., Xia, Z., & Storm, D. R. (2015). The Type 3 Adenylyl Cyclase Is Required for the Survival and Maturation of Newly Generated Granule Cells in the Olfactory Bulb. Plos one, 10(3), e0122057. doi: 10.1371/journal.pone.0122057.

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Researchers cited MBF systems in 20 papers during the week of 3/23/15

Stereo Investigator: journal images sm

Brown, E. C. Z., Steadman, C. J., Lee, T. M., Padmanabhan, V., Lehman, M. N., & Coolen, L. M. (2015). Sex differences and effects of prenatal exposure to excess testosterone on ventral tegmental area dopamine neurons in adult sheep. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.12871.

Chen, L.-X., Ma, S.-M., Zhang, P., Fan, Z.-C., Xiong, M., Cheng, G.-Q., . . . Li, J. (2015). Neuroprotective Effects of Oligodendrocyte Progenitor Cell Transplantation in Premature Rat Brain following Hypoxic-Ischemic Injury. Plos one, 10(3), e0115997. doi: 10.1371/journal.pone.0115997.

Keren, N. I., Taheri, S., Vazey, E. M., Morgan, P. S., Granholm, A.-C. E., Aston-Jones, G. S., & Eckert, M. A. (2015). Histologic validation of locus coeruleus MRI contrast in post-mortem tissue. Neuroimage(0). doi:http://dx.doi.org/10.1016/j.neuroimage.2015.03.020.

Korgan, A. C., Vonkeman, J., Esser, M. J., & Perrot, T. S. (2015). An enhanced home cage modulates hypothalamic CRH-ir Labeling in juvenile rats, with and without sub-threshold febrile convulsions. Developmental Psychobiology, 57(3), 374-381. doi: 10.1002/dev.21300.

Koss, W. A., Lloyd, M. M., Sadowski, R. N., Wise, L. M., & Juraska, J. M. (2015). Gonadectomy before puberty increases the number of neurons and glia in the medial prefrontal cortex of female, but not male, rats. Developmental Psychobiology, 57(3), 305-312. doi: 10.1002/dev.21290.

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Researchers cited MBF systems in 19 papers during the week of 3/16/15

Stereo Investigator:journal images sm

Burianová, J., Ouda, L., & Syka, J. (2015). The influence of aging on the number of neurons and levels of non-phosporylated neurofilament proteins in the central auditory system of rats. [Original Research]. Frontiers in Aging Neuroscience, 7. doi: 10.3389/fnagi.2015.00027.

Collier, T. J., O’Malley, J., Rademacher, D. J., Stancati, J. A., Sisson, K. A., Sortwell, C. E., . . . Steece-Collier, K. (2015). Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration. Neurobiology of Disease(0). doi:http://dx.doi.org/10.1016/j.nbd.2015.03.005.

Filichia, E., Shen, H., Zhou, X., Qi, X., Jin, K., Greig, N., . . . Luo, Y. (2015). Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model. Neuroscience(0). doi:http://dx.doi.org/10.1016/j.neuroscience.2015.03.018.

Filipcik, P., Cente, M., Zilka, N., Smolek, T., Hanes, J., Kucerak, J., . . . Novak, M. (2015). Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease(0). doi: http://dx.doi.org/10.1016/j.bbadis.2015.03.003.

Holmes, G. L., Tian, C., Hernan, A. E., Flynn, S., Camp, D., & Barry, J. (2015). Alterations in sociability and functional brain connectivity caused by early-life seizures are reversed by bumetanide. Neurobiology of Disease(0). doi: http://dx.doi.org/10.1016/j.nbd.2015.02.015.

Li, Q., Loh, D. H., Kudo, T., Truong, D., Derakhshesh, M., Kaswan, Z. M., . . . Colwell, C. S. (2015). Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT. Neurobiology of Disease(0). doi: http://dx.doi.org/10.1016/j.nbd.2015.03.009.

Moyer, C. E., Erickson, S. L., Fish, K. N., Thiels, E., Penzes, P., & Sweet, R. A. (2015). Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice. Cerebral Cortex. doi: 10.1093/cercor/bhv040.

Peterson, S. L., Nguyen, H. X., Mendez, O. A., & Anderson, A. J. (2015). Complement Protein C1q Modulates Neurite Outgrowth In Vitro and Spinal Cord Axon Regeneration In Vivo. The Journal of Neuroscience, 35(10), 4332-4349. http://www.jneurosci.org/content/35/10/4332.short

Neurolucida:

Armañanzas, R., & Ascoli, G. A. (2015). Towards the automatic classification of neurons. Trends in Neurosciences(0). doi: http://dx.doi.org/10.1016/j.tins.2015.02.004.

Briffaud, V., Williams, P., Courty, J., & Broberger, C. (2015). Excitation of Tuberoinfundibular Dopamine Neurons by Oxytocin: Crosstalk in the Control of Lactation. The Journal of Neuroscience, 35(10), 4229-4237.

Chen, B., He, J., Yang, H., Zhang, Q., Zhang, L., Zhang, X., . . . Hao, D. (2015). Repair of spinal cord injury by implantation of bFGF-incorporated HEMA-MOETACL hydrogel in rats. [Article]. Sci. Rep., 5. doi: 10.1038/srep09017.

Collier, T. J., O’Malley, J., Rademacher, D. J., Stancati, J. A., Sisson, K. A., Sortwell, C. E., . . . Steece-Collier, K. (2015). Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration. Neurobiology of Disease(0). doi:http://dx.doi.org/10.1016/j.nbd.2015.03.005.

Fieblinger, T., & Cenci, M. A. (2015). Zooming in on the small: The plasticity of striatal dendritic spines in l-DOPA–Induced dyskinesia. Movement Disorders, n/a-n/a. doi: 10.1002/mds.26139.http://dx.doi.org/10.1002/mds.26139

Hoffmann, J. H. O., Meyer, H. S., Schmitt, A. C., Straehle, J., Weitbrecht, T., Sakmann, B., & Helmstaedter, M. (2015). Synaptic Conductance Estimates of the Connection Between Local Inhibitor Interneurons and Pyramidal Neurons in Layer 2/3 of a Cortical Column. Cerebral Cortex. doi: 10.1093/cercor/bhv039.

Javdani, F., Holló, K., Hegedűs, K., Kis, G., Hegyi, Z., Dócs, K., . . . Antal, M. (2015). Differential expression patterns of K+/Cl- co-transporter 2 in neurons within the superficial spinal dorsal horn of rats. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23774.

Staples, M. C., Kim, A., & Mandyam, C. D. (2015). Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. Molecular and Cellular Neuroscience(0). doi:http://dx.doi.org/10.1016/j.mcn.2015.03.008.

Williams, R., Venkatesh, I., Pearse, D., Udvadia, A., & Bunge, M. (2015). MASH1/Ascl1a Leads to GAP43 Expression and Axon Regeneration in the Adult CNS. PLoS ONE, 10(3), e0118918.

Wong, C., Chabot, N., Kok, M. A., & Lomber, S. G. (2015). Amplified somatosensory and visual cortical projections to a core auditory area, the anterior auditory field, Following early- and late-onset deafness. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23771.

Lucivid:

Filichia, E., Shen, H., Zhou, X., Qi, X., Jin, K., Greig, N., . . . Luo, Y. (2015). Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model. Neuroscience(0). doi:http://dx.doi.org/10.1016/j.neuroscience.2015.03.018.

Researchers cited MBF systems in 14 papers during the week of 3/9/15

Stereo Investigatorjournal images sm

Hawes, J. E., Tesic, D., Whitehouse, A. J., Zosky, G. R., Smith, J. T., & Wyrwoll, C. S. (2015). Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse. Behavioural Brain Research(0). doi:http://dx.doi.org/10.1016/j.bbr.2015.03.008.

Kubínová, L., & Janáček, J. (2015). Confocal stereology: an efficient tool for measurement of microscopic structures. Cell and Tissue Research, 1-16. doi: 10.1007/s00441-015-2138-3.

Lemus, M. B., Bayliss, J. A., Lockie, S. H., Santos, V. V., Reichenbach, A., Stark, R., & Andrews, Z. B. (2015). A stereological analysis of NPY, POMC, orexin, GFAP astrocyte and Iba1 microglia cell number and volume in diet-induced obese male mice. Endocrinology, 0(0), en.2014-1961. doi: doi:10.1210/en.2014-1961.

Lohr, K. M., Stout, K. A., Dunn, A. R., Wang, M., Salahpour, A., Guillot, T. S., & Miller, G. W. (2015). Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity. ACS Chemical Neuroscience. doi: 10.1021/acschemneuro.5b00010.

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Researchers cited MBF systems in 19 papers during the week of 3/2/15

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Datto, J., Bastidas, J., Miller, N., Shah, A. K., Marcillo, A., Dietrich, W. D., & Pearse, D. D. (2015). Female rats demonstrate improved locomotor recovery and greater preservation of white and grey matter following traumatic spinal cord injury compared to males. Journal of Neurotrauma. doi: 10.1089/neu.2014.3702.

Larochelle, A., Bellavance, M.-A., & Rivest, S. (2015). Role of adaptor protein MyD88 in TLR-mediated preconditioning and neuroprotection after acute excitotoxicity. Brain, Behavior, and Immunity(0). doi:http://dx.doi.org/10.1016/j.bbi.2015.02.019.

Navarro, A. I., & Mandyam, C. D. (2015). Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. Neuroscience(0). doi: http://dx.doi.org/10.1016/j.neuroscience.2015.02.043.

Planque, S. A., Nishiyama, Y., Sonoda, S., Lin, Y., Taguchi, H., Hara, M., . . . Paul, S. (2015). Specific Amyloid β Clearance by a Catalytic Antibody Construct. Journal of Biological Chemistry. doi: 10.1074/jbc.M115.641738.

Tsai, M.-S., Lee, M.-L., Chang, C.-Y., Fan, H.-H., Yu, I. S., Chen, Y.-T., . . . Lin, S.-W. (2015). Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development. Neurobiology of Disease(0). doi:http://dx.doi.org/10.1016/j.nbd.2015.02.010.

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Hippocampal Neurons Change After Melatonin Injection

Representative dendrites of dentate gyrus neurons of Siberian hamsters injected with melatonin (stained with Cresyl violet). Ikeno et al found hamsters injected with melatonin displayed decreased spine density on neurons in the dentate gyrus.

Representative dendrites of dentate gyrus neurons of Siberian hamsters injected with melatonin (stained with Cresyl violet). Ikeno et al found hamsters injected with melatonin displayed decreased spine density on neurons in the dentate gyrus. Image courtesy of Tomoko Ikeno, Ph.D.

Night falls and a powerful hormone called melatonin kicks in. The gears of the circadian clock are turning as you get ready for bed and soon drift off to dreamland. But all is not quiet in the brain. In response to the circadian rhythm, neurons are transforming.

A new study published in the journal Hippocampus found that melatonin prompts dendrites to grow longer in one part of the brain, while in another part the hormone causes dendritic spine loss.

In their study, scientists at Ohio State University injected Siberian hamsters with a dose of melatonin in the afternoon, several hours before a natural increase in the hormone would normally occur. Four hours after the injection, they used Neurolucida to examine sections of their brains, reconstructing neurons in two areas of the hippocampus – the CA1 and dentate gyrus. They then used the software to calculate the number of branch points and length of dendrites in their reconstructions. What they saw was longer, more complex dendrites in the CA1 region of the hippocampus of hamsters that received melatonin versus those that received a placebo. Then they analyzed spine density, finding that hamsters that received melatonin had decreased spine density in the dentate gyrus than the control group.

“By using Neurolucida, we found that melatonin treatment induced rapid remodeling of hippocampal neurons and induced a nighttime state of the hippocampal neuronal morphology,” said Dr. Tomoko Ikeno, who worked with Dr. Randy Nelson on the study.

The “nighttime state” she refers to is characterized by the presence of certain hormones produced during the dark hours of night. In their analysis, the researchers saw elevated levels of Period1 and Bmal1 after melatonin injection. These hormones are expressed by genes associated with the circadian clock, and their presence offers evidence that “melatonin functions as a nighttime signal to coordinate the diurnal rhythm” and that this rhythm compels hippocampal neurons to change structurally, according to the paper.

Ikeno, T. and Nelson, R. J. (2014), Acute melatonin treatment alters dendritic morphology and circadian clock gene expression in the hippocampus of Siberian Hamsters. Hippocampus. doi: 10.1002/hipo.22358