Researchers cited MBF systems in 20 papers during the week of 3/23/15

Stereo Investigator: journal images sm

Brown, E. C. Z., Steadman, C. J., Lee, T. M., Padmanabhan, V., Lehman, M. N., & Coolen, L. M. (2015). Sex differences and effects of prenatal exposure to excess testosterone on ventral tegmental area dopamine neurons in adult sheep. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.12871.

Chen, L.-X., Ma, S.-M., Zhang, P., Fan, Z.-C., Xiong, M., Cheng, G.-Q., . . . Li, J. (2015). Neuroprotective Effects of Oligodendrocyte Progenitor Cell Transplantation in Premature Rat Brain following Hypoxic-Ischemic Injury. Plos one, 10(3), e0115997. doi: 10.1371/journal.pone.0115997.

Keren, N. I., Taheri, S., Vazey, E. M., Morgan, P. S., Granholm, A.-C. E., Aston-Jones, G. S., & Eckert, M. A. (2015). Histologic validation of locus coeruleus MRI contrast in post-mortem tissue. Neuroimage(0). doi:http://dx.doi.org/10.1016/j.neuroimage.2015.03.020.

Korgan, A. C., Vonkeman, J., Esser, M. J., & Perrot, T. S. (2015). An enhanced home cage modulates hypothalamic CRH-ir Labeling in juvenile rats, with and without sub-threshold febrile convulsions. Developmental Psychobiology, 57(3), 374-381. doi: 10.1002/dev.21300.

Koss, W. A., Lloyd, M. M., Sadowski, R. N., Wise, L. M., & Juraska, J. M. (2015). Gonadectomy before puberty increases the number of neurons and glia in the medial prefrontal cortex of female, but not male, rats. Developmental Psychobiology, 57(3), 305-312. doi: 10.1002/dev.21290.

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Researchers cited MBF systems in 19 papers during the week of 3/16/15

Stereo Investigator:journal images sm

Burianová, J., Ouda, L., & Syka, J. (2015). The influence of aging on the number of neurons and levels of non-phosporylated neurofilament proteins in the central auditory system of rats. [Original Research]. Frontiers in Aging Neuroscience, 7. doi: 10.3389/fnagi.2015.00027.

Collier, T. J., O’Malley, J., Rademacher, D. J., Stancati, J. A., Sisson, K. A., Sortwell, C. E., . . . Steece-Collier, K. (2015). Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration. Neurobiology of Disease(0). doi:http://dx.doi.org/10.1016/j.nbd.2015.03.005.

Filichia, E., Shen, H., Zhou, X., Qi, X., Jin, K., Greig, N., . . . Luo, Y. (2015). Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model. Neuroscience(0). doi:http://dx.doi.org/10.1016/j.neuroscience.2015.03.018.

Filipcik, P., Cente, M., Zilka, N., Smolek, T., Hanes, J., Kucerak, J., . . . Novak, M. (2015). Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease(0). doi: http://dx.doi.org/10.1016/j.bbadis.2015.03.003.

Holmes, G. L., Tian, C., Hernan, A. E., Flynn, S., Camp, D., & Barry, J. (2015). Alterations in sociability and functional brain connectivity caused by early-life seizures are reversed by bumetanide. Neurobiology of Disease(0). doi: http://dx.doi.org/10.1016/j.nbd.2015.02.015.

Li, Q., Loh, D. H., Kudo, T., Truong, D., Derakhshesh, M., Kaswan, Z. M., . . . Colwell, C. S. (2015). Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT. Neurobiology of Disease(0). doi: http://dx.doi.org/10.1016/j.nbd.2015.03.009.

Moyer, C. E., Erickson, S. L., Fish, K. N., Thiels, E., Penzes, P., & Sweet, R. A. (2015). Developmental Trajectories of Auditory Cortex Synaptic Structures and Gap-Prepulse Inhibition of Acoustic Startle Between Early Adolescence and Young Adulthood in Mice. Cerebral Cortex. doi: 10.1093/cercor/bhv040.

Peterson, S. L., Nguyen, H. X., Mendez, O. A., & Anderson, A. J. (2015). Complement Protein C1q Modulates Neurite Outgrowth In Vitro and Spinal Cord Axon Regeneration In Vivo. The Journal of Neuroscience, 35(10), 4332-4349. http://www.jneurosci.org/content/35/10/4332.short

Neurolucida:

Armañanzas, R., & Ascoli, G. A. (2015). Towards the automatic classification of neurons. Trends in Neurosciences(0). doi: http://dx.doi.org/10.1016/j.tins.2015.02.004.

Briffaud, V., Williams, P., Courty, J., & Broberger, C. (2015). Excitation of Tuberoinfundibular Dopamine Neurons by Oxytocin: Crosstalk in the Control of Lactation. The Journal of Neuroscience, 35(10), 4229-4237.

Chen, B., He, J., Yang, H., Zhang, Q., Zhang, L., Zhang, X., . . . Hao, D. (2015). Repair of spinal cord injury by implantation of bFGF-incorporated HEMA-MOETACL hydrogel in rats. [Article]. Sci. Rep., 5. doi: 10.1038/srep09017.

Collier, T. J., O’Malley, J., Rademacher, D. J., Stancati, J. A., Sisson, K. A., Sortwell, C. E., . . . Steece-Collier, K. (2015). Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration. Neurobiology of Disease(0). doi:http://dx.doi.org/10.1016/j.nbd.2015.03.005.

Fieblinger, T., & Cenci, M. A. (2015). Zooming in on the small: The plasticity of striatal dendritic spines in l-DOPA–Induced dyskinesia. Movement Disorders, n/a-n/a. doi: 10.1002/mds.26139.http://dx.doi.org/10.1002/mds.26139

Hoffmann, J. H. O., Meyer, H. S., Schmitt, A. C., Straehle, J., Weitbrecht, T., Sakmann, B., & Helmstaedter, M. (2015). Synaptic Conductance Estimates of the Connection Between Local Inhibitor Interneurons and Pyramidal Neurons in Layer 2/3 of a Cortical Column. Cerebral Cortex. doi: 10.1093/cercor/bhv039.

Javdani, F., Holló, K., Hegedűs, K., Kis, G., Hegyi, Z., Dócs, K., . . . Antal, M. (2015). Differential expression patterns of K+/Cl- co-transporter 2 in neurons within the superficial spinal dorsal horn of rats. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23774.

Staples, M. C., Kim, A., & Mandyam, C. D. (2015). Dendritic remodeling of hippocampal neurons is associated with altered NMDA receptor expression in alcohol dependent rats. Molecular and Cellular Neuroscience(0). doi:http://dx.doi.org/10.1016/j.mcn.2015.03.008.

Williams, R., Venkatesh, I., Pearse, D., Udvadia, A., & Bunge, M. (2015). MASH1/Ascl1a Leads to GAP43 Expression and Axon Regeneration in the Adult CNS. PLoS ONE, 10(3), e0118918.

Wong, C., Chabot, N., Kok, M. A., & Lomber, S. G. (2015). Amplified somatosensory and visual cortical projections to a core auditory area, the anterior auditory field, Following early- and late-onset deafness. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23771.

Lucivid:

Filichia, E., Shen, H., Zhou, X., Qi, X., Jin, K., Greig, N., . . . Luo, Y. (2015). Forebrain neuronal specific ablation of p53 gene provides protection in a cortical ischemic stroke model. Neuroscience(0). doi:http://dx.doi.org/10.1016/j.neuroscience.2015.03.018.

Researchers cited MBF systems in 14 papers during the week of 3/9/15

Stereo Investigatorjournal images sm

Hawes, J. E., Tesic, D., Whitehouse, A. J., Zosky, G. R., Smith, J. T., & Wyrwoll, C. S. (2015). Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse. Behavioural Brain Research(0). doi:http://dx.doi.org/10.1016/j.bbr.2015.03.008.

Kubínová, L., & Janáček, J. (2015). Confocal stereology: an efficient tool for measurement of microscopic structures. Cell and Tissue Research, 1-16. doi: 10.1007/s00441-015-2138-3.

Lemus, M. B., Bayliss, J. A., Lockie, S. H., Santos, V. V., Reichenbach, A., Stark, R., & Andrews, Z. B. (2015). A stereological analysis of NPY, POMC, orexin, GFAP astrocyte and Iba1 microglia cell number and volume in diet-induced obese male mice. Endocrinology, 0(0), en.2014-1961. doi: doi:10.1210/en.2014-1961.

Lohr, K. M., Stout, K. A., Dunn, A. R., Wang, M., Salahpour, A., Guillot, T. S., & Miller, G. W. (2015). Increased Vesicular Monoamine Transporter 2 (VMAT2; Slc18a2) Protects against Methamphetamine Toxicity. ACS Chemical Neuroscience. doi: 10.1021/acschemneuro.5b00010.

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Researchers cited MBF systems in 19 papers during the week of 3/2/15

Stereo Investigator:journal images sm

Datto, J., Bastidas, J., Miller, N., Shah, A. K., Marcillo, A., Dietrich, W. D., & Pearse, D. D. (2015). Female rats demonstrate improved locomotor recovery and greater preservation of white and grey matter following traumatic spinal cord injury compared to males. Journal of Neurotrauma. doi: 10.1089/neu.2014.3702.

Larochelle, A., Bellavance, M.-A., & Rivest, S. (2015). Role of adaptor protein MyD88 in TLR-mediated preconditioning and neuroprotection after acute excitotoxicity. Brain, Behavior, and Immunity(0). doi:http://dx.doi.org/10.1016/j.bbi.2015.02.019.

Navarro, A. I., & Mandyam, C. D. (2015). Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. Neuroscience(0). doi: http://dx.doi.org/10.1016/j.neuroscience.2015.02.043.

Planque, S. A., Nishiyama, Y., Sonoda, S., Lin, Y., Taguchi, H., Hara, M., . . . Paul, S. (2015). Specific Amyloid β Clearance by a Catalytic Antibody Construct. Journal of Biological Chemistry. doi: 10.1074/jbc.M115.641738.

Tsai, M.-S., Lee, M.-L., Chang, C.-Y., Fan, H.-H., Yu, I. S., Chen, Y.-T., . . . Lin, S.-W. (2015). Functional and structural deficits of the dentate gyrus network coincide with emerging spontaneous seizures in an Scn1a mutant Dravet Syndrome model during development. Neurobiology of Disease(0). doi:http://dx.doi.org/10.1016/j.nbd.2015.02.010.

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Hippocampal Neurons Change After Melatonin Injection

Representative dendrites of dentate gyrus neurons of Siberian hamsters injected with melatonin (stained with Cresyl violet). Ikeno et al found hamsters injected with melatonin displayed decreased spine density on neurons in the dentate gyrus.

Representative dendrites of dentate gyrus neurons of Siberian hamsters injected with melatonin (stained with Cresyl violet). Ikeno et al found hamsters injected with melatonin displayed decreased spine density on neurons in the dentate gyrus. Image courtesy of Tomoko Ikeno, Ph.D.

Night falls and a powerful hormone called melatonin kicks in. The gears of the circadian clock are turning as you get ready for bed and soon drift off to dreamland. But all is not quiet in the brain. In response to the circadian rhythm, neurons are transforming.

A new study published in the journal Hippocampus found that melatonin prompts dendrites to grow longer in one part of the brain, while in another part the hormone causes dendritic spine loss.

In their study, scientists at Ohio State University injected Siberian hamsters with a dose of melatonin in the afternoon, several hours before a natural increase in the hormone would normally occur. Four hours after the injection, they used Neurolucida to examine sections of their brains, reconstructing neurons in two areas of the hippocampus – the CA1 and dentate gyrus. They then used the software to calculate the number of branch points and length of dendrites in their reconstructions. What they saw was longer, more complex dendrites in the CA1 region of the hippocampus of hamsters that received melatonin versus those that received a placebo. Then they analyzed spine density, finding that hamsters that received melatonin had decreased spine density in the dentate gyrus than the control group.

“By using Neurolucida, we found that melatonin treatment induced rapid remodeling of hippocampal neurons and induced a nighttime state of the hippocampal neuronal morphology,” said Dr. Tomoko Ikeno, who worked with Dr. Randy Nelson on the study.

The “nighttime state” she refers to is characterized by the presence of certain hormones produced during the dark hours of night. In their analysis, the researchers saw elevated levels of Period1 and Bmal1 after melatonin injection. These hormones are expressed by genes associated with the circadian clock, and their presence offers evidence that “melatonin functions as a nighttime signal to coordinate the diurnal rhythm” and that this rhythm compels hippocampal neurons to change structurally, according to the paper.

Ikeno, T. and Nelson, R. J. (2014), Acute melatonin treatment alters dendritic morphology and circadian clock gene expression in the hippocampus of Siberian Hamsters. Hippocampus. doi: 10.1002/hipo.22358

 

Researchers cited MBF systems in 38 papers between 2/13/2015 and 2/27/2015

Stereo Investigator:journal images sm

Al-Samerria, S., Al-Ali, I., McFarlane, J. R., & Almahbobi, G. (2015). The impact of passive immunization against BMPR1B and BMP4 on follicle development and ovulation. Reproduction, REP-14-0451.

Beach, L. Q., & Wade, J. (2015). Masculinization of the Zebra Finch Song System: Roles of Oestradiol and the Z-chromosome Gene Tubulin Specific Chaperone Protein A. Journal of Neuroendocrinology, n/a-n/a. doi: 10.1111/jne.12267.

Berggren, K. L., Chen, J., Fox, J., Miller, J., Dodds, L., Dugas, B., . . . Fox, J. H. (2015). Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington’s disease. Redox Biology, 4(0), 363-374. doi:http://dx.doi.org/10.1016/j.redox.2015.02.002.

Boix, J., Padel, T., & Paul, G. (2015). A partial lesion model of Parkinson’s disease in mice – Characterization of a 6-OHDA-induced medial forebrain bundle lesion. Behavioural Brain Research(0). doi:http://dx.doi.org/10.1016/j.bbr.2015.01.053.

Chang, J. C., Leung, M., Gokozan, H. N., Gygli, P. E., Catacutan, F. P., Czeisler, C., & Otero, J. J. (2015). Mitotic Events in Cerebellar Granule Progenitor Cells That Expand Cerebellar Surface Area Are Critical for Normal Cerebellar Cortical Lamination in Mice. Journal of Neuropathology and Experimental Neurology, 74(3), 261-272.

Duan, S., Guan, X., Lin, R., Liu, X., Yan, Y., Lin, R., . . . Gu, H. (2015). Silibinin Inhibits Acetylcholinesterase Activity and Aβ Peptide Aggregation: A Dual-Target Drug for Alzheimer’s Disease Treatment. Neurobiology of Aging(0). doi: http://dx.doi.org/10.1016/j.neurobiolaging

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Stereo Investigator continues to be the leading stereology system

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers – citing it almost three times more than all other stereology systems combined. Researchers tell us they use Stereo Investigator because:

  1. it works with many different microscopes and imaging technologies
  2. it provides unbiased data about neuron populations and regions of interest
  3. of the with strong technical and research support provided by MBF Bioscience
2014

source: google scholar

Dr. Mark West, co-developer of the Optical Fractionator stereology probe and Professor of Medical Neurobiology at Aarhus University in Denmark, sums up why he thinks Stereo Investigator was cited in so many more publications than all other stereology systems combined: “Stereo Investigator is the most reliable tool for collecting unbiased stereology data. It’s backed by excellent technical and research support teams at MBF – you can call to ask about stereology probes, tissue preparation, microscope hardware, basically anything regarding your stereology study.”

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Researchers cited MBF systems in 14 papers during the week of 2/9/15

Stereo Investigator:journal images sm

Chen, H., Qian, K., Chen, W., Hu, B., Blackbourn, L. W. I. V., Du, Z., . . . Zhang, S.-C. (2015). Human-derived neural progenitors functionally replace astrocytes in adult mice. The Journal of Clinical Investigation, 125(3), 0-0. doi: 10.1172/jci69097.

Fields, J., Dumaop, W., Elueteri, S., Campos, S., Serger, E., Trejo, M., . . . Rockenstein, E. (2015). HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders. The Journal of Neuroscience, 35(5), 1921-1938.

Potter, M., Baxter, V., Mathey, R., Alt, J., Rojas, C., Griffin, D., & Slusher, B. (2015). Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine. Journal of Neurovirology, 1-15. doi: 10.1007/s13365-015-0314-6.

Southwell, A. L., Franciosi, S., Villanueva, E. B., Xie, Y., Winter, L. A., Veeraraghavan, J., . . . Hayden, M. R. (2015). Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease. Neurobiology of Disease(0). doi:http://dx.doi.org/10.1016/j.nbd.2015.01.002.

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Researchers cited MBF systems in 15 papers during the week of 2/2/15

Stereo Investigator:journal images sm

Audoy-Rémus, J., Bozoyan, L., Dumas, A., Filali, M., Lecours, C., Lacroix, S., . . . Vallières, L. (2015). GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease. Brain, Behavior, and Immunity(0). doi:http://dx.doi.org/10.1016/j.bbi.2015.01.010.

Côté, M., Poirier, A. A., Aubé, B., Jobin, C., Lacroix, S., & Soulet, D. (2015). Partial depletion of the proinflammatory monocyte population is neuroprotective in the myenteric plexus but not in the basal ganglia in a MPTP mouse model of Parkinson’s disease. Brain, Behavior, and Immunity(0). doi:http://dx.doi.org/10.1016/j.bbi.2015.01.009.

Di Giovanni, V., Walker, K. A., Bushnell, D., Schaefer, C., Sims-Lucas, S., Puri, P., & Bates, C. M. (2015). Fibroblast growth factor receptor–Frs2α signaling is critical for nephron progenitors. Developmental Biology(0). doi: http://dx.doi.org/10.1016/j.ydbio.2015.01.018.

Jackson, K. L., Dayton, R. D., Fisher-Perkins, J. M., Didier, P. J., Baker, K. C., Weimer, M., . . . Klein, R. L. (2015). Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates. Journal of Medical Primatology, n/a-n/a. doi: 10.1111/jmp.12162.http://dx.doi.org/10.1111/jmp.12162

Kodali, M., Parihar, V. K., Hattiangady, B., Mishra, V., Shuai, B., & Shetty, A. K. (2015). Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation. Sci. Rep., 5. doi: 10.1038/srep08075

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How Transplanted Stem Cells Behave in Injured Spinal Cord Tissue

A representative confocal image of spinal cord tissue fluorescently immunolabeled for SC121 in conjunction with GFAP – markers that allowed the researchers to track stem cell differentiation and migration by stereological quantification. (Image provided by study author Dr. Aileen J. Anderson)

A representative confocal image of spinal cord tissue fluorescently immunolabeled for SC121 (red) in conjunction with GFAP (green) – markers that allowed researchers to quantify stem cell differentiation and migration. (Image provided by study author Dr. Aileen J. Anderson)

Research has shown that transplanting human neural stem cells into damaged spinal cords restores locomotor function in a mouse model of spinal cord injury1. Researchers who worked on that study have published another paper examining how these neural stem cells behave in injured tissue as they aid in healing. Learning how stem cells behave in injured tissue will hopefully help researchers develop better treatments for spinal cord injuries.

In the study, researchers used Stereo Investigator to stereologically quantify the survival, migration, proliferation, and differentiation of human neural stem cells transplanted into injured and uninjured mice. Stem cells were analyzed in mouse brain tissue specimens 1, 7, 14, 28, and 98 days after transplantation. The research found that there were fewer stem cells in the injured animals compared to the uninjured animals at all time points, stem cells in injured mice localized near the center of the injury, a delay of stem cell proliferation in injured tissue led to an overall deficit of actively dividing cells, proliferation in injured mice occurred closer to the injection sites (the locations where the stem cells were injected into the mice), and the injured microenvironment increased differentiation to more mature oligodendrocytes.

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