Researchers cited MBF Bioscience systems in 26 papers between 10/19/2018 and 11/2/2018

Stereo Investigator

Castillo-Ruiz, A., Mosley, M., Jacobs, A. J., Hoffiz, Y. C., & Forger, N. G. (2018). Birth delivery mode alters perinatal cell death in the mouse brain. Proceedings of the National Academy of Sciences. doi: https://doi.org/10.1073/pnas.1811962115.

Chen, Y.-H., Lee, H.-J., Lee, M. T., Wu, Y.-T., Lee, Y.-H., Hwang, L.-L., . . . Chiou, L.-C. (2018). Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray. Proceedings of the National Academy of Sciences. doi: https://doi.org/10.1073/pnas.1807991115.

Garcia-Miralles, M., Yusof, N. A. B. M., Tan, J. Y., Radulescu, C. I., Sidik, H., Tan, L. J., . . . Pouladi, M. A. (2018). Laquinimod Treatment Improves Myelination Deficits at the Transcriptional and Ultrastructural Levels in the YAC128 Mouse Model of Huntington Disease. Molecular Neurobiology. doi: 10.1007/s12035-018-1393-1.

Illouz, T., Madar, R., Biragyn, A., & Okun, E. (2018). Restoring microglial and astroglial homeostasis using DNA immunization in a Down Syndrome mouse model. Brain, Behavior, and Immunity. doi: https://doi.org/10.1016/j.bbi.2018.10.004. Continue reading “Researchers cited MBF Bioscience systems in 26 papers between 10/19/2018 and 11/2/2018” »

Huron Digital Pathology and MBF Bioscience Partner to Enable Large-scale, Repeatable Whole Slide Imaging Workflows for Life Science Research

MBF Bioscience now offers customized models of Huron Digital Pathology’s TissueScope™, a line of whole slide scanners, and supports TissueScope images across its range of analysis software.

October 23, 2018 – Huron Digital Pathology and MBF Bioscience are proud to announce their partnership to offer customized models of Huron’s TissueScope whole slide scanners integrated with MBF’s Stereo Investigator® – Whole Slide Edition, NeuroInfo®, Biolucida®, and BrainMaker® software. The partnership gives researchers new tools to visualize and analyze tissue specimens throughout entire organs, large and small, at high-resolution.

“Combining our analysis software with Huron’s whole slide scanners means that researchers can get the most advanced systems for large-scale, repeatable whole slide imaging workflows,” says Jack Glaser, President of MBF Bioscience. “We are pleased to partner with Huron Digital Pathology to provide Huron/MBF whole slide research systems. As the recognized leader in the fields of stereology, brain mapping, and neuron tracing, we are proud to offer systems with such a distinguished company as Huron. This partnership will now allow researchers to effectively work with microscopic specimens that range in size from mice brains to human brains. It is invaluable for researchers working with large brain specimens, especially those investigating the microscopic intricacies of the human brain.”

“By partnering with MBF Bioscience, our goal is to help accelerate life science research,” says Patrick Myles, CEO of Huron Digital Pathology. “Being able to scan any size tissue and then easily manage, visualize, and quantify the data opens up amazing new possibilities for scientific research and exploration.”

The partnership enables Stereo Investigator, NeuroInfo, Biolucida, and BrainMaker software to efficiently provide quantitative analysis workflows for large sets of slides from both individual tissue sections and series of tissue sections. Stereo Investigator – Whole Slide Edition offers analyses for counting and measuring morphological aspects relevant to disease state characterization. BrainMaker and NeuroInfo offer full-resolution section alignment and brain mapping. Biolucida offers slide management and slide access for viewing and analysis at unprecedented speeds from any web-enabled device. The customized versions of TissueScope scanners are available for purchase from MBF Bioscience.

Continue reading “Huron Digital Pathology and MBF Bioscience Partner to Enable Large-scale, Repeatable Whole Slide Imaging Workflows for Life Science Research” »

Researchers cited MBF Bioscience systems in 14 papers between 10/12/2018 and 10/19/2018

Stereo Investigator

Issa, H. A., Staes, N., Diggs-Galligan, S., Stimpson, C. D., Gendron-Fitzpatrick, A., Taglialatela, J. P., . . . Sherwood, C. C. (2018). Comparison of bonobo and chimpanzee brain microstructure reveals differences in socio-emotional circuits. Brain Structure and Function. doi: 10.1007/s00429-018-1751-9.

Jiang, Y., Cao, Z., Ma, H., Wang, G., Wang, X., Wang, Z., . . . Feng, T. (2018). Auricular Vagus Nerve Stimulation Exerts Antiinflammatory Effects and Immune Regulatory Function in a 6-OHDA Model of Parkinson’s Disease. Neurochemical Research, 43(11), 2155-2164. doi: 10.1007/s11064-018-2639-z.

Nuber, S., Rajsombath, M., Minakaki, G., Winkler, J., Müller, C. P., Ericsson, M., . . . Selkoe, D. J. (2018). Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson’s Disease. Neuron, 100(1), 75-90.e75. doi: https://doi.org/10.1016/j.neuron.2018.09.014.

Wood, T. E., Barry, J., Yang, Z., Cepeda, C., Levine, M. S., & Gray, M. (2018). Mutant huntingtin reduction in astrocytes slows disease progression in the bachd conditional Huntington’s disease mouse model. Human Molecular Genetics, ddy363-ddy363. doi: 10.1093/hmg/ddy363.  Continue reading “Researchers cited MBF Bioscience systems in 14 papers between 10/12/2018 and 10/19/2018” »

Researchers cited MBF Bioscience systems in 12 papers between 10/5/2018 and 10/12/2018

Stereo Investigator:

Dufour, B. D., & McBride, J. L. (2019). Normalizing glucocorticoid levels attenuates metabolic and neuropathological symptoms in the R6/2 mouse model of huntington’s disease. Neurobiology of Disease, 121, 214-229. doi: https://doi.org/10.1016/j.nbd.2018.09.025.

Heermann, T., Garrett, L., Wurst, W., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., . . . Hölter, S. M. (2018). Crybb2 Mutations Consistently Affect Schizophrenia Endophenotypes in Mice. Molecular Neurobiology. doi: 10.1007/s12035-018-1365-5.

Hussain, T., Kil, H., Hattiangady, B., Lee, J., Kodali, M., Shuai, B., . . . Aldaz, C. M. (2019). Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Neurobiology of Disease, 121, 163-176. doi: https://doi.org/10.1016/j.nbd.2018.09.026.

Maxan, A., Mason, S., Saint-Pierre, M., Smith, E., Ho, A., Harrower, T., . . . Cicchetti, F. (2018). Outcome of cell suspension allografts in a patient with Huntington’s disease. Annals of Neurology, 0(ja). doi: 10.1002/ana.25354.

Southwell, A. L., Kordasiewicz, H. B., Langbehn, D., Skotte, N. H., Parsons, M. P., Villanueva, E. B., . . . Hayden, M. R. (2018). Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease. Science translational medicine, 10(461). doi: 10.1126/scitranslmed.aar3959
Continue reading “Researchers cited MBF Bioscience systems in 12 papers between 10/5/2018 and 10/12/2018” »

Visit MBF Bioscience at Booth 2235 at SfN 2018 in San Diego

Every year, we look forward to showcasing our new products and latest developments at the Society for Neuroscience’s annual meeting. This year, from November 3 – 7, we’ll be at SfN 2018 in San Diego, at Booth #2235, where our team of expert scientists and engineers will be on hand to offer personalized demonstrations of all of our products.

This year, we are thrilled to introduce two major new software solutions: Vesselucida 360, an application for reconstructing microvascular networks in 3D, and NeuroInfo for automatic identification of brain anatomy in your sections.

We are also excited to showcase the following:

➛ Software and systems

Continue reading “Visit MBF Bioscience at Booth 2235 at SfN 2018 in San Diego” »

Researchers cited MBF Bioscience systems in 21 papers between 9/28/2018 and 10/5/2018

Stereo Investigator:

Anselmi, L., Bove, C., Coleman, F. H., Le, K., Subramanian, M. P., Venkiteswaran, K., . . . Travagli, R. A. (2018). Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat. Npj Parkinson’s Disease, 4(1), 30. doi: 10.1038/s41531-018-0066-0.

Bauman, M. D., Schumann, C. M., Carlson, E. L., Taylor, S. L., Vázquez-Rosa, E., Cintrón-Pérez, C. J., . . . Pieper, A. A. (2018). Neuroprotective efficacy of P7C3 compounds in primate hippocampus. Translational Psychiatry, 8(1), 202. doi: 10.1038/s41398-018-0244-1.

Cope, E. C., Opendak, M., LaMarca, E. A., Murthy, S., Park, C. Y., Olson, L. B., . . . Gould, E. (2018). The effects of living in an outdoor enclosure on hippocampal plasticity and anxiety-like behavior in response to nematode infection. Hippocampus, 0(ja). doi:10.1002/hipo.23033.

Ellwardt, E., Pramanik, G., Luchtman, D., Novkovic, T., Jubal, E. R., Vogt, J., . . . Stroh, A. (2018). Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. Nature Neuroscience, 21(10), 1392-1403. doi: 10.1038/s41593-018-0193-2.
Continue reading “Researchers cited MBF Bioscience systems in 21 papers between 9/28/2018 and 10/5/2018” »

Researchers cited MBF Bioscience systems in 23 papers between 9/7/2018 and 9/21/2018

Stereo Investigator:

Celiker, F. B., Tumkaya, L., Mercantepe, T., Beyazal, M., Turan, A., Beyazal Polat, H., . . . Yilmaz, A. (2018). Effects of Gadodiamide and Gadoteric Acid on Rat Kidneys: A Comparative Study. Journal of Magnetic Resonance Imaging, 0(0). doi: 10.1002/jmri.26266.

Cope, E. C., LaMarca, E. A., Monari, P. K., Olson, L. B., Martinez, S., Zych, A. D., . . . Gould, E. (2018). Microglia play an active role in obesity-associated cognitive decline. [10.1523/JNEUROSCI.0789-18.2018]. The Journal of Neuroscience. doi: https://doi.org/10.1523/JNEUROSCI.0789-18.2018

Dandanell, S., Meinild-Lundby, A.-K., Andersen, A. B., Lang, P. F., Oberholzer, L., Keiser, S., . . . Lundby, C. (2018). Determinants of maximal whole body fat oxidation in elite cross-country skiers: role of skeletal muscle mitochondria. Scandinavian Journal of Medicine and Science in Sports, 0(ja). doi: 10.1111/sms.13298.

Ghuman, H., Mauney, C., Donnelly, J., Massensini, A. R., Badylak, S. F., & Modo, M. (2018). Biodegradation of ECM hydrogel promotes endogenous brain tissue restoration in a rat model of stroke. Acta Biomaterialia. doi: https://doi.org/10.1016/j.actbio.2018.09.020.

Henry, R. J., Doran, S. J., Barrett, J. P., Meadows, V. E., Sabirzhanov, B., Stoica, B. A., . . . Faden, A. I. (2018). Inhibition of miR-155 Limits Neuroinflammation and Improves Functional Recovery After Experimental Traumatic Brain Injury in Mice.  Neurotherapeutics. doi: 10.1007/s13311-018-0665-9. Continue reading “Researchers cited MBF Bioscience systems in 23 papers between 9/7/2018 and 9/21/2018” »

Scientists Discover New “Rosehip” Neuron in Human Brain

Neurolucida and Neurolucida Explorer Used for 3D Reconstruction and Quantitative Analysis

Researchers used Neurolucida to reconstruct a newly discovered type of neuron found only in the human brain, according to a study published in the journal Nature Neuroscience. Known as “rosehip” neurons because of the way they resemble a rose after its petals have fallen off, these cells feature compact, bushy axonal arborizations.

Found in the first layer of the cerebral cortex, a highly complex brain region that is thought to play an important role in consciousness, “rosehip neurons” have not been seen in mice or other laboratory animals, and scientists suggest that they may exist only in humans. Classified as inhibitory neurons, these brain cells form synapses with pyramidal neurons in layer 3 of the cerebral cortex, according to the study.

Led by Dr. Ed Lein, of the Allen Institute for Brain Science, and Dr. Gábor Tamás, a neuroscientist at the University of Szeged in Szeged, Hungary, the research team used Neurolucida to reconstruct rosehip neurons in 3D. Their reconstructions revealed that these cells display morphological characteristics that differ significantly from other types of cells found in this region of the brain.

Scientists used Neurolucida and Neurolucida Explorer to reconstruct and analyze a rosehip neuron. Image Credit: Tamas Lab, University of Szeged

Using Neurolucida Explorer to quantitatively analyze their cell reconstructions, the researchers observed similar numbers of primary dendrites in both rosehip neurons and basket cells, but fewer compared to neurogliaform cells. Meanwhile, they calculated similar total dendritic length and frequency of dendritic nodes in rosehip neurons and neurogliaform cells, but recorded differences in basket cells.

Continue reading “Scientists Discover New “Rosehip” Neuron in Human Brain” »

Researchers cited MBF Bioscience systems in 26 papers between 8/31/2018 and 9/7/2018

Stereo Investigator:

Anderson, M. A., O’Shea, T. M., Burda, J. E., Ao, Y., Barlatey, S. L., Bernstein, A. M., . . . Sofroniew, M. V. (2018). Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. doi: 10.1038/s41586-018-0467-6.

Bae, E.-J., Kim, D.-K., Kim, C., Mante, M., Adame, A., Rockenstein, E., . . . Lee, S.-J. (2018). LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation. Nature Communications, 9(1), 3465. doi: 10.1038/s41467-018-05958-z.

Bok, E., Cho, E. J., Chung, E. S., Shin, W.-H., & Jin, B. K. (2018). Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo. Exp Neurobiol, 27(4), 309-319. doi: https://doi.org/10.5607/en.2018.27.4.309

Chhaya, M. S. J., Quiros-Molina, M. D., Tamashiro-Orrego, M. A. D., Houle, D. J. D., & Detloff, D. M. R. (2018). Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Spinal Cord Injury. Journal of Neurotrauma, 0(ja), null. doi: 10.1089/neu.2018.5819.

Chou, Y.-C., Ho, C.-T., & Pan, M.-H. (2018). Immature Citrus reticulata extract promotes browning of beige adipocytes in high-fat diet-induced C57BL/6 mice. Journal of Agricultural and Food Chemistry. doi: 10.1021/acs.jafc.8b02719. Continue reading “Researchers cited MBF Bioscience systems in 26 papers between 8/31/2018 and 9/7/2018” »

MBF Bioscience’s New Software Vesselucida 360 Reconstructs Microvascular Networks in 3D

Williston, VT – September 5, 2018 – Researchers studying microvascular networks and vessels have a groundbreaking new software application to facilitate their work. Developed by MBF Bioscience, Vesselucida® 360 automatically reconstructs and analyzes microvascular networks in 3D.

Specifically designed to recognize the intricacies of the vascular system, Vesselucida features sophisticated algorithms that quickly and accurately create 3D reconstructions of images and tissue specimens. Built-in analyses provide data on segments and node counts, frequency of anastomoses, as well as metrics on vessel surface and volume.

Automatic reconstruction of vascular structure labeled with tomato lectin
Image courtesy Dr. Stan Watson, University of Michigan, USA

Vesselucida 360 also features a full suite of tools, which lets researchers manually trace and edit 3D reconstructions to fine-tune particularly complex image data. Companion analysis software, Vesselucida Explorer performs sophisticated data analysis for scientists seeking answers to their most challenging research questions.

Continue reading “MBF Bioscience’s New Software Vesselucida 360 Reconstructs Microvascular Networks in 3D” »