Researchers cited MBF systems in 15 papers during the week of 11/16/14

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Hagen, M. W., Riddle, A., McClendon, E., Gong, X., Shaver, D., Srivastava, T., . . . Back, S. A. (2014). Role of Recurrent Hypoxia-Ischemia in Preterm White Matter Injury Severity. Plos one, 9(11), e112800. doi: 10.1371/journal.pone.0112800.

Kanaya, M., Tsuda, M. C., Sagoshi, S., Nagata, K., Morimoto, C., Tha Thu, C. K., . . . Tsukahara, S. (2014). Regional Difference in Sex Steroid Action on Formation of Morphological Sex Differences in the Anteroventral Periventricular Nucleus and Principal Nucleus of the Bed Nucleus of the Stria Terminalis. Plos one, 9(11), e112616. doi: 10.1371/journal.pone.0112616.

Liu, N.-K., Byers, J. S., Lam, T., Lu, Q.-B., Sengelaub, D. R., & Xu, X.-M. (2014). Inhibition of cPLA2 has neuroprotective effects on motoneuron and muscle atrophy following spinal cord injury. Journal of Neurotrauma. doi: 10.1089/neu.2014.3690.

Maass, F., Petersen, J., Hovakimyan, M., Schmitt, O., Witt, M., Hawlitschka, A., . . . Wree, A. (2014). Reduced cerebellar neurodegeneration after combined therapy with cyclodextrin/allopregnanolone and miglustat in NPC1: A mouse model of Niemann-Pick type C1 disease. Journal of Neuroscience Research, n/a-n/a. doi: 10.1002/jnr.23509.

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Researchers cited MBF systems in 12 papers during the week of 11/09/14

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Akkerman, S., Prickaerts, J., Bruder, A. K., Wolfs, K. H. M., De Vry, J., Vanmierlo, T., & Blokland, A. (2014). PDE5 Inhibition Improves Object Memory in Standard Housed Rats but Not in Rats Housed in an Enriched Environment: Implications for Memory Models? Plos one, 9(11), e111692.

Ensminger, A. L., & Fernández-Juricic, E. (2014). Individual Variation in Cone Photoreceptor Density in House Sparrows: Implications for Between-Individual Differences in Visual Resolution and Chromatic Contrast. Plos one, 9(11), e111854.

Keeley, R. J., Bye, C., Trow, J., & McDonald, R. J. (2014). Part I: Strain and sex differences in brain and behaviour of adult rats: Learning and memory, anxiety and volumetric estimates. Behavioural Brain Research(0).

Louis, E. D., Lee, M., Babij, R., Ma, K., Cortés, E., Vonsattel, J.-P. G., & Faust, P. L. (2014). Reduced Purkinje cell dendritic arborization and loss of dendritic spines in essential tremor. Brain, awu314.

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Researchers cited MBF systems in 12 papers during the week of 11/02/14

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Dai, Y., Clark, J., Zheng, K., Kujoth, G. C., Prolla, T. A., & Simon, D. K. (2014). Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice. Neurotoxicology and Teratology(0).

Depboylu, C., Klietz, M., Maurer, L., Oertel, W. H., Kobayashi, K., Weihe, E., . . . Schäfer, M. K. H. (2014). Transcriptional and structural plasticity of tyrosine hydroxylase expressing neurons in both striatum and nucleus accumbens following dopaminergic denervation. Journal of Chemical Neuroanatomy(0).

Katic, J., Loers, G., Kleene, R., Karl, N., Schmidt, C., Buck, F., . . . Schachner, M. (2014). Interaction of the Cell Adhesion Molecule CHL1 with Vitronectin, Integrins, and the Plasminogen Activator Inhibitor-2 Promotes CHL1-Induced Neurite Outgrowth and Neuronal Migration. The Journal of Neuroscience, 34(44), 14606-14623.

Li, J., Geisbush, T. R., Arnold, W. D., Rosen, G. D., Zaworski, P. G., & Rutkove, S. B. (2014). A Comparison of Three Electrophysiological Methods for the Assessment of Disease Status in a Mild Spinal Muscular Atrophy Mouse Model. Plos one, 9(10), e111428. doi: 10.1371/journal.pone.0111428.

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Researchers cited MBF systems in 17 papers during the week of 10/26/14

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Berthet, A., Margolis, E. B., Zhang, J., Hsieh, I., Zhang, J., Hnasko, T. S., . . . Huang, E. J. (2014). Loss of Mitochondrial Fission Depletes Axonal Mitochondria in Midbrain Dopamine Neurons. The Journal of Neuroscience, 34(43), 14304-14317.

Daniel, G., Musso, A., Tsika, E., Fiser, A., Glauser, L., Pletnikova, O., . . . Moore, D. J. (2015). α-Synuclein-induced dopaminergic neurodegeneration in a rat model of Parkinson’s disease occurs independent of ATP13A2 (PARK9). Neurobiology of Disease, 73(0), 229-243.

Fack, F., Espedal, H., Keunen, O., Golebiewska, A., Obad, N., Harter, P. N., . . . Stuhr, L. (2014). Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas. Acta Neuropathologica, 1-17.

Johnston, C. E., Herschel, D. J., Lasek, A. W., Hammer Jr, R. P., & Nikulina, E. M. (2015). Knockdown of ventral tegmental area mu-opioid receptors in rats prevents effects of social defeat stress: Implications for amphetamine cross-sensitization, social avoidance, weight regulation and expression of brain-derived neurotrophic factor. Neuropharmacology, 89(0), 325-334.

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Researchers cited MBF systems in 18 papers during the week of 10/19/14

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Biamonte, F., Latini, L., Giorgi, F. S., Zingariello, M., Marino, R., De Luca, R., . . . Keller, F. (2014). Associations among exposure to methylmercury, reduced Reelin expression, and gender in the cerebellum of developing mice. Neurotoxicology, 45(0), 67-80.

Eiting, T. P., Smith, T. D., & Dumont, E. R. (2014). Olfactory Epithelium in the Olfactory Recess: A Case Study in New World Leaf-Nosed Bats. The Anatomical Record, 297(11), 2105-2112. doi: 10.1002/ar.23030.

Hodor, A., Palchykova, S., Baracchi, F., Noain, D., & Bassetti, C. L. (2014). Baclofen facilitates sleep, neuroplasticity, and recovery after stroke in rats. Annals of Clinical and Translational Neurology, 1(10), 765-777. doi: 10.1002/acn3.115.

Lee, K. H., Lee, R., Lee, W. Y., Kim, D. H., Chung, H. J., Kim, J. H., . . . Song, H. (2014). Identification and In Vitro Derivation of Spermatogonia in Beagle Testis. Plos one, 9(10), e109963. doi: 10.1371/journal.pone.0109963.

Lin, E.-J. D., Sun, M., Choi, E., Magee, D., Stets, C., & During, M. J. (2014). Social overcrowding as a chronic stress model that increases adiposity in mice. Psychoneuroendocrinology. doi: 10.1016/j.psyneuen.2014.10.007.

Malchow, B., Strocka, S., Frank, F., Bernstein, H.-G., Steiner, J., Schneider-Axmann, T., . . . Schmitt, A. (2014). Stereological investigation of the posterior hippocampus in affective disorders. Journal of Neural Transmission, 1-15. doi: 10.1007/s00702-014-1316-x.

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Two 2014 Nobel Prize Laureates Used Neurolucida in their Groundbreaking Research

May-Britt and Edvard Moser

Drs. May-Britt and Edvard Moser Image from GEIR MOGEN / NTNU

Drs. May-Britt and Edvard Moser were awarded the 2014 Nobel Prize in Physiology or Medicine for discovering the cells that form a network for spatial navigation in the brain, and we’re proud to say they are MBF Bioscience customers and used Neurolucida in their research.

In 2006, the Norwegian husband and wife team published a paper in the journal Science entitled “Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex” – a pivotal step in a line of research initiated in 1971 by co-laureate Dr. John O’Keefe (The Hippocampus as a Spatial Map). In their study, the scientists used Neurolucida to create 3D reconstructions of a complex network of neurons that make it possible for rats, and other animals, including humans, to navigate the world around them.

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Researchers cited MBF systems in 16 papers during the week of 10/12/14

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Acker, S. N., Mandell, E. W., Sims-Lucas, S., Gien, J., Abman, S. H., & Galambos, C. (2014). Histologic Identification of Prominent Intrapulmonary Anastomotic Vessels in Severe Congenital Diaphragmatic Hernia. The Journal of Pediatrics(0).

Dixon, K. J., Theus, M. H., Nelersa, C. M., Mier, J., Travieso, L. G., Yu, T.-S., . . . Liebl, D. J. (2014). Endogenous neural stem/progenitor cells stabilize the cortical microenvironment following traumatic brain injury. Journal of Neurotrauma.

Janelidze, S., Nordström, U., Kügler, S., & Brundin, P. (2014). Pre‐existing immunity to AAV2 limits transgene expression following intracerebral AAV2‐based gene delivery in a 6‐OHDA model of Parkinson’s disease. The Journal of Gene Medicine.

Le Belle, Janel E., Sperry, J., Ngo, A., Ghochani, Y., Laks, D. R., López-Aranda, M., . . . Kornblum, Harley I. (2014). Maternal Inflammation Contributes to Brain Overgrowth and Autism-Associated Behaviors through Altered Redox Signaling in Stem and Progenitor Cells. Stem Cell Reports(0).

Polinski, N. K., Gombash, S. E., Manfredsson, F. P., Lipton, J. W., Kemp, C. J., Cole-Strauss, A., . . . Sortwell, C. E. (2014). Recombinant adeno-associated virus 2/5-mediated gene transfer is reduced in the aged rat midbrain. Neurobiology of Aging. doi: 10.1016/j.neurobiolaging.2014.07.047

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Anorexia Accelerates the Development of the Rat Hippocampus


This image stack was used in the study to analyze spine density. Image courtesy of Tara Chowdhury, Ph.D. first author of the study.

To find out how anorexia nervosa changes the brain, scientists at New York University are studying a rat model of the disease called activity-based anorexia (ABA). Previously, they discovered that ABA rats develop unusually robust dendritic branching of neurons in part of the hippocampus. Their new study takes those findings a step further, illuminating more differences between the brains of healthy versus ABA rats, and offering evidence that ABA rats may be developing too early, closing a critical period of development too soon.

But before making any conclusions about ABA brains, the researchers made some interesting discoveries about normal brain development. Using Neurolucida to analyze CA1 pyramidal cells in the stratum radiatum layer of the ventral hippocampus, they found that after puberty, around postnatal day 51, dendrites go through a growth spurt, more than doubling the number of branches seen seven days earlier. This growth spurt is followed by a decrease, or a pruning, which the researchers say is part of the normal maturation process.

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Researchers cited MBF systems in 15 papers during the week of 10/05/14

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Boada, M. D., Gutierrez, S., Aschenbrenner, C. A., Houle, T. T., Hayashida, K.-i., Ririe, D. G., & Eisenach, J. C. (2014). Nerve injury induces a new profile of tactile and mechanical nociceptor input from undamaged peripheral afferents. Journal of Neurophysiology.

Hammels, C., Prickaerts, J., Kenis, G., Vanmierlo, T., Fischer, M., Steinbusch, H. W. M., . . . Rutten, B. P. F. (2014). Differential susceptibility to chronic social defeat stress relates to the number of Dnmt3a-immunoreactive neurons in the hippocampal dentate gyrus. Psychoneuroendocrinology(0).

Nordström, U., Beauvais, G., Ghosh, A., Pulikkaparambil Sasidharan, B. C., Lundblad, M., Fuchs, J., . . . Brundin, P. (2014). Progressive nigrostriatal terminal dysfunction and degeneration in the engrailed1 heterozygous mouse model of Parkinson’s disease. Neurobiology of Disease(0).

Saal, K.-A., Koch, J. C., Tatenhorst, L., Szegő, É. M., Ribas, V. T., Michel, U., . . . Lingor, P. (2014). AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson’s disease in vitro and in vivo. Neurobiology of Disease(0).

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Researchers cited MBF systems in 12 papers during the week of 9/28/14

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Acosta, S. A., Tajiri, N., de la Pena, I., Bastawrous, M., Sanberg, P. R., Kaneko, Y., & Borlongan, C. V. (2014). Alpha-synuclein as a Pathological Link between Chronic Traumatic Brain Injury and Parkinson’s disease. Journal of Cellular Physiology, n/a-n/a. doi: 10.1002/jcp.24830.

Chiu, C.-C., Yeh, T.-H., Lai, S.-C., Wu-Chou, Y.-H., Chen, C.-H., Mochly-Rosen, D., . . . Lu, C.-S. (2014). Neuroprotective effects of aldehyde dehydrogenase 2 activation in rotenone-induced cellular and animal models of parkinsonism. Experimental Neurology(0).

Cyr, M., Parent, M. J., Mechawar, N., Rosa-Neto, P., Soucy, J.-P., Clark, S. D., . . . Bedard, M.-A. (2014). Deficit in sustained attention following selective cholinergic lesion of the pedunculopontine tegmental nucleus in rat, as measured with both post-mortem immunocytochemistry and in vivo PET imaging with [18F]fluoroethoxybenzovesamicol. Behavioural Brain Research(0).

Das, M. M., & Svendsen, C. N. (2014). Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiology of Aging(0).

Kim, A., & Mandyam, C. D. (2014). Methamphetamine affects cell proliferation in the medial prefrontal cortex: A new niche for toxicity. Pharmacology Biochemistry and Behavior(0).

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