Researchers cited MBF systems in 12 papers during the week of 2/24/14

Posted on February 28, 2014 by MBF Bioscience

Stereo Investigator:

Carlon, M. S., Vidović, D., Dooley, J., Mori da Cunha, M., Maris, M., Lampi, Y., . . . Deprest, J. (2014). Immunological ignorance allows long-term gene expression following perinatal rAAV-mediated gene transfer to murine airways. Human Gene Therapy(ja).

Choi, M. L., Begeti, F., Oh, J. H., Lee, S. Y., O’Keeffe, G. C., Clelland, C. D., . . . Barker, R. A. (2014). Dopaminergic manipulations and its effects on neurogenesis and motor function in a transgenic mouse model of Huntington’s disease. Neurobiology of Disease(0).

Depboylu, C. (2014). Non-serine-phosphorylated tyrosine hydroxylase expressing neurons are present in mouse striatum, accumbens and cortex that increase in number following dopaminergic denervation. Journal of Chemical Neuroanatomy.

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Researchers Restore Neuron Branching in Model of Mutant NHE6 Gene

Posted on February 25, 2014 by mbfbioscience

Mice with the NHE6 gene mutation show less dendritic branching. Using Neurolucida, researchers traced a GFP-labeled neuron reconstructed with confocal z stacks in a wild type mouse (left) and a mouse with a mutant NHE6 gene (right). Image courtesy of first author Qing Ouyang, PhD, Alpert Medical School, Brown University.

Children with the neurogenetic disorder Christianson Syndrome experience delays in language and learning; they may also have seizures, and display symptoms of autism. Scientists say these disorders are a result of stunted brain cell growth, which occurs because of a mutation in the gene that produces the protein NHE6—a protein also mutant in several forms of autism.

Neurons in human brains with the mutant gene don’t branch as robustly or form connections as well as neurons in normal brains. But researchers at Brown University may have found a way to restore the ability of these cells to grow properly.

In their study, published in the journal Neuron, senior author Dr. Eric Morrow and his team describe a signaling pathway for neuronal growth involving NHE6. Using a mouse model with an NHE6 gene mutation, they found that reduced levels of NHE6 combined with increased acidity in a cell’s endosome, results in a depletion of the receptor protein TrkB, a key player in the growth and branching of axons and dendrites.

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Researchers cited MBF systems in 20 papers during the week of 2/17/14

Posted on February 21, 2014 by MBF Bioscience

Stereo Investigator:

Byrns, C. N., Pitts, M. W., Gilman, C. A., Hashimoto, A. C., & Berry, M. J. (2014). Mice Lacking Selenoprotein P and Selenocysteine Lyase Exhibit Severe Neurological Dysfunction, Neurodegeneration, and Audiogenic Seizures. Journal of Biological Chemistry. doi: 10.1074/jbc.M113.540682.

Cahill, S. P., Hatchard, T., Abizaid, A., & Holahan, M. R. (2014). An examination of early neural and cognitive alterations in hippocampal-spatial function of ghrelin receptor-deficient rats. Behavioural Brain Research(0).

Corvino, V., Marchese, E., Podda, M. V., Lattanzi, W., Giannetti, S., Di Maria, V., . . . Geloso, M. C. (2014). The Neurogenic Effects of Exogenous Neuropeptide Y: Early Molecular Events and Long-Lasting Effects in the Hippocampus of Trimethyltin-Treated Rats. Plos one, 9(2), e88294. doi: 10.1371/journal.pone.0088294.

Erion, J. R., Wosiski-Kuhn, M., Dey, A., Hao, S., Davis, C. L., Pollock, N. K., & Stranahan, A. M. (2014). Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity. The Journal of Neuroscience, 34(7), 2618-2631.

Hamilton, G. F., Jablonski, S. A., Schiffino, F. L., St. Cyr, S. A., Stanton, M. E., & Klintsova, A. Y. (2014). Exercise and environment as an intervention for neonatal alcohol effects on hippocampal adult neurogenesis and learning. Neuroscience(0).

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Researchers cited MBF systems in 12 papers during the week of 2/10/14

Posted on February 14, 2014 by MBF Bioscience

Stereo Investigator:

Chen, F., Becker, A. J., & LoTurco, J. J. (2014). Contribution of Tumor Heterogeneity in a New Animal Model of CNS Tumors. Molecular Cancer Research. doi: 10.1158/1541-7786.mcr-13-0531.

Dey, A., Hao, S., Erion, J. R., Wosiski-Kuhn, M., & Stranahan, A. M. (2014). Glucocorticoid sensitization of microglia in a genetic mouse model of obesity and diabetes. Journal of Neuroimmunology(0).

Hoffman, A. N., Lorson, N. G., Sanabria, F., Foster Olive, M., & Conrad, C. D. (2014). Chronic stress disrupts fear extinction and enhances amygdala and hippocampal Fos expression in an animal model of post-traumatic stress disorder. Neurobiology of Learning and Memory(0).

Holtman, L., van Vliet, E. A., Appeldoorn, C., Gaillard, P. J., de Boer, M., Dorland, R., . . . Gorter, J. A. (2014). Glutathione pegylated liposomal methylprednisolone administration after the early phase of status epilepticus did not modify epileptogenesis in the rat. Epilepsy Research(0).

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Exercise Heals the Brain After Binge Drinking

Posted on February 10, 2014 by mbfbioscience

The granule cell layer of the dentate gyrus captured using a 100x objective. Image provided by Mark Maynard.

The granule cell layer of the dentate gyrus. Image provided by Mark Maynard.

Binge drinking damages brain regions responsible for memory, decision-making, and behavioral control. After a binge, the brain begins to heal itself but not much is known about this self-repair process. In a study published in PLoS ONE, researchers used rats to find that binge drinking damages the hippocampus, and exercise reverses this damage.

The study found that excessive ethanol killed granule neurons in the dentate gyrus (DG), a part of the hippocampus, and significantly decreased the volume of the DG. Rats that exercised after binging had more DG granule neurons and a larger DG than rats that did not exercise after a binge. In fact, rats that exercised after binging had a similar number of DG neurons and a similar DG volume to that of controls, indicating that exercise almost fully reversed damaged to the DG caused by binge drinking.

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Researchers cited MBF systems in 17 papers during the week of 2/3/14

Posted on February 7, 2014 by MBF Bioscience

Stereo Investigator:

Allen, J. L., Liu, X., Weston, D., Conrad, K., Oberdörster, G., & Cory-Slechta, D. A. (2014). Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson’s disease phenotype in male mice. Neurotoxicology(0).

Botterill, J. J., Fournier, N. M., Guskjolen, A. J., Lussier, A. L., Marks, W. N., & Kalynchuk, L. E. (2014). Amygdala kindling disrupts trace and delay fear conditioning with parallel changes in Fos protein expression throughout the limbic brain. Neuroscience(0).

Gulbrandsen, T. L., & Sutherland, R. J. (2014). Temporary inactivation of the rodent hippocampus: An evaluation of the current methodology. Journal of Neuroscience Methods(0).

Hamodeh, S., Baizer, J., Sugihara, I., & Sultan, F. (2014). Systematic analysis of neuronal wiring of the rodent deep cerebellar nuclei reveals differences reflecting adaptations at the neuronal circuit and internuclear level. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23545.

Kanno, H., Pressman, Y., Moody, A., Berg, R., Muir, E. M., Rogers, J. H., . . . Bunge, M. B. (2014). Combination of Engineered Schwann Cell Grafts to Secrete Neurotrophin and Chondroitinase Promotes Axonal Regeneration and Locomotion after Spinal Cord Injury. The Journal of Neuroscience, 34(5), 1838-1855.

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Researchers cited MBF systems in 10 papers during the week of 1/27/14

Posted on January 31, 2014 by MBF Bioscience

Stereo Investigator:

Conway, A., & Schaffer, D. V. (2014). Biomaterial microenvironments to support the generation of new neurons in the adult brain. Stem Cells, n/a-n/a. doi: 10.1002/stem.1650.

Dias, G. P., Bevilaqua, M. C. d. N., da Luz, A. C. D. S., Fleming, R. L., de Carvalho, L. A., Cocks, G., . . . Gardino, P. F. (2014). Hippocampal biomarkers of fear memory in an animal model of generalized anxiety disorder. Behavioural Brain Research(0).

Grégoire, C.-A., Bonenfant, D., Le Nguyen, A., Aumont, A., & Fernandes, K. J. L. (2014). Untangling the Influences of Voluntary Running, Environmental Complexity, Social Housing and Stress on Adult Hippocampal Neurogenesis. Plos one, 9(1), e86237. doi: 10.1371/journal.pone.0086237.

Neurolucida:

Bartkowska, K., Aniszewska, A., Turlejski, K., & Djavadian, R. L. (2014). Distribution and function of TrkB receptors in the developing brain of the opossum Monodelphis domestica. Developmental Neurobiology, n/a-n/a. doi: 10.1002/dneu.22165.

Loavenbruck, A., Wendelschaefer-Crabbe, G., Sandroni, P., & Kennedy, W. R. (2014). Quantification of Sweat Gland Volume and Innervation in Neuropathy; Correlation with Thermoregulatory Sweat Testing. Muscle and Nerve, n/a-n/a. doi: 10.1002/mus.24185.

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Neurons in the Basal Forebrain are Exquisitely Organized

Posted on January 29, 2014 by mbfbioscience

A micrograph of the nucleus basalis of Meynert, a group of neurons in the basal forebrain that produces most of the acetylcholine supplied to the cerebral cortex.
Image from Wikimedia Commons

The loss of cholinergic neurons is one of the earliest pathological events of Alzheimer’s disease. Cholinergic neurons in the basal forebrain supply the cerebral cortex with acetylcholine, an important neurotransmitter that plays a role in learning, memory, and attention. Details about the function and organization of basal forebrain (BF) neurons are not well understood, but Dr. Laszlo Zaborszky has recently uncovered new information about the structure of this complex area of the brain.

In a paper published in Cerebral Cortex, Dr. Zaborszky and his team report that they discovered exquisite organization in the basal forebrain of rats; the extent of overlap between basal forebrain neuronal populations correlates with the connectivity strength between their cortical targets. This means that basal forebrain neurons that overlap extensively project to frontal and posterior cortical areas that are strongly connected. Connectivity strength between cortical areas is defined by the number of neurons in a defined posterior cortical area that project to a defined area in the frontal cortex. Continue reading “Neurons in the Basal Forebrain are Exquisitely Organized” »

Researchers cited MBF systems in 21 papers during the week of 1/20/14

Posted on January 24, 2014 by MBF Bioscience

Stereo Investigator:

Chabrier, M. A., Cheng, D., Castello, N. A., Green, K. N., & LaFerla, F. M. (2014). Synergistic effects of amyloid-beta and wild-type human tau on dendritic spine loss in a floxed double transgenic model of Alzheimer’s disease. Neurobiology of Disease(0).

Knowlton, N. S., Craig, L. B., Zavy, M. T., & Hansen, K. R. (2014). Validation of the power model of ovarian nongrowing follicle depletion associated with aging in women. Fertility and Sterility(0).

Kong, H., Zeng, X.-N., Fan, Y., Yuan, S.-T., Ge, S., Xie, W.-P., . . . Hu, G. (2014). Aquaporin-4 Knockout Exacerbates Corticosterone-Induced Depression by Inhibiting Astrocyte Function and Hippocampal Neurogenesis. CNS Neuroscience & Therapeutics, n/a-n/a. doi: 10.1111/cns.12222.

Liu, D., Sharp, F. R., Van, K. C., Ander, B. P., Ghiasvand, R., Zhan, X., . . . Lyeth, B. G. (2014). Inhibition of Src Family Kinases Protects Hippocampal Neurons and Improves Cognitive Function after Traumatic Brain Injury. Journal of Neurotrauma(ja).

Sharp, K. G., Yee, K. M., & Steward, O. (2014). A re-assessment of treatment with a tyrosine kinase inhibitor (imatinib) on tissue sparing and functional recovery after spinal cord injury. Experimental Neurology(0).

Smith, A. L., Alexander, M., Rosenkrantz, T. S., Sadek, M. L., & Fitch, R. H. (2014). Sex differences in behavioral outcome following neonatal hypoxia ischemia: Insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic brain injury. Experimental Neurology(0).

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Researchers cited MBF systems in 20 papers during the week of 1/13/14

Posted on January 17, 2014 by MBF Bioscience

Stereo Investigator:

Clarke, J., Langdon, K. D., & Corbett, D. (2014). Early poststroke experience differentially alters periinfarct layer II and III cortex. Journal of Cerebral Blood Flow and Metabolism.

Greene-Schloesser, D., Payne, V., Peiffer, A. M., Hsu, F.-C., Riddle, D. R., Zhao, W., . . . Robbins, M. E. (2014). The Peroxisomal Proliferator-Activated Receptor (PPAR) α Agonist, Fenofibrate, Prevents Fractionated Whole-Brain Irradiation-Induced Cognitive Impairment. Radiation Research. doi: 10.1667/rr13202.1.

Iwasaki, M., Wilcox, J. T., Nishimura, Y., Zweckberger, K., Suzuki, H., Wang, J., . . . Fehlings, M. G. (2014). Synergistic effects of self-assembling peptide and neural stem/progenitor cells to promote tissue repair and forelimb functional recovery in cervical spinal cord injury. Biomaterials(0).

Kabadi, S. V., Stoica, B. A., Loane, D. J., Luo, T., & Faden, A. I. (2014). CR8, a novel inhibitor of CDK, limits microglial activation, astrocytosis, neuronal loss, and neurologic dysfunction after experimental traumatic brain injury. Journal of Cerebral Blood Flow and Metabolism.

Kara, A., Unal, D., Simsek, N., Yucel, A., Yucel, N., & Selli, J. (2014). Ultra-structural changes and apoptotic activity in cerebellum of post-menopausal-diabetic rats: a histochemical and ultra-structural study. Gynecological Endocrinology, 0(0), 1-6. doi: doi:10.3109/09513590.2013.864270.

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MBF Mindset

Quantitative image analysis, C. elegans tracking, and whole slide imaging for biological research

Researchers cited MBF systems in 12 papers during the week of 2/24/14

Researchers Restore Neuron Branching in Model of Mutant NHE6 Gene

Researchers cited MBF systems in 20 papers during the week of 2/17/14

Researchers cited MBF systems in 12 papers during the week of 2/10/14

Exercise Heals the Brain After Binge Drinking

Researchers cited MBF systems in 17 papers during the week of 2/3/14

Researchers cited MBF systems in 10 papers during the week of 1/27/14

Neurons in the Basal Forebrain are Exquisitely Organized

Researchers cited MBF systems in 21 papers during the week of 1/20/14

Researchers cited MBF systems in 20 papers during the week of 1/13/14