Researchers cited MBF systems in 16 papers during the week of 9/28/2015

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Giovanoli, S., Weber-Stadlbauer, U., Schedlowski, M., Meyer, U., & Engler, H. (2015). Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies. Brain, Behavior, and Immunity. doi:

Gokozan, H. N., Baig, F., Corcoran, S., Catacutan, F. P., Gygli, P. E., Takakura, A. C., . . . Otero, J. J. (2015). Area postrema undergoes dynamic postnatal changes in mice and humans. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23903.

Huebner, S. M., Tran, T. D., Rufer, E. S., Crump, P. M., & Smith, S. M. (2015). Maternal Iron Deficiency Worsens the Associative Learning Deficits and Hippocampal and Cerebellar Losses in a Rat Model of Fetal Alcohol Spectrum Disorders. Alcoholism: Clinical and Experimental Research, n/a-n/a. doi: 10.1111/acer.12876.

Maiti, P., Gregg, L. C., & McDonald, M. P. (2015). MPTP-induced executive dysfunction is associated with altered prefrontal serotonergic function. Behavioural Brain Research. doi:

Odacı, E., Hancı, H., İkinci, A., Sönmez, O. F., Aslan, A., Şahin, A., . . . Baş, O. (2015). Maternal exposure to a continuous 900-MHz electromagnetic field provokes neuronal loss and pathological changes in cerebellum of 32-day-old female rat offspring. Journal of Chemical Neuroanatomy. doi:

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Researchers cited MBF systems in 14 papers between 9/11/2015 and 9/25/2015

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Beraldi, R., Chan, C.-H., Rogers, C. S., Kovács, A. D., Meyerholz, D. K., Trantzas, C., . . . Pearce, D. A. (2015). A novel porcine model of Ataxia Telangiectasia reproduces neurological features and motor deficits of human disease. Human Molecular Genetics. doi: 10.1093/hmg/ddv356.

Bernardes, D., Brambilla, R., Bracchi-Ricard, V., Karmally, S., Dellarole, A., Carvalho-Tavares, J., & Bethea, J. R. (2015). Prior regular exercise improves clinical outcome and reduces demyelination and axonal injury in experimental autoimmune encephalomyelitis. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13354.

Montalvo-Javé, E. E., Mendoza-Barrera, G. E., García-Pineda, M. A., Jaime Limón, Á. R., Montalvo-Arenas, C., Castell Rodríguez, A. E., & Tapia Jurado, J. (2015). Histological Analysis of Intra-Abdominal Adhesions Treated with Sodium Hyaluronate and Carboxymethylcellulose Gel. Journal of Investigative Surgery, 1-8. doi: 10.3109/08941939.2015.1076911.

Ruiz, M., Perez-Garcia, G., Ortiz-Virumbrales, M., Méneret, A., Morant, A., Kottwitz, J., . . . Ehrlich, M. E. (2015). Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia. Human Molecular Genetics. doi: 10.1093/hmg/ddv384.

Weisheit, C. E., & Dauer, W. T. (2015). A novel conditional knock-in approach defines molecular and circuit effects of the DYT1 dystonia mutation. Human Molecular Genetics. doi: 10.1093/hmg/ddv355.


Ahn, S., Kim, T.-G., Kim, K.-S., & Chung, S. (2015). Differentiation of human pluripotent stem cells into medial ganglionic eminence vs. caudal ganglionic eminence cells. Methods.

Hsieh, J. T., Lei, B., Sheng, H., Venkatraman, T., Lascola, C. D., Warner, D. S., & James, M. L. (2015). Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage. Neuroendocrinology.

Jiang, Y., Pun, R. Y. K., Peariso, K., Holland, K. D., Lian, Q., & Danzer, S. C. (2015). Olfactory Bulbectomy Leads to the Development of Epilepsy in Mice. Plos one, 10(9), e0138178. doi: 10.1371/journal.pone.0138178.

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Researchers cited MBF systems in 25 papers between 8/28/2015 and 9/11/2015

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Ahmadian, S. S., Rezvanian, A., Peterson, M., Weintraub, S., Bigio, E. H., Mesulam, M. M., & Geula, C. (2015). Loss of Calbindin-D28K is Associated with the Full Range of Tangle Pathology within Basal Forebrain Cholinergic Neurons in Alzheimer’s Disease. Neurobiology of Aging.

Amaral, C., Antonio, B., Oliveira, M. G. M., Hamani, C., Guinsburg, R., & Covolan, L. (2015). Early postnatal nociceptive stimulation results in deficits of spatial memory in male rats. Neurobiology of Learning and Memory.

Ding, H., Underwood, R., Lavalley, N., & Yacoubian, T. A. (2015). 14-3-3 inhibition promotes dopaminergic neuron loss and 14-3-3θ overexpression promotes recovery in the MPTP mouse model of Parkinson’s disease. Neuroscience.

Henstridge, C., Jackson, R., Kim, J., Herrmann, A., Wright, A., Harris, S., . . . Spires-Jones, T. (2015). Post-mortem brain analyses of the Lothian Birth Cohort 1936: extending lifetime cognitive and brain phenotyping to the level of the synapse. Acta Neuropathologica Communications, 3(1), 1-22. doi: 10.1186/s40478-015-0232-0.

Jacobs, R. A., Lundby, A.-K. M., Fenk, S., Gehrig, S., Siebenmann, C., Flück, D., . . . Lundby, C. (2015). Twenty-eight days of exposure to 3,454 m increases mitochondrial volume density in human skeletal muscle. The Journal of physiology, n/a-n/a. doi: 10.1113/jp271118.

Ranasinghe, S., Or, G., Wang, E. Y., Ievins, A., McLean, M. A., Niell, C. M., . . . Sullivan, J. (2015). Reduced Cortical Activity Impairs Development and Plasticity after Neonatal Hypoxia Ischemia. The Journal of Neuroscience, 35(34), 11946-11959.

Sensor, J. D., Suydam, R., George, J. C., Liberman, M. C., Lovano, D., Rhaganti, M. A., . . . Thewissen, J. G. M. (2015). The spiral ganglion and Rosenthal’s canal in beluga whales. Journal of Morphology, n/a-n/a. doi: 10.1002/jmor.20434.

Timbie, C., & Barbas, H. (2015). Pathways for Emotions: Specializations in the Amygdalar, Mediodorsal Thalamic, and Posterior Orbitofrontal Network. The Journal of Neuroscience, 35(34), 11976-11987.

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Stereology Workshop at Obafemi Awolowo University in Nigeria

CaptureStereology Symposium in Nigeria

Dr. Jose Maldonado, Head of MBF Bioscience Latin America and Africa, and Dr. Abraham A.A. Osinubi, Associate Professor, University of Lagos will be hosting a stereology workshop at Obafemi Awolowo University in Nigeria on Sept 16 – 18. The workshop will cover the basics of stereology and how to practically apply it to scientific research.

This is a unique opportunity for attendees to learn from two expert stereologists. Anyone interested in stereology is welcome to attend, including undergraduate and post-graduate students and faculty/researchers from biological and material science, geologists, pathologists, and statisticians.

To register for this workshop, send an email to stating your full name, institution, email address, phone number and status (Student/Faculty).

More information can be found here in the workshop brochure.

Researchers cited MBF systems in 14 papers during the week of 8/24/2015

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Choi, J., Desai, R., Zheng, Y., Yao, M., Dong, Q., Watson, G., . . . Simanainen, U. (2015). Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer. Endocrine-Related Cancer, 22(5), 687-701. doi: 10.1530/erc-15-0203.

Coimbra, J. P., Kaswera-Kyamakya, C., Gilissen, E., Manger, P., & Collin, S. (2015). The Retina of Ansorge’s Cusimanse (Crossarchus ansorgei): Number, Topography and Convergence of Photoreceptors and Ganglion Cells in Relation to Ecology and Behavior. Brain, Behavior and Evolution.

Cotel, M.-C., Lenartowicz, E. M., Natesan, S., Modo, M. M., Cooper, J. D., Williams, S. C. R., . . . Vernon, A. C. (2015). Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses. European Neuropsychopharmacology. doi:

Fan, Y., Kong, H., Ye, X., Ding, J., & Hu, G. (2015). ATP-sensitive potassium channels: uncovering novel targets for treating depression. Brain Structure and Function, 1-12. doi: 10.1007/s00429-015-1090-z.

Gomez, D. L., O’Driscoll, M., Sheets, T. P., Hruban, R. H., Oberholzer, J., McGarrigle, J. J., & Shamblott, M. J. (2015). Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. Plos one, 10(8), e0133862. doi: 10.1371/journal.pone.0133862.

Le, W., Zhang, L., Xie, W., Li, S., & Dani, J. A. (2015). Pitx3 Deficiency Produces Decreased Dopamine Signaling and Induces Motor Deficits in Pitx3(-/-) Mice. Neurobiology of Aging. doi:

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Researchers cited MBF systems in 12 papers during the week of 8/17/2015

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Ba, Q., Cui, C., Wen, L., Feng, S., Zhou, J., & Yang, K. (2015). Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson’s disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway. Biomedicine and Pharmacotherapy. doi:

Cardinale, A., Paldino, E., Giampà, C., Bernardi, G., & Fusco, F. R. (2015). PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s Disease. Plos one, 10(8), e0134482. doi: 10.1371/journal.pone.0134482.

Issa, J. P., Gonzaga, M., Kotake, B. G., de Lucia, C., Ervolino, E., & Iyomasa, M. (2015). Bone repair of critical size defects treated with autogenic, allogenic, or xenogenic bone grafts alone or in combination with rhBMP-2. Clinical Oral Implants Research, n/a-n/a. doi: 10.1111/clr.12622.

Nikolajsen, G. N., Kotynski, K. A., Jensen, M. S., & West, M. J. (2015). Quantitative analysis of the capillary network of aged APPswe/PS1dE9 transgenic mice. Neurobiology of Aging. doi:

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Munich Researchers Use WormLab to Study Blast Effects on C. Elegans


Explosions can tear apart buildings, send shrapnel flying, and hurtle humans into the air. But explosions also cause damage in ways that aren’t as visually apparent. Scientists say the force of a blast can cause brain damage, but questions linger about how the symptoms that emerge after a blast-induced traumatic brain injury are connected to the initial trauma.

In their quest to learn more about how symptoms emerge after a traumatic blast, researchers at the Ludwig-Maximilians University of Munich, in Munich, Germany have developed an animal model of blast-related mild traumatic brain injury (br-mTBI) using C. elegans worms – a popular model organism alternative to vertebrate animals.

In their study, published in Frontiers in Behavioral Neuroscience, the research team used WormLab to analyze thousands of worms. They found that shockwaves either slowed the worms’ movements or rendered them paralyzed. Symptoms played out in a dose-dependent manner, meaning that worms exposed to a higher number of shockwaves displayed a higher severity of symptoms.

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First System for Imaging and Analyzing Large Mammalian Brain Tissue Installed in South Africa

Dr. Paul Manger's new system developed by MBF Bioscience for analyzing large mammalian brain specimens

Dr. Paul Manger’s new system developed by MBF Bioscience for analyzing large mammalian brain specimens

Dr. Paul Manger, Research Professor at the University of the Witwatersrand, South Africa, studies the brain anatomy of various animals to better understand the relationship between brain structure and function. Some of the mammals he studies have very large brains that don’t fit under a conventional research microscope. A team of scientists and microscopy experts at MBF Bioscience developed a new microscope system that enables Dr. Manger to analyze and image whole sections of large brain tissue. This system is the first for imaging and analyzing entire tissue sections of large mammalian brains. It will give Dr. Manger unprecedented analyses of African mammal brains and a way to share large images of tissue specimens with collaborators or a global audience. Continue reading “First System for Imaging and Analyzing Large Mammalian Brain Tissue Installed in South Africa” »

Researchers cited MBF systems in 28 papers between 7/31/2015 and 8/7/2015

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Almeida-Suhett, C. P., Prager, E. M., Pidoplichko, V., Figueiredo, T. H., Marini, A. M., Li, Z., . . . Braga, M. F. M. (2015). GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury. Experimental Neurology, 273, 11-23. doi:

Calvez, J., Lenglos, C., de Ávila, C., Guèvremont, G., & Timofeeva, E. (2015). Differential effects of central administration of relaxin-3 on food intake and hypothalamic neuropeptides in male and female rats. Genes, Brain and Behavior, n/a-n/a. doi: 10.1111/gbb.12236.

Cisbani, G., Drouin-Ouellet, J., Gibrat, C., Saint-Pierre, M., Lagacé, M., Badrinarayanan, S., . . . Cicchetti, F. (2015). Cystamine/cysteamine rescue the dopaminergic system and show neurorestorative properties in an animal model of Parkinson’s disease. Neurobiology of Disease. doi:

Cohn, B. A., Collin, S. P., Wainwright, P. C., & Schmitz, L. (2015). Retinal topography maps in R: New tools for the analysis and visualization of spatial retinal data. Journal of Vision, 15(9), 19-19. doi: 10.1167/15.9.19.

Corenblum, M. J., Flores, A. J., Badowski, M., Harris, D. T., & Madhavan, L. (2015). Systemic human CD34+ cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration. Regenerative Medicine, 10(5), 563-577. doi: 10.2217/rme.15.32.

Dell, L.-A., Spocter, M. A., Patzke, N., Karlson, K. Æ., Alagaili, A. N., Bennett, N. C., . . . Manger, P. R. (2015). Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls. Journal of Chemical Neuroanatomy, 68, 61-76. doi:

Faunes, M., Oñate-Ponce, A., Fernández-Collemann, S., & Henny, P. (2015). Excitatory and inhibitory innervation of the mouse orofacial motor nuclei: A stereological study. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23862.

Liu, Y., Sun, J.-D., Song, L.-K., Li, J., Chu, S.-F., Yuan, Y.-H., & Chen, N.-H. (2015). Environment-contact Administration of Rotenone: A New Rodent Model of Parkinson’s Disease. Behavioural Brain Research. doi:

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Researchers cited MBF systems in 16 papers during the week of 7/20/2015

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Cui, X., Pertile, R., Liu, P., & Eyles, D. W. (2015). Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience. doi:

Deusser, J., Schmidt, S., Ettle, B., Plötz, S., Huber, S., Müller, C. P., . . . Kohl, Z. (2015). Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson’s disease. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13253.

Furlanetti, L. L., Coenen, V. A., Aranda, I. A., & Döbrössy, M. D. (2015). Chronic deep brain stimulation of the medial forebrain bundle reverses depressive-like behavior in a hemiparkinsonian rodent model. Experimental Brain Research, 1-13.

Hong, J., Sha, S., Zhou, L., Wang, C., Yin, J., & Chen, L. (2015). Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons.  Cell Death Dis, 6, e1832. doi: 10.1038/cddis.2015.194.

Kaindlstorfer, C., Sommer, P., Georgievska, B., Mather, R. J., Kugler, A. R., Poewe, W., . . . Stefanova, N. (2015). Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications. Neurotoxicity research, 1-10.

Kumar, N. N., Velic, A., Soliz, J., Shi, Y., Li, K., Wang, S., . . . Lazarenko, R. M. (2015). Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. Science, 348(6240), 1255-1260.

Tang, F.-L., Erion, J. R., Tian, Y., Liu, W., Yin, D.-M., Ye, J., . . . Xiong, W.-C. (2015). VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson’s Disease. The Journal of Neuroscience, 35(29), 10613-10628.

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