Researchers cited MBF systems in 14 papers during the week of 7/13/2015

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Arshad, A., Yang, B., Bienemann, A. S., Barua, N. U., Wyatt, M. J., Woolley, M., . . . Gill, S. S. (2015). Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma. Plos one, 10(7), e0132266. doi: 10.1371/journal.pone.0132266.

Barhwal, K., Das, S. K., Kumar, A., Hota, S. K., Srivastava, R. B., & Kumar, B. (2015). Insulin Receptor A and Sirtuin 1 synergistically improve learning and spatial memory following chronic salidroside treatment during hypoxia. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13225.

Dhillon, S. K., Gunn, A., Jung, Y., Mathai, S., Bennet, L., & Fraser, M. (2015). Lipopolysaccharide-Induced Preconditioning Attenuates Apoptosis and Differentially Regulates TLR4 and TLR7 Gene Expression after Ischemia in the Preterm Ovine Fetal Brain. Developmental Neuroscience.

Garza-Gisholt, E., Kempster, R., Hart, N., & Collin, S. (2015). Visual Specializations in Five Sympatric Species of Stingrays from the Family Dasyatidae. Brain, Behavior and Evolution.

Glasper, E. R., LaMarca, E. A., Bocarsly, M. E., Fasolino, M., Opendak, M., & Gould, E. (2015). Sexual experience enhances cognitive flexibility and dendritic spine density in the medial prefrontal cortex. Neurobiology of Learning and Memory. doi:

Keeley, R. J., Trow, J., & McDonald, R. J. (2015). Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes. Neuroscience. doi:

Pickrell, Alicia M., Huang, C.-H., Kennedy, Scott R., Ordureau, A., Sideris, Dionisia P., Hoekstra, Jake G., . . . Youle, Richard J. (2015). Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron, 87(2), 371-381. doi:

Suo, H., Wang, P., Tong, J., Cai, L., Liu, J., Huang, D., . . . Huang, F. (2015). NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson’s disease. Neuropharmacology. doi:

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Researchers cited MBF systems in 10 papers during the week of 7/6/2015

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Brace, L. R., Kraev, I., Rostron, C. L., Stewart, M. G., Overton, P. G., & Dommett, E. J. (2015). Altered visual processing in a rodent model of Attention-Deficit Hyperactivity Disorder. Neuroscience. doi:

Kim, J. M., Kim, S.-S., & Lee, Y.-D. (2015). Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice. Neuroreport, Publish Ahead of Print. doi: 10.1097/wnr.0000000000000423.

Wang, H., Liu, N.-K., Zhang, Y. P., Deng, L., Lu, Q.-B., Shields, C. B., . . . Xu, X.-M. (2015). Treadmill training induced lumbar motoneuron dendritic plasticity and behavior recovery in adult rats after a thoracic contusive spinal cord injury. Experimental Neurology, 271, 368-378. doi:

Williamson, L. L., McKenney, E. A., Holzknecht, Z. E., Belliveau, C., Rawls, J. F., Poulton, S., . . . Bilbo, S. D. (2015). Got Worms? Perinatal Exposure to Helminths Prevents Persistent Immune Sensitization and Cognitive Dysfunction Induced by Early-Life Infection. Brain, Behavior, and Immunity. doi:

Zhang, Z., Du, X., Xu, H., Xie, J., & Jiang, H. (2015). Lesion of medulla’s catecholaminergic neurons is associated with cardiovascular dysfunction in rotenone-induced Parkinson’s disease rats. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.13012.


Fujiwara, T., Inoue, T., Maruo, T., Rikitake, Y., Ieki, N., Mandai, K., . . . Mizoguchi, A. (2015). Nectin-1 Spots Regulate the Branching of Olfactory Mitral Cell Dendrites. Molecular and Cellular Neuroscience. doi:

Huang, T., Ma, L., & Krimm, R. F. (2015). Postnatal reduction of BDNF regulates the developmental remodeling of taste bud innervation. Developmental Biology. doi:

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Researchers cited MBF systems in 29 papers during the week of 6/29/2015

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Allen, K. M., Fung, S. J., & Shannon Weickert, C. (2015). Cell proliferation is reduced in the hippocampus in schizophrenia. Australian and New Zealand Journal of Psychiatry. doi: 10.1177/0004867415589793

Benarroch, E. E., Schmeichel, A. M., Parisi, J. E., & Low, P. A. (2015). Histaminergic tuberomammillary neuron loss in multiple system atrophy and dementia with Lewy bodies. Movement Disorders, n/a-n/a. doi: 10.1002/mds.26287.

Cowen, S., McLaughlin, S. L., Hobbs, G., Coad, J., Martin, K. H., Olfert, I. M., & Vona-Davis, L. (2015). High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer. Cancers, 7(3), 1125-1142.

Gorris, R., Fischer, J., Erwes, K. L., Kesavan, J., Peterson, D. A., Alexander, M., . . . Brüstle, O. (2015). Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. Glia, n/a-n/a. doi: 10.1002/glia.22882.

Kiyota, T., Morrison, C. M., Tu, G., Dyavarshetty, B., Weir, R. A., Zhang, G., . . . Gendelman, H. E. (2015). Presenilin-1 familial Alzheimer’s disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice. Brain, Behavior, and Immunity(0). doi:

Lazzara, C. A., Riley, R. R., Rane, A., Andersen, J. K., & Kim, Y.-H. (2015). The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy. Brain Research, 1622(0), 127-136. doi:

Lv, E., Deng, J., Yu, Y., Wang, Y., Gong, X., Jia, J., & Wang, X. (2015). Nrf2-ARE signals mediated the anti-oxidative action of electro-acupuncture in an MPTP mouse model of Parkinson’s disease. Free Radical Research, 0(ja), 1-30. doi: doi:10.3109/10715762.2015.1067696.

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Satellite Symposium at SfN: Enhancing the Reproducibility of Your Research Results with Stereology

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Recent headlines decry the alarming amount of irreproducible data in published research papers. MBF Bioscience is hosting a symposium addressing the topic on Sunday, October 18 at 6:30pm entitled “Quantitative Microscopy: Enhancing the Reproducibility of Your Research Results with Stereology.” This symposium, which is a satellite event at the annual Society for Neuroscience meeting, will address how researchers can use stereology to obtain accurate, reproducible data about their histological tissue specimens to drive meaningful discovery by the scientific community at large.

It will be an evening full of engaging speakers with significant expertise in various aspects of stereology, including: stereology theory, the application of stereology in neuroscience research, and why some funding agencies require stereology. Attendees will have a chance to interact with the speakers during the question and answer session following the presentations.

Stereology is the gold standard method for quantifying the number of cells, length of fibers, and the area and volume of structures or regions in tissue specimens. Attend this symposium to learn how it can help you obtain accurate, reproducible data for your research study.

Researchers cited MBF systems in 10 papers during the week of 6/22/15

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Baglietto-Vargas, D., Chen, Y., Suh, D., Ager, R. R., Rodriguez-Ortiz, C. J., Medeiros, R., . . . LaFerla, F. M. (2015). Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13195.

Grodecki, J., Rao, S. S., Short, A. R., Otero, J. J., Lannutti, J. J., Sarkar, A., & Winter, J. O. (2015). Glioma-astrocyte interactions on white matter tract-mimetic aligned electrospun nanofibers. Biotechnology Progress, n/a-n/a. doi: 10.1002/btpr.2123.

Murase, S., Lantz, C., Kim, E., Gupta, N., Higgins, R., Stopfer, M., . . . Quinlan, E. (2015). Matrix Metalloproteinase-9 Regulates Neuronal Circuit Development and Excitability. Molecular Neurobiology, 1-17. doi: 10.1007/s12035-015-9295-y.

Vitek, M., Li, F., & Colton, C. (2015). Apolipoprotein E and Mimetics as Targets and Therapeutics for Alzheimer’s Disease. In G. M. Anantharamaiah & D. Goldberg (Eds.), Apolipoprotein Mimetics in the Management of Human Disease (pp. 157-182): Springer International Publishing.


Fuentealba, Luis C., Rompani, Santiago B., Parraguez, Jose I., Obernier, K., Romero, R., Cepko, Constance L., & Alvarez-Buylla, A. (2015). Embryonic Origin of Postnatal Neural Stem Cells. Cell, 161(7), 1644-1655. doi: 10.1016/j.cell.2015.05.041.

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Researchers cited MBF systems in 34 papers between 5/29/2015 and 6/19/2015

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Acabchuk, R. L., Sun, Y., Wolferz, J. R., Eastman, M. B., Lennington, J. B., Shook, B. A., . . . Conover, J. C. (2015). 3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse. JoVE(99), e52328. doi: doi:10.3791/52328.

Jin, Y., Bouyer, J., Haas, C., & Fischer, I. (2015). Evaluation of the anatomical and functional consequences of repetitive mild cervical contusion using a model of spinal concussion. Experimental Neurology, 271(0), 175-188. doi:

Kim, J. H., Yoo, B. H., Won, S. J., Choi, B. Y., Lee, B., Kim, I., . . . Suh, S. W. (2015). Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats. Neuroendocrinology.

King, B. J., Mann-Gow, T. K., Kida, M., Plante, M. K., Perrapato, S. D., & Zvara, P. (2015). Intraprostatic ethanol diffusion: comparison of two injection methods using ex vivo human prostates. Prostate Cancer Prostatic Dis. doi: 10.1038/pcan.2015.24.

Lee, T., Chana, G., Gorry, P., Ellett, A., Bousman, C., Churchill, M., . . . Everall, I. (2015). Inhibition of catechol-O-methyl transferase (COMT) by tolcapone restores reductions in microtubule-associated protein 2 (MAP2) and synaptophysin (SYP) following exposure of neuronal cells to neurotropic HIV. Journal of Neurovirology, 1-9. doi: 10.1007/s13365-015-0354-y.

Ortega, S. B., Kong, X., Venkataraman, R., Savedra, A. M., Kernie, S. G., Stowe, A. M., & Raman, L. (2015). Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin-specific T cell autoreactivity. Journal of Leukocyte Biology. doi: 10.1189/jlb.5HI0914-447R.

Radley, J. J., & Sawchenko, P. E. (2015). Evidence for involvement of a limbic paraventricular hypothalamic inhibitory network in hypothalamic-pituitary-adrenal axis adaptations to repeated stress. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23815.

Soztutar, E., Colak, E., & Ulupinar, E. (2015). Gender- and anxiety level-dependent effects of perinatal stress exposure on medial prefrontal cortex. Experimental Neurology(0). doi:

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Webinar Video: Automated 3D Neuron Reconstruction


Confocal image of a mouse cerebellum optically cleared with CLARITY. Neurons were reconstructed with Neurolucida 360.


In this webinar, Dr. Dara Dickstein, Assistant Professor at Icahn School of Medicine at Mount Sinai, and Dr. Susan Tappan, Staff Scientist and Neurolucida 360 Product Manager discuss imaging protocols and techniques for automated 3D neuron reconstruction.

Watch the webinar on YouTube

The goal is to help you develop an imaging and quantification strategy for your own research to increase the throughput of your morphologic study.

Watch this webinar to learn:

+ Different methods for tissue preparation
+ Imaging protocols optimized for automated neuron reconstruction
+ How to use Neurolucida 360 – our new automated software for achieving accurate 3D reconstructions of somas, dendrites, spines, and axons


Researchers cited MBF systems in 13 papers during the week of 5/18/15

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Botterill, J. J., Brymer, K. J., Caruncho, H. J., & Kalynchuk, L. E. (2015). Aberrant hippocampal neurogenesis after limbic kindling: Relationship to BDNF and hippocampal-dependent memory. Epilepsy & Behavior(0). doi:

Chocyk, A., Majcher-Maślanka, I., Przyborowska, A., Maćkowiak, M., & Wędzony, K. (2015). Early-life stress increases the survival of midbrain neurons during postnatal development and enhances reward-related and anxiolytic-like behaviors in a sex-dependent fashion. International Journal of Developmental Neuroscience(0). doi:

Fuzzati-Armentero, M.-T., Cerri, S., Levandis, G., Ambrosi, G., Montepeloso, E., Antoninetti, G., . . . Pinna, A. (2015). Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson’s disease. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13162.

He, Q., Koprich, J., Wang, Y., Yu, W.-b., Xiao, B.-g., Brotchie, J., & Wang, J. (2015). Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease. Molecular Neurobiology, 1-11. doi: 10.1007/s12035-015-9173-7.

Iacono, D., Geraci-Erck, M., Peng, H., Rabin, M. L., & Kurlan, R. (2015). Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses. Tremor and Other Hyperkinetic Movements.

Kotterman, M. A., Vazin, T., & Schaffer, D. V. (2015). Enhanced selective gene delivery to neural stem cells in vivo by an adeno-associated viral variant. Development, 142(10), 1885-1892. doi: 10.1242/dev.115253.

Landry, J. P., Hawkins, C., Lee, A., Coté, A., Balaban, E., & Pompeiano, M. (2015). Chick embryos have the same pattern of hypoxic lower-brain activation as fetal mammals. Developmental Neurobiology, n/a-n/a. doi: 10.1002/dneu.22299.

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Researchers cited MBF systems in 16 papers between 5/01/2015 and 5/15/2015

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Can, S., Selli, J., Buyuk, B., Aydin, S., Kocaaslan, R., & Guvendi, G. F. (2015). The Effect of Estrogen Usage on Eccentric Exercise-Induced Damage in Rat Testes. Iran Red Crescent Med J, 17(4), e22521. doi: 10.5812/ircmj.17(4)2015.22521.

Debels, H., Gerrand, Y.-w., Poon, C. J., Abberton, K. M., Morrison, W. A., & Mitchell, G. M. (2015). An adipogenic gel for surgical reconstruction of the subcutaneous fat layer in a rat model. Journal of Tissue Engineering and Regenerative Medicine, n/a-n/a. doi: 10.1002/term.2025.

Janssen, C. I. F., Zerbi, V., Mutsaers, M. P. C., Jochems, M., Vos, C. A., Vos, J. O., . . . Kiliaan, A. J. (2015). Effect of Perinatally Supplemented Flavonoids on Brain Structure, Circulation, Cognition, and Metabolism in C57BL/6J Mice. Neurochemistry International(0). doi:

Laguna, A., Schintu, N., Nobre, A., Alvarsson, A., Volakakis, N., Jacobsen, J. K., . . . Perlmann, T. (2015). Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson’s disease. Nature Neuroscience, advance online publication. doi: 10.1038/nn.4004….

Lakritz, J. R., Bodair, A., Shah, N., O’Donnell, R., Polydefkis, M. J., Miller, A. D., & Burdo, T. H. (2015). Monocyte Traffic, Dorsal Root Ganglion Histopathology, and Loss of Intraepidermal Nerve Fiber Density in SIV Peripheral Neuropathy. The American journal of pathology(0). doi:

Po, K., Siu, A.-H., Lau, B.-M., Chan, J.-M., So, K.-F., & Chan, C. H. (2015). Repeated, high-dose dextromethorphan treatment decreases neurogenesis and results in depression-like behavior in rats. Experimental Brain Research, 1-10. doi: 10.1007/s00221-015-4290-0.

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Researchers cited MBF systems in 15 papers between 4/20/2015 and 4/30/2015

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Chung, E., Kong, X., Goldberg, M. P., Stowe, A. M., & Raman, L. (2015). Erythropoietin-mediated neuroprotection in a pediatric mouse model of chronic hypoxia. Neuroscience Letters, 597(0), 54-59. doi:

Coutellier, L., Gilbert, V., & Shepard, R. (2015). Npas4 deficiency increases vulnerability to juvenile stress in mice. Behavioural Brain Research(0). doi:

Ferrigno, A., Vairetti, M., Ambrosi, G., Rizzo, V., Richelmi, P., Blandini, F., & Armentero, M.-T. (2015). Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6-OHDA lesioned Parkinsonian rats. Clinical and Experimental Pharmacology and Physiology, n/a-n/a. doi: 10.1111/1440-1681.12410.

Hakim, J. S., Esmaeili Rad, M., Grahn, P. J., Chen, B., Knight, A. M., Schmeichel, A. M., . . . Yaszemski, M. J. (2015). Positively charged oligo[poly(ethylene glycol) fumarate] scaffold implantation results in a permissive lesion environment after spinal cord injury in rat. Tissue Engineering Part A. doi: 10.1089/ten.TEA.2015.0019.

Hong, S., Washington, P., Kim, A., Yang, C.-P., Yu, T.-S., & Kernie, S. G. (2015). ApoE Regulates Injury-Induced Activation of Hippocampal Neural Stem and Progenitor Cells. Journal of Neurotrauma. doi: 10.1089/neu.2014.3860.

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