Scientists Discover New “Rosehip” Neuron in Human Brain

Neurolucida and Neurolucida Explorer Used for 3D Reconstruction and Quantitative Analysis

Researchers used Neurolucida to reconstruct a newly discovered type of neuron found only in the human brain, according to a study published in the journal Nature Neuroscience. Known as “rosehip” neurons because of the way they resemble a rose after its petals have fallen off, these cells feature compact, bushy axonal arborizations.

Found in the first layer of the cerebral cortex, a highly complex brain region that is thought to play an important role in consciousness, “rosehip neurons” have not been seen in mice or other laboratory animals, and scientists suggest that they may exist only in humans. Classified as inhibitory neurons, these brain cells form synapses with pyramidal neurons in layer 3 of the cerebral cortex, according to the study.

Led by Dr. Ed Lein, of the Allen Institute for Brain Science, and Dr. Gábor Tamás, a neuroscientist at the University of Szeged in Szeged, Hungary, the research team used Neurolucida to reconstruct rosehip neurons in 3D. Their reconstructions revealed that these cells display morphological characteristics that differ significantly from other types of cells found in this region of the brain.

Scientists used Neurolucida and Neurolucida Explorer to reconstruct and analyze a rosehip neuron. Image Credit: Tamas Lab, University of Szeged

Using Neurolucida Explorer to quantitatively analyze their cell reconstructions, the researchers observed similar numbers of primary dendrites in both rosehip neurons and basket cells, but fewer compared to neurogliaform cells. Meanwhile, they calculated similar total dendritic length and frequency of dendritic nodes in rosehip neurons and neurogliaform cells, but recorded differences in basket cells.

Also, their analysis revealed that the axonal branching of rosehip neurons was more robust than any other type of cell observed in this brain region, with the volume of axonal terminations, or boutons, measuring four times larger than NGFC boutons.

Furthermore, the researchers say that the rosehip neuron has a molecular marker signature of (GAD1+CCK+, CNR1–SST–CALB2–PVALB–), a signature not seen in the mouse cortex.

According to the paper, the researchers still have much to learn about the function of rosehip neurons in the human brain. Because they observed rosehip neurons connecting to their partner neurons – pyramidal neurons, in very specific places, they hypothesize that rosehip neurons might be controlling the flow of information in a distinctive way.

One next step will be to see if postmortem brains from patients with neuropsychiatric disorders display rosehip neurons with alterations, to begin investigating whether or not these newly discovered cells play a role in mental illness.

Boldog E, Bakken TE, Hodge RD, Novotny M, Aevermann BD, Baka J, Bordé S, Jennie L. Close, Diez-Fuertes F, Ding SL, Faragó N, Kocsis AK, Kovács B, Maltzer Z, McCorrison JM, Miller JA, Molnár G, Oláh G, Ozsvár A, Rózsa M, Shehata SI, Smith KA, Sunkin SM, Tran DN, Venepally P, Wall A, Puskás LG, Barzó P, Steemers FJ, Schork NJ, Scheuermann RH, Lasken RS, Lein ES, Tamás G (2018) Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type. Nature Neuroscience doi.org/10.1038/s41593-018-0205-2

Researchers cited MBF Bioscience systems in 26 papers between 8/31/2018 and 9/7/2018

Stereo Investigator:

Anderson, M. A., O’Shea, T. M., Burda, J. E., Ao, Y., Barlatey, S. L., Bernstein, A. M., . . . Sofroniew, M. V. (2018). Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. doi: 10.1038/s41586-018-0467-6.

Bae, E.-J., Kim, D.-K., Kim, C., Mante, M., Adame, A., Rockenstein, E., . . . Lee, S.-J. (2018). LRRK2 kinase regulates α-synuclein propagation via RAB35 phosphorylation. Nature Communications, 9(1), 3465. doi: 10.1038/s41467-018-05958-z.

Bok, E., Cho, E. J., Chung, E. S., Shin, W.-H., & Jin, B. K. (2018). Interleukin-4 Contributes to Degeneration of Dopamine Neurons in the Lipopolysaccharide-treated Substantia Nigra in vivo. Exp Neurobiol, 27(4), 309-319. doi: https://doi.org/10.5607/en.2018.27.4.309

Chhaya, M. S. J., Quiros-Molina, M. D., Tamashiro-Orrego, M. A. D., Houle, D. J. D., & Detloff, D. M. R. (2018). Exercise-Induced Changes to the Macrophage Response in the Dorsal Root Ganglia Prevent Neuropathic Pain after Spinal Cord Injury. Journal of Neurotrauma, 0(ja), null. doi: 10.1089/neu.2018.5819.

Chou, Y.-C., Ho, C.-T., & Pan, M.-H. (2018). Immature Citrus reticulata extract promotes browning of beige adipocytes in high-fat diet-induced C57BL/6 mice. Journal of Agricultural and Food Chemistry. doi: 10.1021/acs.jafc.8b02719.

Golub, Y., Schildbach, E.-M., Touma, C., Kratz, O., Moll, G. H., von Hörsten, S., & Canneva, F. (2018). Role of hypothalamus-pituitary-adrenal axis modulation in the stress-resilient phenotype of DPP4-deficient rats. Behavioural Brain Research. doi: https://doi.org/10.1016/j.bbr.2018.08.029.

Iacono, D., Geraci-Erck, M., Peng, H., Rabin, M. L., & Kurlan, R. (2018). Hypertrophy of nigral neurons in Torsin1A deletion (DYT1) carriers manifesting dystonia. Parkinsonism & Related Disorders. doi: 10.1016/j.parkreldis.2018.08.020.

Komnig, D., Dagli, C. T., Habib, P., Zeyen, T., Schulz, J. B., & Falkenburger, B. H. (2018). Fingolimod (FTY720) is not protective in the subacute MPTP mouse model of Parkinson disease and does not lead to a sustainable increase of brain BDNF. Journal of Neurochemistry, 0(ja). doi: 10.1111/jnc.14575.

Lind, L. A., Murphy, E. R., Lever, T. E., & Nichols, N. L. (2018). Hypoglossal Motor Neuron Death Via Intralingual CTB–saporin (CTB–SAP) Injections Mimic Aspects of Amyotrophic Lateral Sclerosis (ALS) Related to Dysphagia. Neuroscience. doi: https://doi.org/10.1016/j.neuroscience.2018.08.026.

Novello, S., Arcuri, L., Dovero, S., Dutheil, N., Shimshek, D. R., Bezard, E., & Morari, M. (2018). G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice. Neurobiology of Disease, 120, 21-33. doi: https://doi.org/10.1016/j.nbd.2018.08.018.

Page, C. E., & Coutellier, L. (2018). Adolescent stress disrupts the maturation of anxiety-related behaviors and alters the developmental trajectory of the prefrontal cortex in a sex- and age-specific manner. Neuroscience. doi: https://doi.org/10.1016/j.neuroscience.2018.08.030.

Schiaffino, L., Bonafede, R., Scambi, I., Parrella, E., Pizzi, M., & Mariotti, R. (2018). Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model. Scientific Reports, 8(1), 12875. doi: 10.1038/s41598-018-30659-4.

Williams, G. P., Schonhoff, A. M., Jurkuvenaite, A., Thome, A. D., Standaert, D. G., & Harms, A. S. (2018). Targeting of the class II transactivator attenuates inflammation and neurodegeneration in an alpha-synuclein model of Parkinson’s disease. Journal of neuroinflammation, 15(1), 244. doi: https://doi.org/10.1186/s12974-018-1286-2

Yamaguchi, S., Abe, Y., Maejima, S., & Tsukahara, S. (2018). Sexual experience reduces neuronal activity in the central part of the medial preoptic nucleus in male rats during sexual behavior. Neuroscience Letters, 685, 155-159. doi: https://doi.org/10.1016/j.neulet.2018.08.037.

Zhang, Q., Li, C., Zhang, T., Ge, Y., Han, X., Sun, S., . . . Hu, G. (2018). Deletion of Kir6.2/SUR1 potassium channels rescues diminishing of DA neurons via decreasing iron accumulation in PD. Molecular and Cellular Neuroscience. doi: https://doi.org/10.1016/j.mcn.2018.08.006.

Neurolucida:

Anderson, M. A., O’Shea, T. M., Burda, J. E., Ao, Y., Barlatey, S. L., Bernstein, A. M., . . . Sofroniew, M. V. (2018). Required growth facilitators propel axon regeneration across complete spinal cord injury. Nature. doi: 10.1038/s41586-018-0467-6.

Awad, P. N., Amegandjin, C. A., Szczurkowska, J., Carriço, J. N., Fernandes do Nascimento, A. S., Baho, E., . . . Di Cristo, G. (2018). KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner. Cerebral Cortex, bhy198-bhy198. doi: 10.1093/cercor/bhy198.

Daly, D. T., & Ariel, M. (2018). A Novel Cerebellar Commissure and Other Myelinated Axons in the Purkinje Cell Layer of a Pond Turtle (Trachemys Scripta Elegans). Journal of Comparative Neurology, 0(ja). doi: 10.1002/cne.24528.

Inoue, K.-i., Miyachi, S., Nishi, K., Okado, H., Nagai, Y., Minamimoto, T., . . . Takada, M. (2018). Recruitment of calbindin into nigral dopamine neurons protects against MPTP-Induced parkinsonism. Movement Disorders, 0(0). doi: 10.1002/mds.107.

Ito, T., Furuyama, T., Hase, K., Kobayasi, K. I., Hiryu, S., & Riquimaroux, H. (2018). Organization of subcortical auditory nuclei of Japanese house bat (Pipistrellus abramus) identified with cytoarchitecture and molecular expression. Journal of Comparative Neurology, 0(ja). doi: 10.1002/cne.24529.

Jeon, K.-I., Hindman, H. B., Bubel, T., McDaniel, T., DeMagistris, M., Callan, C., & Huxlin, K. R. (2018). Corneal myofibroblasts inhibit regenerating nerves during wound healing. Scientific Reports, 8(1), 12945. doi: 10.1038/s41598-018-30964-y.

Jiang, Y., Coleman, F. H., Kopenhaver Doheny, K., & Travagli, R. A. (2018). Stress Adaptation Upregulates Oxytocin within Hypothalamo-Vagal Neurocircuits. Neuroscience, 390, 198-205. doi: https://doi.org/10.1016/j.neuroscience.2018.08.021.

Patel, Y., Shin, J., Gowland, P. A., Pausova, Z., Paus, T., & consortium, I. (2018). Maturation of the Human Cerebral Cortex During Adolescence: Myelin or Dendritic Arbor? Cerebral Cortex, bhy204-bhy204. doi: 10.1093/cercor/bhy204.

Poll, S., & Fuhrmann, M. (2019). Chapter 14 – Long-Term In Vivo Imaging of Structural Plasticity in Rodents. In D. Manahan-Vaughan (Ed.), Handbook of Behavioral Neuroscience (Vol. 28, pp. 253-262): Elsevier. doi: https://doi.org/10.1016/B978-0-12-812028-6.00014-8

Sobue, A., Kushima, I., Nagai, T., Shan, W., Kohno, T., Aleksic, B., . . . Ozaki, N. (2018). Genetic and animal model analyses reveal the pathogenic role of a novel deletion of RELN in schizophrenia. Scientific Reports, 8(1), 13046. doi: 10.1038/s41598-018-31390-w.

Vaz‐Silva, J., Gomes, P., Jin, Q., Zhu, M., Zhuravleva, V., Quintremil, S., . . . Soares‐Cunha, C. (2018). Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction. The EMBO journal, e99084. doi: 10.15252/embj.201899084

Wang, H., Li, J.-T., Zhang, Y., Liu, R., Wang, X.-D., Si, T.-M., & Su, Y.-A. (2018). Prenatal Exposure to Antipsychotics Disrupts the Plasticity of Dentate Neurons and Memory in Adult Male Mice. International Journal of Neuropsychopharmacology, pyy073-pyy073. doi: https://doi.org/10.1093/ijnp/pyy073

MBF Bioscience’s New Software Vesselucida 360 Reconstructs Microvascular Networks in 3D

Williston, VT – September 5, 2018 – Researchers studying microvascular networks and vessels have a groundbreaking new software application to facilitate their work. Developed by MBF Bioscience, Vesselucida® 360 automatically reconstructs and analyzes microvascular networks in 3D.

Specifically designed to recognize the intricacies of the vascular system, Vesselucida features sophisticated algorithms that quickly and accurately create 3D reconstructions of images and tissue specimens. Built-in analyses provide data on segments and node counts, frequency of anastomoses, as well as metrics on vessel surface and volume.

Automatic reconstruction of vascular structure labeled with tomato lectin
Image courtesy Dr. Stan Watson, University of Michigan, USA

Vesselucida 360 also features a full suite of tools, which lets researchers manually trace and edit 3D reconstructions to fine-tune particularly complex image data. Companion analysis software, Vesselucida Explorer performs sophisticated data analysis for scientists seeking answers to their most challenging research questions.

“For the first time, researchers studying microvasculature and how it is affected by illnesses, injuries and treatments for those afflictions, have a tool specifically designed for these studies,” says Jack Glaser, President of MBF Bioscience. “We believe Vesselucida will have a significant impact in advancing scientific research in this field.”

For a comprehensive evaluation on how Vesselucida 360 can meet your research needs, we invite you to consult with one of our MBF Bioscience staff scientists.

Visit https://www.mbfbioscience.com/vesselucida360 for more information about Vesselucida 360.

 

About MBF Bioscience:

MBF Bioscience creates quantitative imaging and visualization software for stereology, neuron reconstruction, vascular analysis, c. elegans behavior analysis and medical education, integrated with the world’s leading microscope systems, to empower research. Our development team and staff scientists are actively engaged with leading bioscience researchers, constantly working to refine our products based on state-of-the-art scientific advances in the field.

Founded as MicroBrightField, Inc. in 1988, we changed our name to MBF Bioscience in 2005 to reflect the expansion of our products and services to new microscopy techniques in all fields of biological research and education. While we continue to specialize in neuroscience research, our products are also used extensively in the research fields of stem cells, lung, kidney, cardiac, cancer, and toxicology.

MBF Bioscience has grown into a global business, with offices in North America, Europe, Japan, and China, and a dealer network active on five continents.

Our commitment to innovative products and unrivaled customer support has gained high praise from distinguished scientists who use our products all over the world. Our flagship products Stereo Investigator and Neurolucida are the most widely-used analysis systems for stereology and neuron reconstruction.

Researchers cited MBF Bioscience systems in 18 papers between 8/17/2018 and 8/31/2018

Stereo Investigator:

Abdelkarim, H., Marshall, M. S., Scesa, G., Smith, R. A., Rue, E., Marshall, J., . . . Bongarzone, E. R. (2018). α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies. Scientific Reports, 8(1), 12462. doi: 10.1038/s41598-018-30808-9.

Auth, C. S., Weidner, M. T., Popp, S., Strekalova, T., Schmitt-Böhrer, A. G., van den Hove, D. L. A., . . . Waider, J. (2018). Differential anxiety-related behaviours and brain activation in Tph2-deficient female mice exposed to adverse early environment. European Neuropsychopharmacology. doi: https://doi.org/10.1016/j.euroneuro.2018.07.103.

Chatterjee, D., Bhatt, M., Butler, D., De Genst, E., Dobson, C. M., Messer, A., & Kordower, J. H. (2018). Proteasome-targeted nanobodies alleviate pathology and functional decline in an α-synuclein-based Parkinson’s disease model. Npj Parkinson’s Disease, 4(1), 25. doi: 10.1038/s41531-018-0062-4.

Garza-Gisholt, E., Hart, N. S., & Collin, S. P. (2018). Retinal Morphology and Visual Specializations in Three Species of Chimaeras, the Deep-Sea R. pacifica and C. lignaria, and the Vertical Migrator C. milii (Holocephali). Brain, Behavior and Evolution, 1-16. doi: https://doi.org/10.1159/000490655.
Continue reading “Researchers cited MBF Bioscience systems in 18 papers between 8/17/2018 and 8/31/2018” »

Researchers cited MBF Bioscience systems in 19 papers between 8/3/2018 and 8/17/2018

Stereo Investigator:

Badner, A., Hacker, J., Hong, J., Mikhail, M., Vawda, R., & Fehlings, M. G. (2018). Splenic involvement in umbilical cord matrix-derived mesenchymal stromal cell-mediated effects following traumatic spinal cord injury. Journal of neuroinflammation, 15(1), 219. doi: 10.1186/s12974-018-1243-0.

Chiu, C.-C., Lu, C.-S., Weng, Y.-H., Chen, Y.-L., Huang, Y.-Z., Chen, R.-S., . . . Wang, H.-L. (2018). PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. Molecular Neurobiology. doi: 10.1007/s12035-018-1118-5.

Fujita, A., Yamaguchi, H., Yamasaki, R., Cui, Y., Matsuoka, Y., Yamada, K.-i., & Kira, J.-i. (2018). Connexin 30 deficiency attenuates A2 astrocyte responses and induces severe neurodegeneration in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride Parkinson’s disease animal model. Journal of neuroinflammation, 15(1), 227. doi: 10.1186/s12974-018-1251-0.

Imam, A., Bhagwandin, A., Ajao, M. S., Spocter, M. A., Ihunwo, A. O., & Manger, P. R. (2018). The brain of the tree pangolin (Manis tricuspis). II. The olfactory system. Journal of Comparative Neurology, 0(ja). doi: 10.1002/cne.24510.  Continue reading “Researchers cited MBF Bioscience systems in 19 papers between 8/3/2018 and 8/17/2018” »

Researchers cited MBF Bioscience systems in 19 papers between 7/27/2018 and 8/3/2018

Stereo Investigator:

Bassey, R. B., & Gondré-Lewis, M. C. (2018). Combined early life stressors: Prenatal nicotine and maternal deprivation interact to influence affective and drug seeking behavioral phenotypes in rats. Behavioural Brain Research. doi: https://doi.org/10.1016/j.bbr.2018.07.022.

Deniz, Ö. G., Altun, G., Kaplan, A. A., Yurt, K. K., von Bartheld, C. S., & Kaplan, S. (2018). A concise review of optical, physical and isotropic fractionator techniques in neuroscience studies, including recent developments. Journal of Neuroscience Methods. doi: https://doi.org/10.1016/j.jneumeth.2018.07.012.

Milanese, C., Cerri, S., Ulusoy, A., Gornati, S. V., Plat, A., Gabriels, S., . . . Mastroberardino, P. G. (2018). Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease. Cell death & disease, 9(8), 818. doi: 10.1038/s41419-018-0848-7.

Pozner, T., Vistoropsky, Y., Moaraf, S., Heiblum, R., & Barnea, A. (2018). Questioning Seasonality of Neuronal Plasticity in the Adult Avian Brain. Scientific Reports, 8(1), 11289. doi: 10.1038/s41598-018-29532-1.  Continue reading “Researchers cited MBF Bioscience systems in 19 papers between 7/27/2018 and 8/3/2018” »

Researchers cited MBF Bioscience systems in 26 papers between 7/13/2018 and 7/27/2018

Stereo Investigator:

Eriksson, Y., Boström, M., Sandelius, Å., Blennow, K., Zetterberg, H., Kuhn, G., & Kalm, M. (2018). The anti-asthmatic drug, montelukast, modifies the neurogenic potential in the young healthy and irradiated brain. Cell death & disease, 9(7), 775. doi: 10.1038/s41419-018-0783-7.

Kim, D., Yoo, J. M., Hwang, H., Lee, J., Lee, S. H., Yun, S. P., . . . Ko, H. S. (2018). Graphene quantum dots prevent α-synucleinopathy in Parkinson’s disease. Nature Nanotechnology. doi: 10.1038/s41565-018-0179-y.

Olivia, P., J., C. L., Pamela, B. L., G., A. D., & Pierre, L. (2018). Stereological analysis of the rhesus monkey entorhinal cortex. Journal of Comparative Neurology, 0(ja). doi:10.1002/cne.24496.

Pooley, A. E., Benjamin, R. C., Sreedhar, S., Eagle, A. L., Robison, A. J., Mazei-Robison, M. S., . . . Jordan, C. L. (2018). Sex differences in the traumatic stress response: the role of adult gonadal hormones. Biology of Sex Differences, 9(1), 32. doi: 10.1186/s13293-018-0192-8. Continue reading “Researchers cited MBF Bioscience systems in 26 papers between 7/13/2018 and 7/27/2018” »

Researchers cited MBF Bioscience systems in 8 papers between 7/6/2018 and 7/13/2018

Stereo Investigator:

Bok, E., Chung, Y. C., Kim, K.-S., Baik, H. H., Shin, W.-H., & Jin, B. K. (2018). Modulation of M1/M2 polarization by capsaicin contributes to the survival of dopaminergic neurons in the lipopolysaccharide-lesioned substantia nigra in vivo. Experimental and Molecular Medicine, 50(7), 76. doi: 10.1038/s12276-018-0111-4.

Li, S., Yip, A., Bird, J., Soo Seok, B., Chan, A., Godden, K. E., . . . Pompeiano, M. (2018). Melanin-concentrating hormone (MCH) neurons in the developing chick brain. Brain Research. doi: https://doi.org/10.1016/j.brainres.2018.07.001.

Pereira, R., Leite, E., Raimundo, J., Guilherme, S., Puga, S., Santos, M. A., . . . Pereira, P. (2018). Metals(loids) targeting fish eyes and brain in a contaminated estuary – Uncovering neurosensory (un)susceptibility through bioaccumulation, antioxidant and morphometric profiles. Marine Environmental Research. doi: https://doi.org/10.1016/j.marenvres.2018.07.001.

Pooley, A. E., Benjamin, R. C., Sreedhar, S., Eagle, A. L., Robison, A. J., Mazei-Robison, M. S., . . . Jordan, C. L. (2018). Sex differences in the traumatic stress response: PTSD symptoms in women recapitulated in female rats. Biology of Sex Differences, 9(1), 31. doi: 10.1186/s13293-018-0191-9.  Continue reading “Researchers cited MBF Bioscience systems in 8 papers between 7/6/2018 and 7/13/2018” »

Researchers cited MBF Bioscience systems in 13 papers between 6/29/2018 and 7/6/2018

Stereo Investigator:

Aguilar-Valles, A., Haji, N., De Gregorio, D., Matta-Camacho, E., Eslamizade, M. J., Popic, J., . . . Sonenberg, N. (2018). Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nature Communications, 9(1), 2459. doi: 10.1038/s41467-018-04883-5.

Bearer, E. L., Manifold-Wheeler, B. C., Medina, C. S., Gonzales, A., Cháves, F., & Jacobs, R. E. (2018). Alterations of functional circuitry in aging brain and the impact of mutated APP expression. Neurobiology of Aging. doi: https://doi.org/10.1016/j.neurobiolaging.2018.06.018.

Holahan, M. R., Smith, C. A., Luu, B. E., & Storey, K. B. (2018). Preadolescent phthalate (DEHP) exposure is associated with elevated locomotor activity and reward-related behavior and a reduced number of tyrosine hydroxylase positive neurons in post-adolescent male and female rats. Toxicological Sciences, kfy171-kfy171. doi: 10.1093/toxsci/kfy171.

Li, Y., Stockton, M. E., Eisinger, B. E., Zhao, Y., Miller, J. L., Bhuiyan, I., . . . Zhao, X. (2018). Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome. Nature Communications, 9(1), 2494. doi: 10.1038/s41467-018-04869-3.  Continue reading “Researchers cited MBF Bioscience systems in 13 papers between 6/29/2018 and 7/6/2018” »

MBF Bioscience Launches Stereo Investigator Whole Slide Edition for Quantitative Analysis of Whole Slide Image Data

Williston, VT – June 29, 2018 – MBF Bioscience is pleased to announce the launch of the Whole Slide Edition of Stereo Investigator. This is a new version of our renown Stereo Investigator software, designed especially for conducting stereology on images from slide scanners.

Featuring a streamlined, user-friendly interface, this new product includes a variety of probes for quantifying number, length, volume, and surface area of cells, structures, and regions of biological tissue. The software works with all 2D microscope images, and is an especially attractive solution for researchers who work mostly, or exclusively, with slide scanners.

The main benefits of Stereo Investigator – Whole Slide Edition include:
· Accurate, unbiased quantitative analysis of images from slide scanners
· Designed workflows and user-interface specifically for analyzing whole slide images
· Compatible with all popular slide scanning file formats
· Enhanced user interface that is easy to use for 2D stereology probes
· Integrates with our Biolucida image management system
· Affordable
· Includes MBF technical and scientific support
· Free trial versions are available

“We’re very excited about the opportunity this gives to many of our customers who want to use stereology to perform quantitative analysis of their whole slide image data. Stereo Investigator – Whole Slide Edition provides a powerful, lower-cost version of Stereo Investigator with a user interface designed specifically for 2D image data,” says MBF Bioscience Director of Sales & Marketing Mark Barton.

For over a decade, Stereo Investigator has been considered the gold standard for carrying out stereological studies on biological tissue, and is cited in peer reviewed publications ten times more than any other stereology system. With the release of Stereo Investigator – Whole Slide Edition, MBF Bioscience continues its dedication to further assisting the research of our valued customers.

For more information about Stereo Investigator Whole Slide Edition and to request a quote, visit http://www.mbfbioscience.com/stereo-investigator-whole-slide-edition