Researchers cited MBF systems in 11 papers during the week of 7/20/2014

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Aydin, A., Halici, Z., Akoz, A., Karaman, A., Ferah, I., Bayir, Y., . . . Kovaci, H. (2014). Treatment with α-lipoic acid enhances the bone healing after femoral fracture model of rats. Naunyn-Schmiedeberg’s archives of pharmacology, 1-12. doi: 10.1007/s00210-014-1021-1.

Braegger, F. E., Asarian, L., Dahl, K., Lutz, T. A., & Boyle, C. N. (2014). The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.12672.

Richter, F., Fleming, S., Watson, M., Lemesre, V., Pellegrino, L., Ranes, B., . . . Chesselet, M.-F. (2014). A GCase Chaperone Improves Motor Function in a Mouse Model of Synucleinopathy. Neurotherapeutics, 1-17. doi: 10.1007/s13311-014-0294-x.

Rossi, S. L., Mahairaki, V., Zhou, L., Song, Y., & Koliatsos, V. E. (2014). Remodeling of the piriform cortex after lesion in adult rodents. Neuroreport, Publish Ahead of Print, 10.1097/WNR.0000000000000203.

Segura-Puimedon, M., Sahún, I., Velot, E., Dubus, P., Borralleras, C., Rodrigues, A. J., . . . Campuzano, V. (2014). Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder. Human Molecular Genetics. doi: 10.1093/hmg/ddu368.

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Higher Levels of pTau are found in Alzheimer’s Disease Patients with Psychosis


An image of neurofibrillary tangles and neuropil threads from one of the researchers’ earlier pilot studies. As in the study described here, pTau is identified by the AT8 antibody (green). Amyloid deposits are stained blue with the X-34 compound.

People with Alzheimer’s disease suffer from severe memory loss and often have problems focusing, reasoning, and communicating. About half of all Alzheimer’s patients also experience delusions and hallucinations, this is called Alzheimer’s disease with psychosis, and scientists at the University of Pittsburgh are learning more about this severe version of the disease.

In a recent study, researchers at Dr. Robert Sweet’s lab zeroed in on a protein called tau, which forms tangles in the brains of Alzheimer’s patients, and along with amyloid plaques is one of the major hallmarks of the disease. But despite being involved in these pathological conditions, tau and amyloid may instigate other processes as well – namely, synaptic toxicity, which the authors say is “the strongest correlate of cognitive decline in Alzheimer’s disease.”

Recent research suggests that amyloids (misfolded proteins) drive the deterioration of synapses, but phospho-tau (tau, which has undergone phosphorylation), enables the process. So in their study the Pittsburgh research team analyzed the presence of tau in the prefrontal cortex, a region of the brain involved in higher processes, of 45 Alzheimer’s disease patients with and without psychosis.

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Researchers cited MBF systems in 16 papers during the week of 7/13/2014

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Ajioka, I., Jinnou, H., Okada, K., Sawada, M., Saitoh, S., & Sawamoto, K. (2014). Enhancement of Neuroblast Migration into the Injured Cerebral Cortex using Laminin-containing Porous Sponge. Tissue Engineering(ja).

Blomstrand, M., Kalm, M., Grandér, R., Björk-Eriksson, T., & Blomgren, K. (2014). Different reactions to irradiation in the juvenile and adult hippocampus. International Journal of Radiation Biology, 0(ja), 1-17. doi: doi:10.3109/09553002.2014.942015.

Dela Cruz, J. A. D., Schmidt-Kastner, R., Stevens, J. A. A., Steinbusch, H. W. M., & Rutten, B. P. F. (2014). Differential distribution of hypoxia-inducible factor 1-beta (ARNT or ARNT2) in mouse substantia nigra and ventral tegmental area. Journal of Chemical Neuroanatomy(0).

Games, D., Valera, E., Spencer, B., Rockenstein, E., Mante, M., Adame, A., . . . Sacayon, P. (2014). Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson’s Disease-Like Models. The Journal of Neuroscience, 34(28), 9441-9454.

Kayabasoglu, G., Ozbek, E., Yanar, S., Sahin, F., Keles, O., Yilmaz, M., & Guven, M. (2014). The comparison of the viability of crushed, morselized and diced cartilage grafts: a confocal microscopic study. European Archives of Oto-Rhino-Laryngology, 1-8. doi: 10.1007/s00405-014-3192-2.

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Researchers cited MBF systems in 21 papers during the week of 7/6/2014

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Chen, S.-S., Yang, C., Hao, F., Li, C., Lu, T., Zhao, L.-R., & Duan, W.-M. (2014). Intrastriatal GDNF gene transfer by inducible lentivirus vectors protects dopaminergic neurons in a rat model of parkinsonism. Experimental Neurology(0).

Colton, C. A., Wilson, J. G., Everhart, A., Wilcock, D. M., Puoliväli, J., Heikkinen, T., . . . Vitek, M. P. (2014). mNos2 Deletion and Human NOS2 Replacement in Alzheimer Disease Models. Journal of Neuropathology and Experimental Neurology, Publish Ahead of Print, 10.1097/NEN.0000000000000094.

Cullen, C. L., Burne, T. H. J., Lavidis, N. A., & Moritz, K. M. (2014). Low Dose Prenatal Alcohol Exposure Does Not Impair Spatial Learning and Memory in Two Tests in Adult and Aged Rats. Plos one, 9(6), e101482. doi: 10.1371/journal.pone.0101482.

Dijkstra, A. A., Voorn, P., Berendse, H. W., Groenewegen, H. J., Netherlands Brain, B., Rozemuller, A. J. M., & van de Berg, W. D. J. (2014). Stage-dependent nigral neuronal loss in incidental Lewy body and Parkinson’s disease. Movement Disorders, n/a-n/a. doi: 10.1002/mds.25952.

Drobyshevsky, A., Jiang, R., Derrick, M., Luo, K., & Tan, S. (2014). Functional correlates of central white matter maturation in perinatal period in rabbits. Experimental Neurology(0).

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Researchers cited MBF systems in 25 papers during the week of 6/29/2014

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Dowie, M. J., Grimsey, N. L., Hoffman, T., Faull, R. L. M., & Glass, M. (2014). Cannabinoid receptor CB2 is expressed on vascular cells, but not astroglial cells in the post-mortem human Huntington’s disease brain. Journal of Chemical Neuroanatomy(0).

Kim, R. Y., Hoffman, A. S., Itoh, N., Ao, Y., Spence, R., Sofroniew, M. V., & Voskuhl, R. R. (2014). Astrocyte CCL2 Sustains Immune Cell Infiltration in Chronic Experimental Autoimmune Encephalomyelitis. Journal of Neuroimmunology(0).

Petryszyn, S., Beaulieu, J.-M., Parent, A., & Parent, M. (2014). Distribution and morphological characteristics of striatal interneurons expressing calretinin in mice: A comparison with human and nonhuman primates. Journal of Chemical Neuroanatomy(0).

Traub, R. J., Cao, D.-Y., Karpowicz, J., Pandya, S., Ji, Y., Dorsey, S. G., & Dessem, D. (2014). A clinically relevant animal model of TMD and IBS co-morbidity. The Journal of Pain(0).

Blackman, A. V., Grabuschnig, S., Legenstein, R., & Sjöström, P. J. (2014). A Comparison of Manual Neuronal Reconstruction from Biocytin Histology or 2-Photon Imaging: Morphometry and Computer Modeling. Frontiers in Neuroanatomy, 8, 65.

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New Neurons Erase Memories

Dentate gyrus

Neurogenesis occurs in the dentate gyrus, pictured here, from birth through adulthood.

A baby laughs at an elephant at the zoo. A toddler runs across a beach. Small children make memories all the time, but how many will they recall as the years pass? Maybe none at all. The phenomenon is called “infantile amnesia,” and scientists may have pinpointed a reason for why it occurs – neurogenesis.

Researchers at the Hospital for Sick Children in Toronto say that when new brain cells integrate into existing circuitry, they remodel the structure of networks already in place, wiping out the information previously stored there. This process is prevalent in infancy and early childhood because this is the time when new brain cells are being generated faster and more frequently than at any other time in a human being’s life. Humans and other mammals spawn new neurons throughout their lifespans, although the rate of neurogenesis decreases significantly with age.

In their paper, published in Science, the researchers explain how recent studies have focused on how new brain cells can lead to new memories, but the Toronto team speculated that neurogenesis could also wipe away memories. To test their hypothesis, they conducted a series of studies on populations of newborn and adult mice. Neuron development in mice occurs in much the same way as in humans, with rapid cell genesis in infancy that tapers off with age.

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Researchers cited MBF systems in 22 papers during the week of 6/22/2014

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Bajo, V. M., Leach, N. D., Cordery, P. M., Nodal, F. R., & King, A. J. (2014). The cholinergic basal forebrain in the ferret and its inputs to the auditory cortex. European Journal of Neuroscience, n/a-n/a.

Buxbaum, J. N., Roberts, A. J., Adame, A., & Masliah, E. (2014). Silencing of murine transthyretin and retinol binding protein genes have distinct and shared behavioral and neuropathologic effects. Neuroscience(0).

Dell, x, Anno, M. T., Caiazzo, M., Leo, D., Dvoretskova, E., . . . Broccoli, V. (2014). Remote control of induced dopaminergic neurons in parkinsonian rats. The Journal of Clinical Investigation, 124(7), 0-0. doi: 10.1172/jci74664.

Forgione, N., Karadimas, S. K., Foltz, W. D., Satkunendrarajah, K., Lip, A., & Fehlings, M. (2014). Bilateral Contusion-Compression Model of Incomplete Traumatic Cervical Spinal Cord Injury (SCI). Journal of Neurotrauma(ja).

Greene-Schloesser, D. M., Kooshki, M., Payne, V., D`Agostino, R. B., Wheeler, K. T., Metheny-Barlow, L. J., & Robbins, M. E. (2014). Cellular response of the rat brain to single doses of 137Cs γ rays does not predict its response to prolonged “biologically equivalent” fractionated doses. International Journal of Radiation Biology, 0(ja), 1-33.

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Researchers cited MBF systems in 17 papers during the week of 6/15/2014

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Ash, J. A., Velazquez, R., Kelley, C. M., Powers, B. E., Ginsberg, S. D., Mufson, E. J., & Strupp, B. J. (2014). Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice. Neurobiology of Disease(0).

Barratt, H. E., Lanman, T. A., & Carmichael, S. T. (2014). Mouse intracerebral hemorrhage models produce different degrees of initial and delayed damage, axonal sprouting, and recovery. Journal of Cerebral Blood Flow and Metabolism.

Canese, R., Zoratto, F., Altabella, L., Porcari, P., Mercurio, L., de Pasquale, F., . . . Adriani, W. (2014). Persistent modification of forebrain networks and metabolism in rats following adolescent exposure to a 5-HT7 receptor agonist. Psychopharmacology, 1-15.

Emborg, M. E., Hurley, S. A., Joers, V., Tromp, D. P. M., Swanson, C. R., Ohshima-Hosoyama, S., . . . Alexander, A. L. (2014). Titer and Product Affect the Distribution of Gene Expression after Intraputaminal Convection-Enhanced Delivery. Stereotactic and Functional Neurosurgery, 92(3), 182-194.

Healy-Stoffel, M., Omar Ahmad, S., Stanford, J. A., & Levant, B. (2014). Differential effects of intrastriatal 6-hydroxydopamine on cell number and morphology in midbrain dopaminergic subregions of the rat. Brain Research(0).

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Researchers cited MBF systems in 30 papers during the week of 6/8/2014

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Barkan, S., Yom-Tov, Y., & Barnea, A. (2014). A possible relation between new neuronal recruitment and migratory behavior in Acrocephalus warblers. Developmental Neurobiology, n/a-n/a. doi: 10.1002/dneu.22198.

Bethea, C. L., Coleman, K., Phu, K., Reddy, A. P., & Phu, A. (2014). Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience(0).

Coimbra, J. P., Collin, S. P., & Hart, N. S. (2014). Topographic specializations in the retinal ganglion cell layer correlate with lateralized visual behavior, ecology and evolution in cockatoos. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23637.

Dellarole, A., Morton, P., Brambilla, R., Walters, W., Summers, S., Bernardes, D., . . . Bethea, J. R. (2014). Neuropathic pain-induced depressive-like behavior and hippocampal neurogenesis and plasticity are dependent on TNFR1 signaling. Brain, Behavior, and Immunity(0).

Höfling, C., Indrischek, H., Höpcke, T., Waniek, A., Cynis, H., Koch, B., . . . Hartlage-Rübsamen, M. (2014). Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC. International Journal of Developmental Neuroscience(0).

Koh, M. T., Spiegel, A. M., & Gallagher, M. (2014). Age-associated changes in hippocampal-dependent cognition in Diversity Outbred mice. Hippocampus, n/a-n/a. doi: 10.1002/hipo.22311.

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Researchers cited MBF systems in 15 papers during the week of 6/1/2014

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Caldwell, A. S. L., Middleton, L. J., Jimenez, M., Desai, R., McMahon, A. C., Allan, C. M., . . . Walters, K. A. (2014). Characterization of reproductive, metabolic and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models. Endocrinology, en.2014-1196. doi: 10.1210/en.2014-1196.

Davidson, J. O., Drury, P. P., Green, C. R., Nicholson, L. F., Bennet, L., & Gunn, A. J. (2014). Connexin Hemichannel Blockade Is Neuroprotective after Asphyxia in Preterm Fetal Sheep. Plos one, 9(5), e96558. doi: 10.1371/journal.pone.0096558.

Kousik, S. M., Carvey, P. M., & Napier, T. C. (2014). Methamphetamine self-administration results in persistent dopaminergic pathology: implications for Parkinson’s disease risk and reward-seeking. European Journal of Neuroscience, n/a-n/a.

Liu, G., Yu, J., Ding, J., Xie, C., Sun, L., Rudenko, I., . . . Cai, H. (2014). Aldehyde dehydrogenase 1 defines and protects a nigrostriatal dopaminergic neuron subpopulation. The Journal of Clinical Investigation, 124(7), 0-0. doi: 10.1172/jci72176.

Marschallinger, J., Krampert, M., Couillard-Despres, S., Heuchel, R., Bogdahn, U., & Aigner, L. (2014). Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis. Experimental Gerontology(0).

McLean, J. R., Smith, G. A., Rocha, E. M., Hayes, M. A., Beagan, J. A., Hallett, P. J., & Isacson, O. (2014). Widespread neuron-specific transgene expression in brain and spinal cord following synapsin promoter-driven AAV9 neonatal intracerebroventricular injection. Neuroscience Letters(0).

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