Researchers cited MBF systems in 14 papers during the week of 8/24/2015

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Choi, J., Desai, R., Zheng, Y., Yao, M., Dong, Q., Watson, G., . . . Simanainen, U. (2015). Androgen actions via androgen receptor promote PTEN inactivation induced uterine cancer. Endocrine-Related Cancer, 22(5), 687-701. doi: 10.1530/erc-15-0203.

Coimbra, J. P., Kaswera-Kyamakya, C., Gilissen, E., Manger, P., & Collin, S. (2015). The Retina of Ansorge’s Cusimanse (Crossarchus ansorgei): Number, Topography and Convergence of Photoreceptors and Ganglion Cells in Relation to Ecology and Behavior. Brain, Behavior and Evolution.

Cotel, M.-C., Lenartowicz, E. M., Natesan, S., Modo, M. M., Cooper, J. D., Williams, S. C. R., . . . Vernon, A. C. (2015). Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses. European Neuropsychopharmacology. doi: http://dx.doi.org/10.1016/j.euroneuro.2015.08.004.

Fan, Y., Kong, H., Ye, X., Ding, J., & Hu, G. (2015). ATP-sensitive potassium channels: uncovering novel targets for treating depression. Brain Structure and Function, 1-12. doi: 10.1007/s00429-015-1090-z.

Gomez, D. L., O’Driscoll, M., Sheets, T. P., Hruban, R. H., Oberholzer, J., McGarrigle, J. J., & Shamblott, M. J. (2015). Neurogenin 3 Expressing Cells in the Human Exocrine Pancreas Have the Capacity for Endocrine Cell Fate. Plos one, 10(8), e0133862. doi: 10.1371/journal.pone.0133862.

Le, W., Zhang, L., Xie, W., Li, S., & Dani, J. A. (2015). Pitx3 Deficiency Produces Decreased Dopamine Signaling and Induces Motor Deficits in Pitx3(-/-) Mice. Neurobiology of Aging. doi:http://dx.doi.org/10.1016/j.neurobiolaging.2015.08.012.

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Researchers cited MBF systems in 12 papers during the week of 8/17/2015

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Ba, Q., Cui, C., Wen, L., Feng, S., Zhou, J., & Yang, K. (2015). Schisandrin B shows neuroprotective effect in 6-OHDA-induced Parkinson’s disease via inhibiting the negative modulation of miR-34a on Nrf2 pathway. Biomedicine and Pharmacotherapy. doi: http://dx.doi.org/10.1016/j.biopha.2015.07.034.

Cardinale, A., Paldino, E., Giampà, C., Bernardi, G., & Fusco, F. R. (2015). PARP-1 Inhibition Is Neuroprotective in the R6/2 Mouse Model of Huntington’s Disease. Plos one, 10(8), e0134482. doi: 10.1371/journal.pone.0134482.

Issa, J. P., Gonzaga, M., Kotake, B. G., de Lucia, C., Ervolino, E., & Iyomasa, M. (2015). Bone repair of critical size defects treated with autogenic, allogenic, or xenogenic bone grafts alone or in combination with rhBMP-2. Clinical Oral Implants Research, n/a-n/a. doi: 10.1111/clr.12622.

Nikolajsen, G. N., Kotynski, K. A., Jensen, M. S., & West, M. J. (2015). Quantitative analysis of the capillary network of aged APPswe/PS1dE9 transgenic mice. Neurobiology of Aging. doi:http://dx.doi.org/10.1016/j.neurobiolaging.2015.08.004.

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Munich Researchers Use WormLab to Study Blast Effects on C. Elegans

 

Explosions can tear apart buildings, send shrapnel flying, and hurtle humans into the air. But explosions also cause damage in ways that aren’t as visually apparent. Scientists say the force of a blast can cause brain damage, but questions linger about how the symptoms that emerge after a blast-induced traumatic brain injury are connected to the initial trauma.

In their quest to learn more about how symptoms emerge after a traumatic blast, researchers at the Ludwig-Maximilians University of Munich, in Munich, Germany have developed an animal model of blast-related mild traumatic brain injury (br-mTBI) using C. elegans worms – a popular model organism alternative to vertebrate animals.

In their study, published in Frontiers in Behavioral Neuroscience, the research team used WormLab to analyze thousands of worms. They found that shockwaves either slowed the worms’ movements or rendered them paralyzed. Symptoms played out in a dose-dependent manner, meaning that worms exposed to a higher number of shockwaves displayed a higher severity of symptoms.

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First System for Imaging and Analyzing Large Mammalian Brain Tissue Installed in South Africa

Dr. Paul Manger's new system developed by MBF Bioscience for analyzing large mammalian brain specimens

Dr. Paul Manger’s new system developed by MBF Bioscience for analyzing large mammalian brain specimens

Dr. Paul Manger, Research Professor at the University of the Witwatersrand, South Africa, studies the brain anatomy of various animals to better understand the relationship between brain structure and function. Some of the mammals he studies have very large brains that don’t fit under a conventional research microscope. A team of scientists and microscopy experts at MBF Bioscience developed a new microscope system that enables Dr. Manger to analyze and image whole sections of large brain tissue. This system is the first for imaging and analyzing entire tissue sections of large mammalian brains. It will give Dr. Manger unprecedented analyses of African mammal brains and a way to share large images of tissue specimens with collaborators or a global audience.

Oryx retina tissue specimens. Scale bar is in centimeters.

A section of Oryx retina tissue. Scale bar is in centimeters.

To accommodate the large tissue specimens, MBF Bioscience developed the system with a Zeiss Axio Imager Vario microscope which is used in the semiconductor industry for inspecting silicon wafers. The motorized stage, built by Ludl, is enormous – it can hold tissue specimens with dimensions of up to 30cm x 40cm. This hardware, combined with Neurolucida, Stereo Investigator, Continue reading “First System for Imaging and Analyzing Large Mammalian Brain Tissue Installed in South Africa” »

Researchers cited MBF systems in 28 papers between 7/31/2015 and 8/7/2015

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Almeida-Suhett, C. P., Prager, E. M., Pidoplichko, V., Figueiredo, T. H., Marini, A. M., Li, Z., . . . Braga, M. F. M. (2015). GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury. Experimental Neurology, 273, 11-23. doi:http://dx.doi.org/10.1016/j.expneurol.2015.07.028.

Calvez, J., Lenglos, C., de Ávila, C., Guèvremont, G., & Timofeeva, E. (2015). Differential effects of central administration of relaxin-3 on food intake and hypothalamic neuropeptides in male and female rats. Genes, Brain and Behavior, n/a-n/a. doi: 10.1111/gbb.12236.

Cisbani, G., Drouin-Ouellet, J., Gibrat, C., Saint-Pierre, M., Lagacé, M., Badrinarayanan, S., . . . Cicchetti, F. (2015). Cystamine/cysteamine rescue the dopaminergic system and show neurorestorative properties in an animal model of Parkinson’s disease. Neurobiology of Disease. doi:http://dx.doi.org/10.1016/j.nbd.2015.07.012.

Cohn, B. A., Collin, S. P., Wainwright, P. C., & Schmitz, L. (2015). Retinal topography maps in R: New tools for the analysis and visualization of spatial retinal data. Journal of Vision, 15(9), 19-19. doi: 10.1167/15.9.19.

Corenblum, M. J., Flores, A. J., Badowski, M., Harris, D. T., & Madhavan, L. (2015). Systemic human CD34+ cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration. Regenerative Medicine, 10(5), 563-577. doi: 10.2217/rme.15.32.

Dell, L.-A., Spocter, M. A., Patzke, N., Karlson, K. Æ., Alagaili, A. N., Bennett, N. C., . . . Manger, P. R. (2015). Orexinergic bouton density is lower in the cerebral cortex of cetaceans compared to artiodactyls. Journal of Chemical Neuroanatomy, 68, 61-76. doi: http://dx.doi.org/10.1016/j.jchemneu.2015.07.007.

Faunes, M., Oñate-Ponce, A., Fernández-Collemann, S., & Henny, P. (2015). Excitatory and inhibitory innervation of the mouse orofacial motor nuclei: A stereological study. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23862.

Liu, Y., Sun, J.-D., Song, L.-K., Li, J., Chu, S.-F., Yuan, Y.-H., & Chen, N.-H. (2015). Environment-contact Administration of Rotenone: A New Rodent Model of Parkinson’s Disease. Behavioural Brain Research. doi:http://dx.doi.org/10.1016/j.bbr.2015.07.058.

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Researchers cited MBF systems in 16 papers during the week of 7/20/2015

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Cui, X., Pertile, R., Liu, P., & Eyles, D. W. (2015). Vitamin D regulates tyrosine hydroxylase expression: N-cadherin a possible mediator. Neuroscience. doi: http://dx.doi.org/10.1016/j.neuroscience.2015.07.048.

Deusser, J., Schmidt, S., Ettle, B., Plötz, S., Huber, S., Müller, C. P., . . . Kohl, Z. (2015). Serotonergic dysfunction in the A53T alpha-synuclein mouse model of Parkinson’s disease. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13253.

Furlanetti, L. L., Coenen, V. A., Aranda, I. A., & Döbrössy, M. D. (2015). Chronic deep brain stimulation of the medial forebrain bundle reverses depressive-like behavior in a hemiparkinsonian rodent model. Experimental Brain Research, 1-13.

Hong, J., Sha, S., Zhou, L., Wang, C., Yin, J., & Chen, L. (2015). Sigma-1 receptor deficiency reduces MPTP-induced parkinsonism and death of dopaminergic neurons.  Cell Death Dis, 6, e1832. doi: 10.1038/cddis.2015.194.

Kaindlstorfer, C., Sommer, P., Georgievska, B., Mather, R. J., Kugler, A. R., Poewe, W., . . . Stefanova, N. (2015). Failure of Neuroprotection Despite Microglial Suppression by Delayed-Start Myeloperoxidase Inhibition in a Model of Advanced Multiple System Atrophy: Clinical Implications. Neurotoxicity research, 1-10.

Kumar, N. N., Velic, A., Soliz, J., Shi, Y., Li, K., Wang, S., . . . Lazarenko, R. M. (2015). Regulation of breathing by CO2 requires the proton-activated receptor GPR4 in retrotrapezoid nucleus neurons. Science, 348(6240), 1255-1260.

Tang, F.-L., Erion, J. R., Tian, Y., Liu, W., Yin, D.-M., Ye, J., . . . Xiong, W.-C. (2015). VPS35 in Dopamine Neurons Is Required for Endosome-to-Golgi Retrieval of Lamp2a, a Receptor of Chaperone-Mediated Autophagy That Is Critical for α-Synuclein Degradation and Prevention of Pathogenesis of Parkinson’s Disease. The Journal of Neuroscience, 35(29), 10613-10628.

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Researchers cited MBF systems in 14 papers during the week of 7/13/2015

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Arshad, A., Yang, B., Bienemann, A. S., Barua, N. U., Wyatt, M. J., Woolley, M., . . . Gill, S. S. (2015). Convection-Enhanced Delivery of Carboplatin PLGA Nanoparticles for the Treatment of Glioblastoma. Plos one, 10(7), e0132266. doi: 10.1371/journal.pone.0132266.

Barhwal, K., Das, S. K., Kumar, A., Hota, S. K., Srivastava, R. B., & Kumar, B. (2015). Insulin Receptor A and Sirtuin 1 synergistically improve learning and spatial memory following chronic salidroside treatment during hypoxia. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13225.

Dhillon, S. K., Gunn, A., Jung, Y., Mathai, S., Bennet, L., & Fraser, M. (2015). Lipopolysaccharide-Induced Preconditioning Attenuates Apoptosis and Differentially Regulates TLR4 and TLR7 Gene Expression after Ischemia in the Preterm Ovine Fetal Brain. Developmental Neuroscience.

Garza-Gisholt, E., Kempster, R., Hart, N., & Collin, S. (2015). Visual Specializations in Five Sympatric Species of Stingrays from the Family Dasyatidae. Brain, Behavior and Evolution.

Glasper, E. R., LaMarca, E. A., Bocarsly, M. E., Fasolino, M., Opendak, M., & Gould, E. (2015). Sexual experience enhances cognitive flexibility and dendritic spine density in the medial prefrontal cortex. Neurobiology of Learning and Memory. doi: http://dx.doi.org/10.1016/j.nlm.2015.07.007.

Keeley, R. J., Trow, J., & McDonald, R. J. (2015). Strain and sex differences in puberty onset and the effects of THC administration on weight gain and brain volumes. Neuroscience. doi:http://dx.doi.org/10.1016/j.neuroscience.2015.07.024.

Pickrell, Alicia M., Huang, C.-H., Kennedy, Scott R., Ordureau, A., Sideris, Dionisia P., Hoekstra, Jake G., . . . Youle, Richard J. (2015). Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron, 87(2), 371-381. doi:http://dx.doi.org/10.1016/j.neuron.2015.06.034.

Suo, H., Wang, P., Tong, J., Cai, L., Liu, J., Huang, D., . . . Huang, F. (2015). NRSF is an essential mediator for the neuroprotection of trichostatin A in the MPTP mouse model of Parkinson’s disease. Neuropharmacology. doi: http://dx.doi.org/10.1016/j.neuropharm.2015.07.015.

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Researchers cited MBF systems in 10 papers during the week of 7/6/2015

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Brace, L. R., Kraev, I., Rostron, C. L., Stewart, M. G., Overton, P. G., & Dommett, E. J. (2015). Altered visual processing in a rodent model of Attention-Deficit Hyperactivity Disorder. Neuroscience. doi:http://dx.doi.org/10.1016/j.neuroscience.2015.07.003

Kim, J. M., Kim, S.-S., & Lee, Y.-D. (2015). Fas-associated factor 1 promotes in neurofibrillary tangle-mediated cell death of basal forebrain cholinergic neurons in P301L transgenic mice. Neuroreport, Publish Ahead of Print. doi: 10.1097/wnr.0000000000000423.

Wang, H., Liu, N.-K., Zhang, Y. P., Deng, L., Lu, Q.-B., Shields, C. B., . . . Xu, X.-M. (2015). Treadmill training induced lumbar motoneuron dendritic plasticity and behavior recovery in adult rats after a thoracic contusive spinal cord injury. Experimental Neurology, 271, 368-378. doi:http://dx.doi.org/10.1016/j.expneurol.2015.07.004.

Williamson, L. L., McKenney, E. A., Holzknecht, Z. E., Belliveau, C., Rawls, J. F., Poulton, S., . . . Bilbo, S. D. (2015). Got Worms? Perinatal Exposure to Helminths Prevents Persistent Immune Sensitization and Cognitive Dysfunction Induced by Early-Life Infection. Brain, Behavior, and Immunity. doi:http://dx.doi.org/10.1016/j.bbi.2015.07.006.

Zhang, Z., Du, X., Xu, H., Xie, J., & Jiang, H. (2015). Lesion of medulla’s catecholaminergic neurons is associated with cardiovascular dysfunction in rotenone-induced Parkinson’s disease rats. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.13012.

Neurolucida:

Fujiwara, T., Inoue, T., Maruo, T., Rikitake, Y., Ieki, N., Mandai, K., . . . Mizoguchi, A. (2015). Nectin-1 Spots Regulate the Branching of Olfactory Mitral Cell Dendrites. Molecular and Cellular Neuroscience. doi:http://dx.doi.org/10.1016/j.mcn.2015.07.003

Huang, T., Ma, L., & Krimm, R. F. (2015). Postnatal reduction of BDNF regulates the developmental remodeling of taste bud innervation. Developmental Biology. doi: http://dx.doi.org/10.1016/j.ydbio.2015.07.006.

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Researchers cited MBF systems in 29 papers during the week of 6/29/2015

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Allen, K. M., Fung, S. J., & Shannon Weickert, C. (2015). Cell proliferation is reduced in the hippocampus in schizophrenia. Australian and New Zealand Journal of Psychiatry. doi: 10.1177/0004867415589793

Benarroch, E. E., Schmeichel, A. M., Parisi, J. E., & Low, P. A. (2015). Histaminergic tuberomammillary neuron loss in multiple system atrophy and dementia with Lewy bodies. Movement Disorders, n/a-n/a. doi: 10.1002/mds.26287.

Cowen, S., McLaughlin, S. L., Hobbs, G., Coad, J., Martin, K. H., Olfert, I. M., & Vona-Davis, L. (2015). High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer. Cancers, 7(3), 1125-1142.

Gorris, R., Fischer, J., Erwes, K. L., Kesavan, J., Peterson, D. A., Alexander, M., . . . Brüstle, O. (2015). Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. Glia, n/a-n/a. doi: 10.1002/glia.22882.

Kiyota, T., Morrison, C. M., Tu, G., Dyavarshetty, B., Weir, R. A., Zhang, G., . . . Gendelman, H. E. (2015). Presenilin-1 familial Alzheimer’s disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice. Brain, Behavior, and Immunity(0). doi: http://dx.doi.org/10.1016/j.bbi.2015.06.014.

Lazzara, C. A., Riley, R. R., Rane, A., Andersen, J. K., & Kim, Y.-H. (2015). The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy. Brain Research, 1622(0), 127-136. doi:http://dx.doi.org/10.1016/j.brainres.2015.06.018.

Lv, E., Deng, J., Yu, Y., Wang, Y., Gong, X., Jia, J., & Wang, X. (2015). Nrf2-ARE signals mediated the anti-oxidative action of electro-acupuncture in an MPTP mouse model of Parkinson’s disease. Free Radical Research, 0(ja), 1-30. doi: doi:10.3109/10715762.2015.1067696.

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Satellite Symposium at SfN: Enhancing the Reproducibility of Your Research Results with Stereology

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Recent headlines decry the alarming amount of irreproducible data in published research papers. MBF Bioscience is hosting a symposium addressing the topic on Sunday, October 18 at 6:30pm entitled “Quantitative Microscopy: Enhancing the Reproducibility of Your Research Results with Stereology.” This symposium, which is a satellite event at the annual Society for Neuroscience meeting, will address how researchers can use stereology to obtain accurate, reproducible data about their histological tissue specimens to drive meaningful discovery by the scientific community at large.

It will be an evening full of engaging speakers with significant expertise in various aspects of stereology, including: stereology theory, the application of stereology in neuroscience research, and why some funding agencies require stereology. Attendees will have a chance to interact with the speakers during the question and answer session following the presentations.

Stereology is the gold standard method for quantifying the number of cells, length of fibers, and the area and volume of structures or regions in tissue specimens. Attend this symposium to learn how it can help you obtain accurate, reproducible data for your research study.