Researchers cited MBF systems in 14 papers during the week of 10/17/2016

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Bacigaluppi, M., Russo, G. L., Peruzzotti-Jametti, L., Rossi, S., Sandrone, S., Butti, E., . . . Martino, G. (2016). Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes.  The Journal of Neuroscience, 36(41), 10529.

Beck, M. H., Haumesser, J. K., Kühn, J., Altschüler, J., Kühn, A. A., & van Riesen, C. (2016). Short- and long-term dopamine depletion causes enhanced beta oscillations in the cortico-basal ganglia loop of parkinsonian rats. Experimental Neurology, 286, 124-136. doi:

Huang, C.-W., Chen, Y.-W., Lin, Y.-R., Chen, P.-H., Chou, M.-H., Lee, L.-J., . . . Chen, S.-L. (2016). Conditional Knockout of Breast Carcinoma Amplified Sequence 2 (BCAS2) in Mouse Forebrain Causes Dendritic Malformation via β-catenin.  Scientific Reports, 6, 34927. doi: 10.1038/srep34927

Sack, M., Lenz, J. N., Jakovcevski, M., Biedermann, S. V., Falfán-Melgoza, C., Deussing, J., . . . Auer, M. K. (2016). Early effects of a high-caloric diet and physical exercise on brain volumetry and behavior: a combined MRI and histology study in mice. Brain Imaging and Behavior, 1-12. doi: 10.1007/s11682-016-9638-y.

Schelle, J., Häsler, L., Göpfert, J. C., Joos, T. O., Vanderstichele, H., Stoops, E., . . . Kaeser, S. A. (2016). Prevention of tau increase in cerebrospinal fluid of APP transgenic mice suggests downstream effect of BACE1 inhibition. Alzheimer’s & Dementia. doi:

Teo, J. D., Morris, M. J., & Jones, N. M. (2016). Maternal obesity increases inflammation and exacerbates damage following neonatal hypoxic-ischaemic brain injury in rats. Brain, Behavior, and Immunity. doi:

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Researchers cited MBF systems in 22 papers during the week of 10/10/2016

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Acosta, S. A., Tajiri, N., Sanberg, P. R., Kaneko, Y., & Borlongan, C. V. (2016). Increased Amyloid Precursor Protein and Tau Expression Manifests as Key Secondary Cell Death in Chronic Traumatic Brain Injury. Journal of Cellular Physiology, n/a-n/a. doi: 10.1002/jcp.25629.

Chan, A., Li, S., Lee, A. R., Leung, J., Yip, A., Bird, J., . . . Pompeiano, M. (2016). Activation of state-regulating neurochemical systems in newborn and embryonic chicks. Neuroscience. doi:

Gomez-Smith, M., Karthikeyan, S., Jeffers, M. S., Janik, R., Thomason, L. A., Stefanovic, B., & Corbett, D. (2016). A physiological characterization of the Cafeteria diet model of metabolic syndrome in the rat. Physiology and Behavior. doi:

Lei, B., James, M. L., Liu, J., Zhou, G., Venkatraman, T. N., Lascola, C. D., . . . Wang, H. (2016). Neuroprotective pentapeptide CN-105 improves functional and histological outcomes in a murine model of intracerebral hemorrhage. Scientific Reports, 6, 34834. doi: 10.1038/srep34834.

Li, Y. Q., Cheng, Z.-C., Liu, S.-W., Aubert, I., & Wong, C. S. (2016). P53 regulates disruption of neuronal development in the adult hippocampus after irradiation.  Cell Death Discovery, 2, 16072. doi: 10.1038/cddiscovery.2016.72

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Researchers cited MBF systems in 21 papers during the week of 10/3/2016

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Augur, I. F., Wyckoff, A. R., Aston-Jones, G., Kalivas, P. W., & Peters, J. (2016). Chemogenetic Activation of an Extinction Neural Circuit Reduces Cue-Induced Reinstatement of Cocaine Seeking. The Journal of Neuroscience, 36(39), 10174-10180.

Bocchio, M., Fisher, S. P., Unal, G., Ellender, T. J., Vyazovskiy, V. V., & Capogna, M. (2016). Sleep and serotonin modulate paracapsular nitric oxide synthase expressing neurons of the amygdale. [10.1523/ENEURO.0177-16.2016]. eneuro.

Cope, E. C., Briones, B. A., Brockett, A. T., Martinez, S., Vigneron, P.-A., Opendak, M., . . . Gould, E. (2016). Immature neurons and radial glia, but not astrocytes or microglia, are altered in adult Cntnap2 and Shank3 mice, models of autism. [10.1523/ENEURO.0196-16.2016]. eneuro.

Dela Cruz, J. A. D., Coke, T., & Bodnar, R. J. (2016). Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats. (114), e53897. doi: doi:10.3791/53897.

Dixon, K. J., Mier, J., Gajavelli, S., Turbic, A., Bullock, R., Turnley, A. M., & Liebl, D. J. (2016). EphrinB3 restricts endogenous neural stem cell migration after traumatic brain injury. Stem Cell Research. doi:

Fahimi, A., Baktir, M. A., Moghadam, S., Mojabi, F. S., Sumanth, K., McNerney, M. W., . . . Salehi, A. (2016). Physical exercise induces structural alterations in the hippocampal astrocytes: exploring the role of BDNF-TrkB signaling. Brain Structure and Function, 1-12. doi: 10.1007/s00429-016-1308-8.

Fernandez-Gonzalez, P., Benavides-Piccione, R., Leguey, I., Bielza, C., Larrañaga, P., & DeFelipe, J. (2016). Dendritic-branching angles of pyramidal neurons of the human cerebral cortex. Brain Structure and Function, 1-13. doi: 10.1007/s00429-016-1311-0.  Continue reading “Researchers cited MBF systems in 21 papers during the week of 10/3/2016” »

Researchers cited MBF systems in 17 papers during the week of 9/26/2016

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Biedermann, S. V., Auer, M. K., Bindila, L., Ende, G., Lutz, B., Weber-Fahr, W., . . . Fuss, J. (2016). Restricted vs. unrestricted wheel running in mice: Effects on brain, behavior and endocannabinoids. Hormones and Behavior, 86, 45-54. doi:

Choi, E. Y., Tanimura, Y., Vage, P. R., Yates, E. H., & Haber, S. N. (2016). Convergence of prefrontal and parietal anatomical projections in a connectional hub in the striatum. Neuroimage. doi:

García-Cabezas, M. Á., & Barbas, H. (2016). Anterior Cingulate Pathways May Affect Emotions Through Orbitofrontal Cortex. Cerebral Cortex. doi: 10.1093/cercor/bhw284.

Gomez, A. M., Stevens, J. A. A., Mané-Damas, M., Molenaar, P., Duimel, H., Verheyen, F., . . . Martinez-Martinez, P. (2016). Silencing of Dok-7 in Adult Rat Muscle Increases Susceptibility to Passive Transfer Myasthenia Gravis. The American journal of pathology, 186(10), 2559-2568. doi:

Halici, Z., Polat, B., Cadirci, E., Topcu, A., Karakus, E., Kose, D., . . . Bayir, Y. (2016). Inhibiting renin angiotensin system in rate limiting step by aliskiren as a new approach for preventing indomethacin induced gastric ulcers. Chemico-Biological Interactions, 258, 266-275. doi:

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Researchers cited MBF systems in 12 papers during the week of 9/19/2016

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Charvet, C. J., Hof, P. R., Raghanti, M. A., van der Kouwe, A. J., Sherwood, C. C., & Takahashi, E. (2016). Combining diffusion MR tractography with stereology highlights increased cross-cortical integration in primates. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24115.

Coon, E. A., Schmeichel, A. M., Parisi, J. E., Cykowski, M. D., Low, P. A., & Benarroch, E. E. (2016). Medullary neuronal loss is not associated with α-synuclein burden in multiple system atrophy. Movement Disorders, n/a-n/a. doi: 10.1002/mds.26798.

Filichia, E., Hoffer, B., Qi, X., & Luo, Y. (2016). Inhibition of Drp1 mitochondrial translocation provides neural protection in dopaminergic system in a Parkinson’s disease model induced by MPTP. [Article]. Scientific Reports, 6, 32656. doi: 10.1038/srep32656

Hodges, J. L., Yu, X., Gilmore, A., Bennett, H., Tjia, M., Perna, J. F., . . . Zuo, Y. (2016). Astrocytic Contributions to Synaptic and Learning Abnormalities in a Mouse Model of Fragile X Syndrome. Biological Psychiatry. doi:

Komnig, D., Schulz, J. B., Reich, A., & Falkenburger, B. H. (2016). Mice lacking Faim2 show increased cell death in the MPTP mouse model of Parkinson Disease. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13847.

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Stereological Study Reveals Neuron and Glia Proliferation in Hippocampus of Lithium-Treated Mice

Dentate gyruspilot

The optical fractionator probe was used to quantify the number of neurons and glia in the dentate gyrus

Doctors have used lithium to treat patients with bipolar disorder since the 1970s. Known for its efficacy in stabilizing patients’ moods by regulating manic episodes, lithium is also associated with a decreased risk of suicide. But while this naturally occurring element is the most widely prescribed medication for those suffering from bipolar disorder, scientists still have much to learn about how lithium physically affects the brain.

A recent study published in the journal Bipolar Disorders adds to the growing body of evidence that says lithium contributes to cell proliferation in parts of the brain. Conducted by scientists at the University of Mississippi and the VU University Medical Center in Amsterdam, the study revealed an increased number of neurons and glia, and increased astrocyte density in the dentate gyrus of lithium-treated mice versus controls treated with a placebo.

Using the optical fractionator probe in Stereo Investigator, the researchers quantified the number of Nissl stained neurons and glial cells, and calculated astrocyte density. The results showed twenty-five percent more neurons and twenty-one percent more glia in the denate gyrus of lithium-treated mice. They also performed a stereological examination of another brain region – the medial prefrontal cortex (mPFC), but did not witness significant differences between lithium-treated and control mice in this area.

“In this study, particular cortical regions, ie. the fascia dentata in the hippocampus and the mPFC in the cerebral cortex needed to be selected in histological sections of the mice brains,” explained Dr. Harry B.M. Uylings, “therefore the stereological counting procedure applied was the best one. Stereo Investigator greatly assisted in the counting of cells, and the software’s excel data-output was especially beneficial.”

According to the paper, the findings present a more detailed picture of lithium-induced alterations in the dentate gyrus cellular phenotype than previously available, and provide the first evidence for lithium-induced increases in glia and astrocytes.

The authors also explain that while cell number increased in the dentate gyrus of lithium-treated mice, the region’s overall volume as well as that of the greater hippocampus was unaffected by the element. The volume of the dentate gyrus and the hippocampus as a whole was measured with the Cavalieri method in Stereo Investigator.  The researchers describe the dissociation between cell proliferation and volume as “an interesting observation that warrants further investigation.”

Rajkowska, G., Clarke, G., Mahajan, G., Licht, C.M., van de Werd, H.J., Yuan, P., Stockmeier, C.A., Maji, H.K., Uylings, H.B., Differential effect of lithium on cell number in the hippocampus and prefrontal cortex in adult mice: a stereological study. Bipolar Disord. 2016 Feb;18(1):41-51. doi: 10.1111/bdi.12364.

Researchers cited MBF systems in 12 papers during the week of 9/5/2016

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Cai, Y., Chew, C., Muñoz, F., & Sengelaub, D. R. (2016). Neuroprotective effects of testosterone metabolites and dependency on receptor action on the morphology of somatic motoneurons following the death of neighboring motoneurons. Developmental Neurobiology, n/a-n/a. doi: 10.1002/dneu.22445

Langenfurth, A., Gu, S., Bautze, V., Zhang, C., Neumann, J. E., Schüller, U., . . . Glass, R. (2016). Decreased demand for olfactory periglomerular cells impacts on neural precursor cell viability in the rostral migratory stream. Scientific Reports, 6, 32203. doi: 10.1038/srep32203

Lee, Y.-S., Wu, S., Livingston Arinzeh, T., & Bartlett Bunge, M. (2016). Enhanced noradrenergic axon regeneration into Schwann cell-filled PVDF-TrFE conduits after complete spinal cord transection. Biotechnology and Bioengineering, n/a-n/a. doi: 10.1002/bit.26088.

Morita, T., Sasaki, M., Kataoka-Sasaki, Y., Nakazaki, M., Nagahama, H., Oka, S., . . . Honmou, O. (2016). Intravenous infusion of mesenchymal stem cells promotes functional recovery in a model of chronic spinal cord injury. Neuroscience, 335, 221-231. doi:

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Researchers cited MBF systems in 17 papers during the week of 7/18/2016

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Chandra, G., Rangasamy, S. B., Roy, A., Kordower, J. H., & Pahan, K. (2016). Neutralization of RANTES and Eotaxin Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson Disease. Journal of Biological Chemistry, 291(29), 15267-15281. doi: 10.1074/jbc.M116.714824

Doucet-Beaupré, H., Gilbert, C., Profes, M. S., Chabrat, A., Pacelli, C., Giguère, N., . . . Lévesque, M. (2016). Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1520387113

Kalidindi, A., Kelly, S. D., Singleton, K. S., Guzman, D., Merrill, L., Willard, S. L., . . . Neigh, G. N. (2016). Reduced marker of vascularization in the anterior hippocampus in a female monkey model of depression. Physiology and Behavior. doi:

Kobayashi, K., Sano, H., Kato, S., Kuroda, K., Nakamuta, S., Isa, T., . . . Kobayashi, K. (2016). Survival of corticostriatal neurons by Rho/Rho-kinase signaling pathway. Neuroscience Letters. doi:

Lei, P., Ayton, S., Appukuttan, A. T., Moon, S., Duce, J. A., Volitakis, I., . . . Bush, A. I. (2016). Lithium suppression of tau induces brain iron accumulation and neurodegeneration. Molecular Psychiatry. doi: 10.1038/mp.2016.96.

Liang, S.-H., Yin, J.-B., Sun, Y., bai, Y., Zhou, K.-X., Zhao, W.-J., . . . Li, Y.-Q. (2016). Collateral Projections from the Lateral Parabrachial Nucleus to the Paraventricular Thalamic Nucleus and the Central Amygdaloid Nucleus in the Rat. Neuroscience Letters. doi:

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Researchers cited MBF systems in 18 papers during the week of 7/11/2016

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Baufeld, C., Osterloh, A., Prokop, S., Miller, K. R., & Heppner, F. L. (2016). High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia. Acta Neuropathologica, 1-15. doi: 10.1007/s00401-016-1595-4.

Bischoff, S., Schmidt, M., Lehmann, T., Irintchev, A., Schubert, H., Jung, C., . . . Schiffner, R. (2016). Increase of cortical cerebral blood flow and further cerebral microcirculatory effects of Serelaxin in a sheep model.  American Journal of Physiology – Heart and Circulatory Physiology.

Chou, C.-H., & Modo, M. (2016). Human neural stem cell-induced endothelial morphogenesis requires autocrine/paracrine and juxtacrine signaling. Scientific Reports, 6, 29029. doi: 10.1038/srep29029

El Massri, N., Moro, C., Torres, N., Darlot, F., Agay, D., Chabrol, C., . . . Mitrofanis, J. (2016). Near-infrared light treatment reduces astrogliosis in MPTP-treated monkeys.  Experimental Brain Research, 1-8. doi: 10.1007/s00221-016-4720-7.

Janer, A., Prudent, J., Paupe, V., Fahiminiya, S., Majewski, J., Sgarioto, N., . . . Gingras, A. C. (2016). SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome. EMBO Molecular Medicine, e201506159.

Moro, C., Massri, N. E., Darlot, F., Torres, N., Chabrol, C., Agay, D., . . . Benabid, A.-L. (2016). Effects of a higher dose of near-infrared light on clinical signs and neuroprotection in a monkey model of Parkinson’s disease. Brain Research. doi:

Petryszyn, S., Di Paolo, T., Parent, A., & Parent, M. (2016). The number of striatal cholinergic interneurons expressing calretinin is increased in parkinsonian monkeys. Neurobiology of Disease. doi:

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Researchers cited MBF systems in 18 papers during the week of 7/4/2016

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Botterill, J. J., Nogovitsyn, N., Caruncho, H. J., & Kalynchuk, L. E. (2016). Selective plasticity of hippocampal GABAergic interneuron populations following kindling of different brain regions. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24071.

Brahmachari, S., Ge, P., Lee, S. H., Kim, D., Karuppagounder, S. S., Kumar, M., . . . Ko, H. S. (2016). Activation of tyrosine kinase c-Abl contributes to α-synuclein–induced neurodegeneration. The Journal of Clinical Investigation, 126(8). doi: 10.1172/jci85456.

Dautan, D., Souza, A. S., Huerta-Ocampo, I., Valencia, M., Assous, M., Witten, I. B., . . . Mena-Segovia, J. (2016). Segregated cholinergic transmission modulates dopamine neurons integrated in distinct functional circuits. Nature Neuroscience, advance online publication. doi: 10.1038/nn.4335

Opendak, M., Offit, L., Monari, P., Schoenfeld, T. J., Sonti, A. N., Cameron, H. A., & Gould, E. (2016). Lasting Adaptations in Social Behavior Produced by Social Disruption and Inhibition of Adult Neurogenesis. The Journal of Neuroscience, 36(26), 7027-7038.

Shepard, R., Page, C. E., & Coutellier, L. (2016). Sensitivity of the prefrontal GABAergic system to chronic stress in male and female mice: Relevance for sex differences in stress-related disorders. Neuroscience. doi:

Smith, R., Puschmann, A., Schöll, M., Ohlsson, T., van Swieten, J., Honer, M., . . . Hansson, O. (2016). 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers.  Brain.

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