Researchers cited MBF systems in 10 papers during the week of 6/22/15

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Baglietto-Vargas, D., Chen, Y., Suh, D., Ager, R. R., Rodriguez-Ortiz, C. J., Medeiros, R., . . . LaFerla, F. M. (2015). Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13195.

Grodecki, J., Rao, S. S., Short, A. R., Otero, J. J., Lannutti, J. J., Sarkar, A., & Winter, J. O. (2015). Glioma-astrocyte interactions on white matter tract-mimetic aligned electrospun nanofibers. Biotechnology Progress, n/a-n/a. doi: 10.1002/btpr.2123.

Murase, S., Lantz, C., Kim, E., Gupta, N., Higgins, R., Stopfer, M., . . . Quinlan, E. (2015). Matrix Metalloproteinase-9 Regulates Neuronal Circuit Development and Excitability. Molecular Neurobiology, 1-17. doi: 10.1007/s12035-015-9295-y.

Vitek, M., Li, F., & Colton, C. (2015). Apolipoprotein E and Mimetics as Targets and Therapeutics for Alzheimer’s Disease. In G. M. Anantharamaiah & D. Goldberg (Eds.), Apolipoprotein Mimetics in the Management of Human Disease (pp. 157-182): Springer International Publishing.


Fuentealba, Luis C., Rompani, Santiago B., Parraguez, Jose I., Obernier, K., Romero, R., Cepko, Constance L., & Alvarez-Buylla, A. (2015). Embryonic Origin of Postnatal Neural Stem Cells. Cell, 161(7), 1644-1655. doi: 10.1016/j.cell.2015.05.041.

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Researchers cited MBF systems in 34 papers between 5/29/2015 and 6/19/2015

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Acabchuk, R. L., Sun, Y., Wolferz, J. R., Eastman, M. B., Lennington, J. B., Shook, B. A., . . . Conover, J. C. (2015). 3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse. JoVE(99), e52328. doi: doi:10.3791/52328.

Jin, Y., Bouyer, J., Haas, C., & Fischer, I. (2015). Evaluation of the anatomical and functional consequences of repetitive mild cervical contusion using a model of spinal concussion. Experimental Neurology, 271(0), 175-188. doi:

Kim, J. H., Yoo, B. H., Won, S. J., Choi, B. Y., Lee, B., Kim, I., . . . Suh, S. W. (2015). Melatonin Reduces Hypoglycemia-Induced Neuronal Death in Rats. Neuroendocrinology.

King, B. J., Mann-Gow, T. K., Kida, M., Plante, M. K., Perrapato, S. D., & Zvara, P. (2015). Intraprostatic ethanol diffusion: comparison of two injection methods using ex vivo human prostates. Prostate Cancer Prostatic Dis. doi: 10.1038/pcan.2015.24.

Lee, T., Chana, G., Gorry, P., Ellett, A., Bousman, C., Churchill, M., . . . Everall, I. (2015). Inhibition of catechol-O-methyl transferase (COMT) by tolcapone restores reductions in microtubule-associated protein 2 (MAP2) and synaptophysin (SYP) following exposure of neuronal cells to neurotropic HIV. Journal of Neurovirology, 1-9. doi: 10.1007/s13365-015-0354-y.

Ortega, S. B., Kong, X., Venkataraman, R., Savedra, A. M., Kernie, S. G., Stowe, A. M., & Raman, L. (2015). Perinatal chronic hypoxia induces cortical inflammation, hypomyelination, and peripheral myelin-specific T cell autoreactivity. Journal of Leukocyte Biology. doi: 10.1189/jlb.5HI0914-447R.

Radley, J. J., & Sawchenko, P. E. (2015). Evidence for involvement of a limbic paraventricular hypothalamic inhibitory network in hypothalamic-pituitary-adrenal axis adaptations to repeated stress. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23815.

Soztutar, E., Colak, E., & Ulupinar, E. (2015). Gender- and anxiety level-dependent effects of perinatal stress exposure on medial prefrontal cortex. Experimental Neurology(0). doi:

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Webinar Video: Automated 3D Neuron Reconstruction


Confocal image of a mouse cerebellum optically cleared with CLARITY. Neurons were reconstructed with Neurolucida 360.


In this webinar, Dr. Dara Dickstein, Assistant Professor at Icahn School of Medicine at Mount Sinai, and Dr. Susan Tappan, Staff Scientist and Neurolucida 360 Product Manager discuss imaging protocols and techniques for automated 3D neuron reconstruction.

Watch the webinar on YouTube

The goal is to help you develop an imaging and quantification strategy for your own research to increase the throughput of your morphologic study.

Watch this webinar to learn:

+ Different methods for tissue preparation
+ Imaging protocols optimized for automated neuron reconstruction
+ How to use Neurolucida 360 – our new automated software for achieving accurate 3D reconstructions of somas, dendrites, spines, and axons


Researchers cited MBF systems in 13 papers during the week of 5/18/15

Stereo Investigator: journal images sm

Botterill, J. J., Brymer, K. J., Caruncho, H. J., & Kalynchuk, L. E. (2015). Aberrant hippocampal neurogenesis after limbic kindling: Relationship to BDNF and hippocampal-dependent memory. Epilepsy & Behavior(0). doi:

Chocyk, A., Majcher-Maślanka, I., Przyborowska, A., Maćkowiak, M., & Wędzony, K. (2015). Early-life stress increases the survival of midbrain neurons during postnatal development and enhances reward-related and anxiolytic-like behaviors in a sex-dependent fashion. International Journal of Developmental Neuroscience(0). doi:

Fuzzati-Armentero, M.-T., Cerri, S., Levandis, G., Ambrosi, G., Montepeloso, E., Antoninetti, G., . . . Pinna, A. (2015). Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson’s disease. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13162.

He, Q., Koprich, J., Wang, Y., Yu, W.-b., Xiao, B.-g., Brotchie, J., & Wang, J. (2015). Treatment with Trehalose Prevents Behavioral and Neurochemical Deficits Produced in an AAV α-Synuclein Rat Model of Parkinson’s Disease. Molecular Neurobiology, 1-11. doi: 10.1007/s12035-015-9173-7.

Iacono, D., Geraci-Erck, M., Peng, H., Rabin, M. L., & Kurlan, R. (2015). Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses. Tremor and Other Hyperkinetic Movements.

Kotterman, M. A., Vazin, T., & Schaffer, D. V. (2015). Enhanced selective gene delivery to neural stem cells in vivo by an adeno-associated viral variant. Development, 142(10), 1885-1892. doi: 10.1242/dev.115253.

Landry, J. P., Hawkins, C., Lee, A., Coté, A., Balaban, E., & Pompeiano, M. (2015). Chick embryos have the same pattern of hypoxic lower-brain activation as fetal mammals. Developmental Neurobiology, n/a-n/a. doi: 10.1002/dneu.22299.

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Researchers cited MBF systems in 16 papers between 5/01/2015 and 5/15/2015

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Can, S., Selli, J., Buyuk, B., Aydin, S., Kocaaslan, R., & Guvendi, G. F. (2015). The Effect of Estrogen Usage on Eccentric Exercise-Induced Damage in Rat Testes. Iran Red Crescent Med J, 17(4), e22521. doi: 10.5812/ircmj.17(4)2015.22521.

Debels, H., Gerrand, Y.-w., Poon, C. J., Abberton, K. M., Morrison, W. A., & Mitchell, G. M. (2015). An adipogenic gel for surgical reconstruction of the subcutaneous fat layer in a rat model. Journal of Tissue Engineering and Regenerative Medicine, n/a-n/a. doi: 10.1002/term.2025.

Janssen, C. I. F., Zerbi, V., Mutsaers, M. P. C., Jochems, M., Vos, C. A., Vos, J. O., . . . Kiliaan, A. J. (2015). Effect of Perinatally Supplemented Flavonoids on Brain Structure, Circulation, Cognition, and Metabolism in C57BL/6J Mice. Neurochemistry International(0). doi:

Laguna, A., Schintu, N., Nobre, A., Alvarsson, A., Volakakis, N., Jacobsen, J. K., . . . Perlmann, T. (2015). Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson’s disease. Nature Neuroscience, advance online publication. doi: 10.1038/nn.4004….

Lakritz, J. R., Bodair, A., Shah, N., O’Donnell, R., Polydefkis, M. J., Miller, A. D., & Burdo, T. H. (2015). Monocyte Traffic, Dorsal Root Ganglion Histopathology, and Loss of Intraepidermal Nerve Fiber Density in SIV Peripheral Neuropathy. The American journal of pathology(0). doi:

Po, K., Siu, A.-H., Lau, B.-M., Chan, J.-M., So, K.-F., & Chan, C. H. (2015). Repeated, high-dose dextromethorphan treatment decreases neurogenesis and results in depression-like behavior in rats. Experimental Brain Research, 1-10. doi: 10.1007/s00221-015-4290-0.

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Researchers cited MBF systems in 15 papers between 4/20/2015 and 4/30/2015

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Chung, E., Kong, X., Goldberg, M. P., Stowe, A. M., & Raman, L. (2015). Erythropoietin-mediated neuroprotection in a pediatric mouse model of chronic hypoxia. Neuroscience Letters, 597(0), 54-59. doi:

Coutellier, L., Gilbert, V., & Shepard, R. (2015). Npas4 deficiency increases vulnerability to juvenile stress in mice. Behavioural Brain Research(0). doi:

Ferrigno, A., Vairetti, M., Ambrosi, G., Rizzo, V., Richelmi, P., Blandini, F., & Armentero, M.-T. (2015). Selective blockade of mGlu5 metabotropic glutamate receptors is protective against hepatic mitochondrial dysfunction in 6-OHDA lesioned Parkinsonian rats. Clinical and Experimental Pharmacology and Physiology, n/a-n/a. doi: 10.1111/1440-1681.12410.

Hakim, J. S., Esmaeili Rad, M., Grahn, P. J., Chen, B., Knight, A. M., Schmeichel, A. M., . . . Yaszemski, M. J. (2015). Positively charged oligo[poly(ethylene glycol) fumarate] scaffold implantation results in a permissive lesion environment after spinal cord injury in rat. Tissue Engineering Part A. doi: 10.1089/ten.TEA.2015.0019.

Hong, S., Washington, P., Kim, A., Yang, C.-P., Yu, T.-S., & Kernie, S. G. (2015). ApoE Regulates Injury-Induced Activation of Hippocampal Neural Stem and Progenitor Cells. Journal of Neurotrauma. doi: 10.1089/neu.2014.3860.

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Researchers cited MBF systems in 14 papers during the week of 4/13/15

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Drouin-Ouellet, J., Sawiak, S. J., Cisbani, G., Lagacé, M., Kuan, W.-L., Saint-Pierre, M., . . . Cicchetti, F. (2015). Cerebrovascular and blood–brain barrier impairments in Huntington’s disease: Potential implications for its pathophysiology. Annals of Neurology, n/a-n/a. doi: 10.1002/ana.24406.

Furlanetti, L. L., Cordeiro, J. G., Cordeiro, K. K., García, J. A., Winkler, C., Lepski, G. A., . . . Döbrössy, M. D. (2015). Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents. Neurorehabilitation and neural repair. doi: 10.1177/1545968315581419

Pan, J., Li, H., Zhang, B., Xiong, R., Zhang, Y., Kang, W.-Y., . . . Chen, S.-D. (2015). Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway. Plos one, 10(4), e0119204. doi: 10.1371/journal.pone.0119204.


Bizley, J. K., Bajo, V. M., Nodal, F. R., & King, A. J. (2015). Cortico-cortical connectivity within ferret auditory cortex. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23784.

Burke, P. G. R., Kanbar, R., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs. [10.1152/japplphysiol.00164.2015]. Journal of Applied Physiology

Fukumitsu, K., Fujishima, K., Yoshimura, A., Wu, Y. K., Heuser, J., & Kengaku, M. (2015). Synergistic Action of Dendritic Mitochondria and Creatine Kinase Maintains ATP Homeostasis and Actin Dynamics in Growing Neuronal Dendrites. The Journal of Neuroscience, 35(14), 5707-5723. doi: 10.1523/jneurosci.4115-14.2015.

Gombash, S. E., Cowley, C. J., Fitzgerald, J. A., Iyer, C. C., Fried, D., McGovern, V. L., . . . Foust, K. D. (2015). SMN Deficiency Disrupts Gastrointestinal and Enteric Nervous System Function in Mice. Human Molecular Genetics. doi: 10.1093/hmg/ddv127.

Khankan, R. R., Wanner, I. B., & Phelps, P. E. (2015). Olfactory ensheathing cell–neurite alignment enhances neurite outgrowth in scar-like cultures. Experimental Neurology, 269(0), 93-101. doi:

Liao, C.-C., DiCarlo, G. E., Gharbawie, O. A., Qi, H.-X., & Kaas, J. H. (2015). Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23783.

Lőrincz, M. L., Gunner, D., Bao, Y., Connelly, W. M., Isaac, J. T. R., Hughes, S. W., & Crunelli, V. (2015). A Distinct Class of Slow (∼0.2–2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex. The Journal of Neuroscience, 35(14), 5442-5458. doi: 10.1523/jneurosci.3603-14.2015.

Louis, E., Vonsattel, J.-P., & Faust, P. (2015). Reduced Purkinje Cell Dendritic Arborization and Loss of Dendritic Spines in Essential Tremor (S32.001). Neurology, 84(14 Supplement).t

Oyola, M. G., Zuloaga, D. G., Carbone, D., Malysz, A. M., Acevedo-Rodriguez, A., Handa, R. J., & Mani, S. K. (2015). CYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male Mice. Endocrinology, 0(0), en.2014-1786. doi: doi:10.1210/en.2014-1786.

Smafield, T., Pasupuleti, V., Sharma, K., Huganir, R., Ye, B., & Zhou, J. (2015). Automatic Dendritic Length Quantification for High Throughput Screening of Mature Neurons. Neuroinformatics, 1-16. doi: 10.1007/s12021-015-9267-4.


Castro, A., Becerra, M., Jesús Manso, M., & Anadón, R. (2015). Neuronal organization of the brain in the adult amphioxus (Branchiostoma lanceolatum): A study with acetylated tubulin immunohistochemistry. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23785.

Interactive Probe Selector for Stereology

probe selectorSelecting a probe for stereology is an important decision that should be made before you section your tissue. Some probes require thick sections and others require thin sections. We created an Interactive Probe Selector to help you choose the appropriate probe for your research. Give it a try and let us know what you think.Area and Volume Estimation in Stereo Investigator

Researchers cited MBF systems in 17 papers during the week of 4/6/15

Stereo Investigator: journal images sm

Choi, J. L., Tan, J.-K. Y., Sellers, D. L., Wei, H., Horner, P. J., & Pun, S. H. (2015). Guanidinylated block copolymers for gene transfer: A comparison with amine-based materials for in vitro and in vivo gene transfer efficiency. Biomaterials, 54(0), 87-96.

Haney, M. J., Klyachko, N. L., Zhao, Y., Gupta, R., Plotnikova, E. G., He, Z., . . . Batrakova, E. V. (2015). Exosomes as drug delivery vehicles for Parkinson’s disease therapy. Journal of Controlled Release, 207(0), 18-30. doi:

Iqbal, S., Howard, S., & LoGrasso, P. V. (2015). Serum- glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway. Molecular and Cellular Biology. doi: 10.1128/mcb.01510-14.

Meka, D. P., Müller-Rischart, A. K., Nidadavolu, P., Mohammadi, B., Motori, E., Ponna, S. K., . . . Kramer, E. R. (2015). Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. The Journal of Clinical Investigation, 125(5), 0-0. doi: 10.1172/jci79300.

Yue, M., Hinkle, K., Davies, P., Trushina, E., Fiesel, F., Christenson, T., . . . Melrose, H. (2015). Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock in mice. Neurobiology of Disease(0). doi:

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