Researchers cited MBF systems in 38 papers between 2/13/2015 and 2/27/2015

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Al-Samerria, S., Al-Ali, I., McFarlane, J. R., & Almahbobi, G. (2015). The impact of passive immunization against BMPR1B and BMP4 on follicle development and ovulation. Reproduction, REP-14-0451.

Beach, L. Q., & Wade, J. (2015). Masculinization of the Zebra Finch Song System: Roles of Oestradiol and the Z-chromosome Gene Tubulin Specific Chaperone Protein A. Journal of Neuroendocrinology, n/a-n/a. doi: 10.1111/jne.12267.

Berggren, K. L., Chen, J., Fox, J., Miller, J., Dodds, L., Dugas, B., . . . Fox, J. H. (2015). Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington’s disease. Redox Biology, 4(0), 363-374. doi:http://dx.doi.org/10.1016/j.redox.2015.02.002.

Boix, J., Padel, T., & Paul, G. (2015). A partial lesion model of Parkinson’s disease in mice – Characterization of a 6-OHDA-induced medial forebrain bundle lesion. Behavioural Brain Research(0). doi:http://dx.doi.org/10.1016/j.bbr.2015.01.053.

Chang, J. C., Leung, M., Gokozan, H. N., Gygli, P. E., Catacutan, F. P., Czeisler, C., & Otero, J. J. (2015). Mitotic Events in Cerebellar Granule Progenitor Cells That Expand Cerebellar Surface Area Are Critical for Normal Cerebellar Cortical Lamination in Mice. Journal of Neuropathology and Experimental Neurology, 74(3), 261-272.

Duan, S., Guan, X., Lin, R., Liu, X., Yan, Y., Lin, R., . . . Gu, H. (2015). Silibinin Inhibits Acetylcholinesterase Activity and Aβ Peptide Aggregation: A Dual-Target Drug for Alzheimer’s Disease Treatment. Neurobiology of Aging(0). doi: http://dx.doi.org/10.1016/j.neurobiolaging

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Stereo Investigator continues to be the leading stereology system

In 2014 researchers used Stereo Investigator in 698 peer-reviewed papers – citing it almost three times more than all other stereology systems combined. Researchers tell us they use Stereo Investigator because:

  1. it works with many different microscopes and imaging technologies
  2. it provides unbiased data about neuron populations and regions of interest
  3. of the with strong technical and research support provided by MBF Bioscience
2014

source: google scholar

Dr. Mark West, co-developer of the Optical Fractionator stereology probe and Professor of Medical Neurobiology at Aarhus University in Denmark, sums up why he thinks Stereo Investigator was cited in so many more publications than all other stereology systems combined: “Stereo Investigator is the most reliable tool for collecting unbiased stereology data. It’s backed by excellent technical and research support teams at MBF – you can call to ask about stereology probes, tissue preparation, microscope hardware, basically anything regarding your stereology study.”

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Researchers cited MBF systems in 14 papers during the week of 2/9/15

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Chen, H., Qian, K., Chen, W., Hu, B., Blackbourn, L. W. I. V., Du, Z., . . . Zhang, S.-C. (2015). Human-derived neural progenitors functionally replace astrocytes in adult mice. The Journal of Clinical Investigation, 125(3), 0-0. doi: 10.1172/jci69097.

Fields, J., Dumaop, W., Elueteri, S., Campos, S., Serger, E., Trejo, M., . . . Rockenstein, E. (2015). HIV-1 Tat Alters Neuronal Autophagy by Modulating Autophagosome Fusion to the Lysosome: Implications for HIV-Associated Neurocognitive Disorders. The Journal of Neuroscience, 35(5), 1921-1938.

Potter, M., Baxter, V., Mathey, R., Alt, J., Rojas, C., Griffin, D., & Slusher, B. (2015). Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine. Journal of Neurovirology, 1-15. doi: 10.1007/s13365-015-0314-6.

Southwell, A. L., Franciosi, S., Villanueva, E. B., Xie, Y., Winter, L. A., Veeraraghavan, J., . . . Hayden, M. R. (2015). Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease. Neurobiology of Disease(0). doi:http://dx.doi.org/10.1016/j.nbd.2015.01.002.

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Researchers cited MBF systems in 15 papers during the week of 2/2/15

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Audoy-Rémus, J., Bozoyan, L., Dumas, A., Filali, M., Lecours, C., Lacroix, S., . . . Vallières, L. (2015). GPR84 deficiency reduces microgliosis, but accelerates dendritic degeneration and cognitive decline in a mouse model of Alzheimer’s disease. Brain, Behavior, and Immunity(0). doi:http://dx.doi.org/10.1016/j.bbi.2015.01.010.

Côté, M., Poirier, A. A., Aubé, B., Jobin, C., Lacroix, S., & Soulet, D. (2015). Partial depletion of the proinflammatory monocyte population is neuroprotective in the myenteric plexus but not in the basal ganglia in a MPTP mouse model of Parkinson’s disease. Brain, Behavior, and Immunity(0). doi:http://dx.doi.org/10.1016/j.bbi.2015.01.009.

Di Giovanni, V., Walker, K. A., Bushnell, D., Schaefer, C., Sims-Lucas, S., Puri, P., & Bates, C. M. (2015). Fibroblast growth factor receptor–Frs2α signaling is critical for nephron progenitors. Developmental Biology(0). doi: http://dx.doi.org/10.1016/j.ydbio.2015.01.018.

Jackson, K. L., Dayton, R. D., Fisher-Perkins, J. M., Didier, P. J., Baker, K. C., Weimer, M., . . . Klein, R. L. (2015). Initial gene vector dosing for studying symptomatology of amyotrophic lateral sclerosis in non-human primates. Journal of Medical Primatology, n/a-n/a. doi: 10.1111/jmp.12162.http://dx.doi.org/10.1111/jmp.12162

Kodali, M., Parihar, V. K., Hattiangady, B., Mishra, V., Shuai, B., & Shetty, A. K. (2015). Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation. Sci. Rep., 5. doi: 10.1038/srep08075

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How Transplanted Stem Cells Behave in Injured Spinal Cord Tissue

A representative confocal image of spinal cord tissue fluorescently immunolabeled for SC121 in conjunction with GFAP – markers that allowed the researchers to track stem cell differentiation and migration by stereological quantification. (Image provided by study author Dr. Aileen J. Anderson)

A representative confocal image of spinal cord tissue fluorescently immunolabeled for SC121 (red) in conjunction with GFAP (green) – markers that allowed researchers to quantify stem cell differentiation and migration. (Image provided by study author Dr. Aileen J. Anderson)

Research has shown that transplanting human neural stem cells into damaged spinal cords restores locomotor function in a mouse model of spinal cord injury1. Researchers who worked on that study have published another paper examining how these neural stem cells behave in injured tissue as they aid in healing. Learning how stem cells behave in injured tissue will hopefully help researchers develop better treatments for spinal cord injuries.

In the study, researchers used Stereo Investigator to stereologically quantify the survival, migration, proliferation, and differentiation of human neural stem cells transplanted into injured and uninjured mice. Stem cells were analyzed in mouse brain tissue specimens 1, 7, 14, 28, and 98 days after transplantation. The research found that there were fewer stem cells in the injured animals compared to the uninjured animals at all time points, stem cells in injured mice localized near the center of the injury, a delay of stem cell proliferation in injured tissue led to an overall deficit of actively dividing cells, proliferation in injured mice occurred closer to the injection sites (the locations where the stem cells were injected into the mice), and the injured microenvironment increased differentiation to more mature oligodendrocytes.

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Researchers cited MBF systems in 16 papers during the week of 1/26/15

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Canneva, F., Golub, Y., Distler, J., Dobner, J., Meyer, S., & von Hörsten, S. (2015). DPP4-deficient congenic rats display blunted stress, improved fear extinction and increased central NPY. Psychoneuroendocrinology, 53, 195-206. doi: 10.1016/j.psyneuen.2015.01.007.

França, A. S. C., Lobão-Soares, B., Muratori, L., Nascimento, G., Winne, J., Pereira, C. M., . . . Ribeiro, S. (2015). D2 dopamine receptor regulation of learning, sleep and plasticity. European Neuropsychopharmacology(0). doi: http://dx.doi.org/10.1016/j.euroneuro.2015.01.011.

Hollis Ii, E. R., Ishiko, N., Pessian, M., Tolentino, K., Lee-Kubli, C. A., Calcutt, N. A., & Zou, Y. (2015). Remodelling of spared proprioceptive circuit involving a small number of neurons supports functional recovery.  Nat Commun, 6. doi: 10.1038/ncomms7079.

Pantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., . . . Berretta, S. (2015). Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala. Transl Psychiatry, 5, e496. doi: 10.1038/tp.2014.128.

Poudel, A., Savari, O., Striegel, D., Periwal, V., Taxy, J., Millis, J. M., . . . Hara, M. (2015). Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes. Endocrine, 1-10. doi: 10.1007/s12020-015-0534-9.

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Researchers cited MBF systems in 24 papers during the week of 1/19/15

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Brown, B. P., Kang, S. C., Gawelek, K., Zacharias, R. A., Anderson, S. R., Turner, C. P., & Morris, J. K. (2015). In vivo and in vitro ketamine exposure exhibits a dose-dependent induction of activity-dependent neuroprotective protein in rat neurons. Neuroscience(0).

Depboylu, C., Rösler, T. W., de Andrade, A., Oertel, W. H., & Höglinger, G. U. (2015). Systemically administered neuregulin-1β1 rescues nigral dopaminergic neurons via the ErbB4 receptor tyrosine kinase in MPTP mouse models of Parkinson disease. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.13026.

Fujita, S., Mizoguchi, N., Aoki, R., Cui, Y., Koshikawa, N., & Kobayashi, M. (2015). Cytoarchitecture-Dependent Decrease in Propagation Velocity of Cortical Spreading Depression in the Rat Insular Cortex Revealed by Optical Imaging. Cerebral Cortex. doi: 10.1093/cercor/bhu336.

Ho, W. L., Leung, Y., Cheng, S. S. Y., Lok, C. K. M., Ho, Y.-S., Baum, L., . . . Chang, R. C.-C. (2015). Investigating degeneration of the retina in young and aged tau P301L mice. Life Sciences(0). doi:http://dx.doi.org/10.1016/j.lfs.2014.12.019.

Huang, J., Jing, S., Chen, X., Bao, X., Du, Z., Li, H., . . . Fan, X. (2015). Propofol Administration During Early Postnatal Life Suppresses Hippocampal Neurogenesis. Molecular Neurobiology, 1-14. doi: 10.1007/s12035-014-9052-7.

Keeley, R. J., Burger, D. K., Saucier, D. M., & Iwaniuk, A. N. (2015). The size of non-hippocampal brain regions varies by season and sex in Richardson’s ground squirrel. Neuroscience(0). doi:http://dx.doi.org/10.1016/j.neuroscience.2014.12.077.

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Dendritic Spine Loss Reported in Schizophrenia and Bipolar Disorder

Golgi-stained human brain tissue from the dorsolateral prefrontal cortex.

Golgi-stained human brain tissue from the dorsolateral prefrontal cortex.

Schizophrenia and bipolar disorder are very different mental illnesses, but researchers are discovering evidence that the two disorders have some common pathologies. According to a recent study, a shared characteristic appears to be dendritic spine loss.

The researchers used Neurolucida to study pyramidal cells in human brain tissue from individuals with schizophrenia (n=14), individuals with bipolar disorder (n=9) and unaffected control participants (n=19). The pyramidal cells were located in the dorsolateral prefrontal cortex – a region that plays a key role in working memory. Bipolar patients showed significantly reduced spine density (10.5 percent) compared to control. Schizophrenic patients also showed lower spine density (6.5 percent), but this number just missed significance when compared to control patients. Individuals with both illnesses showed a lower number of spines per dendrite, as well as reduced dendritic length compared to controls.

To obtain these results, researchers analyzed 15 Golgi-stained pyramidal cells in each tissue sample. They used Neurolucida to reconstruct the longest dendrite on the pyramidal cells and to mark spines. After the researchers finished reconstructing the cells, Neurolucida provided them with important data about the dendrites and spines.

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Researchers cited MBF systems in 7 papers during the week of 1/12/15

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Friess, S. H., Lapidus, J. B., & Brody, D. L. (2015). Decompressive craniectomy reduces white matter injury following controlled cortical impact in mice. Journal of Neurotrauma. doi: 10.1089/neu.2014.3564.

González-Cabrera, C., Garrido-Charad, F., Roth, A., & Marín, G. J. (2015). The isthmic nuclei providing parallel feedback connections to the avian tectum have different neurochemical identities: Expression of Glutamatergic and Cholinergic Markers in the chick (Gallus gallus). Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23739. http://dx.doi.org/10.1002/cne.23739

Isgor, C., Pare, C., McDole, B., Coombs, P., & Guthrie, K. (2015). Expansion of the dentate mossy fiber–CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus. Neuroscience, 288(0), 10-23. doi: http://dx.doi.org/10.1016/j.neuroscience.2014.12.036.

Schaakxs, D., Kalbermatten, D. F., Pralong, E., Raffoul, W., Wiberg, M., & Kingham, P. J. (2014). Poly-3-hydroxybutyrate strips seeded with regenerative cells are effective promoters of peripheral nerve repair. Journal of Tissue Engineering and Regenerative Medicine, n/a-n/a. doi: 10.1002/term.1980.

Neurolucida:

Kecskes, S., Matesz, C., Gaál, B., & Birinyi, A. (2015). Neural circuits underlying tongue movements for the prey-catching behavior in frog: distribution of primary afferent terminals on motoneurons supplying the tongue. Brain Structure and Function, 1-21. doi: 10.1007/s00429-014-0988-1.

Medalla, M., & Luebke, J. I. (2015). Diversity of Glutamatergic Synaptic Strength in Lateral Prefrontal versus Primary Visual Cortices in the Rhesus Monkey. The Journal of Neuroscience, 35(1), 112-127.

Sun, C., Dayal, A., & Hill, D. L. (2015). Expanded Terminal Fields of Gustatory Nerves Accompany Embryonic BDNF Overexpression in Mouse Oral Epithelia. The Journal of Neuroscience, 35(1), 409-421.

Researchers cited MBF systems in 6 papers during the week of 1/5/15

Stereo Investigator: journal images sm

Friess, S. H., Lapidus, J. B., & Brody, D. L. (2015). Decompressive craniectomy reduces white matter injury following controlled cortical impact in mice. Journal of Neurotrauma. doi: 10.1089/neu.2014.3564.

González-Cabrera, C., Garrido-Charad, F., Roth, A., & Marín, G. J. (2015). The isthmic nuclei providing parallel feedback connections to the avian tectum have different neurochemical identities: Expression of Glutamatergic and Cholinergic Markers in the chick (Gallus gallus). Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23739. http://dx.doi.org/10.1002/cne.23739

Isgor, C., Pare, C., McDole, B., Coombs, P., & Guthrie, K. (2015). Expansion of the dentate mossy fiber–CA3 projection in the brain-derived neurotrophic factor-enriched mouse hippocampus. Neuroscience, 288(0), 10-23. doi: http://dx.doi.org/10.1016/j.neuroscience.2014.12.036.

Schaakxs, D., Kalbermatten, D. F., Pralong, E., Raffoul, W., Wiberg, M., & Kingham, P. J. (2014). Poly-3-hydroxybutyrate strips seeded with regenerative cells are effective promoters of peripheral nerve repair. Journal of Tissue Engineering and Regenerative Medicine, n/a-n/a. doi: 10.1002/term.1980.

Neurolucida:

Mihaljević, B., Benavides-Piccione, R., Guerra, L., DeFelipe, J., Larrañaga, P., & Bielza, C. (2014). Classifying GABAergic interneurons with semi-supervised projected model-based clustering. Artificial Intelligence in Medicine(0). doi: http://dx.doi.org/10.1016/j.artmed.2014.12.010.

Yin, Y.-M., Lu, Y., Zhang, L.-X., Zhang, G.-P., & Zhang, Z.-Q. (2015). Bone marrow stromal cells transplantation combined with ultrashortwave therapy promotes functional recovery on spinal cord injury in rats. Synapse, n/a-n/a. doi: 10.1002/syn.21802.