Ventral Tegmental Dopamine Initiates Fear Extinction by Activating Reward-Processing Circuits in the Amygdala
Zhang X, Flick K, Rizzo M, Pignatelli M, Tonegawa S.
Dopamine from the ventral tegmental area signals unexpected threat
TissueScope™
A fast, and versatile whole slide scanner for quantitative analysisProduct Overview
The TissueScope, engineered in collaboration with Huron Digital Pathology, is a fast and versatile whole slide scanner that is super-charged with MBF Bioscience big data handling technology to easily stream high-quality image data to quantitative analysis with all of MBF Bioscience software.
Key Benefits
- Easy to use
- Fast: <1 minute per slide, 15mm x 15mm @20X
- Sharp, clear image quality up to 40X magnification
- Scan up to twelve standard 1" x 3" slides, or any size up to 6" x 8” for unmatched versatility
- Z-Stack scanning
- Big Data Handling: File format optimized for streaming with Biolucida image server and for analysis
The best in whole slide imaging, only better.
Newly redesigned, the award-winning TissueScope LE scanner sets the standard for versatility, throughput, and ease of use. Scan up to twelve 1” x 3” brightfield slides, up to six 2” x 3” slides, or any size slide up to 6”x 8”.
| Imaging Mode | Brightfield |
| Slide Formats | 25mm x 75mm (1″ x 3″) 50mm x 75mm (2″ x 3″) Whole mount slides up to 150mm x 200mm (6″ x 8″) |
| Optical Resolution | 0.75 NA |
| Resolution (µm/pixel) | 0.2 at 40X 0.4 at 20X |
| Scan Speed | <1 minute per slide, 15mm x 15mm @20X magnification |
| File Format | Non-proprietary 24-bit RGB Pyramidal BigTIFF Uncompressed, or JPEG 2000 Compression Export to JPEG, Flat TIFF and LZW Compressed TIFF |
| Dimensions & Weight | 61cm (24.1″) Width |
| Certification | CSA/UL/CE |
| Warranty | One year |
Download TissueScope product sheet here.
TissueScope: Key Features
Rich analyses
MBF Bioscience has extensive tools and experience extracting scientifically impactful measurements from whole slide images in neuroscience and pathology research.
TissueScope: Key Features
Different slide sizes? Difficult slides? No problem.
Rely on our unique tray-based slide holder to safely scan multiple slide sizes from 1” x 3” to 6” x 8”.
Have faint tissue, chipped slides, thick slides, or multiple bar codes? We can image them.
TissueScope: Key Features
Optimize your workflow with the TissueSnap preview station
The TissueSnap preview station works with our TissueScope scanners to offload time consuming tasks such as preview scanning and batch pre-processing so the scanner can work at peak throughput and performance.
Who Is Using TissueScope?
TissueScope is used across the globe by the most prestigious laboratories.
News About TissueScope
Neuron-Specific Thalamic Connectivity Patterns Encode Spontaneous Movement in Sensory Cortex
Inácio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S.
Movement-correlated neurons in somatosensory cortex receive stronger thalamic
How Certain Movement Control Cells Go Into Overdrive and Cause Unwanted Movements in Parkinson’s
Ryan MB, Girasole AE, Flores AJ, Twedell EL, McGregor MM, Brakaj R, Paletzki RF, Hnasko TS, Gerfen CR, Nelson AB.
Cited in Peer Reviewed Scientific Publications
MBF’s utility is underscored by the number of references it receives in the worlds most important scientific publications.
Jeon, K.-I., A. Kumar, et al.
Blocking Mitochondrial Pyruvate Transport Alters Corneal Myofibroblast Phenotype: A New Target for Treating FibrosisView Publication
Wang, Z., D. Zheng, et al.
Enabling Survival of Transplanted Neural Precursor Cells in the Ischemic BrainView Publication
da Silva, S. P., C. C. M. de Castro, et al.
Neuropathological and sociodemographic factors associated with the cortical amyloid load in aging and Alzheimer’s diseaseView Publication
Wang, W., T. Sherry, et al.
An intestinal sphingolipid confers intergenerational neuroprotectionView Publication
Beers, D., D. Goniotaki, et al.
Barcodes distinguishing morphology of neuronal tauopathyView Publication
Emily, P., D. Sarah, et al.
Circuit-Specific Plasticity of Callosal Inputs Underlies Cortical TakeoverView Publication
Zhang, L., V. S. Hernandez, et al.
"Behavioral role of PACAP signaling reflects its selective distribution in glutamatergic and GABAergic neuronal subpopulations." eLife 10: e61718.View Publication
Leung, C., S. Robbins, et al. (2020).
"SPARC: Distribution of Intrinsic Cardiac Neurons in 3D Reconstructed Hearts of F344 Rat." The FASEB Journal 34(S1): 1-1.View Publication
Sullivan, A.E., Tappan, S.J., Angstman, P.J. et al.
A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling. Neuroinform (2021). https://doi.org/10.1007/s12021-021-09530-xView Publication
Frequently Asked Questions (FAQ)
Does TissueScope only work with brightfield images?
Currently, it only supports brightflield images.
How fast is the scanner?
<1 minute per slide, 15mm x 15mm at 20X magnification.
Can TissueScope accomodate different slide sizes?
Yes. Our unique tray-based slide holder safely scans multiple
slide sizes from 1” x 3” to 6” x 8”.
Can TissueScope image chipped slides?
Whether you have thick slides, chipped slides, or multiple bar codes - we can image them.
Testimonials
"I rarely have encountered a company so committed to support and troubleshooting as MBF."
"MBF Bioscience is extremely responsive to the needs of scientists and is genuinely interested in helping all of us in science do the best job we can."
"I am so happy to be a customer of your company. I always get great help related with your product or not. With the experienced members, you are the best team I've ever met. All of your staff are very kind and helpful. Thank you for your great help and support all the time."
"We’ve been very happy for many years with MBF products and the course of upgrades and improvements. Your service department is outstanding. I have gotten great help from the staff with the software and hardware."
"Our experience with the MBF equipment and especially the MBF people has been outstanding. I cannot speak any higher about their professionalism and attention for our needs."
"MBF provides excellent technical support and helps you to find the best technical tools for your research challenges on morphometry."
Robust Professional Support
Our service sets us apart, with a team that includes Ph.D. neuroscientists, experts in microscopy, stereology, neuron reconstruction, and image processing. We’ve also developed a host of additional support services, including:
- Forums
We have over 25 active forums where open discussions take place.
>> Learn More - On-Site/Training
We’ve conducted over 750 remote software installations.
>> Learn More - Webinars
We’ve created over 55 webinars that demonstrate our products & their uses.
>> Learn More
Request more Information
At MBF, we’ve spent decades understanding the needs of researchers and their labs — and have a suite of products and solutions that have been specifically designed for the needs of today’s most important and advanced labs. Our commitment to you is to spend time with you discussing the needs of your lab — so that we can make sure the solutions we provide for you are exactly what you’ll need. It’s part of our commitment to supporting you — before, during, and after you’ve made your decision. We look forward to talking with you!
