ClearScope® *coming soon*

Image Cleared Tissues of Any Size, with Unparalleled Resolution and Efficiency

ClearScope is a revolutionary light sheet theta microscope system designed to work with a wide range of cleared specimens. Its imaging technology has been developed through a collaboration between scientists at Columbia University and MBF Bioscience. ClearScope is designed to meet the unique challenges inherent to imaging cleared brain specimens with high-resolution optics suitable for distinguishing subcellular structures including dendritic spines.

ClearScope utilizes a patent pending approach called Lightsheet Theta Microscopy that provides ClearScope with important advantages over other light sheet microscopy methods:

  • Unprecedented capabilities for imaging large specimens, including tissue slabs from non-human primates and humans
  • Also ideal for smaller specimens such as whole mouse and rat brains
  • High-volumetric optical resolution over an exceptionally large lateral area to capture all the necessary details of the entire specimen
  • High speed quantitative image acquisition
  • Efficient data compression and image database management
  • Ability to map and trace neural structures and vessel using MBF's full suite of acclaimed software
  • Powerful analysis tools and techniques from MBF's unique data analysis software

ClearScope Performance Specifications


  • Objective Lens Magnifications = 20x and 10x
  • Numerical Aperture = 0.95
  • Horizontal (XY) optical resolution: 0.35 μm (20x objective), or 0.55µm (10x objective)
  • Vertical (Z) optical resolution:  0.67μm
  • Maximum Slide Size = virtually unlimited lateral dimensions
  • Maximum Imaging Depth = 8.2mm
  • Single field of view pixel resolution: 2048 x 2048 px
  • Image digitization: 16 bit
  • Laser lines: 405 / 488 / 638 / 561 / 785 nm
  • Specimen chambers for whole mouse or rat brains, tissue slabs from primates, plus custom chambers available


Compatible with many tissue clearing techniques including


Observe a 3D Whole Brain Reconstruction Acquired with LSTM

Developed, Tested, and Supported by Expert Scientists

Clear Scope has been developed through years of collaborative research between scientists at Columbia University and MBF. As with all of our products at MBF, we work directly with academic and institutional researchers to build innovative products that support the needs of the research and medical communities. We interact with our customers and collaborators daily, continuously adding features and analyses to make sure our hardware and software products are continuously improving and stay up to date with the latest scientific discoveries. To see examples of how researchers have used Light Sheet Theta Microscopy for their own research consult the following publication:

Light Sheet Theta Microscopy for High-resolution Quantitative Imaging of Large Biological Systems. Migliori B, Datta MS, Dupre C, Apak MC, Asano S, Gao R, Boyden ES, Hermanson O, Yuste R, Tomer R. bioRxiv 119289, Aug 30, 2017; doi: https://doi.org/10.1101/119289.


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