Researchers cited MBF systems in 28 papers during the week of 03/06/2017

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Akkhawattanangkul, Y., Maiti, P., Xue, Y., Aryal, D., Wetsel, W. C., Hamilton, D., . . . McDonald, M. P. (2017). Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. Genes, Brain and Behavior, n/a-n/a. doi: 10.1111/gbb.12377.

Chung, Y. C., Baek, J. Y., Kim, S. R., Ko, H. W., Bok, E., Shin, W.-H., . . . Jin, B. K. (2017). Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson/’s disease. Experimental and Molecular Medicine, 49, e298. doi: 10.1038/emm.2016.159.

Hajheidari, S., Sameni, H. R., Bandegi, A. R., & Miladi-gorji, H. (2017). Effects of prolonged abstinence from METH on the hippocampal BDNF levels, neuronal numbers and apoptosis in methamphetamine-sensitized rats. Neuroscience Letters, 645, 80-85. doi: http://dx.doi.org/10.1016/j.neulet.2017.02.051.

Krishnasamy, S., Weng, Y.-C., Thammisetty, S. S., Phaneuf, D., Lalancette-Hebert, M., & Kriz, J. (2017). Molecular imaging of nestin in neuroinflammatory conditions reveals marked signal induction in activated microglia. Journal of neuroinflammation, 14(1), 45. doi: 10.1186/s12974-017-0816-7.

Langley, M., Ghosh, A., Charli, A., Sarkar, S., Ay, M., Luo, J., . . . Kanthasamy, A. (2017). Mito-apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & redox signaling. doi: 10.1089/ars.2016.6905.

Leal-Campanario, R., Alarcon-Martinez, L., Rieiro, H., Martinez-Conde, S., Alarcon-Martinez, T., Zhao, X., . . . Macknik, S. L. (2017). Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy.  Scientific Reports, 7, 43276. doi: 10.1038/srep43276

Mao, Z., Liu, C., Ji, S., Yang, Q., Ye, H., Han, H., & Xue, Z. (2017). The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson’s Disease in Rats. Neurochemical Research, 1-12. doi: 10.1007/s11064-017-2185-0.

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Dr. Robert Ogilvie to Receive the Henry Gray Distinguished Educator Award

Dr. Ogilvie PhotoAspiring medical doctors and life science researchers in the U.S. learn histology to understand the cellular organization of tissues and organs. In the past, microscopes were the only equipment available for viewing cells and other microscopic structures in tissue specimens. Now, more and more students are learning histology with virtual microscope slides – high-resolution digital images of tissue specimens that can be viewed on a computer over the Internet.

Dr. Robert Ogilvie has been teaching histology with virtual slides for over 15 years. He is a pioneer in the field of virtual microscopy; striving to make learning histology more active and accessible to the next generation of doctors and  researchers.

Dr. Ogilvie has won numerous teaching awards throughout his 45 year teaching career, including the most recent one – the 2016 Henry Gray Distinguished Educator Award which is the American Association of Anatomists’ highest education award. He will accept the award on Tuesday, April 5 at the 129th Annual Meeting of the American Association of Anatomists that is meeting at the same time as many other societies as a part of the Experimental Biology Meeting (EB2016) in San Diego, CA. After accepting the award he will present a lecture titled ‘On the Way to Virtual’ where he will discuss his experiences using virtual microscopy to teach histology. The talk will culminate with an example of a fully online histology course he teaches using Biolucida, Blackboard, and WebMic – a virtual microscopy program he helped develop. Enrollment doubled when the course was offered online, and it remains popular for students from a wide range of majors.

Watch a six minute video that illustrates and describes the essential components of the online histology course offered by the Department of Biological Sciences at the University of South Carolina

Watch this 3 minute video of Dr. Ogilvie teaching histology with virtual slides and Biolucida

 

Researchers cited MBF systems in 19 papers during the week of 10/26/2015

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Bernstock, J. D., Lee, Y.-j., Peruzzotti-Jametti, L., Southall, N., Johnson, K. R., Maric, D., . . . Hallenbeck, J. M. (2015). A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation. Journal of Cerebral Blood Flow and Metabolism. doi: 10.1177/0271678×15609939.

Haeussner, E., Aschauer, B., Burton, G. J., Huppertz, B., Edler von Koch, F., Müller-Starck, J., . . . Frank, H.-G. (2015). Does 2D-Histologic identification of villous types of human placentas at birth enable sensitive and reliable interpretation of 3D structure? Placenta. doi: http://dx.doi.org/10.1016/j.placenta.2015.10.003.

Kumar, A., Alvarez-Croda, D.-M., Stoica, B. A., Faden, A. I., & Loane, D. J. (2015). Microglial/macrophage polarization dynamics following traumatic brain injury. Journal of Neurotrauma. doi: 10.1089/neu.2015.4268.

Nam, J. H., Park, E. S., Won, S.-Y., Lee, Y. A., Kim, K. I., Jeong, J. Y., . . . Jin, B. K. (2015). TRPV1 on astrocytes rescues nigral dopamine neurons in Parkinson’s disease via CNTF. [10.1093/brain/awv297]. Brain.

Peck, J. D., Quaas, A. M., Craig, L. B., Soules, M. R., Klein, N. A., & Hansen, K. R. (2015). Lifestyle factors associated with histologically derived human ovarian non-growing follicle count in reproductive age women. Human Reproduction. doi: 10.1093/humrep/dev271.

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First System for Imaging and Analyzing Large Mammalian Brain Tissue Installed in South Africa

Dr. Paul Manger's new system developed by MBF Bioscience for analyzing large mammalian brain specimens

Dr. Paul Manger’s new system developed by MBF Bioscience for analyzing large mammalian brain specimens

Dr. Paul Manger, Research Professor at the University of the Witwatersrand, South Africa, studies the brain anatomy of various animals to better understand the relationship between brain structure and function. Some of the mammals he studies have very large brains that don’t fit under a conventional research microscope. A team of scientists and microscopy experts at MBF Bioscience developed a new microscope system that enables Dr. Manger to analyze and image whole sections of large brain tissue. This system is the first for imaging and analyzing entire tissue sections of large mammalian brains. It will give Dr. Manger unprecedented analyses of African mammal brains and a way to share large images of tissue specimens with collaborators or a global audience. Continue reading “First System for Imaging and Analyzing Large Mammalian Brain Tissue Installed in South Africa” »

Researchers cited MBF systems in 29 papers during the week of 6/29/2015

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Allen, K. M., Fung, S. J., & Shannon Weickert, C. (2015). Cell proliferation is reduced in the hippocampus in schizophrenia. Australian and New Zealand Journal of Psychiatry. doi: 10.1177/0004867415589793

Benarroch, E. E., Schmeichel, A. M., Parisi, J. E., & Low, P. A. (2015). Histaminergic tuberomammillary neuron loss in multiple system atrophy and dementia with Lewy bodies. Movement Disorders, n/a-n/a. doi: 10.1002/mds.26287.

Cowen, S., McLaughlin, S. L., Hobbs, G., Coad, J., Martin, K. H., Olfert, I. M., & Vona-Davis, L. (2015). High-Fat, High-Calorie Diet Enhances Mammary Carcinogenesis and Local Inflammation in MMTV-PyMT Mouse Model of Breast Cancer. Cancers, 7(3), 1125-1142.

Gorris, R., Fischer, J., Erwes, K. L., Kesavan, J., Peterson, D. A., Alexander, M., . . . Brüstle, O. (2015). Pluripotent stem cell-derived radial glia-like cells as stable intermediate for efficient generation of human oligodendrocytes. Glia, n/a-n/a. doi: 10.1002/glia.22882.

Kiyota, T., Morrison, C. M., Tu, G., Dyavarshetty, B., Weir, R. A., Zhang, G., . . . Gendelman, H. E. (2015). Presenilin-1 familial Alzheimer’s disease mutation alters hippocampal neurogenesis and memory function in CCL2 null mice. Brain, Behavior, and Immunity(0). doi: http://dx.doi.org/10.1016/j.bbi.2015.06.014.

Lazzara, C. A., Riley, R. R., Rane, A., Andersen, J. K., & Kim, Y.-H. (2015). The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy. Brain Research, 1622(0), 127-136. doi:http://dx.doi.org/10.1016/j.brainres.2015.06.018.

Lv, E., Deng, J., Yu, Y., Wang, Y., Gong, X., Jia, J., & Wang, X. (2015). Nrf2-ARE signals mediated the anti-oxidative action of electro-acupuncture in an MPTP mouse model of Parkinson’s disease. Free Radical Research, 0(ja), 1-30. doi: doi:10.3109/10715762.2015.1067696.

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Researchers cited MBF systems in 14 papers during the week of 4/13/15

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Drouin-Ouellet, J., Sawiak, S. J., Cisbani, G., Lagacé, M., Kuan, W.-L., Saint-Pierre, M., . . . Cicchetti, F. (2015). Cerebrovascular and blood–brain barrier impairments in Huntington’s disease: Potential implications for its pathophysiology. Annals of Neurology, n/a-n/a. doi: 10.1002/ana.24406.

Furlanetti, L. L., Cordeiro, J. G., Cordeiro, K. K., García, J. A., Winkler, C., Lepski, G. A., . . . Döbrössy, M. D. (2015). Continuous High-Frequency Stimulation of the Subthalamic Nucleus Improves Cell Survival and Functional Recovery Following Dopaminergic Cell Transplantation in Rodents. Neurorehabilitation and neural repair. doi: 10.1177/1545968315581419

Pan, J., Li, H., Zhang, B., Xiong, R., Zhang, Y., Kang, W.-Y., . . . Chen, S.-D. (2015). Small Peptide Inhibitor of JNK3 Protects Dopaminergic Neurons from MPTP Induced Injury via Inhibiting the ASK1-JNK3 Signaling Pathway. Plos one, 10(4), e0119204. doi: 10.1371/journal.pone.0119204.

Neurolucida:

Bizley, J. K., Bajo, V. M., Nodal, F. R., & King, A. J. (2015). Cortico-cortical connectivity within ferret auditory cortex. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23784.

Burke, P. G. R., Kanbar, R., Viar, K. E., Stornetta, R. L., & Guyenet, P. G. (2015). Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs. [10.1152/japplphysiol.00164.2015]. Journal of Applied Physiology

Fukumitsu, K., Fujishima, K., Yoshimura, A., Wu, Y. K., Heuser, J., & Kengaku, M. (2015). Synergistic Action of Dendritic Mitochondria and Creatine Kinase Maintains ATP Homeostasis and Actin Dynamics in Growing Neuronal Dendrites. The Journal of Neuroscience, 35(14), 5707-5723. doi: 10.1523/jneurosci.4115-14.2015.

Gombash, S. E., Cowley, C. J., Fitzgerald, J. A., Iyer, C. C., Fried, D., McGovern, V. L., . . . Foust, K. D. (2015). SMN Deficiency Disrupts Gastrointestinal and Enteric Nervous System Function in Mice. Human Molecular Genetics. doi: 10.1093/hmg/ddv127.

Khankan, R. R., Wanner, I. B., & Phelps, P. E. (2015). Olfactory ensheathing cell–neurite alignment enhances neurite outgrowth in scar-like cultures. Experimental Neurology, 269(0), 93-101. doi:http://dx.doi.org/10.1016/j.expneurol.2015.03.025.

Liao, C.-C., DiCarlo, G. E., Gharbawie, O. A., Qi, H.-X., & Kaas, J. H. (2015). Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23783.

Lőrincz, M. L., Gunner, D., Bao, Y., Connelly, W. M., Isaac, J. T. R., Hughes, S. W., & Crunelli, V. (2015). A Distinct Class of Slow (∼0.2–2 Hz) Intrinsically Bursting Layer 5 Pyramidal Neurons Determines UP/DOWN State Dynamics in the Neocortex. The Journal of Neuroscience, 35(14), 5442-5458. doi: 10.1523/jneurosci.3603-14.2015.

Louis, E., Vonsattel, J.-P., & Faust, P. (2015). Reduced Purkinje Cell Dendritic Arborization and Loss of Dendritic Spines in Essential Tremor (S32.001). Neurology, 84(14 Supplement).t

Oyola, M. G., Zuloaga, D. G., Carbone, D., Malysz, A. M., Acevedo-Rodriguez, A., Handa, R. J., & Mani, S. K. (2015). CYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male Mice. Endocrinology, 0(0), en.2014-1786. doi: doi:10.1210/en.2014-1786.

Smafield, T., Pasupuleti, V., Sharma, K., Huganir, R., Ye, B., & Zhou, J. (2015). Automatic Dendritic Length Quantification for High Throughput Screening of Mature Neurons. Neuroinformatics, 1-16. doi: 10.1007/s12021-015-9267-4.

Biolucida:

Castro, A., Becerra, M., Jesús Manso, M., & Anadón, R. (2015). Neuronal organization of the brain in the adult amphioxus (Branchiostoma lanceolatum): A study with acetylated tubulin immunohistochemistry. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23785.

Researchers cited MBF systems in papers 18 during the week of 4/28/2014

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Aungst, S. L., Kabadi, S. V., Thompson, S. M., Stoica, B. A., & Faden, A. I. (2014). Repeated mild traumatic brain injury causes chronic neuroinflammation, changes in hippocampal synaptic plasticity, and associated cognitive deficits. Journal of Cerebral Blood Flow and Metabolism.

Bissonnette, S., Muratot, S., Vernoux, N., Bezeau, F., Calon, F., Hébert, S. S., & Samadi, P. (2014). The effect of striatal pre-enkephalin overexpression in the basal ganglia of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.12596.

Büchele, F., Döbrössy, M., Hackl, C., Jiang, W., Papazoglou, A., & Nikkhah, G. (2014). Two-step grafting significantly enhances the survival of foetal dopaminergic transplants and induces graft-derived vascularisation in a 6-OHDA model of Parkinson’s disease. Neurobiology of Disease(0).

Erin M. Gibson, David Purger, Christopher W. Mount, Andrea K. Goldstein, Grant L. Lin, Lauren S. Wood, Ingrid Inema, Sarah E. Miller, Gregor Bieri, J. Bradley Zuchero, Ben A. Barres, Pamelyn J. Woo, Hannes Vogel, and Michelle Monje.(2014).Neuronal Activity Promotes Oligodendrogenesis and Adaptive Myelination in the Mammalian Brain. Science.

Jacob, T. G., Raghav, R., Kumar, A., Garg, P. K., & Roy, T. S. (2014). Duration of injury correlates with necrosis in caerulein-induced experimental acute pancreatitis: implications for pathophysiology. International Journal of Experimental Pathology, n/a-n/a. doi: 10.1111/iep.12081.

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Popular open access virtual slide collection has a new home

We are happy to announce that Biolucida, our learning management software, is now hosting the Iowa Virtual Slidebox. This vast repository of digitized tissue specimens is open to the public and is free of charge. Virtual slides in this collection are used by educators around the world to teach histopathology and histology.

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“Educators and students will now have easier and quicker access to virtual slides from the Iowa Virtual Slidebox,” said Dr. Nathan O’Connor, Biolucida product manager. “In addition, MBF can offer fully annotated versions of these slides that highlight specific structures or areas of interest within the specimens.”

The collection was curated by Fred Dee, MD, a pathologist at the University of Iowa who is a pioneer in using virtual slides for medical education. “We created this virtual slide collection with a grant from the National Library of Medicine to provide an efficient open source alternative for histology and histopathology course directors around the world, as traditional laboratory based glass slide microscopy was beginning to disappear from curricula,” said Dr. Dee. “The Iowa Virtual Slidebox has been hosted by MBF Bioscience since 2001. We are extremely pleased that MBF Bioscience will continue that tradition with their new Biolucida software.”

Biolucida is a learning platform that uses virtual slides  ̶  high-resolution digital images of tissue specimens  ̶  to simulate the experience of using a light microscope, complete with the ability to focus in z through specimens. It supports images that are hundreds of gigabytes in size, and it is web-based so educators and students can view the slides from any computer with an internet connection.

To download the app and view the Iowa Collection on Biolucida at full resolution, free of charge, please fill out this short form.

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Researchers cited MBF systems in 17 papers during the week of 2/3/14

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Allen, J. L., Liu, X., Weston, D., Conrad, K., Oberdörster, G., & Cory-Slechta, D. A. (2014). Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson’s disease phenotype in male mice. Neurotoxicology(0).

Botterill, J. J., Fournier, N. M., Guskjolen, A. J., Lussier, A. L., Marks, W. N., & Kalynchuk, L. E. (2014). Amygdala kindling disrupts trace and delay fear conditioning with parallel changes in Fos protein expression throughout the limbic brain. Neuroscience(0).

Gulbrandsen, T. L., & Sutherland, R. J. (2014). Temporary inactivation of the rodent hippocampus: An evaluation of the current methodology. Journal of Neuroscience Methods(0).

Hamodeh, S., Baizer, J., Sugihara, I., & Sultan, F. (2014). Systematic analysis of neuronal wiring of the rodent deep cerebellar nuclei reveals differences reflecting adaptations at the neuronal circuit and internuclear level. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.23545.

Kanno, H., Pressman, Y., Moody, A., Berg, R., Muir, E. M., Rogers, J. H., . . . Bunge, M. B. (2014). Combination of Engineered Schwann Cell Grafts to Secrete Neurotrophin and Chondroitinase Promotes Axonal Regeneration and Locomotion after Spinal Cord Injury. The Journal of Neuroscience, 34(5), 1838-1855.

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Researchers cited MBF systems in 16 papers during the week of 12/16/13

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Acosta, S. A., Diamond, D. M., Wolfe, S., Tajiri, N., Shinozuka, K., Ishikawa, H., . . . Borlongan, C. V. (2013). Influence of Post-Traumatic Stress Disorder on Neuroinflammation and Cell Proliferation in a Rat Model of Traumatic Brain Injury. Plos one, 8(12), e81585. doi: 10.1371/journal.pone.0081585.

Daubaras, M., Dal Bo, G., & Flores, C. (2013). Target-dependent expression of the netrin-1 receptor, UNC5C, in projection neurons of the ventral tegmental area. Neuroscience(0).

Gabehart, K., Correll, K. A., Yang, J., Collins, M. L., Loader, J. E., Leach, S., . . . Dakhama, A. (2013). Transcriptome profiling of the newborn mouse lung response to acute ozone exposure. Toxicological Sciences. doi: 10.1093/toxsci/kft276.

Kalm, M., Roughton, K., & Blomgren, K. (2013). Lipopolysaccharide sensitized male and female juvenile brains to ionizing radiation. Cell death & disease, 4(12), e962.

Riddle, A., Maire, J., Cai, V., Nguyen, T., Gong, X., Hansen, K., . . . Back, S. A. (2013). Hemodynamic and Metabolic Correlates of Perinatal White Matter Injury Severity. Plos one, 8(12), e82940. doi: 10.1371/journal.pone.0082940.

Continue reading “Researchers cited MBF systems in 16 papers during the week of 12/16/13” »