NeuroInfo Version History

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NeuroInfo® Version 2023.2.1 (Latest Version)

Released November 2023

New Features and Enhancements

  • Added a new analysis tool for reporting experimental brain region volumes and intensities; these results can be exported to Excel
  • In the Brain Region Ontology list, subregions can be automatically selected when the region is selected
  • Markers can now be placed in the 3D visualization window
  • Improved rendering and display responsiveness for millions of markers in 3D views
  • Increased the speed of Map Experiment to Atlas for millions of markers from hours to minutes

NeuroInfo® Version 2023.1.1

Released May 2023

New Features and Enhancements

  • Image registration (alignment) to a reference brain atlas has been completely re-engineered to include new Volume Registration tools and to make registration easier to use, more dynamic, and more robust. Highlights include:
    • Using the new Register Volume process, you can align 3D volumes, either from intact, unsectioned tissue (e.g., cleared tissue) or blockface images, to a reference-brain atlas.
    • Registering 3D serial-section reconstructions to an atlas using the Register Sections set of tools has been enhanced with updated registration algorithms
    • Registration-integrated 3D visualization makes it easier to register experimental images to an atlas.
    • Atlas calibration has been incorporated into the registration process, streamlining your work.
    • New Map Atlas to Experiment tool, in combination with the updated Map Experiment to Atlas tool provides the capability to bidirectionally map experimental and atlas information.
    • New ability to assign brain regions to the left or right hemisphere
    • New ability to create and edit groups of anatomical structures of interest that can be used across experiments.
    • Updated Waxholm rat-brain atlas included
  • Faster Assemble Serial Sections (previously called the BrainMaker workflow) workflow processing to obtain 3D reconstructions from serial-section image sets.
  • Nikon ND2 and Olympus VSI image formats are now supported
  • Improved handling of multiple image formats, including CZI and some TIFF file types
  • New Pipelines ribbon houses features previously located in the Automatic section of the Registration Ribbon
  • New Batch Pipeline enables easy-to-use batch image filtering of multiple images—find it on the Pipelines ribbon
  • In the Cell detection workflow, the image source is now automatically updated based on the image modality selected

NeuroInfo® Version 2022.1.1

Released April 2022

New Features and Enhancements

  • Re-engineered BrainMaker workflow includes numerous enhancements, including a new Contact sheet that makes reordering sections easier
  • Additional image formats are now supported
  • Image selection will match between the BrainMaker workflow and the Image Organizer

NeuroInfo® Version 2021.1.4

Released September 2021

New Features and Enhancements

  • Updated image processing and handling engines that greatly increase capabilities for image analysis and image loading and saving
  • Section registration to atlases now includes a section-spacing constraint to improve the registration of brain volumes
  • Additional AI classifiers are included

NeuroInfo® 2021.1.3

Released April 2021

New Features and Enhancements:

  • Illumination correction that minimizes acquisition artifacts in fluorescent whole slide images
  • New deep learning classifiers for detecting pyramidal cells
  • Improved image loading, handling, and writing
  • Reporting and saving average and summed intensities in brain regions
  • Improved region editing in the 3D viewing window
  • Clearer progress reporting and filter strength utilization in the cell detection workflow interface
  • Faster and more stable connections to Biolucida slide servers from NeuroInfo
  • Improved section detection in whole slide images

NeuroInfo® Version 2021.1.1

Released November 2020

New Features and Enhancements:

  • Automated cell detection capabilities have been expanded
    • Improvements to the speed and accuracy
    • Now includes neural-network classifiers for intelligent identification and couting of specific neuronal subtypes
  • A new, smart image background correction enables clear visualization and interpretation of compiled brain volumes
  • New high-performance imaging engine that reads, renders, and writes big microscopy image and trace data that speeds up to 5000x faster than previous versions

NeuroInfo® Version 2020.1.1

Released November 2019

New Features and Enhancements:

  • New interface and methodology for registering series of sections through whole mouse brains
  • New technology for detecting cells in brain volumes and mapping cell coordinates to the Allen Atlas CCF for whole-brain screening of populations with objective anatomic specificity
  • Added ability to use a single section to influence the registration of other sections from the same brain
  • New tool for specifying cut orientation and spatial calibration correction for histological artifacts
  • Automated installation of the latest mouse brain atlas from the Allen Institute

NeuroInfo® Version 2019.1.1

Released April 2019

New Features and Enhancements:

  • Full specification of anatomic coordinates based on tissue cutting orientation
  • Support for Huron, HDF5, and bigTiff formants
  • Improved matching to the latest Allen Mouse Brain Atlas
  • BrainMaker workflow included; ability to save as external XMP
  • 3D automated cell detection improved speed and text number box included with the filter strength sliders
  • 3D contour tracing added
  • 3D marker placement added