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Scientific Applications & Use Cases

MBF Bioscience >  Blog > Scientific Applications & Use Cases
June 9, 2025

MBF Bioscience Introduces SLICE™: We Reimagined Light Sheet Microscopes From the Ground Up

by Pasang
in SLICE, Company News, Press Release, Microscopy Imaging Systems, MBF Products & Service Solutions, Light Sheet
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FOR IMMEDIATE RELEASE   MBF Bioscience Introduces SLICE™: We Reimagined Light Sheet Microscopes From the Ground Up   Breakthrough system combines high performance with unprecedented affordability and compact design, making cutting-edge light sheet microscopy accessible to labs of all sizes   WILLISTON, VT – June 9, 2025 – MBF Bioscience, a world leader in quantitative microscopy solutions, today announced the commercial launch of SLICE™, a revolutionary light sheet microscope that represents...

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January 23, 2025

Adaptive Optics for MBF Bioscience’s ScanImage using Phaseform’s Deformable Phase Plate Technology

by mbf_admin
in 2 Photon, Company News, Scientific Applications & Use Cases, ScanImage®, Press Release, MBF Products & Service Solutions, Additional Subject Matter, Multi-Photon Microscopy Solutions
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MBF Bioscience and Phaseform are delighted to announce a breakthrough collaboration that integrates Phaseform’s advanced Adaptive Optics (AO) solutions into MBF Bioscience’s renowned ScanImage software for multiphoton and laser scanning microscopes. This joint development opens the door for researchers across neuroscience, developmental biology, cancer research, and other fields to achieve unmatched image clarity and depth, all while preserving their existing microscopy workflows.   Seamless Adaptive Optics...

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October 2, 2024

Introducing SLICE™: A new era in low-cost, high-performance light-sheet microscopy

by Pasang
in SLICE, Company News, Scientific Applications & Use Cases, Press Release, Light Sheet
Comments

Throughout my career, I've been driven by a singular goal: to advance scientific research by making cutting-edge tools accessible to researchers worldwide. Today, I'm thrilled to share news that I believe will significantly impact our field.   In just a few days, at the Society for Neuroscience meeting in Chicago, we will be unveiling SLICE – our new affordable light sheet microscope that truly redefines what's possible...

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May 1, 2023

Light Beads Microscopy: A Breakthrough in Volumetric in vivo Brain Imaging

by Pasang
in Light Beads Microscopy, 2 Photon, ScanImage®, Scientific Applications & Use Cases, MBF Products & Service Solutions, Multi-Photon Microscopy Solutions, Microscopic Imaging & Analysis, Multi-Photon Imaging
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In their recent publication, Jeffrey Demas and co-authors introduced “Light Beads Microscopy”, an important technological breakthrough in 2 photon microscopy. The authors demonstrated how their innovative microscopy approach can be used to observe the activity of individual neurons in vivo in large volumes of mouse cortex, offering a long-sought approach to studying brain encoding.   Light Beads Microscopy is a new method of two-photon microscopy optimized for...

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May 1, 2023

Exploring the Relationship between Lifespan and Quality of Life in C. Elegans Mutants

by Pasang
in Software Applications For Quantitive Analysis, WormLab®, Scientific Applications & Use Cases, WormLab®Imaging System, MBF Products & Service Solutions, Additional Subject Matter, C.elegans Behavioral Analysis Solutions, C. Elegans, Worm Tracking
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The question of whether an increased lifespan is associated with increased quality of life has been a topic of interest in the field of aging research. While there is evidence that improved somatic maintenance in model organisms can lead to increased longevity, recent studies have suggested that long-lived mutants may actually spend a higher percentage of their lives in an unhealthy state compared to non-mutants....

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January 12, 2023

Mini2P miniature microscope and ScanImage

by Pasang
in 2 Photon, ScanImage®, Scientific Applications & Use Cases, MBF Products & Service Solutions, vDAQ, Multi-Photon Microscopy Solutions, Mini2P, Multi-Photon Imaging
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ScanImage software from MBF Bioscience, along with the accompanying vDAQ acquisition and control card with analog to digital, digital to analog, breakout board, is built to control many combinations of hardware in order to carry out in-vivo imaging on a cellular scale. This makes it possible to observe the neural activities, such as those indicated by calcium concentration or voltage changes, of specific neuronal types...

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January 12, 2023

Unprecedented study reveals structure-function adaptations in the facial nucleus of elephants

by Pasang
in Stereo Investigator®, Software & Microscope Integrated Systems, Scientific Applications & Use Cases, MBF Products & Service Solutions, Additional Subject Matter, Stereology, Optical Fractionator
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Using specimens that were collected over three decades from zoos, researchers at Humboldt University of Berlin examined facial motor control in African and Asian elephants. As described in their recent paper in Science Advances, they examined cell number, size, and position in the facial nucleus; conducted quantitative nerve tracing, and performed comparative analyses with other animals and between the two elephant types. The researchers found...

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September 28, 2022

Researchers quantify cortical cell numbers in cleared tissue with new unbiased stereology technique

by Pasang
in Software Applications For Quantitive Analysis, Scientific Applications & Use Cases, MBF Products & Service Solutions, Cleared Tissue and Whole Organ Research, Additional Subject Matter, Stereo Investigator®Cleared Tissue, Light Sheet, Optical Fractionator
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The Image Volume Fractionator probe, available in Stereo Investigator - Cleared Tissue Edition, is facilitating huge efficiency gains for quantifying the number of cells.   At Dr. Patrick R. Hof’s lab at the Icahn School of Medicine at Mount Sinai, researchers imaged the cerebral cortex using light-sheet fluorescence microscopy and quantified the number of neurons, including those that express proteins involved in Alzheimer’s disease and schizophrenia, using...

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June 28, 2022

NYU scientists use ScanImage to monitor dopamine-induced brain activity in a model of Parkinson’s disease

by Pasang
in 2 Photon, Scientific Applications & Use Cases, ScanImage®, MBF Products & Service Solutions, Additional Subject Matter, Multi-Photon Microscopy Solutions, Parkinson’s Disease, Multi-Photon Imaging
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Humans and animal species can move in controlled motion sequences because of a delicate balance in the signaling of certain neurons in the area of the brain called the striatum. In this brain region, some neurons tell muscles to move, while others tell muscles to hold steady. In the brains of patients with Parkinson’s disease, more of the neurons that signal movement are activated resulting...

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March 21, 2022

Characterizing a novel target to combat obesity

by Pasang
in WormLab®, Scientific Applications & Use Cases, WormLab®Imaging System, MBF Products & Service Solutions, Additional Subject Matter, C.elegans Behavioral Analysis Solutions, C. Elegans, Worm Tracking
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Obesity has reached epidemic levels worldwide. It is a major cause of deadly illnesses, such as diabetes, cardiovascular disease, and some cancers, and has been linked to reduced quality of life and poor mental health outcomes. Efforts to combat this epidemic have so far failed to have an appreciable impact.   Seeking novel targets with the potential to move the needle on obesity-linked cardiometabolic disorders, a research...

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