Ventura-Antunes L, Nackenoff A, Romero-Fernandez W, et al.
Cerebral amyloid angiopathy is marked by profound arteriolar degeneration and stiffening. This study links vascular smooth muscle cell loss to amyloid deposition and elevated lysyl oxidase activity. ... Read More
Gama Sosa, M.A., De Gasperi, R., Pryor, D. et al.
Repetitive low-level blast exposure triggers progressive neurovascular degeneration long after injury. Delayed inflammation and vascular remodeling drive chronic synaptic and neuronal loss. ... Read More
Yao Y, Taub AB, LeSauter J, Silver R.
The brain’s circadian clock may communicate through a previously unknown vascular route. This study identifies a novel portal system linking the suprachiasmatic nucleus to the OVLT.... Read More
Jacobsen NL, Norton CE, Shaw RL, Cornelison DDW, Segal SS.
Skeletal muscle injury triggers profound but reversible disruption of the capillary network. This study reveals how microvessels regenerate through a transient, disorganized phase before restoring normal architecture. ... Read More
Alese OM, Wilson AC, Tessier KM, Loavenbruck A, Dedeker C, Lassig AA.
Three-dimensional analysis of cutaneous microvasculature reveals structural features linked to surgical wound healing. Increased isolated vascular elements are associated with poorer post-operative outcomes. ... Read More
Brady EL, Prado O, Johansson F, Mitchell SN, Martinson AM, Karbassi E, Reinecke H, Murry CE, Davis J, Stevens KR.
The success of engineered tissues depends strongly on the host environment. This study shows that host species and implant site critically shape vascular integration and cardiomyocyte engraftment. ... Read More
Fopiano KA, Zhazykbayeva S, El-Battrawy I, Buncha V, Pearson WM, Hardell DJ, Lang L, Hamdani N, Bagi Z.
Inhibition of PDE9A improves diastolic dysfunction and restores coronary microvascular integrity in a HFpEF model. These benefits are linked to reduced oxidative stress and enhanced antioxidant defenses. ... Read More
Button EB, Boyce GK, Wilkinson A, Stukas S, Hayat A, Fan J, Wadsworth BJ, Robert J, Martens KM, Wellington CL.
Apolipoprotein A-I plays a protective role against amyloid and vascular pathology in Alzheimer’s disease. Loss of apoA-I exacerbates cortical amyloid deposition and cerebrovascular astrogliosis. ... Read More