Hrvatin S, Sun S, Wilcox OF, Yao H, Lavin-Peter AJ, Cicconet M, Assad EG, Palmer ME, Aronson S, Banks AS, Griffith EC, Greenberg ME.
Glutamatergic Adcyap1-positive neurons in the preoptic hypothalamus drive fasting-induced torpor. Activating these neurons alone is sufficient to induce hypothermia and inactivity.... Read More
Barik A, Sathyamurthy A, Thompson J, Seltzer M, Levine A, Chesler A.
A defined spinoparabrachial Tacr1 circuit selectively signals sustained, but not acute, noxious stimuli. Activation of this pathway amplifies pain while suppressing itch. ... Read More
Flanigan, M.E., Aleyasin, H., Li, L. et al.
Aggression can be intrinsically rewarding and is shaped by specific brain circuits. This study identifies an orexin-sensitive inhibitory microcircuit in the lateral habenula that promotes aggression and its rewarding properties. ... Read More
O'Neal TJ, Bernstein MX, MacDougall DJ, Ferguson SM.
Heroin-conditioned cues selectively enhance dMSN and dopamine activity while inhibiting iMSNs in the nucleus accumbens. These pathway-specific dynamics drive reward learning. ... Read More
Lange G, Gnazzo F, Faust RP, Beeler JA.
Repeated psychostimulant exposure reshapes dopamine–acetylcholine interactions in the nucleus accumbens. This study reveals sensitized, opposing adaptations in neuromodulator signaling during drug exposure. ... Read More
Hollon NG, Williams EW, Howard CD, Li H, Traut TI, Jin X.
Dopamine release is suppressed when rewards are the expected outcome of self-initiated actions. These signals reveal sequence-specific prediction errors during goal-directed behavior. ... Read More
Murphy, K. R., Farrell, J. S., Gomez, J. L., Stedman, Q. G., Li, N., Leung, S. A., Good, C. H., Qiu, Z., Firouzi, K., Butts Pauly, K., Khuri-Yakub, B. P. T., Michaelides, M., Soltesz, I., & de Lecea, L.
A fiber photometry–coupled ultrasound system enables real-time, cell type–specific neuromodulation in freely moving mice. Optimized stimulation preferentially activates inhibitory circuits in epilepsy. ... Read More