Scholler J, Jonsson J, Jordá-Siquier T, Gantar I, Batti L, Cheeseman BL, Pagès S, Sbalzarini IF, Lamy CM.
APR-native processing through pAPRica enables massive ClearScope datasets to be compressed, segmented and analyzed rapidly and accurately on standard hardware, supporting scalable whole-organ histopathology.... Read More
Dayton H, Kiss J, Wei M, Chauhan S, LaMarre E, Cornell WC, Morgan CJ, Janakiraman A, Min W, Tomer R, Price-Whelan A, Nirody JA, Dietrich LEP.
Aligned clonal architectures within P. aeruginosa biofilms define nutrient flow, metabolic zoning and antibiotic tolerance. Mutants with disrupted pili or O-antigen features lose this organization and exhibit heightened sensitivity to tobramycin.... Read More
Datta MS, Chen Y, Chauhan S, Zhang J, De La Cruz ED, Gong C, Tomer R.
Chronic ketamine induces widespread, region-specific changes in TH+ neurons and their projections, enhancing dopaminergic input to associative cortex while diminishing signaling to sensory and striatal regions.... Read More
Fay MG, Lang PJ, Denu DS, O'Connor NJ, Haydock B, Blaisdell J, Roussel N, Wilson A, Aronson SM, Angstman PJ, Gong C, Butola T, Devinsky O, Basu J, Tomer R, Glaser JR.
A fully integrated LSTM platform, ClearScope provides sub-cellular lateral resolution and uniform axial performance across large cleared specimens, independent of their XY dimensions. Automated index correction and guided scanning workflows support high-quality... Read More
Migliori B, Datta MS, Dupre C, Apak MC, Asano S, Gao R, Boyden ES, Hermanson O, Yuste R, Tomer R.
A non-orthogonal illumination design combined with synchronized light-sheet and focal-plane scanning allows LSTM to achieve deep, uniform, high-resolution imaging in large intact tissues, outperforming traditional LSFM in clarity and coverage.... Read More