The Signature System for Stereology

The Signature System for Stereology

The Gold Standard for Unbiased Stereology

Both brightfield and multi-channel fluorescent stereology research is made possible with the Stereo Investigator Signature system. With this versatile system you can:

  • Use fully integrated and automatic multi-channel fluorescence microscopy to acquire 3D images using systematic random sampling for unbiased stereology. 
  • Image data can be exported to another PC for offline analysis
  • Get accurate stereological data from tissue stained for brightfield microscopy or darkfield microscopy without having to acquire any image data.
  • Acquire 2D virtual slides (slide scanning) suitable for stereology, and then analyze the images on another computer
  • Perform 3D Serial Section Reconstructions for 3D visualization of volumes
  • Get helpful technical and research support quickly. We provide a single point of technical support for everything we provide (no pointing fingers at 3rd parties or shareware providers). Call us with your stereology questions, or any technical support question whether it's hardware or software related
Read about the Advanced System or Value Package if the Signature System doesn't fit your needs

A system for brightfield stereology configured on a Zeiss microscope



Signature systems are configured with a motorized brightfield and fluorescent microscope from a leading manufacturer. Each system is custom configured for stereology based on the needs of an individual lab or core facility, though a typical Signature system includes:

MBF Software - The Gold Standard

  • Stereo Investigator software
  • Stereo Investigator Desktop: software to acquire images at the microscope and then analyze them on another computer
  • Control module: controls the motorized microscope, including the XY stage, fluorescent illuminator, filter cubes, and motorized filter turret for optimal fully-automatic multi-channel fluorescent imaging
  • Image Stack module with fully integrated workflow for acquiring image stacks for stereology
  • 2D Slide Scanning module 
  • 3D Serial Section Reconstruction module (for reconstructing a region of interest in 3D)
  • Deconvolution module (for clarifying acquired images)
  • 4-years of Software Upgrades and technical support are included

Hardware From Leading Manufacturers

  • Custom configured, research microscope for stereology. Automatic multi-channel fluorescence microscope with high quality objective lenses, LED illumination, custom filters and motorized components. Also may include brightfield, darkfield or DIC optics
  • Dual cameras (color for brightfield and monochrome for fluorescence)
  • High-precision XYZ encoded motorized stage system
  • 64-bit PC, 32GB RAM, 1GB video card, dual 24” monitors
  • For more details on system components, please visit the hardware webpage



Personalized, Helpful Technical and Research support

  • 2-days on-site installation and training
  • 2-year warranty on hardware


    Additional Software Options


    • Neurolucida software for neuron tracing
    • Biolucida for image management and sharing can be added at any time

      Professional Technical Support

      When you call us you will speak with a person - not an automated system. Talk to us about your hardware, software, or experimental design questions. Our team includes Ph.D. neuroscientists and experts in microscopy, stereology, neuron tracing, and image processing; ready to help you over the phone or online.

      Customer Reviews

      "Stereo Investigator is the gold standard for unbiased stereology, and I can't say enough to praise the technical support provided by MBF Bioscience."
      Bob Jacobs, Ph.D.
      Colorado College
      "We've used Stereo Investigator for 10+ years. The technical support is outstanding, and the company itself is highly responsive to their customers."
      Glenn Rosen, Ph.D.
      Harvard Medical Center
      "We have used Stereo Investigator for over 10 years now. The service and technical support is always great and they keep adding new updates with more tools."
      Paula Bickford, Ph.D.
      University of South Florida

      Watch These Webinars About Stereo Investigator

      What is Bias?
      What is Bias?
      Staining for Stereology Q&A webinar with Dr. Susan Tappan
      Staining for Stereology Q&A
      Stereology concepts & probe selection - Webinar
      Stereology Concepts & Probe Selection
      Stereology Question & Answer Webinar
      Stereology Q&A session

      Still Have Questions? Just Ask!

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