Vogt J, Paul F, Aktas O, Müller-Wielsch K, Dörr J, Dörr S, Bharathi BS, Glumm R, Schmitz C, Steinbusch H, Raine CS, Tsokos M, Nitsch R, Zipp F.
Multiple sclerosis involves substantial loss of lower motor neurons, not just demyelination. This study identifies immune-mediated, TRAIL-dependent neurodegeneration as a key mechanism. ... Read More
Couto B, Forrest SL, Fearon C, Lee S, Knott S, Li J, Fox SH, Tartaglia MC, Lang AE, Kovacs GG.
Progressive supranuclear palsy shows unexpected cytotoxic T-cell infiltration in the midbrain. This immune signature distinguishes PSP from Parkinson’s disease and control brains. ... Read More
Storkebaum, E., Lambrechts, D., Dewerchin, M. et al.
Continuous delivery of VEGF provides robust neuroprotection in rat models of ALS. Motoneuron survival, neuromuscular connectivity, and lifespan are significantly preserved. ... Read More
Wu J, Kharebava G, Piao C, Stoica BA, Dinizo M, Sabirzhanov B, Hanscom M, Guanciale K, Faden AI.
Neuronal apoptosis after spinal cord injury is driven in part by E2F1/CDK1 signaling. Inhibiting this pathway significantly reduces neuronal loss and promotes neuroprotection. ... Read More
Zhang QW, Deng XX, Sun X, Xu JX, Sun FY.
Physical exercise enhances neural repair after ischemic stroke. This study shows that treadmill training promotes axon regeneration of newborn projection neurons and improves motor recovery. ... Read More
Henny P, Brown MT, Micklem BR, Magill PJ, Bolam JP.
Using integrated light and electron microscopy, this work provides precise estimates of synapse number and distribution on single neurons. The approach enables quantitative links between neuronal structure and function. ... Read More
Riudavets MA, Iacono D, Resnick SM, O'Brien R, Zonderman AB, Martin LJ, Rudow G, Pletnikova O, Troncoso JC.
Some individuals remain cognitively normal despite significant Alzheimer’s pathology. This study identifies distinctive neuronal structural features that may underlie resilience to neurodegeneration. ... Read More
Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR.
Amyloid plaque accumulation varies dramatically across commonly used AβPP transgenic mouse models. This quantitative comparison reveals large differences in plaque timing, burden, and regional distribution. ... Read More
Kreczmanski P, Heinsen H, Mantua V, Woltersdorf F, Masson T, Ulfig N, Schmidt-Kastner R, Korr H, Steinbusch HW, Hof PR, Schmitz C.
Structural vascular alterations have been proposed as contributors to schizophrenia, yet direct anatomical evidence remains limited. Using unbiased stereological methods, this study examined whether microvessel architecture is altered in key subcortical regions of the human brain. ... Read More
Gama Sosa MA, Gasperi RD, Rocher AB, Wang AC, Janssen WG, Flores T, Perez GM, Schmeidler J, Dickstein DL, Hof PR, Elder GA.
Presenilin-1 familial Alzheimer’s disease mutations cause progressive microvascular degeneration in the hippocampus. These vascular defects arise independently of amyloid plaque deposition. ... Read More