Konopaske GT, Lange N, Coyle JT, Benes FM.
Both schizophrenia and bipolar disorder displayed decreased spine density and dendritic length in layer III pyramidal neurons of the DLPFC, with marked reductions in total spines per dendrite. These structural deficits point to overlapping synaptic abnormalities across the two disorders.... Read More
Avior Y, Ron S, Kroitorou D, Albeldas C, Lerner V, Corneo B, Nitzan E, Laifenfeld D, Cohen Solal T.
Neurons generated from bupropion responders showed increased synaptic puncta, elongated dendritic spines and distinct transcriptional responses compared with nonresponders. These in vitro signatures parallel clinical outcomes and point to candidate biomarkers for personalized antidepressant selection.... Read More
Földy C, Malenka RC, Südhof TC.
Neuroligin-3 mutations disrupt tonic endocannabinoid control of inhibition at CCK basket cell synapses, revealing a shared synaptic mechanism that alters inhibitory balance independent of structural changes.... Read More
Lázaro J, Hertel M, Sherwood CC, Muturi M, Dechmann DKN.
Common shrews exhibit large, reversible seasonal shifts in brain and regional volumes, driven by neuronal shrinkage and dendritic retraction rather than altered cell counts. The hypothalamus, thalamus and select cortical and striatal regions show the strongest changes, consistent with energetic adaptation to winter conditions.... Read More
Kusnoor SV, Parris J, Muly EC, Morgan JI, Deutch AY.
Parafascicular neurons express high levels of Cbln1 and innervate medium spiny neurons, and Cbln1 deletion increases MSN spine density while leaving dendritic architecture unchanged. These findings indicate a regulatory role for Cbln1 in limiting excitatory thalamostriatal input.... Read More
Wei L, Simen A, Mane S, Kaffman A.
Early life stress suppressed LBP expression in the developing hippocampus and led to increased spine density, abnormal spine structure and impaired cognition in adulthood. LBP knockout mice showed similar synaptic and behavioral abnormalities, indicating LBP’s role in microglia-mediated synaptic refinement.... Read More
Papp T, Ferenczi Z, Szilagyi B, Petro M, Varga A, Kókai E, Berenyi E, Olah G, Halmos G, Szucs P, Meszar Z.
Diagnostic-level ultrasound modestly increases basal dendritic branching and activates mechanosensitive signaling pathways in developing cortical neurons, with repeated exposure amplifying markers of neuronal activation.... Read More
Glaser JR, Glaser EM.
Neurolucida brings precise 3D neuron tracing and morphometry to standard personal computers through integrated stage control, image combination and interactive graphics.... Read More
Van der Loos H, Glaser EM.
Neocortical pyramidal neurons can form autapses, self-synaptic loops onto their own basal dendrites that may provide a localized feedback mechanism for modulating excitatory drive.... Read More
Glaser EM, Van der Loos H.
A computerized light-microscopy system that recorded 3D coordinates and performed real-time geometric calculations enabled fast, accurate measurement of Golgi-stained neurons. The platform cut analysis time from ~24 hours to ~45 minutes and produced reproducible micron-scale measurements.... Read More