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NeuroInfo Case Studies

MBF Bioscience >  Blog > NeuroInfo Case Studies
October 15, 2006

How Certain Movement Control Cells Go Into Overdrive and Cause Unwanted Movements in Parkinson’s

by Pasang
in NeuroInfo Case Studies
Comments

Ryan MB, Girasole AE, Flores AJ, Twedell EL, McGregor MM, Brakaj R, Paletzki RF, Hnasko TS, Gerfen CR, Nelson AB.

 

A specific group of striatal direct-pathway neurons becomes hyperactive during levodopa-induced dyskinesia. Enhanced excitatory inputs and heightened D1 receptor sensitivity cause excessive firing, identifying a key circuit element that drives dyskinesia....

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October 12, 2006

Quantitative Brain-Wide Neuronal Mapping Through Three-Dimensional Reconstruction and Atlas Alignment of Serial Tissue Sections

by Pasang
in NeuroInfo Case Studies
Comments

Eastwood BS, Hooks BM, Paletzki RF, O’Connor NJ, Glaser JR, Gerfen CR.

 

Serial-section images aligned to a reference atlas enables accurate, brain-wide quantification of labeled neurons and axons. Using automated detection and multistage registration, this approach yields high-precision whole-brain maps from standard histology....

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October 10, 2006

Molecular Taxonomy Links Transcriptional Identity to Functional Specialization in Brain-Wide Spinal Projecting Neurons

by Pasang
in NeuroInfo Case Studies
Comments

Winter, C.C., Jacobi, A., Su, J. et al.

 

Single-nucleus sequencing, spatial transcriptomics, and whole-brain reconstructions reveal 76 distinct spinal-projecting neuron types. Defined by transcriptional signatures, anatomy, and physiology, these subclasses link molecular identity to specialized roles in descending motor control....

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September 20, 2006

Automated Brain Mapping Tool Helps Scientists Accurately Identify Where They’re Looking in the Brain

by Pasang
in NeuroInfo Case Studies
Comments

Tappan SJ, Eastwood BS, O’Connor N, Wang Q, Ng L, Feng D, Hooks BM, Gerfen CR, Hof PR, Schmitz C, Glaser JR.

 

NeuroInfo uses multi-stage 3D registration to align mouse brain sections to the Allen CCF v3 with expert-level accuracy. Tested across labs and imaging modalities, it provides a fast, objective, and reproducible solution for identifying brain regions. ...

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September 16, 2006

Different Brain Cells Use Different Strategies to Communicate with Movement Control Centers

by Pasang
in NeuroInfo Case Studies
Comments

Hooks BM, Papale AE, Paletzki RF, Feroze MW, Eastwood BS, Couey JJ, Winnubst J, Chandrashekar J, Gerfen CR.
 
IT-type and PT-type cortical neurons show distinct projection patterns to the striatum. IT neurons create broad, consistent corticostriatal maps, while PT neurons form more focal and variable inputs, revealing cell-type–specific organization of motor-control pathways....

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February 26, 2006

Neuron-Specific Thalamic Connectivity Patterns Encode Spontaneous Movement in Sensory Cortex

by Pasang
in NeuroInfo Case Studies
Comments

Inácio AR, Lam KC, Zhao Y, Pereira F, Gerfen CR, Lee S.

 

Movement-correlated neurons in somatosensory cortex receive stronger thalamic glutamatergic input and weaker motor cortical input than uncorrelated cells. Silencing thalamus reduces movement responses, indicating that stable movement encoding in wS1 is primarily driven by thalamic circuits....

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January 17, 2006

Ventral Tegmental Dopamine Initiates Fear Extinction by Activating Reward-Processing Circuits in the Amygdala

by Pasang
in NeuroInfo Case Studies
Comments

Zhang X, Flick K, Rizzo M, Pignatelli M, Tonegawa S.

 

Dopamine from the ventral tegmental area signals unexpected threat omission to D1-rich neurons in the basolateral amygdala. Manipulating this pathway alters extinction behavior, showing that VTA-to-BLA dopamine acts as a teaching signal that drives fear extinction memory formation....

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