Core Facilities Solution

 

The Core Facilities Solution Suite

 An entire suite of our most popular software for quantitative image analysis

MBF Bioscience now offers a unique, application-specific set of tools bundled into one comprehensive software suite. Fine-tune your research with a variety of our most popular software applications which allow you to target the specific cellular structures you want and produce superior quantitative analysis. Using automatic and editing tools within your 3D reconstructions, you have the ability to navigate across a variety of pathways with precision, accuracy and speed to achieve your results. Moving easily across the cellular landscape with a high level of control, you’ll understand why this software is the industry leader with the most comprehensive set of built in analyses, and is so much more than a generic image processing tool.

The new Core Facilities Solution Suite is now available as an annual subscription or a perpetual license  with special discounted pricing for core facilities.  The software licenses are provided on a single USB dongle and the annual subscription includes software upgrades and remote online technical support.

Benefits of the Core Facilities Solution Suite:

  • Increase the use of all your imaging instruments as our software can be used with image data from confocal, wide field, SIM, two-photon, light sheet and brightfield microscopes as well as whole slide scanners.
  • Import data easily with support for all of the most popular image file formats from Zeiss, Leica, Aperio, Olympus, Nikon, Hamamatsu, Huron and images from our new ClearScope light sheet microscope
  • Produce unbiased, quantifiable results with NIH-funded, award-winning scientific software
  • Receive full support from MBF’s technical support team, available to all users, with remote online technical support. Plus all the software has a built-in knowledge base
  • Save when you purchase all of the software as a suite rather than individual separate licenses
  • Generate a high impact with your research using MBF software tools that have helped researchers publish over 15,000 peer-reviewed papers in leading journals
  • Effortlessly move to any Windows 10 PC with the mobile license (dongle)
  • Access to 8 different software applications shown below

 

Neurolucida 360 Studio:  Quickly and accurately reconstruct neurons in 3D and obtain reliable data about the specific neuronal structures such as axons, basal dendrites, apical dendrites, and axon-carrying dendrites while generating sophisticated analyses using the built-in analysis software.

Annual subscription includes one license for Neurolucida Explorer for morphometric analysis and the following features:

  • Full 3D environment for image visualization, rotation and zooming
  • Smart manual mode for targeted manual neuron tracing in 3D
  • User-guided mode for quick and easy semi-automatic neuron tracing in 3D
  • Automatic mode for the fastest fully automatic neuron tracing in 3D
  • Clean Up feature for automatic auditing of tracing; exclusive to Studio package
  • Batch mode for unattended automatic neuron tracing of multiple image files
  • Large volume reconstruction mode for instant navigation and integrated subvolume tracing in very large images
  • Automatic dendritic spine detection, modeling, classification
  • Automatic detection and modeling of putative synapses; exclusive to Studio package
  • Automatic varicosity detection; exclusive to Studio package
  • Image montaging for automated 3D alignment of multiple 3D image stacks
  • Handles big, high-resolution brightfield & fluorescence (wide field, confocal, two-photon & light sheet) images
 

 

 

Vesselucida 360: Quickly and accurately reconstruct microvasculature in 3D and obtain reliable data about the length, connections and complexity of microvessels while generating sophisticated analyses using the built-in analysis software.

Annual subscription includes one license for Vesselucida Explorer and the following features:

  • Full 3D environment for image visualization, rotation and zooming
  • Smart manual mode for targeted manual vessel tracing in 3D
  • User-guided mode for quick and easy semi-automatic vessel tracing in 3D 
  • Automatic mode for the fastest fully automatic vessel tracing in 3D
  • Batch mode for unattended automatic vessel tracing of multiple image files
  • Handles big, high-resolution brightfield & fluorescence (widefield, confocal, two-photon & light sheet) images
 

 

 

Stereo Investigator—Microscope Edition:  Use your Stereo Investigator - Microscope Edition system to acquire a series of image stacks using systematic random sampling.  Then use your Stereo Investigator - Desktop Edition system to perform unbiased stereology offline.  You can run all the same probes for different types of analyses without having to worry that your tissue will degrade and fade. The annual subscription includes the following features:

  • Built in, unbiased analyses to :
▪ Find the number of cells in a region of interest
▪ Find the surface area of a region of interest
▪ Perform 3D serial section reconstruction and determine volume of a region of interest
 

 

Stereo Investigator—Cleared Tissue:  Perform unbiased stereology on whole or partial specimens that have been cleared using methods such as CLARITY, 3DISCO, FluoClearBABB, etc. that have been imaged using light sheet, confocal scanning, or two-photon microscopes.

  • Capability to directly read image data from:
▪ light sheet microscopes
▪ confocal microscopes
▪ two-photon microscopes
▪ 3D image stacks 
 
 

 

 

Stereo Investigator—Whole Slide Edition: Unbiased stereology for whole slide images. Specially designed for analyzing large whole slide images. The annual subscription includes the following features:

  • Capable of directly reading most common file formats from slides scanners including:
▪ Zeiss
▪ Leica\Aperio
▪ Huron
▪ Olympus
▪ Hamamatsu
 

 

TissueMakerAutomatically generate a full resolution 3D reconstruction of any organ or tissue sample from serial sections so that you can easily view cells, structures, and lesions. The software includes the following features:

  • Open and sort multiple virtual slides
  • Specify serial section order across slides
  • Automatic alignment of serial sections with option for manual intervention
  • Automatic correction of upside-down and flipped sections
  • Save registered sections as 3D volumes at selectable output resolutions
  • 3D visualization of aligned volumes
  • read all major whole-slide image file formats
 

 

 

NeuroInfo: Aligns whole slide images of experiments sections with Allen Mouse Brain Atlas, delineates anatomical regions and automatically detects cells. The software includes the following features:

  • Register serial section images of any orientation to the Allen Mouse Brain Atlas
  • Delineates anatomies in the experimental anatomic space
  • Automatic cell detection and reporting on cell number within selected anatomies
  • Corrects for distortion due to histological processing
  • Combines all image measurements to anatomies in the Allen Mouse Brain Atlas for cross-cohort, or experiment comparisons
 

 

Microfile+: Uses state-of-the-art compression methods to efficiently and accurately convert 2D and 3D images from almost any source and format into manageable, standardized experimental results. The annual subscription includes the following features:

  • Converts whole slide images, confocal stacks and standard images into the jpeg2000 format.
  • File support for open and zoomable large file, including
▪ MBF JPEG2000
▪ JPEG
▪ generic TIFF
▪ Vesalius/CaliberID TIFF
▪ Flowview Olympus TIFF
▪ OME TIFF
▪ Keyence TIFF
▪ Imaris TIFF
▪ Zeiss LSM
▪ Huron SVS
▪ Leica SVS
▪ CaliberID
▪ HDF5
▪ Imaris IMS
▪ NDPI
▪ DICOM
▪ ND2
▪ LIF
 

 

Professional Technical Support

When you call us you will speak with a person - not an automated system. Talk to us about your hardware, software, or experimental design questions. Our team includes Ph.D. neuroscientists and experts in microscopy, stereology, neuron tracing, and image processing; ready to help you over the phone or online.

Still Have Questions? Just Ask!

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