What's new

New features and improvements in version 2026

Improved acquisition speed by more that 2x in some modes.
New Image Filters interface saves time by enabling you to run selected filters sequentially and create filter sequences so you can quickly apply the same filter(s) with the same settings to other images.
New Outside Eraser filter removes fluorescent objects from the image that are external to the image volume (e.g., contaminants in the media).
New Destriping filter removes the pattern along the illumination axis created by structures in the light path that absorb or scatter light.
Image histogram now updates when previewing image filters so changes to the dynamic range and colors can be seen before applying the filters to the image.
New camera cooling controls added to Camera Settings improve ability to adequately cool the camera without introducing vibration.
New Dark-Field and Fixed-Pattern Noise corrections added to the Tissue Scan workflow and Camera Settings to remove distracting artifacts, such as hot pixels, from an image at the time of acquisition.
Improved Snapshot settings, including resolution and quality, in the 3D Visualization window provide more choices for the appearance of saved snapshots.
Legend display added for Color Maps in the 3D Visualization window enabling you to quickly decipher what each color represents.
Enhanced 3D scale bar in the 3D Visualization window.
Updated selection for Static and Depth Color Maps.
Updated setting locations in the Movies interface.

Sliders for moving the stage in X, Y, and Z now report step sizes in µm.
The Software Joystick graphics now better reflect the distance the stage will move when different controls are clicked.

New ability to control the left and right light sheet Offset using the mouse wheel.
Keyboard shortcuts to enable right and left light sheet illumination are now available.
A new Advanced checkbox enables you to toggle between basic and advanced light sheet control modes.
New controls for applying light sheet settings identified using the SLICE Alignment workflow or to save the current Adjusted settings.

A new Tone Mapping image filter is now available.

To apply the filter to a single image, go to the Image ribbon and choose Tone Mapping from the Image Filters dropdown menu.
To process multiple images, use the Batch Filter tool on the Image ribbon.

You can now re-stitch acquired image tiles into a single larger image without having to manually delete the AssemblyComplete.txt file.

New Flight Mode enables you to create movies with a first-person perspective, similar to what you would see while wearing a gaming headset.
You can now choose color-channel display on a per-clip basis.
There are two new export-resolution modes that enable you to create higher resolution movie outputs in some cases.
- High Quality Export: Exports the highest possible image quality based on available GPU memory.
- Max Quality Export: Attempts to use more than 100% of available GPU memory to export the maximum attainable video resolution.
Progress bars were added to display the progress of image loading and video export.

Go to the Movies page.

SLICE-specific metadata is now included in image files and collected in a dedicated text document within the image-acquisition folder.
The system now checks for available space on remote drives before starting image acquisition using the Tissue Scan workflow.

The SLICE Alignment workflow was added to guide users through the light sheet alignment process.
There is a new option in the Tissue Scan Workflow to change the image resolution when saving the final image. This is useful for downsampling images.
New ability to save a 3D subvolume image stack.
Additional SLICE metadata has been added to the AcquisitionSettings.txt file.