BrightSLICE User Guide

Version 2025

Overview

The system offers the power of advanced light-sheet microscopy at a fraction of the cost of conventional systems. It can achieve high quality, in-focus imaging throughout large samples.

BrightSLICE software runs the SLICE microscope.

How it works

Projected light sheet microscopy (pLSM, patents pending) is a cutting-edge imaging technique that uses dynamic, modulated light sheets for high resolution visualization of cleared samples. This innovative approach enables multi-resolution imaging, compatibility with a variety of clearing methods and minimal photobleaching making it particularly valuable for fields like developmental biology, neuroscience, and other areas requiring detailed analysis of cleared intact specimens.

SLICE embodies these advancements, delivering a compact design and user-friendly interface that makes cutting-edge imaging technology accessible to labs of all sizes.

What's new

View the release notes (PDF).

Resources

Review SLICE system laser safety recommendations.

See the list of fluorescent dyes and proteins compatible with imaging using the SLICE system.

Review our white paper, A Practical Guide to Selecting Compression Levels for 3D Light Sheet Fluorescent Microscopy Data (PDF).

Read our white paper on how to streamline handling, processing, and analyzing extensive datasets from light sheet microscopes (PDF).

More information coming soon

If you need help right away, contact our Technical Services Team:

On the web at www.mbfbioscience.com/advanced-support

Or telephone +1 (802) 288-9290, Monday–Friday, 9:00am – 5:00pm EST. Excluding US holidays