We are pleased to announce the release of Stereo Investigator^® version 2024.1.3, which introduces key updates to offline software licensing. These updates enhance the functionality and ensure uninterrupted use of the software on systems without internet access.

Key Updates

• Offline Licensing Update:
  Reactivation is now required for systems operating without internet connectivity.

• Activation Process:
  To obtain a new offline Activation Key, please fill out this webform. Detailed instructions for completing the offline authorization process will be provided.

• Support Documentation:
  Step-by-step instructions for offline activation are available in the Stereo Investigator User Guide for your convenience.

For additional support or questions, please contact our customer support team at support@mbfbioscience.com.

The post Stereo Investigator Software Update: Version 2024.1.3 appeared first on MBF Bioscience.

The facial nucleus, present in vertebrate animals, is a group of neurons in the brainstem that receives instructions from neurons in the cortex to direct movement of the muscles of the face. For this paper, the authors characterized the facial nucleus of two similar species, African and Asian elephants, with muscular, dexterous trunks. These species’ faces share many similarities, but have distinctly different ear size and trunk morphology—areas controlled by the facial nucleus. The authors used varied methods, matched to the available elephant material, including Nissl staining, cell counting, axonal osmium tetroxide stains, somata drawings, cell fiber counting, and nerve tracing to examine the facial nucleus in specimens from African (n=4) and Asian elephants (n=4 elephants). Stereo Investigator^® software was used to acquire images of thin sections, conduct stereological procedures, and measure cell size and axon diameter.

Two methods were used to quantify cell populations in the elephant facial nucleus, an unbiased stereology approach and a model-based stereology strategy that consisted of complete counts of cell pieces in every tenth section were used. Using unbiased stereology, the researchers counted ~200-300 cells per specimen with the Stereo Investigator optical fractionator probe. To confirm their results, the research team next counted ~5000–8,000 cells and cell fragments per specimen, then corrected for double-counted cells. The results were equivalent; however, the unbiased stereology approach was much less time consuming.

The researchers found that the facial nucleus in elephants is much larger than in most mammals and it is comprised of approximately five-fold more neurons, but at significantly lower neuronal density. African elephants were found to have more neurons in the medial facial subnucleus than Asian elephants, consistent with their much larger and more expressive ears. Dorsal and lateral facial subnuclei, which control movement of the trunk, were elongated compared to other vertebrate mammals and contained many more neurons than land-based species. Interestingly, these regions had a distinct proximal-to-distal cells size increase. Comparison with other species and between newborn and adult elephants suggest that this increase in size is needed for to support the extreme axonal volumes associated with trunk innervation. These cell-size gradients were found to be a unique feature of the elephant facial nucleus. Finally, the research team identified a high-density motor fovea that they believe are associated with the tip of the trunk in African elephants. Asian and African elephants’ trunks differ in that Asian elephants have one dorsal trunk finger and they tend to engage much of their trunk in grasping objects by wrapping them in their trunks, whereas African elephants’ trunks have dorsal and ventral fingers that are often used to pinch objects. Their work suggests that African elephants have more neurons associated with the trunk tip than do Asian elephants and that control of African elephants’ trunk fingers resides in the motor foveae they identified.

The research described here relied heavily on cell-count data that was most efficiently obtained using the optical fractionator probe in Stereo Investigator^®. The authors found strong relationships between the number, density, and size of neurons and the position and function of elephant facial morphology. Their results pose interesting avenues for future research, including the role of ear movement in “auditory and infrasound perception” and follow-up studies on the cell-size differences found in the putative trunk representation in the facial nucleus and how these differences may be involved with elephants’ presumed need to compensate for inherent nerve conduction delays associated with their large size.

Learn more about industry-leading Stereo Investigator^® systems for image acquisition and stereological studies.

View our webinar that introduces Stereo Investigator^® and unbiased stereology.

Reference:

Kaufmann, L. V., Schneeweiß, U., Maier, E., Hildebrandt, T., & Brecht, M. (2022). Elephant Facial Motor Control. Science Advances, 8(43). https://doi.org/10.1126/sciadv.abq2789

The post Unprecedented study reveals structure-function adaptations in the facial nucleus of elephants appeared first on MBF Bioscience.

The file format is used in our products for neuroscience research for important applications such as digital neuron tracing, brain mapping and stereological analyses. MBF Bioscience products, including Neurolucida, Neurolucida 360, Stereo Investigator, Vesselucida 360, and NeuroInfo use this neuromorphological file format.

This file format has evolved over several decades through input and requests from many scientists who’ve been using our products. The current format is truly a collaborative effort between MBF and our users.

“We are very pleased to have received this endorsement from the INCF. It recognizes our ongoing efforts in supporting open and FAIR neuroscience, and our commitment to supporting neuroscience researchers. We’ve established rigorous standards and processes for the file format so that it can be confidently used by the entire research community”, said Jack Glaser, President of MBF Bioscience.

What does this mean for researchers who use MBF products? It expands opportunities for data sharing between individual researchers, laboratories, and within larger collaborative research initiatives. Also, it will be easier for third-party software tools to be developed and maintained that extend the usefulness of the data generated by MBF products.

The official INCF announcement stated, “The committee is pleased to see an open format from a commercial entity go through the endorsement process, and applaud MBF Bioscience for taking this very important step in support of open and FAIR neuroscience. The committee considers the governance process for MBF Bioscience’s neuromorphological file format to be well elaborated, with a sufficient mechanism for the user community to request format updates.”

MBF Bioscience and the INCF will work together to further improve the FAIRness of the standard, including implementation of the governance policy and modification of the standard’s license from the CC-BY-ND-NC to a CC-BY-ND.

The standard number is INCFSN-22-01.

Read the review report, with community feedback in comments: https://f1000research.com/documents/10-712

Read the full INCF endorsement here: https://www.incf.org/blog/incf-endorses-mbf-neuromorphological-file-format

Read a recent publication on the format:

A.E. Sullivan, S. J. Tappan, P. J. Angstman, A. Rodriguez, G. C. Thomas, D. M. Hoppes, M. A. Abdul-Karim, M. L. Heal & Jack R. Glaser. A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling. Neuroinform (2021). https://doi.org/10.1007/s12021-021-09530-x

The post INCF endorses the MBF Bioscience neuromorphological file format appeared first on MBF Bioscience.

Babies with IUGR may develop health problems such as low resistance to infection. They may also have a hard time handling the stress of a vaginal birth. One possible cause of IUGR is that the fetus is not getting enough nutrients from the placenta.

In order to learn more about the structural differences in placentas in normal versus IUGR pregnancies, scientists at the Ludwig Maximilian University of Munich used Stereo Investigator to image tissue in both cases–finding that there are indeed quantifiable differences between the two.

One main difference is that the villi, the finger-like structures that allow nutrients and oxygen to flow from the mother to the baby, are smaller in volume in IUGR cases. Of the two types of villi present in a pregnancy, only one type—the contractile villi (the ones with muscle cells in their surrounding sheaths) were smaller. There was no difference in size between non-contractile villi in normal and IUGR placentas.

The figure shows Tukey plots of core clinical and gross anatomic data.

IUGRHowever, in both types of villi in IUGR placentas, the researchers observed reduced blood vessel volume, longer diffusion distances (distance from fetal to maternal blood), and less branching.

To achieve these results, the researchers extracted six tissue samples from 21 placentas (10 normal, 11 IUGR), and used an MBF Bioscience system comprising microscope, motorized stage, camera, z-encoder, and Stereo Investigator to image samples.

“This combination of software and hardware in the Stereo Investigator system makes it possible to image the tissue sections using systematic random sampling and perform unbiased stereology probes to estimate the percent by volume of different components of the placenta, the amount of branching of the villi, and the diffusion distance. The system allows for unbiased estimates in an efficient manner,” says MBF Bioscience Staff Scientist Dr. Dan Peruzzi.

In their study, the Munich researchers combined three Stereo Investigator probes, including the area fraction fractionator probe (used to estimate percentage by volume) and the probe used to measure diffusion distance, in a novel way.

Citation:

Barapatre, N., Kampfer, C., Henschen, S., Schmitz, C., Edler von Koch, F., Frank, H.G., Growth restricted placentas show severely reduced volume of villous components with perivascular myofibroblasts. Placenta, (109) 2021. https://doi.org/10.1016/j.placenta.2021.04.006

The post Differences Associated with Fetal Growth Restriction are Found Using Stereo Investigator appeared first on MBF Bioscience.

Set for release this spring, the new and improved Stereo Investigator will include a new imaging engine, display engine, automatic camera alignment, automatic lens calibration, the double disector, and live video zooming.  

“I’m excited to say that Stereo Investigator keeps getting better in so many ways. What is common among all these new features is increased functionality, more efficiency and better performance,” says MBF Bioscience Product Manager Nathan Liese.  

The new imaging engine will especially help working with large images, whether they are from the SRS image acquisition, confocal or light sheet microscopes. “Users will be amazed by how much faster they can work with their images”, says Nathan. 

The software’s new automatic alignment and calibration features will be game-changers for researchers with large turn over, especially for those working in core facilities and large labs with many users.  

These new features eliminate the time-consuming process of manually aligning the camera and calibrating lenses. The new automatic camera alignment and calibration functionality promises to convert a formerly complex process that previously could take five to 20-minutes, to a simple one that takes a few minutes. 

Two other new features: Double Disector and Live Video Zooming were specific requests from our users, and help make Stereo Investigator an even more comprehensive tool for stereology studies. Double Disector facilitates the counting process in cases where populations of multiple types need to be quantified within the same study, and Live Video Zooming offers the added convenience of digital zooming to examine hard to see objects.  

Overall Stereo Investigator’s new imaging engine and new tracing engine make the software more powerful than ever, with the ability to handle larger images, load data files much faster, open and save files faster, and more effectively use your computer’s resources. 

The post Stereo Investigator Microscope Edition Gets New Imaging Engine, Automatic Alignment, and More appeared first on MBF Bioscience.

Some inflammation is normal in a healthy mammalian brain. But as the brain ages, processes can break down, leading to chronic neuroinflammation. This can develop into Alzheimer’s disease, dementia, and other neurodegenerative diseases.

Scientists at Prof. Gerald Muench’s lab, at Western Sydney University say that curcumin, a substance in the spice turmeric, has the potential to lower inflammation in the brain.

In two recent studies, the researchers, led by Dr. Erika Gyengesi, used Stereo Investigator and Neurolucida 360 to reconstruct and quantify glial cells in the brains of mice after feeding them two different curcumin formulations.

“MBF Bioscience’s software helped us immensely to differentiate and follow the changes caused by chronic microglia activation in various areas of the brain during aging, but also to quantify the effects of different modified curcumin products, which otherwise would have been impossible,” said Dr. Gyengesi.

In a study published February, 2020 in Scientific Reports: “Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model,” (Ullah et al, 2020), the researchers describe positive results after feeding GFAP-IL6 mice — a mouse model of chronic neuroinflammation — 500 ppm of Longvida® Optimised Curcumin (LC) over a course of six months.

Effect of MC on the morphological characteristics of microglial cells in the hippocampus. (A) Morphological assessment of reactive and non-reactive microglia in the hippocampus. (B–H) Microglia in the inflamed mice have significantly larger soma area, soma perimeter and processes compared with the WT mice. High dose MC significantly reduced soma area and soma perimeter compared with GFAP-IL6 mice. However, the same high dose MC significantly increased the number of nodes compared with the GFAP-Il6 mice. It has no effect on the convex area, convex perimeter, dendritic length and number of processes. Significance = *p < 0.05, **p < 0.001, ***p < 0.0001, ****p < 0.0001.

Stereological analysis of the mouse brains revealed lower levels of activated microglia in the hippocampus (26 percent less) and in the cerebellum (48 percent less) in GFAP-IL6 mice that were fed the curcumin diet, compared to GFAP-IL6 mice fed a normal diet. They also quantified astrocytes — another cell type activated in response to neuroinflammation, finding decreased levels in the hippocampus (30 percent less). TSPO+ cells — another marker of brain inflammation, decreased as well (by 24 percent in the hippocampus and 31 percent in the cerebellum) in the experimental mice compared to controls.

Dr. Gyengesi and her team then checked to see what effect the curcumin formulation had on cell morphology. Using Neurolucida 360 they reconstructed 16 to 20 astrocytes in the hippocampus of each brain of the four different cohorts (wild type normal-fed, wild type LC-fed, GFAP-IL6 normal-fed, GFAP-IL6 LC fed).

They found that in GFAP-IL6 mice, LC decreased “dendritic length of microglia and the convex area, convex perimeter, dendritic length, nodes and number of processes of astrocytes in the hippocampus.” The curcumin formulation also decreased the unusually enlarged soma area and perimeter of neurons in the cerebellum. Increased pre- and postsynaptic protein levels and improved balance were observed as well in LC-fed GFAP-IL6 mice.

In another study, published by the group earlier this year, in the journal Frontiers in Neuroscience, “Evaluation of Phytosomal Curcumin as an Anti-inflammatory Agent for Chronic Glial Activation in the GFAP-IL6 Mouse Model” (Ullah et al, 2020), the researchers tested a different curcumin formulation. This time, they fed GFAP-IL6 mice a soy-lecithin based phytosomal curcumin formulation (Meriva® curcumin).

After feeding the GFAP-IL6 mice three doses of Meriva curcumin over a period of just four weeks, they saw promising results. They quantified lower numbers of activated microglia in the hippocampus (26.2 percent less) and in the cerebellum (48 percent less) compared to those in the population of GFAP-IL6 mice, which was fed a normal diet. Lower levels of GFAP+ astrocytes were also observed in this group.

As in the previous study, the scientists witnessed morphological differences in the mice fed the curcumin diet, including a decrease in the size of the already enlarged soma.

“Using Neurolucida and Stereo Investigator, we have demonstrated that various curcumin formulations with increased bioavailablity have the capability to attenuate chronic inflammatory pathology, by not only reducing activated glial numbers but also reversing their activated morphological state,” said Dr. Gyengesi.

Citations:

Ullah F, Asgarov R, Venigalla M, Liang H, Niedermayer G, Münch G, Gyengesi E. Effects of a solid lipid curcumin particle formulation on chronic activation of microglia and astroglia in the GFAP-IL6 mouse model. Sci Rep. 2020;10(1):2365. Published 2020 Feb 11. doi:10.1038/s41598-020-58838-2 https://pubmed.ncbi.nlm.nih.gov/32047191/

Ullah F, Liang H, Niedermayer G, Münch G, Gyengesi E. Evaluation of Phytosomal Curcumin as an Anti-inflammatory Agent for Chronic Glial Activation in the GFAP-IL6 Mouse Model. Front Neurosci. 2020;14:170. Published 2020 Mar 12. doi:10.3389/fnins.2020.00170 https://pubmed.ncbi.nlm.nih.gov/32226360/

The post Curcumin Lowers Neuroinflammation in Mouse Model appeared first on MBF Bioscience.

Today, the journal Science published a paper authored by a research team led by Dr. Ed Boyden of MIT and Nobel Prize recipient Dr. Eric Betzig of Janelia Research Campus. Among the authors are MBF Bioscience Scientific Director Dr. Susan Tappan and Senior Software Engineer Alfredo Rodriguez. In the paper, the researchers introduce new analyses for neural circuits at nanoscale resolutions.

Combining microscopy methods that create high resolution 3D images from whole brains and tissue that have been made physically larger, the researchers imaged a mouse cortex and fruit fly brain in their study “Cortical column and whole-brain imaging of neural circuits with molecular contrast and nanoscale resolution (Gao et al, 2019).”

By creating enhanced processing and analysis tools in MBF Bioscience’s Stereo Investigator and Neurolucida 360 software, Dr. Tappan and Mr. Rodriguez analyzed these images to obtain comprehensive morphometrics of delicate dendritic spines at a greater accuracy than ever before.

GAO ET AL./SCIENCE 2019

“We combined expansion microscopy and lattice light sheet microscopy (ExLLSM) to image the nanoscale spatial relationships between proteins across the thickness of the mouse cortex or the entire Drosophila brain, including synaptic proteins at dendritic spines, myelination along axons, and presynaptic densities at dopaminergic neurons in every fly neuropil domain.” (Gao et al, 2019)

While several forms of microscopy exist that have the ability to image subcellular neural elements, scientists say that each of these methods is lacking in one way or another. According to the paper, the combination of expansion microscopy with lattice-light sheet microscopy gives the most effective results, while considerably decreasing the time spent carrying out the experiment.

“I believe this type of imaging represents a major milestone in terms of the accuracy that can be achieved in dendritic spine morphometry from light microscopy,” Mr. Rodriguez said.

In their part of the study, Dr. Tappan and Mr. Rodriguez first confirmed that physically increasing the size of the tissue did not cause damage to the internal structure, by analyzing 1,500 dendritic spines in seven layers of the mouse cortex that had undergone expansion. The larger spine heads and necks observed in layers four and five (closest to the somata) compared to layers two, three, and six, were consistent with measurements achieved in earlier studies.

“Confirming that dendritic spine morphometry results are in agreement with previously published scientific literature is essential to demonstrate that the expansion microscopy technique doesn’t alter the tissue in damaging ways,” explained Dr. Tappan. “This demonstrates the utility of the technique for permitting accurate measurements of these very small features.”

In order to ensure the technology would be capable of analyzing these extremely high-resolution images with accuracy, MBF Bioscience enhanced Neurolucida 360 so that the software would take advantage of the increased resolution rendered by the ExLLSM data. With the upgraded technology, Dr. Tappan and Mr. Rodriguez were able to more accurately reconstruct dendritic spines and obtain new morphometric values, such as spine neck diameter, for the first time. The enhanced software also gave them the ability to observe and measure the entire neck of the dendritic spine, identify each point where the spine attaches to its dendrite, and measure the extent of the head and neck along the spine backbone. While these measurements had been computed before, Mr. Rodriguez explained that the technology’s ability to offer such a high resolution allowed for more accurate results.

To address the possibility that such high-resolution data might result in intracellular structures appearing granular, the developers integrated appropriate imaging filters into Neurolucida 360 to smooth the labeled dendritic structures prior to 3D reconstruction.

While the research team at MBF Bioscience focused on dendritic spine analysis in the mouse cortex, the study also describes a host of other analyses in this brain region, including the quantification of lysosomes and mitochondria, synaptic proteins, and the analysis of axon myelination patterns. In addition, the researchers imaged an entire fruit fly brain and traced neurons projecting into the part of the brain responsible for sleep, navigation, and visual memory. They also analyzed the axonal branches of olfactory projection neurons, observing differences in number and size of boutons — the tiny vesicles at axon terminals — in five different fruit fly brains. Finally, they measured distances between synapses, calculating density differences in various regions of the brain.

“It’s an exciting example of how big data is transforming science in unprecedented ways and it’s amazing to be right there at the forefront of it all,” said Dr. Tappan. “At MBF Bioscience, we are committed to innovating our methods and analyses to keep pace with the driving forces of scientific research.”

R.Gao, S. M. Asano, S. Upadhyayula, I. Pisarev, D. E. Milkie, T. Liu, V. Singh, A. Graves, G. H. Huynh, Y. Zhao, J. Bogovic, J. Colonell, C. M. Ott, C. Zugates, S. Tappan, A. Rodriguez, K. R. Mosaliganti, S. Sheu, H. A. Pasolli, S. Pang, C. S. Xu, S. G. Megason, H. Hess, J. Lippincott-Schwartz, A. Hantman, G. M. Rubin, T. Kirchhausen, S. Saalfeld, Y. Aso, E.S. Boyden, E. Betzig. “Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution.” Science. Published online January 17, 2019. doi: 10.1126/science.aau8302

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Analyzing cellular populations within specific anatomies in brain images requires expertise in both neuroanatomy and cellular identification. This typically involves a scientist comparing experimental images with a reference atlas and manually delineating anatomical regions and marking cell populations within. NeuroInfo^®, a revolutionary new technology from MBF Bioscience, enables researchers to automatically identify and delineate mouse brain regions based on the publicly available Allen Mouse Brain Reference Atlas.

“NeuroInfo has the potential to greatly improve our understanding of how mental disorders influence neuronal cell populations,” says Nathan O’Connor Ph.D., product manager at MBF Bioscience. “Because it makes identifying brain regions substantially faster and more accurate, researchers will be able to explore many more brain regions.”

“The Allen Mouse Brain Reference Atlas is a valuable tool to assist scientists in their research. We’re thrilled that MBF has chosen to integrate this resource into NeuroInfo,” stated Amy Bernard, Ph.D., Product Architect at the Allen Institute for Brain Science.

“Using this remarkable technology, neuroscientists will obtain more repeatable, objective analyses that have been possible to date. Thanks to the integration with the Allen Mouse Brain Reference Atlas, these analyses will be more standardized so that they can be compared across experiments and laboratories,” says Jack Glaser, President.

NeuroInfo can be used with MBF Bioscience’s slide scanning software and virtually all commercial whole slide scanners. The data from NeuroInfo seamlessly integrates with MBF Bioscience’s products including Neurolucida, Stereo Investigator, Biolucida, and BrainMaker.

The tools in NeuroInfo allow researchers to automatically delineate anatomies in the experimental specimens, and detect cells within these anatomies. NeuroInfo yields data that can be invaluable to better understand the organization and composition of the nervous system, and to further knowledge in neurogenomics, transcriptomics, proteomics, and connectomics.

The National Institute of Mental Health provides funding to support the development of NeuroInfo.

The post MBF Bioscience unveils whole mouse brain automatic region delineation and cell mapping with the Allen Mouse Brain Reference Atlas appeared first on MBF Bioscience.

DNA damage occurs in human cells at a constant rate. These cells are usually able to repair themselves, but sometimes deficiencies in certain genes cause the repair process to shut down. When damaged DNA isn’t fixed, mutations can occur that cause accelerated aging or cancerous tumors to form (Hoeijmakers, 2009). Scientists at Erasmus University Medical Center in Rotterdam have found a way to slow down the process – at least in mice.

In a study published in Nature, the researchers report that when mice deficient in the DNA-repair genes Ercc1 or Xpg are put on a restricted diet, they experience better overall health and increased lifespans compared to DNA-repair-deficient mice fed a normal diet. They also found significantly lower levels of neurodegeneration in the brains and spinal cords of diet restricted animals compared to controls.

“Here we report that a dietary restriction of 30 percent tripled the median and maximal remaining lifespans of these progeroid mice, strongly retarding numerous aspects of accelerated aging Mice undergoing dietary restriction retained 50 percent more neurons and maintained full motor function far beyond the lifespan of mice fed ad libitum,” (Vermeij, et al 2016).

Since the DNA-repair-deficient mice were already smaller and weaker than normal mice, the Rotterdam researchers wondered whether diet restriction would be beneficial or detrimental to their health. They found that gradually restricting the diets of DNA-repair-deficient mice starting at age seven weeks increased their median lifespans from 10 to 35 weeks in males and 13 to 39 weeks in females as compared to controls.

They also saw significant differences in the levels of neurodegeneration between these two populations. Using Stereo Investigator, they found 50 percent more neurons in the brains of diet-restricted mice compared to those fed a normal diet. They also saw lower levels of cells expressing p53 – a protein expressed in response to DNA damage – in diet-restricted mice.

According to the authors, dietary restriction may not fix defects in DNA repair mechanisms, but it may help to reduce the severity and speed at which the damage occurs.

“Our findings establish the Ercc1 mouse as a powerful model organism for health-sustaining interventions, reveal potential for reducing endogenous DNA damage, facilitate a better understanding of the molecular mechanism of dietary restriction and suggest a role for counterintuitive dietary-restriction-like therapy for human progeroid genome instability syndromes and possibly neurodegeneration in general,” (Vermeij, et al 2016).

Vermeij W.P., Dollé M.E.T., Reiling E., Jaarsma D., Payan-Gomez C, Bombardieri C.R., Wu H., Roks A.J.M., Botter S.M., van der Eerden B.C., Youssef S.A., Kuiper R.V., Nagarajah B., van Oostrom C.T., Brandt R.M.C., Barnhoorn S., Imholz S., Pennings J.L.A., de Bruin A., Gyenis Á., Pothof J, Vijg J, van Steeg H., and Hoeijmakers J.H.J. (2016) Restricted diet delays accelerated aging and genomic stress in DNA repair deficient mice. Nature 537, 427-431, doi:10.1038/nature19329

Hoeijmakers JH (2009) DNA Damage, aging, and cancer. N Engl J Med; 361:1475-1485, DOI: 10.1056/NEJMra0804615

Stock image of DNA used in accordance with the CC0 public domain license.

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We are happy to announce the release of Neurolucida and Stereo Investigator version 2017. This version features a completely revamped user interface that’s intuitive and easy to navigate.

“Neurolucida and Stereo Investigator version 2017 are completely redesigned to improve the user experience and increase productivity,” said Jack Glaser, President of MBF Bioscience. “The new interface makes collecting accurate data much quicker and easier.”

Version 2017 has many new performance features in addition to the new user interface. It handles large image data more efficiently, gives users the ability to dynamically edit digital reconstructions in an interactive 3D environment, and much more. Neurolucida users will also see many improvements to Neurolucida Explorer – the companion software to Neurolucida that performs all the quantitative analyses generated from neurons that are digitally reconstructed with Neurolucida.

Highlights of Stereo Investigator and Neurolucida version 2017 include:

• Easier Navigation – The ribbon bar design is task-oriented to make it easy to find what you need. A dynamic search bar and a quick access toolbar also aid productivity.

• Improved Organization – Frequently used tools are prominent and easy to access. Tools are grouped by their function, and advanced settings are easily accessible.

• Cleaner and simpler – The new user interface is modern and intuitive, making it easier to learn and to train new lab members.

• Support for the latest technological advancements in microscopic imaging devices and computer hardware.

See version 2017 in action

MBF Bioscience will exhibit and demo Neurolucida and Stereo Investigator version 2017 at the annual Experimental Biology meeting April 23 – 25 in Chicago, Illinois.

Get a quick overview of the new user interface in these 2-minute videos:

• Neurolucida version 2017
• Stereo Investigator version 2017

Register for the upcoming webinar “Using the Optical Fractionator Probe to Estimate Number of Cells”

The post MBF Bioscience Unveils Redesigned Interface for Neurolucida and Stereo Investigator version 2017 appeared first on MBF Bioscience.