Reference

Fay, M. G., Lang, P. J., Denu, D. S., et al. (2026). ClearScope: A Fully Integrated Light-Sheet Theta Microscope for Sub-Micron-Resolution Imaging Without Lateral Size Constraints. Journal of Imaging. https://doi.org/10.3390/jimaging12030118

Background

Three-dimensional imaging of intact organs and large tissue samples is critical for studying neural connectivity and structural changes in neurological disorders. While light sheet microscopy has become a leading tool for imaging cleared tissues, conventional systems face a fundamental limitation: the orthogonal arrangement of illumination and detection optics constrains the lateral size of specimens that can be imaged — making it impossible to capture intact large rodent brains or human tissue sections in their entirety.

About ClearScope

ClearScope is based on light sheet theta microscopy (LSTM), a technology developed by Professor Raju Tomer and colleagues at Columbia University. Unlike traditional light sheet systems, LSTM uses two oblique illumination paths paired with perpendicular detection optics — enabling imaging of specimens with effectively unconstrained lateral dimensions while maintaining subcellular resolution.

Part of our broader light sheet microscopy platform – built to push the boundaries of 3D imaging

ClearScope is a technological cousin to SLICE, MBF Bioscience’s newest light sheet microscope system. Together they reflect our commitment to expanding the boundaries of 3D biological imaging — from connectomics and systems neuroscience to vascular biology, cancer biology, and organoid research.

We’re grateful to our collaborators at Columbia University and NYU Langone Health for their partnership in this work.

The post Breaking the size barrier: ClearScope light sheet microscope paper published in Journal of Imaging appeared first on MBF Bioscience.

As CEO, Glaser will focus on long-term strategy and major partnerships. As President, Dr. Pessino will oversee day-to-day operations and execution of the company’s strategic plans.

“This isn’t me stepping back, it’s us stepping up,” said Glaser. “These are challenging times in the science world, and this change ensures I can focus on positioning us for the long haul while Veronica makes sure we’re running as efficiently and effectively as possible every single day.”

Since joining as COO last summer, Dr. Pessino has driven measurable improvements across the organization, streamlining operations and bringing sharper focus to product development and go-to-market strategy. “She quickly grasped not just the nuts and bolts of our business, but its soul, what makes MBF special, what we bring to the world, what our customers need, and what our team values,” Glaser said.

The post MBF Bioscience Announces Leadership Transition: Dr. Veronica Pessino Promoted to President appeared first on MBF Bioscience.

Now available through our online store:

• Fiber Optic Cannulae

• Patch Cords

• Ceramic Split Sleeves

• Additional consumables

This new platform was created with your research needs in mind—offering a simple, streamlined experience so you can get what you need quickly and reliably.

Key Benefits:

• Order anytime
• Easy, secure checkout
• Fast, dependable delivery
• Bulk ordering options available

Can’t find what you’re looking for? Our team is here to help. Email us at info@mbfbioscience.com and we’ll assist you in locating the right tools for your setup.

At MBF Bioscience, we remain committed to supporting your research with high-quality products and responsive service.

🛒 Explore the store today and simplify your fiber photometry workflow.

The post Introducing the MBF Bioscience Web Store for our Neurophotometrics Fiber Photometry Consumables appeared first on MBF Bioscience.

MBF Bioscience Introduces SLICE™: We Reimagined Light Sheet Microscopes From the Ground Up

Breakthrough system combines high performance with unprecedented affordability and compact design, making cutting-edge light sheet microscopy accessible to labs of all sizes

WILLISTON, VT – June 9, 2025 – MBF Bioscience, a world leader in quantitative microscopy solutions, today announced the commercial launch of SLICE™, a revolutionary light sheet microscope that represents a paradigm shift in advanced imaging technology. Invented by leading researchers at Columbia University, this patent-pending innovation delivers advanced 3D imaging capabilities to research labs of all sizes while offering performance that surpasses systems costing ten times more.

Breaking Down Barriers to Advanced Imaging

SLICE addresses one of the most significant challenges in modern biological research: the limited accessibility of high-performance light sheet microscopy due to high costs and complex infrastructure requirements. This innovative system offers high sub-micron resolution imaging of biological samples, making it ideal for both individual laboratories and core facilities, effectively democratizing access to what was previously available only to well-funded institutions.

“For over three decades, MBF Bioscience has been committed to putting powerful research tools in the hands of scientists everywhere,” said Jack Glaser, President and Co-founder of MBF Bioscience. “To advance science, we had to change the math. SLICE represents the embodiment of that mission—delivering the performance researchers need at a price point that makes advanced light sheet microscopy accessible to labs that previously couldn’t afford this technology. We’re not just selling a microscope, we’re opening doors to discoveries that might never have happened otherwise.”

Dr. Raju Tomer, Associate Professor of Biological Sciences at Columbia University and inventor of the technology underlying SLICE, added: “When we developed this approach, our goal was to overcome the fundamental limitations that have kept light sheet microscopy out of reach for so many researchers. SLICE realizes that vision—it’s a system that doesn’t compromise on scientific capability while dramatically reducing the barriers to entry. I’m excited to see how the broader research community will use this technology to push the boundaries of what’s possible in biological imaging.”

Technical Innovation Meets Practical Design

SLICE comes equipped with powerful software for tera-voxel visualization, seamless image stitching, and sophisticated post-processing. The system’s compact, benchtop-ready design enables placement in diverse research environments, including higher biosafety level facilities, small lab spaces, and even inside incubators where experiments are conducted.

Key features of SLICE include:

• Exceptional Performance-to-Cost Ratio: Performance surpassing systems costing ten times as much
• Multi-wavelength Compatibility: 3 illumination wavelengths for popular labels such as: GFP, Thy1-GFP, eYFP, Alexa 514, 633, 647, mCherry, tdTomato
• Versatile Clearing Compatibility: Compatible with iDISCO, CLARITY, SHANEL, CUBIC, BINAREE and virtually all other optical clearing techniques
• Comprehensive Software: BrightSLICE software for acquisition, visualization, and post-processing
• Seamless Integration: Seamlessly integrates with MBF Bioscience’s suite of analytical tools, including Neurolucida 360, NeuroInfo and NeuroDeblur

Expanding Research Capabilities

The SLICE system enables researchers to image labeled cells and neuronal processes throughout cleared tissue with exceptional clarity and speed. A wide range of proteins and dyes can be used with SLICE, including c-Fos, tdTomato, mCherry, podocalyxin, CD31, Acta2, mScarlet, and Thy1-eYFP, making it suitable for diverse research applications across neuroscience, developmental biology, cancer research, and beyond.

Advanced image stitching produces 3D image volumes suitable for MBF Bioscience’s AI-based quantitative analysis software to produce accurate data for analyzing morphometry, cell populations, sub-cellular processes, vasculature and fluorescence properties, enabling researchers to conduct sophisticated analyses previously limited to specialized facilities.

About MBF Bioscience

MBF Bioscience is a biotech company that develops microscopy software and hardware for bioscience research and education. MBF Bioscience’s primary location is Williston, Vermont, United States and has offices that market, sell, and support its line of hardware and software products in Ashburn, Virginia; San Diego, California; Europe, and Asia. The company was founded in 1988 as MicroBrightField, Inc. by the father and son team of Dr. Edmund Glaser and Jack Glaser, and has been instrumental in advancing quantitative microscopy for over three decades.

MBF has received numerous awards for innovation, customer service, and employee satisfaction, including the US Small Business Administration’s Tibbetts Award for excellence in high technology, the Vermont Small Business Person of the Year award, and the Best Places to Work in Vermont award. MBF’s tools have been cited in over 16,000 peer-reviewed journal publications, underscoring the company’s impact on global scientific research.

Availability and Pricing

SLICE is now available for order, with 30-day lead time for delivery. The complete system, including the light sheet microscope, BrightSLICE software, and computer workstation, is priced under $75,000 – representing exceptional value for advanced 3D imaging capabilities. For demonstrations, technical specifications, or ordering information, visit www.mbfbioscience.com/products/slice or contact MBF Bioscience directly.

Media Contact: Pasang Sherpa, Marketing Manager

Phone: +1 (802) 288-9290

Email: pasang@mbfbioscience.com

The post MBF Bioscience Introduces SLICE™: We Reimagined Light Sheet Microscopes From the Ground Up appeared first on MBF Bioscience.

This Year’s Winning Pieces

• 1st Place: Totally Tubular by Joey Tidei, Loyola University Chicago
• 2nd Place: Neurosphere by Adam Soos, Semmelweis University
• 3rd Place: Unwelcome Guest: SARS-CoV-2 Arriving in the Brain by Danielle Beckman, UC Davis Center for Neuroscience

Each of these stunning pieces showcases the complexity and beauty of neuroscience through artistic expression. Whether exploring cellular structures, neural networks, or the interaction of pathogens with the brain, these works offer a fascinating glimpse into the world of neuroscience.

Inspired by these works? Our monthly NeuroArt contest is the perfect opportunity to showcase your creativity and passion for neuroscience. Whether you’re an artist, scientist, or someone who appreciates the beauty of the brain, we welcome your submissions.

Thank you for being part of the NeuroArt community—we can’t wait to see what you create next!

The post Celebrating the NeuroArt Image Contest Annual Grand Prize Winners appeared first on MBF Bioscience.

The ongoing freeze and efforts to slash NIH funding pose an existential threat to the future of biomedical research. As scientists, we see firsthand how federal investment in research leads to medical breakthroughs that benefit all people—curing diseases, improving quality of life, and strengthening our nation’s position as a leader in innovation. Yet, despite the undeniable impact of biomedical research, funding is being slashed, and attempts to stall critical programs are underway. If these cuts continue, the consequences will be felt for decades.

Scientific progress does not happen overnight. It is the result of sustained funding, collaboration, and commitment. Drastic budget reductions will stall projects, disrupt labs, and drive talented researchers—especially early-career scientists—out of the field. The ripple effect will be devastating, slowing the development of new treatments, vaccines, and technologies that millions rely on.

Particularly alarming is the targeting of programs designed to support historically excluded groups, including people of color, women, and LGBTQ scientists. Cutting these initiatives is not only unjust but short-sighted. Diversity in science drives innovation. The strongest scientific breakthroughs arise from collaboration among people with different perspectives, experiences, and expertise. If we push talented minds out of research, we all lose.

What are we doing about it? We are mobilizing. We are working with academic institutions and industry partners to educate the public on the necessity of NIH funding. We are calling on our representatives and senators to demand support for biomedical research. We encourage all scientists, students, and allies to join us in this fight—write, call, and speak up. Science cannot be a partisan issue when human lives are at stake. We urge policymakers to recognize what is at risk and take action to protect the future of biomedical research. The cost of inaction is simply too high.

For further discussion on the impact of NIH funding changes, listen to Vermont Edition, where Jack Glaser, CEO/Founder, shares insights on how these shifts affect research. Listen here.

We want to hear from you. What challenges are you facing? How can we help? Reach out—let’s navigate this together.

Sincerely,
MBF Bioscience 

The post Protecting the Future of Biomedical Research: A Call to Defend NIH Funding appeared first on MBF Bioscience.

Our Open Office Hours are designed to be interactive and flexible, allowing attendees to explore specific product features, discuss applications, and gain insights into best practices for using our technology effectively. These sessions are not only an opportunity to address immediate concerns but also to learn about advancements in our software and hardware solutions that could enhance your research efficiency. Additionally, they provide a space to connect with fellow scientists and professionals, fostering a collaborative environment where ideas and experiences can be shared.

Sessions are held every Tuesday at 12 PM ET and are conducted virtually, making them easily accessible to researchers worldwide. There is no need for formal scheduling—simply join the session at your convenience to engage with our team and other attendees. Whether you have specific technical questions, need troubleshooting assistance, or simply want to explore new ways to integrate MBF Bioscience technology into your work, we welcome you to participate.

We look forward to connecting with you and supporting your research efforts.

📅 Every Tuesday at 12 PM ET |  📋 Register here

The post MBF Bioscience Open Office Hours: Connect with Our Product Experts appeared first on MBF Bioscience.

MBF Bioscience and Phaseform are delighted to announce a breakthrough collaboration that integrates Phaseform’s advanced Adaptive Optics (AO) solutions into MBF Bioscience’s renowned ScanImage software for multiphoton and laser scanning microscopes. This joint development opens the door for researchers across neuroscience, developmental biology, cancer research, and other fields to achieve unmatched image clarity and depth, all while preserving their existing microscopy workflows.

The post Adaptive Optics for MBF Bioscience’s ScanImage using Phaseform’s Deformable Phase Plate Technology appeared first on MBF Bioscience.

In just a few days, at the Society for Neuroscience meeting in Chicago, we will be unveiling SLICE – our new affordable light sheet microscope that truly redefines what’s possible in imaging technology. SLICE is the result of our collaboration with leading microscopy researchers at Columbia University, embodying our mission to support “Big Science in labs of all sizes”.

What makes SLICE extraordinary and such a transformative technology? Let me share some key points:

• Performance on par with systems costing ten times as much
• Resolution of ~1 μm laterally and ~5 μm axially, resolves cells and neuronal processes throughout the brain
• Three-wavelength imaging capability
• Compatible with iDISCO, CLARITY, SHANEL, BINAREE and other optical clearing techniques

Most importantly, we’re offering SLICE at an introductory price under $50,000 for a limited time, including lasers and a computer workstation. This is not just a price point; it’s a statement of our commitment to democratizing access to advanced research tools.

I personally invite you to visit us at Booth 781 during SfN to learn about our exclusive conference offers designed to make this innovative technology even more accessible. See SLICE in action, and let’s discuss how it can propel your research forward. If you can’t make it to SfN, please visit our website SLICE for detailed information.

In my 30 years in this field, I’ve seen many advances, but SLICE stands out as a true game-changer. It has the potential to accelerate research across multiple disciplines, and I couldn’t be more excited to share it with you.

We pride ourselves in helping scientists make new discoveries, which is why we are determined to do things that allow more researchers to make more discoveries.

I look forward to your feedback and to seeing the groundbreaking research that SLICE will enable in your labs.

Sincerely,

Jack Glaser

President, MBF Bioscience

The post Introducing SLICE™: A new era in low-cost, high-performance light-sheet microscopy appeared first on MBF Bioscience.

Since their inception, NIMH’s SBIR/STTR programs have been a catalyst for numerous small businesses, propelling them to become global leaders or attractive acquisition targets. Notable early beneficiaries include Acadia Pharmaceuticals, Alkermes, and Neurocrine Biosciences, among others.

MBF Bioscience, originally known as MicroBrightField, stands out as a shining example of NIMH’s successful investment in innovation. As a pioneer in developing cutting-edge microscopy and image analysis software for neuroscience research, MBF has transformed the landscape of brain structure and function studies. Our state-of-the-art tools have become indispensable to researchers worldwide, significantly advancing our collective understanding of neurological and psychiatric disorders. The impact of MBF’s contributions is evidenced by the impressive tally of nearly 20,000 peer-reviewed publications that have utilized our products in their research.

In recognition of its outstanding contributions, MBF Bioscience, along with several other NIMH-funded businesses, has been honored with the prestigious Tibbetts Award from the U.S. Small Business Administration. This accolade celebrates companies that exemplify the spirit of the SBIR/STTR programs through their economic, technical, and societal impact.

The success stories of MBF Bioscience and other NIMH-supported companies underscore the institute’s vital role in identifying and nurturing groundbreaking ideas from their inception. NIMH’s early-stage funding has been instrumental in bringing a multitude of innovative technologies and treatments to fruition, ultimately benefiting millions of individuals affected by mental health conditions.

As NIMH charts its course for the future, its ongoing support for small businesses through the SBIR and STTR programs promises to fuel the next wave of innovations in mental health technology and care delivery. The remarkable achievements of the past 75 years, exemplified by companies like MBF Bioscience, lay a solid foundation for continued growth and breakthroughs in this critical field.

The feature of MBF Bioscience in NIMH’s anniversary blog not only highlights our company’s achievements but also reinforces the importance of continued investment in mental health research and technology. As we move forward, we remain committed to pushing the boundaries of neuroscience research tools, inspired by NIMH’s enduring support and the potential to make a lasting impact on mental health care.

Read the article here: https://www.nimh.nih.gov/about/director/messages/2024/driving-innovation-in-mental-health-technology-through-small-business-programs 

The post NIMH Celebrates 75 Years of Innovation: MBF Bioscience Featured in Anniversary Blog appeared first on MBF Bioscience.