WILLISTON, VT – August 18, 2025 – MBF Bioscience today proudly announces that its revolutionary light sheet microscope, SLICE™, has been awarded a Microscopy Today Innovation Award. This prestigious recognition celebrates SLICE as a game-changing solution that is transforming the light sheet microscopy landscape by delivering superior performance at an exceptionally accessible price point, democratizing advanced 3D imaging and empowering laboratories of all sizes to pursue breakthrough research.

The Microscopy Today Innovation Award recognizes instruments and accessories that represent significant advancements in the field of microscopy. SLICE was selected for its innovative engineering, which addresses the critical barriers of cost and complexity that have long limited access to high-end light sheet technology.

“We are truly honored to receive the Microscopy Today Innovation Award, as it is a powerful validation of our mission to democratize advanced science,” said Jack Glaser, President of MBF Bioscience. “SLICE was born from the idea that breakthrough research shouldn’t be constrained by budget or complexity. This award is a testament to our team’s commitment to creating a new standard that delivers superior image quality and unmatched value to every lab.”

Unlike legacy systems that typically cost hundreds of thousands of dollars, SLICE is a complete turnkey solution available for under $75,000. Its innovative optical design delivers demonstrably higher image quality, with clearer images and increased signal-to-noise than many more expensive systems. The SLICE offering also includes the powerful BrightSLICE software, providing a seamless acquisition-to-analysis workflow without the need for costly external licenses.

Dr. Raju Tomer, Associate Professor at Columbia University and the inventor of the foundational technology behind SLICE, added, ” We are deeply honored by this recognition from the global microscopy community for our efforts to make high-performance light-sheet microscopy accessible to all. We have seen firsthand how this technology can profoundly transform our understanding of biological systems, yet it has remained largely inaccessible to most researchers and clinicians worldwide. We hope this breakthrough will catalyze new discoveries and empower data-driven innovations in human health. We are very grateful to our collaborators at MBF Bioscience for helping turn this vision into reality.”

The SLICE system’s transparent and all-inclusive annual support model further sets it apart, with a predictable annual fee that covers both hardware maintenance and comprehensive software support. This approach, combined with its streamlined design, makes SLICE an ideal solution for academic labs, microscopy core facilities, and biopharmaceutical R&D teams seeking to accelerate their research pipelines.

About MBF Bioscience

MBF Bioscience is a pioneering developer of advanced microscopy and imaging solutions, specializing in multi-photon microscopy, light sheet microscopy, unbiased stereology, neuron tracing, fiber photometry, and AI-powered image analysis systems for neuroscience and life sciences researchers. With over 35 years of innovation, MBF Bioscience transforms scientific discovery by creating cutting-edge tools that deliver unparalleled accuracy, reproducibility, and research acceleration to help scientists worldwide to push the boundaries of what’s possible.

Media Contact: Pasang Sherpa, Marketing Manager

Phone: +1 (802) 288-9290

Email: pasang@mbfbioscience.com

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Now available through our online store:

• Fiber Optic Cannulae

• Patch Cords

• Ceramic Split Sleeves

• Additional consumables

This new platform was created with your research needs in mind—offering a simple, streamlined experience so you can get what you need quickly and reliably.

Key Benefits:

• Order anytime
• Easy, secure checkout
• Fast, dependable delivery
• Bulk ordering options available

Can’t find what you’re looking for? Our team is here to help. Email us at info@mbfbioscience.com and we’ll assist you in locating the right tools for your setup.

At MBF Bioscience, we remain committed to supporting your research with high-quality products and responsive service.

🛒 Explore the store today and simplify your fiber photometry workflow.

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MBF Bioscience Introduces SLICE™: We Reimagined Light Sheet Microscopes From the Ground Up

Breakthrough system combines high performance with unprecedented affordability and compact design, making cutting-edge light sheet microscopy accessible to labs of all sizes

WILLISTON, VT – June 9, 2025 – MBF Bioscience, a world leader in quantitative microscopy solutions, today announced the commercial launch of SLICE™, a revolutionary light sheet microscope that represents a paradigm shift in advanced imaging technology. Invented by leading researchers at Columbia University, this patent-pending innovation delivers advanced 3D imaging capabilities to research labs of all sizes while offering performance that surpasses systems costing ten times more.

Breaking Down Barriers to Advanced Imaging

SLICE addresses one of the most significant challenges in modern biological research: the limited accessibility of high-performance light sheet microscopy due to high costs and complex infrastructure requirements. This innovative system offers high sub-micron resolution imaging of biological samples, making it ideal for both individual laboratories and core facilities, effectively democratizing access to what was previously available only to well-funded institutions.

“For over three decades, MBF Bioscience has been committed to putting powerful research tools in the hands of scientists everywhere,” said Jack Glaser, President and Co-founder of MBF Bioscience. “To advance science, we had to change the math. SLICE represents the embodiment of that mission—delivering the performance researchers need at a price point that makes advanced light sheet microscopy accessible to labs that previously couldn’t afford this technology. We’re not just selling a microscope, we’re opening doors to discoveries that might never have happened otherwise.”

Dr. Raju Tomer, Associate Professor of Biological Sciences at Columbia University and inventor of the technology underlying SLICE, added: “When we developed this approach, our goal was to overcome the fundamental limitations that have kept light sheet microscopy out of reach for so many researchers. SLICE realizes that vision—it’s a system that doesn’t compromise on scientific capability while dramatically reducing the barriers to entry. I’m excited to see how the broader research community will use this technology to push the boundaries of what’s possible in biological imaging.”

Technical Innovation Meets Practical Design

SLICE comes equipped with powerful software for tera-voxel visualization, seamless image stitching, and sophisticated post-processing. The system’s compact, benchtop-ready design enables placement in diverse research environments, including higher biosafety level facilities, small lab spaces, and even inside incubators where experiments are conducted.

Key features of SLICE include:

• Exceptional Performance-to-Cost Ratio: Performance surpassing systems costing ten times as much
• Multi-wavelength Compatibility: 3 illumination wavelengths for popular labels such as: GFP, Thy1-GFP, eYFP, Alexa 514, 633, 647, mCherry, tdTomato
• Versatile Clearing Compatibility: Compatible with iDISCO, CLARITY, SHANEL, CUBIC, BINAREE and virtually all other optical clearing techniques
• Comprehensive Software: BrightSLICE software for acquisition, visualization, and post-processing
• Seamless Integration: Seamlessly integrates with MBF Bioscience’s suite of analytical tools, including Neurolucida 360, NeuroInfo and NeuroDeblur

Expanding Research Capabilities

The SLICE system enables researchers to image labeled cells and neuronal processes throughout cleared tissue with exceptional clarity and speed. A wide range of proteins and dyes can be used with SLICE, including c-Fos, tdTomato, mCherry, podocalyxin, CD31, Acta2, mScarlet, and Thy1-eYFP, making it suitable for diverse research applications across neuroscience, developmental biology, cancer research, and beyond.

Advanced image stitching produces 3D image volumes suitable for MBF Bioscience’s AI-based quantitative analysis software to produce accurate data for analyzing morphometry, cell populations, sub-cellular processes, vasculature and fluorescence properties, enabling researchers to conduct sophisticated analyses previously limited to specialized facilities.

About MBF Bioscience

MBF Bioscience is a biotech company that develops microscopy software and hardware for bioscience research and education. MBF Bioscience’s primary location is Williston, Vermont, United States and has offices that market, sell, and support its line of hardware and software products in Ashburn, Virginia; San Diego, California; Europe, and Asia. The company was founded in 1988 as MicroBrightField, Inc. by the father and son team of Dr. Edmund Glaser and Jack Glaser, and has been instrumental in advancing quantitative microscopy for over three decades.

MBF has received numerous awards for innovation, customer service, and employee satisfaction, including the US Small Business Administration’s Tibbetts Award for excellence in high technology, the Vermont Small Business Person of the Year award, and the Best Places to Work in Vermont award. MBF’s tools have been cited in over 16,000 peer-reviewed journal publications, underscoring the company’s impact on global scientific research.

Availability and Pricing

SLICE is now available for order, with 30-day lead time for delivery. The complete system, including the light sheet microscope, BrightSLICE software, and computer workstation, is priced under $75,000 – representing exceptional value for advanced 3D imaging capabilities. For demonstrations, technical specifications, or ordering information, visit www.mbfbioscience.com/products/slice or contact MBF Bioscience directly.

Media Contact: Pasang Sherpa, Marketing Manager

Phone: +1 (802) 288-9290

Email: pasang@mbfbioscience.com

The post MBF Bioscience Introduces SLICE™: We Reimagined Light Sheet Microscopes From the Ground Up appeared first on MBF Bioscience.

MBF Bioscience and Phaseform are delighted to announce a breakthrough collaboration that integrates Phaseform’s advanced Adaptive Optics (AO) solutions into MBF Bioscience’s renowned ScanImage software for multiphoton and laser scanning microscopes. This joint development opens the door for researchers across neuroscience, developmental biology, cancer research, and other fields to achieve unmatched image clarity and depth, all while preserving their existing microscopy workflows.

The post Adaptive Optics for MBF Bioscience’s ScanImage using Phaseform’s Deformable Phase Plate Technology appeared first on MBF Bioscience.

In just a few days, at the Society for Neuroscience meeting in Chicago, we will be unveiling SLICE – our new affordable light sheet microscope that truly redefines what’s possible in imaging technology. SLICE is the result of our collaboration with leading microscopy researchers at Columbia University, embodying our mission to support “Big Science in labs of all sizes”.

What makes SLICE extraordinary and such a transformative technology? Let me share some key points:

• Performance on par with systems costing ten times as much
• Resolution of ~1 μm laterally and ~5 μm axially, resolves cells and neuronal processes throughout the brain
• Three-wavelength imaging capability
• Compatible with iDISCO, CLARITY, SHANEL, BINAREE and other optical clearing techniques

Most importantly, we’re offering SLICE at an introductory price under $50,000 for a limited time, including lasers and a computer workstation. This is not just a price point; it’s a statement of our commitment to democratizing access to advanced research tools.

I personally invite you to visit us at Booth 781 during SfN to learn about our exclusive conference offers designed to make this innovative technology even more accessible. See SLICE in action, and let’s discuss how it can propel your research forward. If you can’t make it to SfN, please visit our website SLICE for detailed information.

In my 30 years in this field, I’ve seen many advances, but SLICE stands out as a true game-changer. It has the potential to accelerate research across multiple disciplines, and I couldn’t be more excited to share it with you.

We pride ourselves in helping scientists make new discoveries, which is why we are determined to do things that allow more researchers to make more discoveries.

I look forward to your feedback and to seeing the groundbreaking research that SLICE will enable in your labs.

Sincerely,

Jack Glaser

President, MBF Bioscience

The post Introducing SLICE™: A new era in low-cost, high-performance light-sheet microscopy appeared first on MBF Bioscience.

MBF Bioscience Announces the Acquisition of Neurophotometrics

Williston, VT – 10.26.2023 — MBF Bioscience, a leading provider of cutting-edge solutions in the field of bioscience, is pleased to announce the latest addition to its family – Neurophotometrics (NPM). This acquisition is a significant milestone in our commitment to advancing scientific research and innovation.

The acquisition of NPM combines two companies with a shared deep passion for helping scientists bring new insights and discoveries to the future of bioscience. MBF and NPM will work closely together to develop new products and bridge technologies to advance bioscience.

 “We are thrilled to welcome NPM to the MBF Bioscience family,” said Jack Glaser, president of MBF Bioscience. “NPM’s expertise in developing optical equipment for neuroscience research, and its commitment to innovation complement our own mission and values perfectly. Together, we can build a new generation of exceptional tools to support the future of scientific research.”

“We are excited to join forces with MBF Bioscience,” said Sage Aronson, Neurophotometrics. “MBF’s global reach and resources will enable us to bring our products and services to more scientists around the world. We share MBF’s commitment to providing the highest quality technical support, and we look forward to working together to create a brighter future for bioscience.”

MBF is committed to providing our customers with the best possible products and services, and the acquisition of NPM will further strengthen MBF’s ability to do so.

Please don’t hesitate to reach out to us at the contact number below. We continue to rely on your insight, perspective, and advice about how we can serve you better today to enable exciting discoveries tomorrow.

Thanks for being part of this amazing journey.

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Contact Information: MBF Bioscience | 1-802-288-9290 | info@mbfbioscience.com

The post MBF Bioscience Announces the Acquisition of Neurophotometrics appeared first on MBF Bioscience.

Dr. Edward Boyden and his team at MIT are doing just that. The process, known as expansion microscopy (ExM), physically enlarges brain tissue so that even extremely small molecular structures are viewable on a conventional light microscope.

In his 2016 TED Talk, Dr. Boyden says: “Can we make [the brain] bigger? Big enough that you can peer inside and see all the tiny building blocks, the biomolecules, how they’re organized in three dimensions, the structure…. if we could get that, maybe we could have a better understanding of how the brain is organized to yield thoughts and emotions and actions and sensations. Maybe we could pinpoint the exact changes in the brain that result in diseases like Alzheimer’s, epilepsy, and Parkinson’s.”

Thanks to a grant from the National Institute of Mental Health (NIMH), MBF Bioscience, is teaming together with Dr. Boyden’s group to develop high performance, advanced software to analyze tissue processed by expansion microscopy. The new software will be able to perform comprehensive spatial distribution analysis of molecular structures, such as populations of messenger RNAs and proteins.

“The goal is to be able to pinpoint the exact molecular changes that occur in brain disorders in order to identify new therapeutic targets,” says MBF Bioscience President Jack Glaser.

The groundbreaking technological advantage of ExM is the ability to isotropically expand tissue and increase the size of biological structures. This allows nanoscale-resolution, light-microscopic imaging of objects that are too small to be observed without expansion due to the diffraction limit of light.

Among other benefits, ExM allows small structures to be imaged with a wider range of microscopy techniques. Processing tissue for ExM also allows repeated hybridization (for investigations of mRNAs) and/or repeated antibody staining (for investigations of proteins) of the same tissue, combined with repeated microscopic imaging rounds.

An important innovation in our new system is to empower biologists by giving them the ability to perform all of these tasks without the need to have a computer scientist on staff to run software scripts developed for each step of this kind of complex analysis.

ExM and our new software will enable substantial advancements in research studies focusing on alterations in the spatial transcriptome and proteome of neurons associated with neurodevelopmental, neuropsychiatric, neurodegenerative, and neurological disorders as well as in aging research and drug development.

The post MBF Bioscience Receives Grant from the NIMH to Develop Next-Generation Software for Analyzing Expansion Microscopy-Processed Tissue appeared first on MBF Bioscience.

The University of Vermont, the state’s largest employer, led the list of recipients, but right behind UVM is another, lesser known powerhouse in the biomedical research community—MBF Bioscience.

An award-winning Vermont business, MBF Bioscience engineers microscope-based quantitative imaging and visualization solutions to help researchers on the cutting edge of creating a better future for humanity—a future with less disease, enhanced creativity, and heightened physical, mental, and emotional health.

MBF Bioscience helps these scientific leaders illuminate their discoveries, analyze their information, empower their research, and enhance the certainty and speed with which they can publish and share their insights.

“The NIH grants we receive are SBIR grants, which are dedicated to commercializing technology to support biomedical research. And what’s even more important is that we act as an ally to support the scientific community and build technology that advances bioscience in general. So, the benefits from the grants don’t just stop with us — as we commercialize products, they continue to add and fuel advancements in research labs around the world at scale far into the future.” says MBF Bioscience President Jack Glaser.

“It has been a challenging year for our customers,” says Jack Glaser,” these NIH grants help make sure that important research continues moving forward, even in difficult economic times.

Over the past year, while the NIH has spearheaded the effort to combat COVID-19, the agency has continued to support research in labs across the country. This scientific support is essential to making progress in America’s health and wellbeing beyond the pandemic.

Nationwide, support from NIH grants in 2020 led to 536,338 jobs and generated $91.35 billion in economic activity, demonstrating that the value of NIH-funded research extends far beyond improving our health. The NIH supports discoveries and trains a workforce that helps the United States remain the global leader in the life sciences industry.

For that, we’re grateful.

About MBF Bioscience

Headquartered in Williston, VT, MBF Bioscience is a leading provider of microscope-based image analysis tools to researchers around the world. Founded in 1988, MBF has received numerous awards for innovation, customer service, and employee satisfaction, including the US Small Business Administration’s Tibbetts Award for excellence in high technology, the Vermont Small Business Person of the Year award, and the Best Places to Work in Vermont award. MBF’s tools have been cited in over 16,000 peer-reviewed journal publications.

###

Contact:

Pasang Sherpa
Marketing Manager
1-802-288-9290
pasang@mbfbioscience.com

The post 2020 NIH Grants support jobs and economic vitality in Vermont — UVM and MBF Bioscience lead the way appeared first on MBF Bioscience.

Vidrio and MBF share a deep passion for helping scientists reveal the fundamental structures and functions of the brain. Our teams are committed to serving the neuroscience community by providing innovative hardware and software tools to help researchers achieve their goals. We are driven to do our part to move our companies, the scientific community, and humanity forward, and we believe that by joining forces, we can build the next generation of truly exceptional tools to support the future of scientific research.

Because together we can do so much more than we could separately.

We’re excited to show you what great new things we’re going to do next. And that will come in due time. But, for now, we want to focus on what won’t change. We’re still committed to developing and improving the products and services you depend on. We’re still focused on providing the high-quality, responsive support you expect. And we still pledge to do all of this the way we always have—with an empathetic, scientist-first approach.

Please don’t hesitate to reach out to either or both of us at the contact numbers below. We continue to rely on you for insight, perspective, and advice about how we can serve you better today, to enable exciting discoveries tomorrow.

Thanks for being part of this amazing journey.

###

Contact Information:

MBF Bioscience | 1-802-288-9290  | info@mbfbioscience.com
Vidrio Technologies | 1-571-209-4591 | operations@vidriotech.com

The post MBF Announces the Acquisition of Vidrio Technologies appeared first on MBF Bioscience.

We suspect 2020 will always be remembered as the year of big, unexpected questions.

Questions like, “How will we do our work together if we’re all working from our homes?”

“When will we be able to move around freely again?”

“How quickly will the economy bounce back post pandemic?”

Questions like these have challenged each and every one of us to remain optimistic, curious, and mindful about what the future holds.

Luckily for us, we’re kind of in the “big question” business. It’s one of the many benefits of serving the neuroscience community. We remain in awe of all of the dedicated scientists using our products to unlock the brain’s secrets, discover new insights, and help people around the world. We’re proud of our history within the scientific community, supporting this important work in every way we can.

Albert Einstein said: “In the midst of every crisis lies great opportunity.” It’s something we’ve been thinking about during this time — how can we do even more to help the scientists we work with?

We have some great news to share. We want you to be among the first to know that the people of MBF Bioscience have combined with the people of Vidrio Technologies.

We recognized that together we can do so much more than we could separately. Jointly, our teams are committed to serving the neuroscience community by providing innovative hardware and software tools for research that will help humanity in its understanding of the structure and function of the brain. We are driven to do our part to move our companies, the scientific community, and humanity forward.

We’re excited to show you what great new things we’re going to do next. And that will come in due time. But for now, we want to focus on what won’t change. We’re still committed to developing and improving the products and services you’ve come to depend on; we’re still focused on providing the high quality, responsive support you expect; and we still pledge to do all of this the way we always have, with an empathetic, scientist-first approach.

Please don’t hesitate to reach out to either or both of us at the contact numbers below. We continue to rely on you for insight, perspective, and advice about how we can serve you better today, to enable exciting discoveries tomorrow.

Thanks for being part of this amazing journey.

###

Contact Information:

MBF Bioscience | 1-802-288-9290  | info@mbfbioscience.com
Vidrio Technologies | 1-571-209-4591 | operations@vidriotech.com

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