Product Demonstrations

Click on any of the video demonstration tiles below to see MBF products in action.

Stereo Investigator

Design-based stereology has taken its place as the standard methodology for quantitative histology used in biomedical research. This approach to stereology is used in the identification of subtle yet important alterations in the morphology of the central nervous system based on disturbances during development or in neuropsychiatric and neurodegenerative diseases.

• Measurements of objects (including size, shape and number) are obtained in an unbiased way by implementation of proven techniques which include geometric overlays, mathematical formulae, counting rules, and systematic random sampling methods.
• Results are accurate, efficient and more reliable than other ad hoc quantitative analyses.
• Stereology provides an important contribution to the advancement in biomedical research by improving the consistency and dependability of quantitative analytical results produced in the laboratory and reported in scientific publications.

Neurolucida

Neurolucida is advanced scientific software for performing brain mapping, neuron tracing, anatomical mapping, and morphometry. Neurolucida has the flexibility to handle data in many formats: using live images from digital or video cameras; stored image sets from confocal microscopes, electron microscopes, and scanning tomographic sources, or through the microscope oculars using our patented Lucivid™. Neurolucida controls a motorized XYZ stage for integrated navigation through tissue sections, allowing for sophisticated analysis from many fields-of-view. Neurolucida’s Serial Section Manager integrates unlimited sections into a single data file, maintaining each section in appropriate 3D space for full quantitative analysis.

Autoneuron

AutoNeuron offers a very significant reduction in the time and effort required to reconstruct neurons in 2D and 3D. An innovative tracing algorithm (patented) quickly explores the entire image volume and identifies neuronal processes and somas. AutoNeuron models neuronal trees as branching structures; complete with branch nodes, roots, and endings. Available as a plug-in module for Neurolucida, the reconstruction model created by AutoNeuron can be viewed and edited within Neurolucida. Diameters of the axons and dendrites are recorded at each traced point. Somas are reconstructed as a 3D volume using a set of contours.

Virtual Slice Module

Virtual Slice scans through a tissue slice at high magnification and creates an image montage of the specimen. This Virtual Slice montage is of a much higher resolution than images obtained using a low magnification lens. In fact, it is often impossible to view a single tissue section in its entirety even with the microscope’s lowest power objective lens. Virtual Slice removes this limitation, opening the doors to numerous new visualization and quantification possibilities.

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