Researchers cited MBF systems in 42 papers between 4/7/2017 and 4/21/2017

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Ay, M., Luo, J., Langley, M., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2017). Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse Models of Parkinson’s Disease. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.14033.

Carryl, H., Van Rompay, K., De Paris, K., & Burke, M. (2017). Hippocampal Neuronal Loss in Infant Macaques Orally Infected with Virulent Simian Immunodeficiency Virus (SIV). Brain Sciences, 7(4), 40.

Galinato, M. H., Lockner, J. W., Fannon-Pavlich, M. J., Sobieraj, J. C., Staples, M. C., Somkuwar, S. S., . . . Mandyam, C. D. (2017). A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse. Molecular Psychiatry. doi: 10.1038/mp.2017.46.

Gilles, Y. D., & Polston, E. K. (2017). Effects of social deprivation on social and depressive-like behaviors and the numbers of oxytocin expressing neurons in rats. Behavioural Brain Research SreeTestContent1, 328, 28-38. doi:

Hamilton, G. F., Hernandez, I. J., Krebs, C. P., Bucko, P. J., & Rhodes, J. S. (2017). Neonatal alcohol exposure reduces number of parvalbumin-positive interneurons in the medial prefrontal cortex and impairs passive avoidance acquisition in mice deficits not rescued from exercise. Neuroscience. doi:

Jinhua, H., Zhao, M., Shuangcheng, H., Yuanran, Z., Rui, N., Wei, L., . . . Jian, Y. (2017). Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway. Biochemical Pharmacology. doi:

Kafetzopoulos, V., Kokras, N., Sotiropoulos, I., Oliveira, J. F., Leite-Almeida, H., Vasalou, A., . . . Dalla, C. (2017). The nucleus reuniens: a key node in the neurocircuitry of stress and depression. Molecular Psychiatry. doi: 10.1038/mp.2017.55.

Lear, C. A., Davidson, J. O., Mackay, G. R., Drury, P. P., Galinsky, R., Quaedackers, J. S., . . . Bennet, L. (2017). Antenatal dexamethasone before asphyxia promotes cystic neural injury in preterm fetal sheep by inducing hyperglycemia. Journal of Cerebral Blood Flow and Metabolism, 0271678X17703124. doi: 10.1177/0271678×17703124.

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Researchers cited MBF systems in 27 papers between 3/20/2017 and 3/30/2017

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Abe, C., Inoue, T., Inglis, M. A., Viar, K. E., Huang, L., Ye, H., . . . Guyenet, P. G. (2017). C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. Nature Neuroscience, advance online publication. doi: 10.1038/nn.4526

Caldwell, A. S. L., Edwards, M. C., Desai, R., Jimenez, M., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2017). Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1616467114.

Castro-Hernández, J., Adlard, P. A., & Finkelstein, D. I. (2017). Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion. Scientific Reports, 7, 44426. doi: 10.1038/srep44426.

Dawes, W. J., Zhang, X., Fancy, S. P., Rowitch, D., & Marino, S. (2017). Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone. Developmental Neuroscience.

Drobyshevsky, A., & Quinlan, K. A. (2017). Spinal cord injury in hypertonic newborns after antenatal hypoxia-ischemia in a rabbit model of cerebral palsy. Experimental Neurology, 293, 13-26. doi:

El Massri, N., Lemgruber, A. P., Rowe, I. J., Moro, C., Torres, N., Reinhart, F., . . . Mitrofanis, J. (2017). Photobiomodulation-induced changes in a monkey model of Parkinson’s disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum. Experimental Brain Research, 1-14. doi: 10.1007/s00221-017-4937-0.

Hühner, L., Rilka, J., Gilsbach, R., Zhou, X., Machado, V., & Spittau, B. (2017). Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo. Frontiers in Molecular Neuroscience, 10(62). doi: 10.3389/fnmol.2017.00062.

Meng, L., Huang, T., Sun, C., Hill, D. L., & Krimm, R. (2017). BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section. Experimental Neurology, 293, 27-42. doi:

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Researchers cited MBF systems in 27 papers during the week of 03/13/2017

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Ambrosi, G., Kustrimovic, N., Siani, F., Rasini, E., Cerri, S., Ghezzi, C., . . . Blandini, F. (2017). Complex Changes in the Innate and Adaptive Immunity Accompany Progressive Degeneration of the Nigrostriatal Pathway Induced by Intrastriatal Injection of 6-Hydroxydopamine in the Rat. Neurotoxicity research, 1-11. doi: 10.1007/s12640-017-9712-2.

Chen, B. K., Madigan, N. N., Hakim, J. S., Dadsetan, M., McMahon, S. S., Yaszemski, M. J., & Windebank, A. J. (2017). GDNF Schwann cells in hydrogel scaffolds promote regional axon regeneration, remyelination and functional improvement after spinal cord transection in rats. Journal of Tissue Engineering and Regenerative Medicine, n/a-n/a. doi: 10.1002/term.2431.

Cheng, L., Lau, W. K. W., Fung, T. K. H., Lau, B. W. M., Chau, B. K. H., Liang, Y., . . . Lee, T. M. C. (2017). PM2.5 Exposure Suppresses Dendritic Maturation in Subgranular Zone in Aged Rats.  Neurotoxicity research, 1-8. doi: 10.1007/s12640-017-9710-4.

Herrera-Soto, A., Díaz-Veliz, G., Mora, S., Muñoz, P., Henny, P., Steinbusch, H. W. M., & Segura-Aguilar, J. (2017). On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo.  Neurotoxicity research, 1-7. doi: 10.1007/s12640-017-9719-8.

Kaufling, J., Girard, D., Maitre, M., Leste-Lasserre, T., & Georges, F. (2017). Species-specific diversity in the anatomical and physiological organization of the BNST-VTA pathway. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.13554.

Keiner, S., Niv, F., Neumann, S., Steinbach, T., Schmeer, C., Hornung, K., . . . Redecker, C. (2017). Effect of skilled reaching training and enriched environment on generation of oligodendrocytes in the adult sensorimotor cortex and corpus callosum. BMC Neuroscience, 18(1), 31. doi: 10.1186/s12868-017-0347-2.

Mikrogeorgiou, A., Sato, Y., Kondo, T., Hattori, T., Sugiyama, Y., Ito, M., . . . Kazama, T. (2017). Dedifferentiated Fat Cells as a Novel Source for Cell Therapy to Target Neonatal Hypoxic-Ischemic Encephalopathy. Developmental Neuroscience.

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Researchers cited MBF systems in 28 papers during the week of 03/06/2017

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Akkhawattanangkul, Y., Maiti, P., Xue, Y., Aryal, D., Wetsel, W. C., Hamilton, D., . . . McDonald, M. P. (2017). Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. Genes, Brain and Behavior, n/a-n/a. doi: 10.1111/gbb.12377.

Chung, Y. C., Baek, J. Y., Kim, S. R., Ko, H. W., Bok, E., Shin, W.-H., . . . Jin, B. K. (2017). Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson/’s disease. Experimental and Molecular Medicine, 49, e298. doi: 10.1038/emm.2016.159.

Hajheidari, S., Sameni, H. R., Bandegi, A. R., & Miladi-gorji, H. (2017). Effects of prolonged abstinence from METH on the hippocampal BDNF levels, neuronal numbers and apoptosis in methamphetamine-sensitized rats. Neuroscience Letters, 645, 80-85. doi:

Krishnasamy, S., Weng, Y.-C., Thammisetty, S. S., Phaneuf, D., Lalancette-Hebert, M., & Kriz, J. (2017). Molecular imaging of nestin in neuroinflammatory conditions reveals marked signal induction in activated microglia. Journal of neuroinflammation, 14(1), 45. doi: 10.1186/s12974-017-0816-7.

Langley, M., Ghosh, A., Charli, A., Sarkar, S., Ay, M., Luo, J., . . . Kanthasamy, A. (2017). Mito-apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & redox signaling. doi: 10.1089/ars.2016.6905.

Leal-Campanario, R., Alarcon-Martinez, L., Rieiro, H., Martinez-Conde, S., Alarcon-Martinez, T., Zhao, X., . . . Macknik, S. L. (2017). Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy.  Scientific Reports, 7, 43276. doi: 10.1038/srep43276

Mao, Z., Liu, C., Ji, S., Yang, Q., Ye, H., Han, H., & Xue, Z. (2017). The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson’s Disease in Rats. Neurochemical Research, 1-12. doi: 10.1007/s11064-017-2185-0.

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Researchers cited MBF systems in 12 papers during the week of 02/27/2017

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Cao, M., Wu, Y., Ashrafi, G., McCartney, A. J., Wheeler, H., Bushong, E. A., . . . De Camilli, P. (2017). Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron, 93(4), 882-896.e885. doi:

Makinson, C. D., Tanaka, B. S., Sorokin, J. M., Wong, J. C., Christian, C. A., Goldin, A. L., . . . Huguenard, J. R. (2017). Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron. doi:

Mor, D. E. (2016). The toxic interaction of dopamine and alpha-synuclein: Implications for Parkinson’s disease. University of Pennsylvania. Retrieved from….

Patzlaff, N. E., Nemec, K. M., Malone, S. G., Li, Y., & Zhao, X. (2017). Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. Human Molecular Genetics.

Shepherd, D. (2016). Examining the effects of anti-Nogo-A immunotherapy on post-stroke neurogenesis in the adult rat. Loyola University Chicago. Retrieved from….

Shobin, E., Bowley, M. P., Estrada, L. I., Heyworth, N. C., Orczykowski, M. E., Eldridge, S. A., . . . Rosene, D. L. (2017). Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. GeroScience, 1-22. doi: 10.1007/s11357-017-9965-y.

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Researchers cited MBF systems in 14 papers between 1/20/2017 and 1/27/2017

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Doerr, J., Schwarz, M. K., Wiedermann, D., Leinhaas, A., Jakobs, A., Schloen, F., . . . Brüstle, O. (2017). Whole-brain 3D mapping of human neural transplant innervation. Nature Communications, 8, 14162. doi: 10.1038/ncomms14162

Fields, J. A., Metcalf, J., Overk, C., Adame, A., Spencer, B., Wrasidlo, W., . . . Masliah, E. (2017). The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. Journal of Neurovirology, 1-14. doi: 10.1007/s13365-016-0502-z.

Haidar, M., Guèvremont, G., Zhang, C., Bathgate, R. A. D., Timofeeva, E., Smith, C. M., & Gundlach, A. L. (2017). Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in ‘Floxed-RXFP3′ Mice Impairs Spatial Memory. Hippocampus, n/a-n/a. doi: 10.1002/hipo.22709.

Kelly, S. C., He, B., Perez, S. E., Ginsberg, S. D., Mufson, E. J., & Counts, S. E. (2017). Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease. Acta Neuropathologica Communications, 5(1), 8. doi: 10.1186/s40478-017-0411-2.

Shen, X.-L., Song, N., Du, X.-X., Li, Y., Xie, J.-X., & Jiang, H. (2017). Nesfatin-1 protects dopaminergic neurons against MPP+/MPTP-induced neurotoxicity through the C-Raf–ERK1/2-dependent anti-apoptotic pathway. Scientific Reports, 7, 40961. doi: 10.1038/srep40961

Turner, R. C., Naser, Z. J., Lucke-Wold, B. P., Logsdon, A. F., Vangilder, R. L., Matsumoto, R. R., . . . Rosen, C. L. (2017). Single low-dose lipopolysaccharide preconditioning: neuroprotective against axonal injury and modulates glial cells. [Lipopolysaccharide preconditioning, oncostatin M receptor, diffuse axonal injury, gliosis, neuroprotection]. Neuroimmunology and Neuroinflammation, 4(1), 6-15.

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Researchers cited MBF systems in 25 papers between 1/13/2017 and 1/20/2017

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Allegra, M., Spalletti, C., Vignoli, B., Azzimondi, S., Busti, I., Billuart, P., . . . Caleo, M. (2017). Pharmacological rescue of adult hippocampal neurogenesis in a mouse model of X-linked intellectual disability. Neurobiology of Disease, 100, 75-86.

Anan, J., Hijioka, M., Kurauchi, Y., Hisatsune, A., Seki, T., & Katsuki, H. (2017). Cortical hemorrhage-associated neurological deficits and tissue damage in mice are ameliorated by therapeutic treatment with nicotine. Journal of Neuroscience Research, n/a-n/a. doi: 10.1002/jnr.24016.

Ardestani, P. M., Evans, A. K., Yi, B., Nguyen, T., Coutellier, L., & Shamloo, M. (2017). Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer’s disease using a biased and selective beta-1 adrenergic receptor partial agonist. Neuropharmacology.

Estrada, L. I., Robinson, A. A., Amaral, A. C., Giannaris, E. L., Heyworth, N. C., Mortazavi, F., . . . Rosene, D. L. (2017). Evaluation of Long-Term Cryostorage of Brain Tissue Sections for Quantitative Histochemistry. Journal of Histochemistry and Cytochemistry, 0022155416686934. doi: 10.1369/0022155416686934.

Klocke, C., Allen, J. L., Sobolewski, M., Mayer-Pröschel, M., Blum, J. L., Lauterstein, D., . . . Cory-Slechta, D. A. (2017). Neuropathological Consequences of Gestational Exposure to Concentrated Ambient Fine and Ultrafine Particles in the Mouse. Toxicological Sciences. doi: 10.1093/toxsci/kfx010.

Loris, Z. B., Pieper, A. A., & Dalton Dietrich, W. (2017). The neuroprotective compound P7C3-A20 promotes neurogenesis and improves cognitive function after ischemic stroke. Experimental Neurology, 290, 63-73. doi:

Luo, L., Chen, J., Su, D., Chen, M., Luo, B., Pi, R., . . . Wang, R. (2017). L-F001, a Multifunction ROCK Inhibitor Prevents 6-OHDA Induced Cell Death Through Activating Akt/GSK-3beta and Nrf2/HO-1 Signaling Pathway in PC12 Cells and Attenuates MPTP-Induced Dopamine Neuron Toxicity in Mice. Neurochemical Research, 1-10. doi: 10.1007/s11064-016-2117-4.

Moore, B. A., Tyrrell, L. P., Pita, D., Bininda-Emonds, O. R. P., & Fernández-Juricic, E. (2017). Does retinal configuration make the head and eyes of foveate birds move? . Scientific Reports, 7, 38406. doi: 10.1038/srep38406

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Uncovering the role of microglia in fetal alcohol spectrum disorders


Representative images of Iba-1+ microglia in the postnatal day 10 rat hippocampus. Image courtesy of Anna Klintsova, PhD.

Children born with fetal alcohol spectrum disorders face a range of physical and cognitive impairments including long-term deficits in learning, behavior, and immune function. In a paper published in Neuroscience, Dr. Anna Klintsova and her lab at the University of Delaware report that activation of the brain’s immune response may contribute to some of the damage caused by fetal alcohol spectrum disorders.

In their study, the researchers used Stereo Investigator and Neurolucida to examine the hypothesis that exposure to alcohol while the brain is growing rapidly is associated with abnormal microglial activation and high levels of pro-inflammatory proteins which impair learning-related plasticity; leading to neuro-developmental and psychopathological disorders.

“My lab has been using both Stereo Investigator and Neurolucida for more than a decade in all quantitative neuroanatomical studies, including the featured one,” said Dr. Anna Klintsova. “We find this software to be user-friendly, reliable and essential for obtaining unbiased results.”

They used Stereo Investigator to quantify the number of microglia in the hippocampus of neonatal rats who were exposed to alcohol during the equivalent of the third trimester of a human pregnancy. The researchers expected to see an increased number of microglia in alcohol-exposed neonatal rats, however they found a decreased number of microglia. Despite the decrease in microglia number, there was a significant increase in pro-inflammatory proteins expressed by microglia and an increase in microglial activation.

To measure microglial activation, the researchers quantified the area of cell territory using Neurolucida. Activated microglia have a smaller cell territory than resting microglia, so the smaller cell territory found in alcohol exposed rats indicates a more active state.

This research supports the hypothesis that abnormal microglia activation plays a role in fetal alcohol spectrum disorders, however more research is needed to further understand the relationship.

Boschen, K., Ruggiero, M.J., Klintsova, A.Y., (2016) Neonatal binge alcohol exposure increases microglial activation in the developing rat hippocampus. Neuroscience 324: 355–366. DOI: 10.1016/j.neuroscience.2016.03.033


Researchers cited MBF systems in 21 papers between 12/16/2016 and 1/6/2017

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Campolo, M., Casili, G., Biundo, F., Crupi, R., Cordaro, M., Cuzzocrea, S., & esposito, e. (2016). The neuroprotective effect of dimethyl fumarate in a MPTP-mouse model of Parkinson’s disease: involvement of reactive oxygen species/nuclear factor-κB/nuclear transcription factor related to NF-E2. Antioxidants & redox signaling. doi: 10.1089/ars.2016.6800.

Charvet, C. J., Stimpson, C. D., Kim, Y. D., Raghanti, M. A., Lewandowski, A. H., Hof, P. R., . . . Sherwood, C. C. (2016). Gradients in cytoarchitectural landscapes of the isocortex: diprotodont marsupials in comparison to eutherian mammals. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24160.

Embury, C. M., Dyavarshetty, B., Lu, Y., Wiederin, J. L., Ciborowski, P., Gendelman, H. E., & Kiyota, T. (2016). Cathepsin B Improves ß-Amyloidosis and Learning and Memory in Models of Alzheimer’s Disease. Journal of Neuroimmune Pharmacology, 1-13. doi: 10.1007/s11481-016-9721-6.

Güleç, A., Bakkalbaşı, B. Ç., Cumbul, A., Uslu, Ü., Alev, B., & Yarat, A. (2017). Effects of local platelet-rich plasma injection on the rate of orthodontic tooth movement in a rat model: A histomorphometric study. American Journal of Orthodontics and Dentofacial Orthopedics, 151(1), 92-104. doi:

Hoeijmakers, L., Ruigrok, S. R., Amelianchik, A., Ivan, D., Dam, A.-M. v., Lucassen, P. J., & Korosi, A. (2017). Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer’s disease mouse model. Brain, Behavior, and Immunity. doi:

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Researchers cited MBF systems in 18 papers during the week of 12/12/2016

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Alberico, S. L., Kim, Y.-C., Lence, T., & Narayanan, N. S. (2016). Axial levodopa-induced dyskinesias and neuronal activity in the dorsal striatum. Neuroscience. doi:

Forgione, N., Chamankhah, M., & Fehlings, M. (2016). A Mouse Model of Bilateral Cervical Contusion-Compression Spinal Cord Injury. Journal of Neurotrauma. doi: 10.1089/neu.2016.4708.

Gasser, E., Johannssen, H. C., Rülicke, T., Zeilhofer, H. U., & Stoffel, M. (2016). Foxa1 is essential for development and functional integrity of the subthalamic nucleus. Scientific Reports, 6, 38611. doi: 10.1038/srep38611

Ghosh, A., Tyson, T., George, S., Hildebrandt, E. N., Steiner, J. A., Madaj, Z., . . . Brundin, P. (2016). Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson’s disease. [10.1126/scitranslmed.aag2210]. Science translational medicine, 8(368), 368ra174.

Jacinto, L. R., Mata, R., Novais, A., Marques, F., & Sousa, N. (2016). The habenula as a critical node in chronic stress-related anxiety. Experimental Neurology. doi:

Jobe, E. M., Gao, Y., Eisinger, B. E., Mladucky, J. K., Giuliani, C. C., Kelnhofer, L. E., & Zhao, X. (2016). Methyl-CpG binding protein MBD1 regulates neuronal lineage commitment through maintaining adult neural stem cell identity. [10.1523/JNEUROSCI.1075-16.2016]. The Journal of Neuroscience.

Mandolesi, G., De Vito, F., Musella, A., Gentile, A., Bullitta, S., Fresegna, D., . . . Mori, F. (2016). miR-142-3p is a key regulator of IL-1β-dependent synaptopathy in neuroinflammation. Journal of Neuroscience, 0851-0816.

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