MBF Bioscience unveils whole mouse brain automatic region delineation and cell mapping with the Allen Mouse Brain Reference Atlas

An experimental coronal mouse brain section automatically aligned to the Allen Mouse Brain Reference Atlas

Analyzing cellular populations within specific anatomies in brain images requires expertise in both neuroanatomy and cellular identification. This typically involves a scientist comparing experimental images with a reference atlas and manually delineating anatomical regions and marking cell populations within. NeuroInfo®, a revolutionary new technology from MBF Bioscience, enables researchers to automatically identify and delineate mouse brain regions based on the publicly available Allen Mouse Brain Reference Atlas.

“NeuroInfo has the potential to greatly improve our understanding of how mental disorders influence neuronal cell populations,” says Nathan O’Connor Ph.D., product manager at MBF Bioscience. “Because it makes identifying brain regions substantially faster and more accurate, researchers will be able to explore many more brain regions.”

“The Allen Mouse Brain Reference Atlas is a valuable tool to assist scientists in their research. We’re thrilled that MBF has chosen to integrate this resource into NeuroInfo,” stated Amy Bernard, Ph.D., Product Architect at the Allen Institute for Brain Science.

“Using this remarkable technology, neuroscientists will obtain more repeatable, objective analyses that have been possible to date. Thanks to the integration with the Allen Mouse Brain Reference Atlas, these analyses will be more standardized so that they can be compared across experiments and laboratories,” says Jack Glaser, President.

NeuroInfo can be used with MBF Bioscience’s slide scanning software and virtually all commercial whole slide scanners. The data from NeuroInfo seamlessly integrates with MBF Bioscience’s products including Neurolucida, Stereo Investigator, Biolucida, and BrainMaker.

The tools in NeuroInfo allow researchers to automatically delineate anatomies in the experimental specimens, and detect cells within these anatomies. NeuroInfo yields data that can be invaluable to better understand the organization and composition of the nervous system, and to further knowledge in neurogenomics, transcriptomics, proteomics, and connectomics.

The National Institute of Mental Health provides funding to support the development of NeuroInfo.

Leica Microsystems and MBF Bioscience announce a partnership in the United States to offer analysis systems for life science research

Leica and MBF partner to offer life science research solutionsLeica Microsystems’ microscopes can now fully integrate with Neurolucida and Stereo Investigator software for analyzing cells in neuroscience research.

Buffalo Grove, IL, USA.    Leica Microsystems and MBF Bioscience today announce a partnership to offer Leica Microsystems’ microscopes fully integrated with MBF’s Neurolucida and Stereo Investigator software in the United States.  This partnership gives researchers new tools to analyze tissue specimens and discover information about the brain, spinal cord, eye, and lung.

“Combining our analysis software with Leica microscopes means that researchers can get a fully integrated system for collecting accurate, reliable data from their tissue specimens,” says Jack Glaser, President of MBF Bioscience. “We are pleased to partner with Leica Microsystems to provide integrated systems. As leading companies in the fields of stereology and neuron tracing, we are proud to offer systems with such a distinguished company as Leica Microsystems.”

This tight integration allows Neurolucida and Stereo Investigator software to display the microscope image onto a computer monitor for analysis. The software automatically adjusts Leica microscope components, such as the fluorescent filters and objective lenses, based on the research task. Integration is necessary for researchers performing unbiased stereology with Stereo Investigator, which requires the software to drive the motorized stage to random locations on the tissue specimen for unbiased quantification of cell populations. Researchers using Neurolucida software for neuron reconstruction, a technique to analyze the shape and size of neurons, will save a lot of time using a fully integrated system. For example, Neurolucida will automatically move the microscope stage when a researcher reconstructs a neuron that extends beyond the field of view.

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