Researchers cited MBF systems in 8 papers during the week of 06/19/2017

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Kaur, C., Pal, I., Saini, S., Jacob, T. G., Nag, T. C., Thakar, A., . . . Roy, T. S. (2017). Comparison of unbiased stereological estimation of total number of cresyl violet stained neurons and parvalbumin positive neurons in the adult human spiral ganglion. Journal of Chemical Neuroanatomy. doi:

Mani, B. K., Osborne-Lawrence, S., Mequinion, M., Lawrence, S., Gautron, L., Andrews, Z. B., & Zigman, J. M. (2017). The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting. Molecular Metabolism. doi: 10.1016/j.molmet.2017.06.011.

Martinez, E. M., Young, A. L., Patankar, Y. R., Berwin, B. L., Wang, L., von Herrmann, K. M., . . . Havrda, M. C. (2017). Nlrp3 is required for inflammatory changes and nigral cell loss resulting from chronic intragastric rotenone exposure in mice. Toxicological Sciences.…

Po, K. K.-t., Leung, J. W.-h., Chan, J. N.-m., Fung, T. K.-h., Sánchez-Vidaña, D. I., Sin, E. L.-l., . . . Siu, A. M.-h. (2017). Protective effect of Lycium Barbarum polysaccharides on dextromethorphan-induced mood impairment and neurogenesis suppression. Brain Research Bulletin, 134, 10-17. doi:  Continue reading “Researchers cited MBF systems in 8 papers during the week of 06/19/2017” »

Researchers cited MBF systems in 25 papers between 6/10/2017 and 6/16/2017

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Arawaka, S., Sato, H., Sasaki, A., Koyama, S., & Kato, T. (2017). Mechanisms underlying extensive Ser129-phosphorylation in α-synuclein aggregates. Acta Neuropathologica Communications, 5(1), 48.

Birkl, C., Carassiti, D., Hussain, F., Langkammer, C., Enzinger, C., Fazekas, F., . . . Ropele, S. (2017). Assessment of ferritin content in multiple sclerosis brains using temperature-induced R*2 changes. Magnetic Resonance in Medicine, n/a-n/a. doi: 10.1002/mrm.26780.

Boudewyn, L. C., Sikora, J., Kuchar, L., Ledvinova, J., Grishchuk, Y., Wang, S. L., . . . Walkley, S. U. (2017). N-butyl-deoxynojirimycin delays motor deficits, cerebellar microgliosis, and Purkinje cell loss in a mouse model of mucolipidosis type IV. Neurobiology of Disease. doi:

Chaves, P. P., Valdoria, C. M., Amorim, M. C. P., & Vasconcelos, R. O. (2017). Ontogenetic development of the inner ear saccule and utricle in the Lusitanian toadfish: Potential implications for auditory sensitivity. Hearing Research. doi:

Ebenezer, G. J., Liu, Y., Judge, D. P., Cunningham, K., Truelove, S., Carter, N. D., . . . Polydefkis, M. (2017). Cutaneous nerve biomarkers in transthyretin familial amyloid polyneuropathy. Annals of Neurology, n/a-n/a. doi: 10.1002/ana.24972.

Fischer, D. L., Kemp, C. J., Cole-Strauss, A., Polinski, N. K., Paumier, K. L., Lipton, J. W., . . . Sortwell, C. E. (2017). Subthalamic Nucleus Deep Brain Stimulation Employs TrkB Signaling for Neuroprotection and Functional Restoration. The Journal of Neuroscience.

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Researchers cited MBF systems in 17 papers during the week of 05/08/2017

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Day, N. L., Carle, M. S., & Floyd, C. L. (2017). Post-injury administration of a combination of memantine and 17β-estradiol is protective in a rat model of traumatic brain injury. Neurochemistry International. doi:

El-Agnaf, O., Overk, C., Rockenstein, E., Mante, M., Florio, J., Adame, A., . . . Rissman, R. A. (2017). Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiology of Disease, 104, 85-96. doi:

Matsuda, W., Ehara, A., Nakadate, K., Yoshimoto, K., & Ueda, S. (2017). Effects of environmental enrichment on the activity of the amygdala in micrencephalic rats exposed to a novel open field. Congenital Anomalies, n/a-n/a. doi: 10.1111/cga.12228.

Musacchio, T., Rebenstorff, M., Fluri, F., Brotchie, J. M., Volkmann, J., Koprich, J. B., & Ip, C. W. (2017). STN-DBS is neuroprotective in the A53T α-synuclein Parkinson’s disease rat model. Annals of Neurology, n/a-n/a. doi: 10.1002/ana.24947.

Soares, J. I., Valente, M. C., Andrade, P. A., Maia, G. H., & Lukoyanov, N. V. (2017). Reorganization of the septohippocampal cholinergic fiber system in experimental epilepsy. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24235.

Yoshii, Y., Inoue, T., Uemura, Y., Iwasaki, Y., Yada, T., Nakabeppu, Y., & Noda, M. (2017). Complexity of Stomach–Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease Model Mice. Neurochemical Research, 1-8. doi: 10.1007/s11064-017-2281-1.  Continue reading “Researchers cited MBF systems in 17 papers during the week of 05/08/2017” »

Researchers cited MBF systems in 42 papers between 4/7/2017 and 4/21/2017

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Ay, M., Luo, J., Langley, M., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2017). Molecular Mechanisms Underlying Protective Effects of Quercetin Against Mitochondrial Dysfunction and Progressive Dopaminergic Neurodegeneration in Cell Culture and MitoPark Transgenic Mouse Models of Parkinson’s Disease. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.14033.

Carryl, H., Van Rompay, K., De Paris, K., & Burke, M. (2017). Hippocampal Neuronal Loss in Infant Macaques Orally Infected with Virulent Simian Immunodeficiency Virus (SIV). Brain Sciences, 7(4), 40.

Galinato, M. H., Lockner, J. W., Fannon-Pavlich, M. J., Sobieraj, J. C., Staples, M. C., Somkuwar, S. S., . . . Mandyam, C. D. (2017). A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse. Molecular Psychiatry. doi: 10.1038/mp.2017.46.

Gilles, Y. D., & Polston, E. K. (2017). Effects of social deprivation on social and depressive-like behaviors and the numbers of oxytocin expressing neurons in rats. Behavioural Brain Research SreeTestContent1, 328, 28-38. doi:

Hamilton, G. F., Hernandez, I. J., Krebs, C. P., Bucko, P. J., & Rhodes, J. S. (2017). Neonatal alcohol exposure reduces number of parvalbumin-positive interneurons in the medial prefrontal cortex and impairs passive avoidance acquisition in mice deficits not rescued from exercise. Neuroscience. doi:

Jinhua, H., Zhao, M., Shuangcheng, H., Yuanran, Z., Rui, N., Wei, L., . . . Jian, Y. (2017). Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway. Biochemical Pharmacology. doi:

Kafetzopoulos, V., Kokras, N., Sotiropoulos, I., Oliveira, J. F., Leite-Almeida, H., Vasalou, A., . . . Dalla, C. (2017). The nucleus reuniens: a key node in the neurocircuitry of stress and depression. Molecular Psychiatry. doi: 10.1038/mp.2017.55.

Lear, C. A., Davidson, J. O., Mackay, G. R., Drury, P. P., Galinsky, R., Quaedackers, J. S., . . . Bennet, L. (2017). Antenatal dexamethasone before asphyxia promotes cystic neural injury in preterm fetal sheep by inducing hyperglycemia. Journal of Cerebral Blood Flow and Metabolism, 0271678X17703124. doi: 10.1177/0271678×17703124.

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Researchers cited MBF systems in 27 papers between 3/20/2017 and 3/30/2017

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Abe, C., Inoue, T., Inglis, M. A., Viar, K. E., Huang, L., Ye, H., . . . Guyenet, P. G. (2017). C1 neurons mediate a stress-induced anti-inflammatory reflex in mice. Nature Neuroscience, advance online publication. doi: 10.1038/nn.4526

Caldwell, A. S. L., Edwards, M. C., Desai, R., Jimenez, M., Gilchrist, R. B., Handelsman, D. J., & Walters, K. A. (2017). Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1616467114.

Castro-Hernández, J., Adlard, P. A., & Finkelstein, D. I. (2017). Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion. Scientific Reports, 7, 44426. doi: 10.1038/srep44426.

Dawes, W. J., Zhang, X., Fancy, S. P., Rowitch, D., & Marino, S. (2017). Moderate-Grade Germinal Matrix Haemorrhage Activates Cell Division in the Neonatal Mouse Subventricular Zone. Developmental Neuroscience.

Drobyshevsky, A., & Quinlan, K. A. (2017). Spinal cord injury in hypertonic newborns after antenatal hypoxia-ischemia in a rabbit model of cerebral palsy. Experimental Neurology, 293, 13-26. doi:

El Massri, N., Lemgruber, A. P., Rowe, I. J., Moro, C., Torres, N., Reinhart, F., . . . Mitrofanis, J. (2017). Photobiomodulation-induced changes in a monkey model of Parkinson’s disease: changes in tyrosine hydroxylase cells and GDNF expression in the striatum. Experimental Brain Research, 1-14. doi: 10.1007/s00221-017-4937-0.

Hühner, L., Rilka, J., Gilsbach, R., Zhou, X., Machado, V., & Spittau, B. (2017). Interleukin-4 Protects Dopaminergic Neurons In vitro but Is Dispensable for MPTP-Induced Neurodegeneration In vivo. Frontiers in Molecular Neuroscience, 10(62). doi: 10.3389/fnmol.2017.00062.

Meng, L., Huang, T., Sun, C., Hill, D. L., & Krimm, R. (2017). BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section. Experimental Neurology, 293, 27-42. doi:

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Researchers cited MBF systems in 27 papers during the week of 03/13/2017

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Ambrosi, G., Kustrimovic, N., Siani, F., Rasini, E., Cerri, S., Ghezzi, C., . . . Blandini, F. (2017). Complex Changes in the Innate and Adaptive Immunity Accompany Progressive Degeneration of the Nigrostriatal Pathway Induced by Intrastriatal Injection of 6-Hydroxydopamine in the Rat. Neurotoxicity research, 1-11. doi: 10.1007/s12640-017-9712-2.

Chen, B. K., Madigan, N. N., Hakim, J. S., Dadsetan, M., McMahon, S. S., Yaszemski, M. J., & Windebank, A. J. (2017). GDNF Schwann cells in hydrogel scaffolds promote regional axon regeneration, remyelination and functional improvement after spinal cord transection in rats. Journal of Tissue Engineering and Regenerative Medicine, n/a-n/a. doi: 10.1002/term.2431.

Cheng, L., Lau, W. K. W., Fung, T. K. H., Lau, B. W. M., Chau, B. K. H., Liang, Y., . . . Lee, T. M. C. (2017). PM2.5 Exposure Suppresses Dendritic Maturation in Subgranular Zone in Aged Rats.  Neurotoxicity research, 1-8. doi: 10.1007/s12640-017-9710-4.

Herrera-Soto, A., Díaz-Veliz, G., Mora, S., Muñoz, P., Henny, P., Steinbusch, H. W. M., & Segura-Aguilar, J. (2017). On the Role of DT-Diaphorase Inhibition in Aminochrome-Induced Neurotoxicity In Vivo.  Neurotoxicity research, 1-7. doi: 10.1007/s12640-017-9719-8.

Kaufling, J., Girard, D., Maitre, M., Leste-Lasserre, T., & Georges, F. (2017). Species-specific diversity in the anatomical and physiological organization of the BNST-VTA pathway. European Journal of Neuroscience, n/a-n/a. doi: 10.1111/ejn.13554.

Keiner, S., Niv, F., Neumann, S., Steinbach, T., Schmeer, C., Hornung, K., . . . Redecker, C. (2017). Effect of skilled reaching training and enriched environment on generation of oligodendrocytes in the adult sensorimotor cortex and corpus callosum. BMC Neuroscience, 18(1), 31. doi: 10.1186/s12868-017-0347-2.

Mikrogeorgiou, A., Sato, Y., Kondo, T., Hattori, T., Sugiyama, Y., Ito, M., . . . Kazama, T. (2017). Dedifferentiated Fat Cells as a Novel Source for Cell Therapy to Target Neonatal Hypoxic-Ischemic Encephalopathy. Developmental Neuroscience.

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Researchers cited MBF systems in 28 papers during the week of 03/06/2017

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Akkhawattanangkul, Y., Maiti, P., Xue, Y., Aryal, D., Wetsel, W. C., Hamilton, D., . . . McDonald, M. P. (2017). Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. Genes, Brain and Behavior, n/a-n/a. doi: 10.1111/gbb.12377.

Chung, Y. C., Baek, J. Y., Kim, S. R., Ko, H. W., Bok, E., Shin, W.-H., . . . Jin, B. K. (2017). Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson/’s disease. Experimental and Molecular Medicine, 49, e298. doi: 10.1038/emm.2016.159.

Hajheidari, S., Sameni, H. R., Bandegi, A. R., & Miladi-gorji, H. (2017). Effects of prolonged abstinence from METH on the hippocampal BDNF levels, neuronal numbers and apoptosis in methamphetamine-sensitized rats. Neuroscience Letters, 645, 80-85. doi:

Krishnasamy, S., Weng, Y.-C., Thammisetty, S. S., Phaneuf, D., Lalancette-Hebert, M., & Kriz, J. (2017). Molecular imaging of nestin in neuroinflammatory conditions reveals marked signal induction in activated microglia. Journal of neuroinflammation, 14(1), 45. doi: 10.1186/s12974-017-0816-7.

Langley, M., Ghosh, A., Charli, A., Sarkar, S., Ay, M., Luo, J., . . . Kanthasamy, A. (2017). Mito-apocynin Prevents Mitochondrial Dysfunction, Microglial Activation, Oxidative Damage and Progressive Neurodegeneration in MitoPark Transgenic Mice. Antioxidants & redox signaling. doi: 10.1089/ars.2016.6905.

Leal-Campanario, R., Alarcon-Martinez, L., Rieiro, H., Martinez-Conde, S., Alarcon-Martinez, T., Zhao, X., . . . Macknik, S. L. (2017). Abnormal Capillary Vasodynamics Contribute to Ictal Neurodegeneration in Epilepsy.  Scientific Reports, 7, 43276. doi: 10.1038/srep43276

Mao, Z., Liu, C., Ji, S., Yang, Q., Ye, H., Han, H., & Xue, Z. (2017). The NLRP3 Inflammasome is Involved in the Pathogenesis of Parkinson’s Disease in Rats. Neurochemical Research, 1-12. doi: 10.1007/s11064-017-2185-0.

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Researchers cited MBF systems in 12 papers during the week of 02/27/2017

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Cao, M., Wu, Y., Ashrafi, G., McCartney, A. J., Wheeler, H., Bushong, E. A., . . . De Camilli, P. (2017). Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron, 93(4), 882-896.e885. doi:

Makinson, C. D., Tanaka, B. S., Sorokin, J. M., Wong, J. C., Christian, C. A., Goldin, A. L., . . . Huguenard, J. R. (2017). Regulation of Thalamic and Cortical Network Synchrony by Scn8a. Neuron. doi:

Mor, D. E. (2016). The toxic interaction of dopamine and alpha-synuclein: Implications for Parkinson’s disease. University of Pennsylvania. Retrieved from….

Patzlaff, N. E., Nemec, K. M., Malone, S. G., Li, Y., & Zhao, X. (2017). Fragile X related protein 1 (FXR1P) regulates proliferation of adult neural stem cells. Human Molecular Genetics.

Shepherd, D. (2016). Examining the effects of anti-Nogo-A immunotherapy on post-stroke neurogenesis in the adult rat. Loyola University Chicago. Retrieved from….

Shobin, E., Bowley, M. P., Estrada, L. I., Heyworth, N. C., Orczykowski, M. E., Eldridge, S. A., . . . Rosene, D. L. (2017). Microglia activation and phagocytosis: relationship with aging and cognitive impairment in the rhesus monkey. GeroScience, 1-22. doi: 10.1007/s11357-017-9965-y.

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Exercise changes astrocytes and eases symptoms of neurodegenerative disorders

Astrocytes (GFAP) in the dentate gyrus of a mouse hippocampus. Image courtesy of Dr. Ahmad Salehi, Stanford University. 

It is well known that physical exercise eases the symptoms of neurodegenerative disorders like Alzheimer’s disease and helps to prevent their onset. Researchers at Stanford University are working on figuring out how it happens.

In their study, published in the journal Brain Structure and Function, scientists in Dr. Ahmad Salehi’s lab examined the effects of physical exercise on astrocytes in a region of the mouse brain that is critical for cognition – the dentate gyrus of the hippocampus. Previous studies have shown that an increase in the expression of brain-derived neurotrophic factor (Bdnf) occurs in this region after exercise (Philips, Salehi et al 2014). Bdnf is a protein that supports the survival of existing neurons and encourages new growth, playing an important role in cognitive function.

While the current study reconfirms that exercise generates increased levels of Bdnf (more than a fourfold increase in exercised mice versus non-exercised mice), it also describes several new findings including increased synaptic load in the dentate gyrus, alterations in the morphology of astrocytes, and changes in the orientation of astrocytic projections toward dentate granule cells.

The authors speculate that the changes they observed may be attributed to increased expression of a receptor called TrkB, which astrocytes express in response to increases in Bdnf levels. According to the paper, TrkB binds to Bdnf, activating the mechanisms behind neuronal development.

“Our study suggests that astrocytes actively respond and could indeed mediate the positive effects of physical exercise on the central nervous system and potentially counter degenerative processes during aging and neurodegenerative disorders,” (Fahimi, et al 2016).

The researchers used Neurolucida to determine the location, the extent, and orientation of astrocytic projections, finding a significant increase in the length of astrocytic projections in exercised mice.

“Neurolucida is one of the very few systems that combines complex morphometrical quantification with beautiful display of the results,” said Dr. Salehi, Clinical Professor, Department of Psychiatry and Behavioral Sciences at Stanford Medical School.

Since astrocytes help prevent excitotoxicity in the brain by removing excess glutamate from extracellular space, the researchers speculate that the increased length of astrocytic projections they observed in exercised mice could make this process more efficient.

Differences in the orientation of astrocytic projections were also reported, with the majority of projections of exercised mice directed toward the dentate granule cell layer – a region featuring increased levels of Bdnf release and synthesis after exercise.

The number of astrocytes in the molecular layer of the dentate gyrus in exercised and non-exercised mice was quantified with Stereo Investigator, however, there was no significant difference in astrocyte populations between the two groups.

“In summary, our study suggests that astrocytes constitute an important element in mediating the positive effects of physical exercise in the dentate gyrus of the hippocampus. Furthermore, it appears that physical exercise-induced release of Bdnf by the DG leads to a significant alteration in structure and function of astrocytes in protection against glutamate toxicity during aging and a number of neurodegenerative disorders,” (Fahimi et al 2016)

Fahimi, A., Baktir, M.A., Moghadam, S., Mojabi, F.S., Sumanth, K., McNerney, M.W., Ponnusamy, R., Salehi, A. Brain Struct Funct (2016). doi:10.1007/s00429-016-1308-8

Phillips, C., Baktir, M.A., Srivatsam, M., Salehi, A. Front. Cell. Neurosci., (2014)

Researchers cited MBF systems in 14 papers between 1/20/2017 and 1/27/2017

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Doerr, J., Schwarz, M. K., Wiedermann, D., Leinhaas, A., Jakobs, A., Schloen, F., . . . Brüstle, O. (2017). Whole-brain 3D mapping of human neural transplant innervation. Nature Communications, 8, 14162. doi: 10.1038/ncomms14162

Fields, J. A., Metcalf, J., Overk, C., Adame, A., Spencer, B., Wrasidlo, W., . . . Masliah, E. (2017). The anticancer drug sunitinib promotes autophagyand protects from neurotoxicity in an HIV-1 Tat model of neurodegeneration. Journal of Neurovirology, 1-14. doi: 10.1007/s13365-016-0502-z.

Haidar, M., Guèvremont, G., Zhang, C., Bathgate, R. A. D., Timofeeva, E., Smith, C. M., & Gundlach, A. L. (2017). Relaxin-3 Inputs Target Hippocampal Interneurons and Deletion of Hilar Relaxin-3 Receptors in ‘Floxed-RXFP3′ Mice Impairs Spatial Memory. Hippocampus, n/a-n/a. doi: 10.1002/hipo.22709.

Kelly, S. C., He, B., Perez, S. E., Ginsberg, S. D., Mufson, E. J., & Counts, S. E. (2017). Locus coeruleus cellular and molecular pathology during the progression of Alzheimer’s disease. Acta Neuropathologica Communications, 5(1), 8. doi: 10.1186/s40478-017-0411-2.

Shen, X.-L., Song, N., Du, X.-X., Li, Y., Xie, J.-X., & Jiang, H. (2017). Nesfatin-1 protects dopaminergic neurons against MPP+/MPTP-induced neurotoxicity through the C-Raf–ERK1/2-dependent anti-apoptotic pathway. Scientific Reports, 7, 40961. doi: 10.1038/srep40961

Turner, R. C., Naser, Z. J., Lucke-Wold, B. P., Logsdon, A. F., Vangilder, R. L., Matsumoto, R. R., . . . Rosen, C. L. (2017). Single low-dose lipopolysaccharide preconditioning: neuroprotective against axonal injury and modulates glial cells. [Lipopolysaccharide preconditioning, oncostatin M receptor, diffuse axonal injury, gliosis, neuroprotection]. Neuroimmunology and Neuroinflammation, 4(1), 6-15.

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