The Nobel Prize in Physiology or Medicine was awarded to Drs. Thomas Südhof, James Rothman, and Randy Schekman for discovering the principles of how molecules are transported within cells and in between cells and how they are delivered to the right place at the right time. Disruptions in this precise system are implicated in numerous neurological and immunological disorders.
Dr. Sudhof uncovered how neurotransmitters are released into a synaptic cleft precisely when they need to be. His research explained the molecular machinery that responds to an influx of calcium and signals the release of neurotransmitters.