Researchers cited MBF systems in 11 papers during the week of 6/6/2016

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Aghoghovwia, B. E., & Oorschot, D. E. (2016). Absolute number of parvicellular and magnocellular neurons in the red nucleus of the rat midbrain: a stereological study. Journal of Anatomy, n/a-n/a. doi: 10.1111/joa.12495.

Mehta, P., Premkumar, B., & Morris, R. (2016). Production of high quality brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB) RNA from isolated populations of rat spinal cord motor neurons obtained by Laser Capture Microdissection (LCM). Neuroscience Letters. doi:

Rau, K. K., Hill, C. E., Harrison, B. J., Venkat, G., Koenig, H. M., Cook, S. B., . . . Petruska, J. C. (2016). Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons. Experimental Neurology. doi:

Singh-Bains, M. K., Tippett, L. J., Hogg, V. M., Synek, B. J., Roxburgh, R. H., Waldvogel, H. J., & Faull, R. L. M. (2016). Globus pallidus degeneration and clinico-pathological features of Huntington’s disease. Annals of Neurology, n/a-n/a. doi: 10.1002/ana.24694.

Sturm, E., Fellner, L., Krismer, F., Poewe, W., Wenning, G. K., & Stefanova, N. (2016). Neuroprotection by Epigenetic Modulation in a Transgenic Model of Multiple System Atrophy.. Neurotherapeutics, 1-9. doi: 10.1007/s13311-016-0447-1.

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Researchers cited MBF systems in 15 papers between 5/20/2016 and 6/3/2016

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Acabchuk, R., Briggs, D. I., Angoa-Pérez, M., Powers, M., Wolferz, R., Soloway, M., . . . Conover, J. C. (2016). Repeated mild traumatic brain injury causes focal response in lateral septum and hippocampus. Concussion. doi: 10.2217/cnc-2015-0001.

Gully, J. C., Sergeyev, V. G., Bhootada, Y., Mendez-Gomez, H., Meyers, C. A., Zolotukhin, S., . . . Gorbatyuk, O. S. (2016). Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson’s disease. Neuroscience Letters. doi:

Hendrikx, G., Vries, M. H., Bauwens, M., De Saint-Hubert, M., Wagenaar, A., Guillaume, J., . . . Mottaghy, F. M. (2016). Comparison of LDPI to SPECT perfusion imaging using 99mTc-sestamibi and 99mTc-pyrophosphate in a murine ischemic hind limb model of neovascularization. EJNMMI Research, 6(1), 1-10. doi: 10.1186/s13550-016-0199-2.

Mangus, L. M., Dorsey, J. L., Weinberg, R. L., Ebenezer, G. J., Hauer, P., Laast, V. A., & Mankowski, J. L. (2016). Tracking Epidermal Nerve Fiber Changes in Asian Macaques: Tools and Techniques for Quantitative Assessment. Toxicologic Pathology. doi: 10.1177/0192623316650286.

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Researchers cited MBF systems in 22 papers during the week of 5/9/2016

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García-Lezana, T., Oria, M., Romero-Giménez, J., Bové, J., Vila, M., Genescà, J., . . . Cordoba, J. (2016). Cerebellar neurodegeneration in a new rat model of episodic hepatic encephalopathy. Journal of Cerebral Blood Flow and Metabolism. doi: 10.1177/0271678×16649196.

Gordon, R., Singh, N., Lawana, V., Ghosh, A., Harischandra, D. S., Jin, H., . . . Kanthasamy, A. (2016). Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson’s disease. Neurobiology of Disease. doi:

Huttenrauch, M., Brausz, A., Kurdakova, A., Borgers, H., Klinker, F., Liebetanz, D., . . . Wirths, O. (2016). Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model. Transl Psychiatry, 6, e800. doi: 10.1038/tp.2016.65.

K.G, B., G, M.-N., & H, G. (2016). Early life stress accelerates behavioral and neural maturation of the hippocampus in male mice. Hormones and Behavior. doi:

Larpthaveesarp, A., Georgevits, M., Ferriero, D. M., & Gonzalez, F. F. (2016). Delayed erythropoietin therapy improves histological and behavioral outcomes after transient neonatal stroke. Neurobiology of Disease, 93, 57-63. doi:

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Researchers cited MBF systems in 10 papers during the week of 5/2/2016

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Aytan, N., Choi, J.-K., Carreras, I., Brinkmann, V., Kowall, N. W., Jenkins, B. G., & Dedeoglu, A. (2016). Fingolimod modulates multiple neuroinflammatory markers in a mouse model of Alzheimer’s disease. Scientific Reports, 6, 24939. doi: 10.1038/srep24939.

Helseth, A., Adil, S., Linabarger, M., Arehart, E., Fainberg, N., Singh, D., . . . Mikati, M. (2016). Novel Knock-in Mouse Model of Genetic Atp1a3 Dysfunction (S52. 006). Neurology, 86(16 Supplement), S52. 006.

Li, Y., Stockton, M. E., Bhuiyan, I., Eisinger, B. E., Gao, Y., Miller, J. L., . . . Zhao, X. (2016). MDM2 inhibition rescues neurogenic and cognitive deficits in a mouse model of fragile X syndrome. [10.1126/scitranslmed.aad9370]. Science translational medicine, 8(336), 336ra361-336ra361.

Lim, D. C., Brady, D. C., Soans, R., Kim, E. Y., Valverde, L., Keenan, B. T., . . . Pack, A. I. (2016). Different Cyclical Intermittent Hypoxia Severities have Different Effects on Hippocampal Microvasculature. [10.1152/japplphysiol.01040.2015]. Journal of Applied Physiology.

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Researchers cited MBF systems in 18 papers during the week of 4/25/2016

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Drzewiecki, C. M., Willing, J., & Juraska, J. M. (2016). Synaptic number changes in the medial prefrontal cortex across adolescence in male and female rats: A role for pubertal onset. Synapse, n/a-n/a. doi: 10.1002/syn.21909.

Inoue, T., Abe, C., Sung, S.-s. J., Moscalu, S., Jankowski, J., Huang, L., . . . Okusa, M. D. (2016). Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through α7nAChR+ splenocytes. The Journal of Clinical Investigation, 126(5). doi: 10.1172/jci83658.

Miller, A. N., Deal, D., Green, J., Houle, T., Brown, W., Thore, C., . . . Webb, L. X. (2016). Use of the Reamer/Irrigator/Aspirator Decreases Carotid and Cranial Embolic Events in a Canine Model. The Journal of Bone & Joint Surgery, 98(8), 658-664.

Ouda, L., Jílek, M., & Syka, J. (2016). Expression of c-Fos in rat auditory and limbic systems following 22-kHz calls. Behavioural Brain Research, 308, 196-204. doi:

Pantazopoulos, H., Wiseman, J. T., Markota, M., Ehrenfeld, L., & Berretta, S. (2016). Decreased numbers of somatostatin-expressing neurons in the amygdala of subjects with bipolar disorder or schizophrenia: Relationship to circadian rhythms. Biological Psychiatry. doi:

Scheinert, R. B., Haeri, M. H., Lehmann, M. L., & Herkenham, M. (2016). Therapeutic effects of stress-programmed lymphocytes transferred to chronically stressed mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry. doi:

Türer, A., Coşkun Türer, Ç., Durmuşlar, M. C., Balli, U., & Önger, M. E. (2016). The influence of oral administration of rosuvastatin on calvarial bone healing in rats. Journal of Cranio-Maxillofacial Surgery. doi: Continue reading “Researchers cited MBF systems in 18 papers during the week of 4/25/2016” »

Researchers cited MBF systems in 10 papers during the week of 4/18/2016

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Darkazalli, A., Ismail, A. A. O., Abad, N., Grant, S. C., & Levenson, C. W. (2016). Use of human mesenchymal stem cell treatment to prevent anhedonia in a rat model of traumatic brain injury. Restorative Neurology and Neuroscience(Preprint), 1-9.

Deep, S. N., Baitharu, I., Sharma, A., Gurjar, A. K. S., Prasad, D., & Singh, S. B. (2016). Neuroprotective Role of L-NG-Nitroarginine Methyl Ester (L-NAME) against Chronic Hypobaric Hypoxia with Crowding Stress (CHC) Induced Depression-Like Behaviour.  Plos one, 11(4), e0153371. doi: 10.1371/journal.pone.0153371.

Delbary-Gossart, S., Lee, S., Baroni, M., Lamarche, I., Arnone, M., Canolle, B., . . . Beattie, M. S. (2016). A novel inhibitor of p75-neurotrophin receptor improves functional outcomes in two models of traumatic brain injury. Brain.

Gómez-López, S., Martínez-Silva, A. V., Montiel, T., Osorio-Gómez, D., Bermúdez-Rattoni, F., Massieu, L., & Escalante-Alcalde, D. (2016). Neural ablation of the PARK10 candidate Plpp3 leads to dopaminergic transmission deficits without neurodegeneration. Scientific Reports, 6, 24028. doi: 10.1038/srep24028

Haus, D. L., López-Velázquez, L., Gold, E. M., Cunningham, K. M., Perez, H., Anderson, A. J., & Cummings, B. J. (2016). Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury. Experimental Neurology. doi:

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Iron Deficiency Worsens Fetal Alcohol Spectrum Disorders

An immunostained image of myelin basic protein in the cerebella of a mouse brain with an iron-sufficient diet compared with the brain of a mouse exposed to alcohol and fed an iron-insufficient diet. It shows the reduced cerebellar size due to the ID-alcohol combination. Green is MBP immunostain, blue is DAPI for nuclei.

An immunostained image of myelin basic protein in the cerebella of a mouse brain with an iron-sufficient diet compared with the brain of a mouse exposed to alcohol and fed an iron-insufficient diet. It shows the reduced cerebellar size due to the ID-alcohol combination. Green is MBP immunostain, blue is DAPI for nuclei. Image courtesy of Susan Smith, PhD.

If a pregnant woman drinks alcohol, she risks giving birth to a baby with physical and cognitive deficits – characteristics of fetal alcohol spectrum disorders. In a new study, researchers say that when the mother is low in iron, the consequences are even worse.

The scientists examined two groups of pregnant rats – one group was fed an iron sufficient diet while the other was fed a diet with insufficient iron levels. The offspring from both groups were exposed to alcohol from 4 to 9 days after birth – a time when their brains are going through a growth spurt and are particularly sensitive to alcohol. They were compared to offspring who received an iron-sufficient diet but were not exposed to alcohol. This growth spurt correlates to a growth spurt in humans that occurs during the third trimester of pregnancy.

The researchers used delay and trace eye blink classical conditioning methods to assess the offspring’s learning and memory. Learning impairments were reported in both alcohol-exposed groups regardless of their iron status, but more extreme impairments were seen in iron deficient rats compared to iron sufficient rats. After the behavioral tests were completed, the researchers studied the cerebellum and hippocampus – brain regions involved in learning and memory – at a cellular level.

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Researchers cited MBF systems in 20 papers during the week of 3/14/2016

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Bayliss, J. A., Lemus, M. B., Stark, R., Santos, V. V., Thompson, A., Rees, D. J., . . . Davies, J. S. (2016). Ghrelin-AMPK Signaling Mediates the Neuroprotective Effects of Calorie Restriction in Parkinson’s Disease. The Journal of Neuroscience, 36(10), 3049-3063.

Chen, X., Rivard, L., Naqvi, S., Nakada, S., Padbury, J. F., Sanchez-Esteban, J., . . . Stonestreet, B. S. (2016). Expression and localization of Inter-alpha Inhibitors in rodent brain. Neuroscience, 324, 69-81. doi:

Chou, A., Morganti, J. M., & Rosi, S. (2016). Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior. Plos one, 11(3), e0151418. doi: 10.1371/journal.pone.0151418.

Harris, N. G., Verley, D. R., Gutman, B. A., & Sutton, R. L. (2016). Bi-directional changes in fractional anisotropy after experiment TBI: Disorganization and reorganization? Neuroimage. doi:

Humann, J., Mann, B., Gao, G., Moresco, P., Ramahi, J., Loh, Lip N., . . . Tuomanen, Elaine I. (2016). Bacterial Peptidoglycan Transverses the Placenta to Induce Fetal Neuroproliferation and Aberrant Postnatal Behavior. Cell Host & Microbe, 19(3), 388-399. doi:

Mustafa, G., Hou, J., Tsuda, S., Nelson, R., Sinharoy, A., Wilkie, Z., . . . Bose, P. (2016). Trigeminal neuroplasticity underlies allodynia in a preclinical model of mild closed head traumatic brain injury (cTBI). Neuropharmacology. doi:

Noguchi, K. K., Johnson, S. A., Kristich, L. E., Martin, L. D., Dissen, G. A., Olsen, E. A., . . . Brambrink, A. M. (2016). Lithium Protects Against Anaesthesia Neurotoxicity In The Infant Primate Brain. [Article]. Scientific Reports, 6, 22427. doi: 10.1038/srep22427.

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Researchers cited MBF systems in 19 papers during the week of 2/29/2016

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Barkan, S., Roll, U., Yom-Tov, Y., Wassenaar, L. I., & Barnea, A. (2016). Possible linkage between neuronal recruitment and flight distance in migratory birds. Scientific Reports, 6, 21983. doi: 10.1038/srep21983.

Chan, E. C., Kuo, S.-M., Kong, A. M., Morrison, W. A., Dusting, G. J., Mitchell, G. M., . . . Liu, G.-S. (2016). Three Dimensional Collagen Scaffold Promotes Intrinsic Vascularisation for Tissue Engineering Applications. Plos one, 11(2), e0149799. doi: 10.1371/journal.pone.0149799.

Chen, Z.-Z., Yang, D.-D., Zhao, Z., Yan, H., Ji, J., & Sun, X.-L. (2016). Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemia. Life Sciences, 150, 8-14.

Comba, R., Gervais, N., Mumby, D., & Holahan, M. (2015). Emergence of spatial behavioral function and associated mossy fiber connectivity and c-Fos labeling patterns in the hippocampus of rats. F1000Research, 4, 396. doi: 10.12688/f1000research.6822.1.

Cope, E. C., Morris, D. R., Gower-Winter, S. D., Brownstein, N. C., & Levenson, C. W. (2016). Effect of zinc supplementation on neuronal precursor proliferation in the rat hippocampus after traumatic brain injury. Experimental Neurology, 279, 96-103. doi:

Leon, J., Sakumi, K., Castillo, E., Sheng, Z., Oka, S., & Nakabeppu, Y. (2016). 8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.Scientific Reports, 6, 22086. doi: 10.1038/srep22086

Liang, J.-q., Wang, L., He, J.-c., & Hua, X.-d. (2016). Verbascoside promotes the regeneration of tyrosine hydroxylase-immunoreactive neurons in the substantia nigra. Neural Regeneration Research, 11(1), 101.

Naaldijk, Y., Jäger, C., Fabian, C., Leovsky, C., Blüher, A., Rudolph, L., . . . Stolzing, A. (2016). Effect of systemic transplantation of bone marrow-derived mesenchymal stem cells on neuropathology markers in APP/PS1 Alzheimer mice. Neuropathology and Applied Neurobiology, n/a-n/a. doi: 10.1111/nan.12319.

Spangenberg, E. E., Lee, R. J., Najafi, A. R., Rice, R. A., Elmore, M. R. P., Blurton-Jones, M., . . . Green, K. N. (2016). Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology. Brain. doi: 10.1093/brain/aww016.

Thome, A. D., Harms, A. S., Volpicelli-Daley, L. A., & Standaert, D. G. (2016). microRNA-155 Regulates Alpha-Synuclein-Induced Inflammatory Responses in Models of Parkinson Disease. The Journal of Neuroscience, 36(8), 2383-2390.

Trouche, S., Perestenko, P. V., van de Ven, G. M., Bratley, C. T., McNamara, C. G., Campo-Urriza, N., . . . Dupret, D. (2016). Recoding a cocaine-place memory engram to a neutral engram in the hippocampus.  Nature Neuroscience, advance online publication. doi: 10.1038/nn.4250


Bajic, D. (2016). Combining Anterograde Tracing and Immunohistochemistry to Define Neuronal Synaptic Circuits.

Biggs, B. T., Tang, T., & Krimm, R. F. (2016). Insulin-Like Growth Factors Are Expressed in the Taste System, but Do Not Maintain Adult Taste Buds. PLoS ONE, 11(2), e0148315. doi: 10.1371/journal.pone.0148315.

Branchereau, P., Cattaert, D., Delpy, A., Allain, A.-E., Martin, E., & Meyrand, P. (2016). Depolarizing GABA/glycine synaptic events switch from excitation to inhibition during frequency increases. . Scientific Reports, 6, 21753. doi: 10.1038/srep21753

Ibrahim, S., Hu, W., Wang, X., Gao, X., He, C., & Chen, J. (2016). Traumatic Brain Injury Causes Aberrant Migration of Adult-Born Neurons in the Hippocampus. Scientific Reports, 6, 21793. doi: 10.1038/srep21793

Kántor, O., Mezey, S., Adeghate, J., Naumann, A., Nitschke, R., Énzsöly, A., . . . Somogyvári, Z. (2016). Calcium buffer proteins are specific markers of human retinal neurons. Cell and Tissue Research, 1-22.

Spangenberg, E. E., Lee, R. J., Najafi, A. R., Rice, R. A., Elmore, M. R. P., Blurton-Jones, M., . . . Green, K. N. (2016). Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology. Brain. doi: 10.1093/brain/aww016.

Trillaud-Doppia, E., Paradis-Isler, N., & Boehm, J. (2016). A single amino acid difference between the intracellular domains of amyloid precursor protein and amyloid-like precursor protein 2 enables induction of synaptic depression and block of long-term potentiation. Neurobiology of Disease. doi:

Wang, L., Conner, J. M., Nagahara, A. H., & Tuszynski, M. H. (2016). Rehabilitation drives enhancement of neuronal structure in functionally relevant neuronal subsets. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1514682113.

Dr. Robert Ogilvie to Receive the Henry Gray Distinguished Educator Award

Dr. Ogilvie PhotoAspiring medical doctors and life science researchers in the U.S. learn histology to understand the cellular organization of tissues and organs. In the past, microscopes were the only equipment available for viewing cells and other microscopic structures in tissue specimens. Now, more and more students are learning histology with virtual microscope slides – high-resolution digital images of tissue specimens that can be viewed on a computer over the Internet.

Dr. Robert Ogilvie has been teaching histology with virtual slides for over 15 years. He is a pioneer in the field of virtual microscopy; striving to make learning histology more active and accessible to the next generation of doctors and  researchers.

Dr. Ogilvie has won numerous teaching awards throughout his 45 year teaching career, including the most recent one – the 2016 Henry Gray Distinguished Educator Award which is the American Association of Anatomists’ highest education award. He will accept the award on Tuesday, April 5 at the 129th Annual Meeting of the American Association of Anatomists that is meeting at the same time as many other societies as a part of the Experimental Biology Meeting (EB2016) in San Diego, CA. After accepting the award he will present a lecture titled ‘On the Way to Virtual’ where he will discuss his experiences using virtual microscopy to teach histology. The talk will culminate with an example of a fully online histology course he teaches using Biolucida, Blackboard, and WebMic – a virtual microscopy program he helped develop. Enrollment doubled when the course was offered online, and it remains popular for students from a wide range of majors.

Watch a six minute video that illustrates and describes the essential components of the online histology course offered by the Department of Biological Sciences at the University of South Carolina

Watch this 3 minute video of Dr. Ogilvie teaching histology with virtual slides and Biolucida