If one area isn’t working, another part can step in. Plasticity is one of the brain’s most beautiful attributes. Recent research has documented the organ’s ability to compensate in the face of damage, and now a new study identifies a key region for compensation when the damage occurs in the hippocampus.
The region is the medial prefrontal cortex (mPFC). It’s an integral part of the hippocampal-prefrontal-amygdala circuit involved with memory formation – specifically with contextual fear memories. In their study, published last month in Proceedings of the National Academy of Sciences, researchers at the University of California, Los Angeles identify a microcircuit in the mPFC that can encode memories when the dorsal hippocampus is damaged.