Bringing Virtual Slides to the Medical Education Classroom with Biolucida Cloud 2.0

BC_liverMicroscopes and glass slides are on their way to becoming obsolete in medical and science courses. MBF Bioscience just unveiled Biolucida Cloud 2.0, software that simulates the experience of using a light microscope, complete with the ability to focus through specimens. This software enables educators to integrate virtual slides — high-resolution digital images of specimens mounted on glass slides — into their course materials and tests.

Thanks to Biolucida Cloud 2.0, educators and students are no longer bound to the traditional classroom and lab, and the limitations of glass slides are a thing of the past.

According to Nate O’Connor, Product Manager, “educators can be sure that every student sees the same images, and they can give all students experience with rare cases without putting delicate glass slides at risk.”  Students can access tissue specimens from home or the library and “it’s much easier to collaborate with study groups using a computer monitor instead of taking turns looking through oculars,” adds O’Connor.

Biolucida Cloud’s architecture is specially designed to allow many users to simultaneously access big images (with file size reaching hundreds of gigabytes) and navigate through them quickly and smoothly. Moreover, it also allows educators to use any 2D or 3D virtual slide, whether it was acquired with a slide scanner or imaging software.

Visit our website for more information, or register for our free Biolucida webinar on April 10, 2013.

Take a Look at the Latest Research Using MBF Systems (week of 3/11/13)


Our systems were mentioned in 18 published research papers last week alone.  Take a closer look at some of the research…


Upcoming Webinar: Stereology Concepts & Probe Selection

Area and Volume Estimation in Stereo InvestigatorStereology is considered the gold standard methodology for unbiased and precise quantification of microscopic biological features of tissues. Yet, researchers are often confused about how to properly design an experiment which effectively and efficiently employs stereology.  This webinar is designed to demystify the core concepts of stereology ( isotropy, systematic random sampling, tissue preparation, bias) to help participants confidently design their next experiment.

In this webinar led by Drs. Susan Tappan and Dan Peruzzi, participants will learn:

  • how to choose the correct probes for estimation of object number, length, surface  area, and regional volume.
  • how to select the most suitable type of tissue sectioning.
  • how to perform systematic sampling properly.

Go to our website to register for our free webinar “Stereology Concepts & Probe Selection” which will take place Thursday, March 28 at 12 noon US Eastern Standard Time.

You may also be interested in watching our previous webinars.

Take a Look at the Latest Research Using MBF Systems (week of 3/2/13)


Our systems were mentioned in 19 published research papers last week alone.  Take a closer look at some of the research…

 Stereo Investigator:

  • Alexander, M., Smith, A. L., Rosenkrantz, T. S., & Fitch, R. H. (2013). Therapeutic Effect of Caffeine Treatment Immediately Following Neonatal Hypoxic-Ischemic Injury on Spatial Memory in Male Rats. Brain Sciences3(1), 177-190. doi: 10.3390/brainsci3010177
  • Bauernfeind, A. L., de Sousa, A. A., Avasthi, T., Dobson, S. D., Raghanti, M. A., Lewandowski, A. H., … & Sherwood, C. C. (2013). A volumetric comparison of the insular cortex and its subregions in primates. Journal of Human Evolution. doi: 10.1016/j.jhevol.2012.12.003
  • Contet, C., Kim, A., Le, D., Iyengar, S. K., Kotzebue, R. W., Yuan, C. J., … & Mandyam, C. D. (2013). μ‐Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche. Addiction Biology. doi: 10.1111/adb.12040                                               Continue reading “Take a Look at the Latest Research Using MBF Systems (week of 3/2/13)” »

Stereology Expert Prof. Mark West Teaches Workshop in Woods Hole Next Week


Stereology has many applications from counting cells in the brains of birds at the Animal Cognition Lab at Luther College in Iowa, to estimating cell populations in rat models of dementia in Newfoundland, or counting cells in the brain stems of rats with Huntington’s disease across the ocean in the Netherlands.

Scientists around the world use stereology to study a range of different types of diseases and disorders, and are finding that this sophisticated research method is the most efficient and effective way to quantitatively analyze the size, shape, and number of objects in biological tissue.

Next week, Dr. Mark West, a professor at the University of Aarhus in Denmark, teaches a “NeuroStereology Workshop” at the Marine Biological Laboratory in Woods Hole, Massachusetts. A stereology expert and pioneer for nearly four decades, Dr. West is the most cited author of scientific papers on the application of modern stereological methods to the nervous system.

“The unique aspect of the new design-based stereology is that, unlike previously available methods, these methods involve no prerequisite information about the structural features being quantified, and emphasize the importance of estimates of total quantities such as number, length, surface, and volume,” Dr. West told us last year in an interview about his book Basic Stereology For Biologists and Neuroscientists (2012, Cold Spring Harbor Laboratory Press).

The course takes place Saturday, March 16 – Thursday, March 21 and focuses on teaching students how to design, supervise, and critically evaluate unbiased stereological studies of the nervous system.

Learn more about the workshop at

Do you use stereology in your research? We’d love to know what you’re studying. Tell us in the comments section.

To stay updated on MBF Bioscience company and customer news, “like” us on Facebook and follow us on Twitter.

Take a Look at the Latest Research Using MBF Systems (week of 2/18/13)


Our systems were mentioned in 10 published research papers last week alone.  Take a closer look at some of the research…


  • Garske, A. K., Lawyer, C. R., Peterson, B. M., & Illig, K. R. (2013). Adolescent Changes in Dopamine D1 Receptor Expression in Orbitofrontal Cortex and Piriform Cortex Accompany an Associative Learning Deficit. PLoS ONE8(2). doi: 10.1371/journal.pone.0056191
  • Négyessy, L., Pálfi, E., Ashaber, M., Palmer, C., Jákli, B., Friedman, R. M., … & Roe, A. W. (2013). Intrinsic horizontal connections process global tactile features in the primary somatosensory cortex: Neuroanatomical evidence.Journal of Comparative Neurology. doi: 10.1002/cne.23317

Continue reading “Take a Look at the Latest Research Using MBF Systems (week of 2/18/13)” »

Take a Look at the Latest Research Using MBF Systems (week of 2/11/13)


Our systems were mentioned in 21 published research papers last week alone.  Take a closer look at some of the research…


  • Abbott, S. B., DePuy, S. D., Nguyen, T., Coates, M. B., Stornetta, R. L., & Guyenet, P. G. (2013). Selective Optogenetic Activation of Rostral Ventrolateral Medullary Catecholaminergic Neurons Produces Cardiorespiratory Stimulation in Conscious Mice. The Journal of Neuroscience33(7), 3164-3177. doi: 10.1523/​JNEUROSCI.1046-12.2013
  • Barr, T. P., Albrecht, P. J., Hou, Q., Mongin, A. A., Strichartz, G. R., & Rice, F. L. (2013). Air-Stimulated ATP Release from Keratinocytes Occurs through Connexin Hemichannels. PLOS ONE8(2), e56744. doi: 10.1371/journal.pone.0056744
  • De Lorme, K. C., & Sisk, C. L. (2013). Pubertal testosterone programs context-appropriate agonistic behavior and associated neural activation patterns in male Syrian hamsters. Physiology & Behavior. doi: 10.1016/j.physbeh.2013.02.003
  • Favero, M., & Castro-Alamancos, M. A. (2013). Synaptic Cooperativity Regulates Persistent Network Activity in Neocortex. The Journal of Neuroscience33(7), 3151-3163. doi: 10.1523/​JNEUROSCI.4424-12.2013

Continue reading “Take a Look at the Latest Research Using MBF Systems (week of 2/11/13)” »

Take a Look at the Latest Research Using MBF Systems (week of 2/4/13)



Our systems were mentioned in 13 published research papers last week alone.  Take a closer look at some of the research…




  • Brumberg, C. (2012). Chia-Chien Chen, Danny Tam & Joshua. Brain Struct Funct217, 435-446. doi: 10.1007/s00429-011-0342-9
  • DeFelipe, J., López-Cruz, P. L., Benavides-Piccione, R., Bielza, C., Larrañaga, P., Anderson, S., … & Ascoli, G. A. (2013). New insights into the classification and nomenclature of cortical GABAergic interneurons. Nature Reviews Neuroscience. doi: doi:10.1038/nrn3444
  • Ibi, D., Nagai, T., Nakajima, A., Mizoguchi, H., Kawase, T., Tsuboi, D., … & Yamada, K. (2013). Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice. Glia. doi: 10.1002/glia.22461
  • Nakamoto, K. T., Mellott, J. G., Killius, J., Storey-Workley, M. E., Sowick, C. S., & Schofield, B. R. (2013). Analysis of excitatory synapses in the guinea pig inferior colliculus: a study using electron microscopy and GABA immunocytochemistry. Neuroscience. doi: 10.1016/j.neuroscience.2013.01.061
  • Szucs, P., Luz, L. L., Pinho, R., Aguiar, P., Antal, Z., Tiong, S. Y., … & Safronov, B. V. (2013). Axon diversity of lamina I local‐circuit neurons in the lumbar spinal cord. Journal of Comparative Neurology. doi: 10.1002/cne.23311
  • Villar-Cerviño, V., Molano-Mazón, M., Catchpole, T., Valdeolmillos, M., Henkemeyer, M., Martínez, L. M., … & Marín, O. (2013). Contact Repulsion Controls the Dispersion and Final Distribution of Cajal-Retzius Cells. Neuron,77(3), 457-471. doi: 10.1016/j.neuron.2012.11.023


Stereo Investigator:

  • Brenhouse, H. C., Lukkes, J. L., & Andersen, S. L. (2013). Early Life Adversity Alters the Developmental Profiles of Addiction-Related Prefrontal Cortex Circuitry. Brain Sciences3(1), 143-158. doi: 10.3390/brainsci3010143
  • Dursun, İ., Jakubowska-Doğru, E., Elibol-Can, B., van der List, D., Chapman, B., Qi, L., & Berman, R. F. (2013). Effects of early postnatal alcohol exposure on the developing retinogeniculate projections in C57BL/6 mice. Alcohol. doi: 10.1016/j.alcohol.2012.12.013
  • Jonsson, S., Wiberg, R., McGrath, A. M., Novikov, L. N., Wiberg, M., Novikova, L. N., & Kingham, P. J. (2013). Effect of Delayed Peripheral Nerve Repair on Nerve Regeneration, Schwann Cell Function and Target Muscle Recovery.PLOS ONE8(2), e56484. doi:10.1371/journal.pone.0056484
  • Raman, L., Kong, X., & Kernie, S. G. (2013). Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice. Neuroscience Letters. doi: 10.1016/j.neulet.2013.01.045
  • Roth, T. C., Chevalier, D. M., LaDage, L. D., & Pravosudov, V. V. (2013). Variation in hippocampal glial cell numbers in food‐caching birds from different climates. Developmental Neurobiology. doi: 10.1002/dneu.22074
  • Wang, S., Bates, J., Li, X., Schanz, S., Chandler-Militello, D., Levine, C., … & Goldman, S. A. (2013). Human iPSC-Derived Oligodendrocyte Progenitor Cells Can Myelinate and Rescue a Mouse Model of Congenital Hypomyelination. Cell Stem Cell12(2), 252-264. doi: 10.1016/j.stem.2012.12.002


Neuroinformatica (now replaced by Biolucida Cloud):

  • Bonser, S. P., de Permentier, P., Green, J., Velan, G. M., Adam, P., & Kumar, R. K. (2013). Engaging students by emphasising botanical concepts over techniques: innovative practical exercises using virtual microscopy. Journal of Biological Education, (ahead-of-print), 1-5. doi: 10.1080/00219266.2013.764344

Take a Look at the Latest Research Using MBF Systems (week of 1/28/13)



Our systems were mentioned in 13 published research papers last week alone.  Take a closer look at some of the research…




  • Akyüz, N., Rost, S., Mehanna, A., Bian, S., Loers, G., Oezen, I., … & Schachner, M. (2013). Dermatan 4- O-sulfotransferase1 ablation accelerates peripheral nerve regeneration. Experimental Neurology. doi: 10.1016/j.expneurol.2013.01.025
  • Carmel, J. B., Kimura, H., Berrol, L. J., & Martin, J. H. (2013). Motor cortex electrical stimulation promotes axon outgrowth to brain stem and spinal targets that control the forelimb impaired by unilateral corticospinal injury. European Journal of Neuroscience. doi: 10.1111/ejn.12119
  • Cisbani, G., Freeman, T. B., Soulet, D., Saint-Pierre, M., Gagnon, D., Parent, M., … & Cicchetti, F. (2013). Striatal allografts in patients with Huntington’s disease: impact of diminished astrocytes and vascularization on graft viability.Brain. doi: 10.1093/brain/aws359
  • Cullen, C. L., Burne, T. H., Lavidis, N. A., & Moritz, K. M. (2013). Low Dose Prenatal Ethanol Exposure Induces Anxiety-Like Behaviour and Alters Dendritic Morphology in the Basolateral Amygdala of Rat Offspring. PLOS ONE8(1), e54924. doi:10.1371/journal.pone.0054924
  • Hughes, D. I., Boyle, K. A., Kinnon, C. M., Bilsland, C., Quayle, J. A., Callister, R. J., & Graham, B. A. (2013). HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus. Neuroscience. doi: 10.1016/j.neuroscience.2013.01.028

Stereo Investigator:

  • Carmel, J. B., Kimura, H., Berrol, L. J., & Martin, J. H. (2013). Motor cortex electrical stimulation promotes axon outgrowth to brain stem and spinal targets that control the forelimb impaired by unilateral corticospinal injury. European Journal of Neurosciencedoi: 10.1111/ejn.12119
  • Chen, C. D., Sloane, J. A., Li, H., Aytan, N., Giannaris, E. L., Zeldich, E., … & Abraham, C. R. (2013). The Antiaging Protein Klotho Enhances Oligodendrocyte Maturation and Myelination of the CNS. The Journal of Neuroscience33(5), 1927-1939. doi: 10.1523/​JNEUROSCI.2080-12.2013
  • Gould, K. L., Gilbertson, K. E., Hrvol, A. J., Nelson, J. C., Seyfer, A. L., Brantner, R. M., & Kamil, A. C. (2013). Differences in Relative Hippocampus Volume and Number of Hippocampus Neurons among Five Corvid SpeciesBrain, Behavior and Evolution81(1), 56-70.
  • Gyengesi, E., Andrews, Z. B., Paxinos, G., & Zaborszky, L. (2013). Distribution of secretagogin-containing neurons in the basal forebrain of mice, with special reference to the cholinergic corticopetal system. Brain Research Bulletin. doi: 10.1016/j.brainresbull.2013.01.009
  • He, Z., Ferguson, S. A., Cui, L., Greenfield Jr, L. J., & Paule, M. G. (2013). Role of Neural Stem Cell Activity in Postweaning Development of the Sexually Dimorphic Nucleus of the Preoptic Area in Rats. PLOS ONE8(1), e54927. doi:10.1371/journal.pone.0054927
  • Inan, M., Blázquez-Llorca, L., Merchán-Pérez, A., Anderson, S. A., DeFelipe, J., & Yuste, R. (2013). Dense and Overlapping Innervation of Pyramidal Neurons by Chandelier Cells. The Journal of Neuroscience33(5), 1907-1914. doi: 10.1523/​JNEUROSCI.4049-12.2013
  • Karasinska, J. M., de Haan, W., Franciosi, S., Ruddle, P., Fan, J., Kruit, J. K., … & Hayden, M. R. (2013). ABCA1 influences neuroinflammation and neuronal death. Neurobiology of Disease. doi: 10.1016/j.nbd.2013.01.018
  • Morales-Medina, J. C., Juarez, I., Venancio-García, E., Cabrera, S. N., Menard, C., Yu, W., … & Quirion, R. (2013). Impaired structural hippocampal plasticity is associated with emotional and memory deficits in the olfactory bulbectomized rat. Neuroscience. doi: 10.1016/j.neuroscience.2013.01.037
  • Wang, X., Zielinski, M. C., Misawa, R., Wen, P., Wang, T. Y., Wang, C. Z., … & Hara, M. (2013). Quantitative Analysis of Pancreatic Polypeptide Cell Distribution in the Human Pancreas. PLOS ONE8(1), e55501. doi:10.1371/journal.pone.0055501


Meet the Team: Mark Barton, Director of Sales and Marketing

Mark Barton

Name: Mark Barton

Position: Director of Sales and Marketing

How long have you been working at MBF Bioscience?: 7.5 years

What do you do?: My responsibilities are primarily to manage all of our sales and marketing efforts. I work together with every department, and every day is something different.  I work with customers to help them make the most of their research budgets when they need new equipment for their lab; I work with our software development team to help decide what new features we want to add to our products; I work with our marketing team to help find new ways for our customers to learn about our products and services; I work with our operations team to make sure new orders are processed, delivered and installed on time, and I’m here to support our sales team and make sure they have all of the most up-to-date information. I also work with the management team to plan for the future and make sure we’re all on the same page. I learn something new every day.

What are you working on right now? This past year we implemented a new CRM (customer relationship management) system and phase II will be starting in 2013 so we are planning for that.  We also updated our website in 2012 and continue to add new content. We’re always looking for new products to integrate with our software and constantly testing them to make sure they meet our expectations. We’ll be adding some new hardware to our list of supported products and have some new reseller agreements so we can offer these to our customers as complete turn-key solutions.

What are some of the highlights MBF is working on for 2013? The Neuroscience Conference is the biggest event of the year for Sales and Marketing and we invested in a new booth design in 2012.  We were very pleased with how well it helped us communicate with our customers at the 2012 meeting in New Orleans and now it’s time to plan for San Diego. Two products we released in the last two years, Biolucida Cloud and WormLab, have both been very well received and we look forward to making these even better in 2013.

What new things has the company been involved with lately? We opened an office in Brazil (MBF Bioscience – South America). Dr. Jose Maldonado worked with us for several years here in Vermont and moved to Brazil to help us support our customers in South America, Mexico and also Africa. In terms of our new products, we have some exciting things on the horizon: this year we plan to attend a trade show for researchers that work with C. elegans to show our new WormLab software. Also, our development team is putting a lot of time and energy into Biolucida Cloud right now and it really shows.  We’re very excited about all of the feedback we have been receiving from our customers. Our new Biolucida Cloud product manager is very focused on helping us launch this exciting new technology.
How do you spend your free time? I love to be active so I spend a lot of time outdoors with my family. In the warmer weather I run, hike, kayak, and go mountain biking, and in the cooler weather I go cross-country skiing with my wife, or alpine skiing or snowboarding with my daughters. My wife and I like to stay fit. We have practiced martial arts together for the last 13 years; we ran our first Spartan Beast obstacle course race at the Killington Ski Resort in September (14 miles, 6,000 feet of vertical climbing, and 30 obstacles to challenge us), and in  December, we dressed in Santa Claus suits (along with 2,000 other “Santas”) and ran a 5k in Burlington to raise money for a summer camp for children with cancer.  It was a lot of fun and a great cause.
What was the last vacation you took? This past April I went to Sanibel-Captiva islands in Florida with my family and we made a quick visit to some theme parks along the way. Lots of fun in the sun and relaxing on the beach.

To learn more about the MBF Bioscience team, “like” us on Facebook and follow us on Twitter.